We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - D4GXZ3 (PMD_HALVD)
Protein
Phosphomevalonate decarboxylase
Gene
mvaD
Organism
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Status
Functioni
Catalyzes the decarboxylation of mevalonate 5-phosphate (MVAP) to isopentenyl phosphate (IP). Functions in an alternate mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
1 PublicationCatalytic activityi
- EC:4.1.1.991 Publication
Activity regulationi
Is strongly inhibited by 6-fluoromevalonate monophosphate but shows negligible inhibition by 6-fluoromevalonate diphosphate (a potent inhibitor of the classical mevalonate pathway).1 Publication
Kineticsi
kcat is 3.5 sec(-1).
- KM=159 µM for (R,S)-5-phosphomevalonate1 Publication
- KM=75 µM for (R)-5-phosphomevalonate1 Publication
- KM=289 µM for ATP1 Publication
- Vmax=5.6 µmol/min/mg enzyme1 Publication
pH dependencei
Optimum pH is about 7.5.1 Publication
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- carboxy-lyase activity Source: InterPro
GO - Biological processi
- isoprenoid biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | Lyase |
Biological process | Isoprene biosynthesis, Lipid biosynthesis, Lipid metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 4.1.1.99, 29377 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphomevalonate decarboxylase (EC:4.1.1.991 Publication)Short name: PMD Alternative name(s): Mevalonate monophosphate decarboxylase |
Gene namesi | Name:mvaD Ordered Locus Names:HVO_1412 ORF Names:C498_11676 |
Organismi | Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) |
Taxonomic identifieri | 309800 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Stenosarchaea group › Halobacteria › Haloferacales › Haloferacaceae › Haloferax › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000429253 | 1 – 324 | Phosphomevalonate decarboxylaseAdd BLAST | 324 |
Family & Domainsi
Sequence similaritiesi
Belongs to the phosphomevalonate decarboxylase family.Curated
Phylogenomic databases
eggNOGi | arCOG02937, Archaea |
HOGENOMi | CLU_040369_0_0_2 |
OMAi | LTLHAMM |
OrthoDBi | 50204at2157 |
Family and domain databases
Gene3Di | 3.30.230.10, 1 hit 3.30.70.890, 1 hit |
InterProi | View protein in InterPro IPR036554, GHMP_kinase_C_sf IPR006204, GHMP_kinase_N_dom IPR005935, Mev_decarb IPR041431, Mvd1_C IPR020568, Ribosomal_S5_D2-typ_fold IPR014721, Ribosomal_S5_D2-typ_fold_subgr |
Pfami | View protein in Pfam PF00288, GHMP_kinases_N, 1 hit PF18376, MDD_C, 1 hit |
PIRSFi | PIRSF015950, Mev_P_decrbx, 1 hit |
SUPFAMi | SSF54211, SSF54211, 1 hit SSF55060, SSF55060, 1 hit |
i Sequence
Sequence statusi: Complete.
D4GXZ3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKATAKAHPI QGLVKYHGMR DTERRMPYHD SISVCTAPSH TQTTVEFRPD
60 70 80 90 100
ADEDVYVIGG EEVEGRGAER IQAVVDRVRE LAGFDHRVRL ESENSFPSNI
110 120 130 140 150
GFGSSASGFA AAAMALAEAA DLDMTRPEVS TIARRGSASA ARAVTGAFSH
160 170 180 190 200
LYSGMNDTDC RSERIETDLE DDLRIVAAHV PAYKETEQAH AEAADSHMFQ
210 220 230 240 250
ARMAHIHAQI DDMRDALYDG DFDAAFELAE HDSLSLAATT MTGPAGWVYW
260 270 280 290 300
QPRTIAVFNA VRKLRNEEDV PVYFSTDTGA SVYINTTEEH VDRVEEAVAD
310 320
CGVETDVWGV GGPAEVLDES EALF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001956 Genomic DNA Translation: ADE02509.1 AOHU01000090 Genomic DNA Translation: ELY28351.1 |
RefSeqi | WP_004043526.1, NZ_AOHU01000090.1 |
Genome annotation databases
EnsemblBacteriai | ADE02509; ADE02509; HVO_1412 ELY28351; ELY28351; C498_11676 |
GeneIDi | 8926402 |
KEGGi | hvo:HVO_1412 |
PATRICi | fig|309800.29.peg.2226 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001956 Genomic DNA Translation: ADE02509.1 AOHU01000090 Genomic DNA Translation: ELY28351.1 |
RefSeqi | WP_004043526.1, NZ_AOHU01000090.1 |
3D structure databases
SMRi | D4GXZ3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 309800.C498_11676 |
Genome annotation databases
EnsemblBacteriai | ADE02509; ADE02509; HVO_1412 ELY28351; ELY28351; C498_11676 |
GeneIDi | 8926402 |
KEGGi | hvo:HVO_1412 |
PATRICi | fig|309800.29.peg.2226 |
Phylogenomic databases
eggNOGi | arCOG02937, Archaea |
HOGENOMi | CLU_040369_0_0_2 |
OMAi | LTLHAMM |
OrthoDBi | 50204at2157 |
Enzyme and pathway databases
BRENDAi | 4.1.1.99, 29377 |
Family and domain databases
Gene3Di | 3.30.230.10, 1 hit 3.30.70.890, 1 hit |
InterProi | View protein in InterPro IPR036554, GHMP_kinase_C_sf IPR006204, GHMP_kinase_N_dom IPR005935, Mev_decarb IPR041431, Mvd1_C IPR020568, Ribosomal_S5_D2-typ_fold IPR014721, Ribosomal_S5_D2-typ_fold_subgr |
Pfami | View protein in Pfam PF00288, GHMP_kinases_N, 1 hit PF18376, MDD_C, 1 hit |
PIRSFi | PIRSF015950, Mev_P_decrbx, 1 hit |
SUPFAMi | SSF54211, SSF54211, 1 hit SSF55060, SSF55060, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PMD_HALVD | |
Accessioni | D4GXZ3Primary (citable) accession number: D4GXZ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 14, 2014 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 23, 2022 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families