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Entry version 57 (11 Dec 2019)
Sequence version 1 (18 May 2010)
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Protein

Multidrug resistance protein MdtC

Gene

yegO

Organism
Erwinia amylovora (strain CFBP1430)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransportUniRule annotationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multidrug resistance protein MdtCUniRule annotationSAAS annotation
Alternative name(s):
Multidrug transporter MdtCUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:yegOImported
Synonyms:mdtCUniRule annotation
Ordered Locus Names:EAMY_2264Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiErwinia amylovora (strain CFBP1430)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri665029 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeErwinia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001841 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei336 – 353HelicalUniRule annotationAdd BLAST18
Transmembranei360 – 384HelicalUniRule annotationAdd BLAST25
Transmembranei431 – 451HelicalUniRule annotationAdd BLAST21
Transmembranei463 – 490HelicalUniRule annotationAdd BLAST28
Transmembranei526 – 545HelicalUniRule annotationAdd BLAST20
Transmembranei853 – 871HelicalUniRule annotationAdd BLAST19
Transmembranei904 – 929HelicalUniRule annotationAdd BLAST26
Transmembranei949 – 970HelicalUniRule annotationAdd BLAST22
Transmembranei982 – 1008HelicalUniRule annotationAdd BLAST27

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneUniRule annotationSAAS annotation, Cell membrane, Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtC forms a heteromultimer with MdtB.

UniRule annotationSAAS annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
665029.EAMY_2264

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
D4HWP9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105BZS Bacteria
COG0841 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000158127

KEGG Orthology (KO)

More...
KOi
K07789

Identification of Orthologs from Complete Genome Data

More...
OMAi
AMDRSPV

Database of Orthologous Groups

More...
OrthoDBi
145346at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.2090.10, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_01424 MdtC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R
IPR023931 Multidrug-R_MdtC

The PANTHER Classification System

More...
PANTHERi
PTHR32063 PTHR32063, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00873 ACR_tran, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00702 ACRIFLAVINRP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82714 SSF82714, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D4HWP9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFLSLFIYR PVATSLLTLA LVLSGLLGFR MLPVASLPQM DFPVIVVSAS
60 70 80 90 100
LPGASPETMA SSVATPLERA LGRIAGVSEM TSSSSLGSTE VVLMFDFDRD
110 120 130 140 150
INGAARDVQG AINAAQSLLP SGMPRRPSYR KVNPSDAPIM IMTLSSDTFS
160 170 180 190 200
PGQLYDYAST QLAQRLSQID GVGDVTIGGS SLPAVRVDLN PQALFNQGVS
210 220 230 240 250
LDAVRTTIAN ANVRRPQGAI DDRQQRWWLK TNDELHTAAE YRPLVIRYHQ
260 270 280 290 300
GAAVRLQDVA TVTDSVENVR NAGMSNARPA VLVVIRKSPQ ANVIDTIDRI
310 320 330 340 350
RDEVPQLRKT IPAAIQLEIA QDSSATIRAS LHEVEQSLAV SVGLVVLVVF
360 370 380 390 400
AFLRSGRATL IPAVAVPVSL IGTFAAMYLC GFSLNNLSLM ALTVASGFVV
410 420 430 440 450
DDAIVVLENI SRHVEAGLKP LQAALLGGRE VGFTVVSMSV SLIAVFIPLL
460 470 480 490 500
MQGGIIGRFF REFAITLSVS IAISLVISLT LTPVMCARLL RSSAPRQQPR
510 520 530 540 550
RRGFGRMLLV VQQGYGRALH RVLDHARWAL LVFVASLGLT VYLFISMPKT
560 570 580 590 600
FMPEQDTGRL MGFIQADQST SFQAMRSKVE HFMRVVHADP AVESVVGFTG
610 620 630 640 650
GWETNSGAMF IALKPLSTRG DNAQQVIARL RSKLAKEAGA TLWLRAVQDI
660 670 680 690 700
RIGARQSDGG YQYSLLSDSL DDLRQWQPKI RRAFASLPEL VDVNSDQQDK
710 720 730 740 750
GAEMALTYDR TRMARLGIDV ADVNGLLNNA FGQRQISTIY QPLNQYQVVM
760 770 780 790 800
GVDARYAQDI NALNQMYVTN HQGQPIPLSS FASWQPANAP LSVEHEGLSA
810 820 830 840 850
VSTLSFNLPE GVSLSQAAAA IDRSVIALGM PSSVRGSFSG TAAVFEQTQS
860 870 880 890 900
SQLWLILAAI ATVYIVLGML YESYVHPLTI LSTLPSAGMG ALLALKLFNT
910 920 930 940 950
PFSLIALIGI LLLIGIVKKN AIMMVDFALQ AQRQDGMPVR EAIFQASLLR
960 970 980 990 1000
FRPIIMTTLA AMLGALPLVL SSGDGAELRQ PLGITIVGGL VVSQLLTLFT
1010 1020
TPVVYLYMDK LRRKPRWRPV PAQS
Length:1,024
Mass (Da):110,892
Last modified:May 18, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i324369485B6AF4DA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FN434113 Genomic DNA Translation: CBA21381.1

NCBI Reference Sequences

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RefSeqi
WP_004158348.1, NC_013961.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CBA21381; CBA21381; EAMY_2264

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8914524

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
eam:EAMY_2264

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|665029.3.peg.2173

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN434113 Genomic DNA Translation: CBA21381.1
RefSeqiWP_004158348.1, NC_013961.1

3D structure databases

SMRiD4HWP9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi665029.EAMY_2264

Genome annotation databases

EnsemblBacteriaiCBA21381; CBA21381; EAMY_2264
GeneIDi8914524
KEGGieam:EAMY_2264
PATRICifig|665029.3.peg.2173

Phylogenomic databases

eggNOGiENOG4105BZS Bacteria
COG0841 LUCA
HOGENOMiHOG000158127
KOiK07789
OMAiAMDRSPV
OrthoDBi145346at2

Family and domain databases

Gene3Di3.30.2090.10, 2 hits
HAMAPiMF_01424 MdtC, 1 hit
InterProiView protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R
IPR023931 Multidrug-R_MdtC
PANTHERiPTHR32063 PTHR32063, 1 hit
PfamiView protein in Pfam
PF00873 ACR_tran, 1 hit
PRINTSiPR00702 ACRIFLAVINRP
SUPFAMiSSF82714 SSF82714, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD4HWP9_ERWAC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4HWP9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 18, 2010
Last sequence update: May 18, 2010
Last modified: December 11, 2019
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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