Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Trichophyton verrucosum (strain HKI 0517)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei266PROSITE-ProRule annotation1
Active sitei458PROSITE-ProRule annotation1
Active sitei520PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERitriru-q5j6j0 Carboxypeptidase_S10
MEROPSiS10.001

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
ORF Names:TRV_08055
OrganismiTrichophyton verrucosum (strain HKI 0517)
Taxonomic identifieri663202 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeTrichophyton
Proteomesi
  • UP000008383 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000040748818 – 124By similarityAdd BLAST107
ChainiPRO_0000407489125 – 543Carboxypeptidase Y homolog AAdd BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi179 ↔ 419By similarity
Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi313 ↔ 327By similarity
Disulfide bondi337 ↔ 360By similarity
Disulfide bondi344 ↔ 353By similarity
Disulfide bondi382 ↔ 389By similarity
Glycosylationi509N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi663202.XP_003017935.1

Structurei

3D structure databases

SMRiD4DLI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
KOiK13289
OrthoDBiEOG092C1EU7

Family and domain databases

Gene3Di3.40.50.1820, 2 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D4DLI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLTTGLLA TAALAAAQEQ HVLQAEDGHG QAPQRDASIF DETLQKFQSS
60 70 80 90 100
LEDGISHFWS EMKTNFKDYL PLISLPKKHT RRPDSEWDHV VRGADIESVW
110 120 130 140 150
VQGADGEKRR EIDGKLHNYD LRVKAVDPSK LGVDPGVKQY SGYLDDNDAD
160 170 180 190 200
KHLFYWFFES RNDPKNDPVV LWLNGGPGCS SLTGLFLELG PATIDKNLKV
210 220 230 240 250
VSNPYSWNSN ASVIFLDQPV NVGFSYSGSS VSDTVAAGKD VYALLTLFFK
260 270 280 290 300
QFPEYASQDF HISGESYAGH YIPVFAAEIL SHKNTNINLK SALIGNGLTD
310 320 330 340 350
PLTQYPQYRP MACGEGGYPA VLDQGTCRSM DNSLERCLSL IETCYSSESA
360 370 380 390 400
WVCVPAAMYC NSAILAPYQQ TGMNPYDVRT KCEDMASLCY PQLNAITKWL
410 420 430 440 450
NQESVMQALG VEVQSYESCN SGINRDFLFH GDWMKPYHRL VPSVLEKIPV
460 470 480 490 500
LIYAGDADFI CNWLGNLAWT DALEWPGHKK FAEAKLEDLK IVNNKDKGKK
510 520 530 540
IGQVKSSGNF TFMRIFGAGH MVPLNQPEAS LEFFNRWLGG EWH
Length:543
Mass (Da):60,657
Last modified:May 18, 2010 - v1
Checksum:i8CFE0E24E4B01FA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACYE01000509 Genomic DNA Translation: EFE37290.1
RefSeqiXP_003017935.1, XM_003017889.1

Genome annotation databases

EnsemblFungiiEFE37290; EFE37290; TRV_08055
GeneIDi9579811
KEGGitve:TRV_08055

Similar proteinsi

Entry informationi

Entry nameiCBPYA_TRIVH
AccessioniPrimary (citable) accession number: D4DLI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 18, 2010
Last modified: February 28, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health