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Protein

Phosphocarrier protein HPr

Gene

ptsH1

Organism
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain (By similarity). Is involved in fructose transport.By similarity1 Publication

Miscellaneous

PTS-type transport systems are very rare in archaea.

Activity regulationi

Phosphorylation on Ser-47 inhibits the phosphoryl transfer from enzyme I to HPr.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei14Pros-phosphohistidine intermediatePROSITE-ProRule annotation1

GO - Biological processi

Keywordsi

Biological processPhosphotransferase system, Sugar transport, Transport

Protein family/group databases

TCDBi8.A.8.1.4 the phosphotransferase system hpr (hpr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphocarrier protein HPr
Gene namesi
Name:ptsH1
Ordered Locus Names:HVO_1497
ORF Names:C498_11246
OrganismiHaloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Taxonomic identifieri309800 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHaloferacalesHaloferacaceaeHaloferax
Proteomesi
  • UP000011532 Componenti: Unassembled WGS sequence
  • UP000008243 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004289861 – 89Phosphocarrier protein HPrAdd BLAST89

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47Phosphoserine; by HPrK/PPROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

Expression is highly up-regulated in presence of fructose.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi309800.HVO_1497

Structurei

3D structure databases

SMRiD4GYE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 89HPrPROSITE-ProRule annotationAdd BLAST89

Sequence similaritiesi

Belongs to the HPr family.Curated

Phylogenomic databases

eggNOGiarCOG04543 Archaea
COG1925 LUCA
HOGENOMiHOG000278398
KOiK11189
OMAiPEDGLHA
OrthoDBiPOG093Z0KWC

Family and domain databases

CDDicd00367 PTS-HPr_like, 1 hit
Gene3Di3.30.1340.10, 1 hit
InterProiView protein in InterPro
IPR000032 HPr-like
IPR035895 HPr-like_sf
IPR001020 PTS_HPr_His_P_site
PfamiView protein in Pfam
PF00381 PTS-HPr, 1 hit
PRINTSiPR00107 PHOSPHOCPHPR
SUPFAMiSSF55594 SSF55594, 1 hit
TIGRFAMsiTIGR01003 PTS_HPr_family, 1 hit
PROSITEiView protein in PROSITE
PS51350 PTS_HPR_DOM, 1 hit
PS00369 PTS_HPR_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

D4GYE3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERTVTVVPE DGLHARPASK FVETANKFDA DVQLGRADED DLVPAASMLA
60 70 80
VTGLGVGHDE SVRLVAEGDD AEAALDALED ILSTPEAKQ
Length:89
Mass (Da):9,359
Last modified:May 18, 2010 - v1
Checksum:i7A0B355161D7117E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001956 Genomic DNA Translation: ADE03675.1
AOHU01000090 Genomic DNA Translation: ELY28265.1
RefSeqiWP_004043438.1, NZ_AOHU01000090.1

Genome annotation databases

EnsemblBacteriaiADE03675; ADE03675; HVO_1497
ELY28265; ELY28265; C498_11246
GeneIDi8925514
KEGGihvo:HVO_1497
PATRICifig|309800.29.peg.2143

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001956 Genomic DNA Translation: ADE03675.1
AOHU01000090 Genomic DNA Translation: ELY28265.1
RefSeqiWP_004043438.1, NZ_AOHU01000090.1

3D structure databases

SMRiD4GYE3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi309800.HVO_1497

Protein family/group databases

TCDBi8.A.8.1.4 the phosphotransferase system hpr (hpr) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADE03675; ADE03675; HVO_1497
ELY28265; ELY28265; C498_11246
GeneIDi8925514
KEGGihvo:HVO_1497
PATRICifig|309800.29.peg.2143

Phylogenomic databases

eggNOGiarCOG04543 Archaea
COG1925 LUCA
HOGENOMiHOG000278398
KOiK11189
OMAiPEDGLHA
OrthoDBiPOG093Z0KWC

Family and domain databases

CDDicd00367 PTS-HPr_like, 1 hit
Gene3Di3.30.1340.10, 1 hit
InterProiView protein in InterPro
IPR000032 HPr-like
IPR035895 HPr-like_sf
IPR001020 PTS_HPr_His_P_site
PfamiView protein in Pfam
PF00381 PTS-HPr, 1 hit
PRINTSiPR00107 PHOSPHOCPHPR
SUPFAMiSSF55594 SSF55594, 1 hit
TIGRFAMsiTIGR01003 PTS_HPr_family, 1 hit
PROSITEiView protein in PROSITE
PS51350 PTS_HPR_DOM, 1 hit
PS00369 PTS_HPR_HIS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPTHP_HALVD
AccessioniPrimary (citable) accession number: D4GYE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 14, 2014
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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