Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein translocase subunit SecA

Gene

secA

Organism
Propionibacterium acnes (strain SK137)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 107ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, TranslocationUniRule annotation, Transport
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotationImported
Ordered Locus Names:HMPREF0675_4372Imported
OrganismiPropionibacterium acnes (strain SK137)Imported
Taxonomic identifieri553199 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesPropionibacteriaceaeCutibacterium
Proteomesi
  • UP000008987 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation
  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, CytoplasmUniRule annotation, Membrane

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 614SECA_MOTOR_DEADInterPro annotationAdd BLAST614

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili719 – 739Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMiHOG000218168
KOiK03070
OMAiFEYDEVM

Family and domain databases

HAMAPiMF_01382 SecA, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000185 SecA
IPR020937 SecA_CS
IPR011115 SecA_DEAD
IPR014018 SecA_motor_DEAD
IPR011130 SecA_preprotein_X-link_dom
IPR011116 SecA_Wing/Scaffold
IPR036266 SecA_Wing/Scaffold_sf
IPR036670 SecA_X-link_sf
PANTHERiPTHR30612 PTHR30612, 2 hits
PfamiView protein in Pfam
PF07517 SecA_DEAD, 1 hit
PF01043 SecA_PP_bind, 1 hit
PF07516 SecA_SW, 1 hit
PRINTSiPR00906 SECA
SMARTiView protein in SMART
SM00957 SecA_DEAD, 1 hit
SM00958 SecA_PP_bind, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
SSF81767 SSF81767, 1 hit
SSF81886 SSF81886, 1 hit
TIGRFAMsiTIGR00963 secA, 1 hit
PROSITEiView protein in PROSITE
PS01312 SECA, 1 hit
PS51196 SECA_MOTOR_DEAD, 1 hit

Sequencei

Sequence statusi: Complete.

D4HEB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLMDRVLHA GEGKIIRRLN RIVGQVNSIE EDYVAMDDDE LAGQTADFRQ
60 70 80 90 100
RLDNGESLDR LLPEAFATVR EASKRVLGKR HFDVQIMGGA ALHQCNIAEM
110 120 130 140 150
KTGEGKTLVG LLPAYLEGLL GEGVHIVTVN DYLARVQSEQ MGRVHRFLGL
160 170 180 190 200
SISAILSDMP PMARKEAYKA DVTYGTNNEF GFDYLRDNMA SSLSECVQRG
210 220 230 240 250
HHYAIVDEVD SILVDEARTP LIISGPAEEN KQWYPEFAKI VSRLERDVDY
260 270 280 290 300
EVDEKKRTVS VLGHGITVVE ERLGIENLYE SANTPLIGYL NNAIKAKELF
310 320 330 340 350
HRDKDYVVVG GEVLIVDEHT GRTLAGRRYN EGLHQALEAK EHVEIKDEYQ
360 370 380 390 400
TLATITLQNY FRMYDKLAGM TGTAKTEESE FQKIYGLGVI PIPTNRPMIR
410 420 430 440 450
KDQKDLIYRT EDAKFDAIIA DVVERHEAGQ PILIGTASVA KSELLSEKLR
460 470 480 490 500
RAGVPHKVLN AKHHESEAAI VALAGRKGAV TVSTNMAGRG TDIILGGNPE
510 520 530 540 550
FLTELDLREK GLDPLEDQDA YQTAWNNTLA KYEEQSQAEH NEVEGLGGLY
560 570 580 590 600
VIGSERHESR RIDNQLRGRS GRQGDPGESR FYLSLQDELM RLFKPEVIDR
610 620 630 640 650
AMVTLKMPED MPIESKWVSR QIESAQKQVE AQNFEMRKNV LKYDDVMNRQ
660 670 680 690 700
RHVIYGDRRK VLEGADVEAE LRATTDRVVE AGVRKYAEGY SEDWDLDAMW
710 720 730 740 750
NEIGTVYPVG LDLDEYADCQ DVEELIEDFK ADAQEAYDRR ESELGEATMR
760 770 780 790 800
QLEREVLLTV LDRKWREHLY EMDYLREGIG LRAMAQRDPL VEYQREGGDM
810 820 830 840 850
FNSMMDSFKE EVVGFLFNLE IETGPQVGLV TDDGGNPVTA DSVLPKGNRP
860 870 880 890 900
RRALTYSAPD EQGEAETTSE GGQKPRGEGN RAARRSAASK KPKNRRNKKR

R
Length:901
Mass (Da):101,748
Last modified:May 18, 2010 - v1
Checksum:i9E022C42FACAF9CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001977 Genomic DNA Translation: ADE00710.1

Genome annotation databases

EnsemblBacteriaiADE00710; ADE00710; HMPREF0675_4372
KEGGipak:HMPREF0675_4372

Similar proteinsi

Entry informationi

Entry nameiD4HEB5_PROAS
AccessioniPrimary (citable) accession number: D4HEB5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 18, 2010
Last sequence update: May 18, 2010
Last modified: April 25, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health