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Protein

L-lactate dehydrogenase

Gene

lldD

Organism
Citrobacter youngae ATCC 29220
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.UniRule annotationSAAS annotation

Cofactori

FMNUniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei24SubstrateUniRule annotation1
Binding sitei106FMNUniRule annotation1
Binding sitei127FMNUniRule annotation1
Binding sitei129SubstrateUniRule annotation1
Binding sitei155FMNUniRule annotation1
Binding sitei164SubstrateUniRule annotation1
Binding sitei251FMNUniRule annotation1
Active sitei275Proton acceptorUniRule annotation1
Binding sitei278SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi306 – 330FMNUniRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
LigandFlavoprotein, FMNUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotationSAAS annotation (EC:1.1.-.-UniRule annotationSAAS annotation)
Gene namesi
Name:lldDUniRule annotation
ORF Names:CIT292_10400Imported
OrganismiCitrobacter youngae ATCC 29220Imported
Taxonomic identifieri500640 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeCitrobacterCitrobacter freundii complex
Proteomesi
  • UP000003880 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell inner membrane SAAS annotation; Peripheral membrane protein SAAS annotation
  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneSAAS annotation, Cell membrane, Membrane

Interactioni

Protein-protein interaction databases

STRINGi500640.CIT292_10400

Structurei

3D structure databases

ProteinModelPortaliD4BIN3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 380FMN hydroxy acid dehydrogenaseInterPro annotationAdd BLAST380

Sequence similaritiesi

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DMF Bacteria
COG1304 LUCA

Family and domain databases

CDDicd02809 alpha_hydroxyacid_oxid_FMN, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01559 L_lact_dehydr, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR012133 Alpha-hydoxy_acid_DH_FMN
IPR000262 FMN-dep_DH
IPR037396 FMN_HAD
IPR008259 FMN_hydac_DH_AS
IPR020920 LldD
PfamiView protein in Pfam
PF01070 FMN_dh, 1 hit
PIRSFiPIRSF000138 Al-hdrx_acd_dh, 1 hit
PROSITEiView protein in PROSITE
PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit
PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

D4BIN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIISAASDYR AAAQRILPPF LFHYIDGGAY AERTLRRNVE DLSEVALRQR
60 70 80 90 100
VLKNMSDLSL ETKLFNETLS MPVALAPVGL CGMYARRGEV QAAAAADAKG
110 120 130 140 150
IPFTLSTVSV CPIEEVAPTI KRPMWFQLYV LRDRGFMRNA LERAKVAGCS
160 170 180 190 200
TLVFTVDMPT PGARYRDAHS GMSGPNAALR RYWQAVTHPQ WAWDVGLHGR
210 220 230 240 250
PHDLGNISTY LGKPTGLEDY IGWLANNFDP SISWKDLEWI REFWDGPMVI
260 270 280 290 300
KGILDPEDAR DAVRFGADGI VVSNHGGRQL DGVLSSARAL PAIADAVKGD
310 320 330 340 350
ITILADSGIR NGLDVVRMIA LGADSVLLGR AYLYALATHG QAGVANLLNL
360 370 380 390 400
IEKEMKVAMT LTGAKSISEI SRDSLVQELG KSLPAALAPL AQGSAGGRCR

DDLQAATL
Length:408
Mass (Da):44,185
Last modified:May 18, 2010 - v1
Checksum:i80245D8D18504A07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABWL02000023 Genomic DNA Translation: EFE06277.1
RefSeqiWP_006687600.1, NZ_GG730302.1

Genome annotation databases

EnsemblBacteriaiEFE06277; EFE06277; CIT292_10400

Similar proteinsi

Entry informationi

Entry nameiD4BIN3_9ENTR
AccessioniPrimary (citable) accession number: D4BIN3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 18, 2010
Last sequence update: May 18, 2010
Last modified: March 28, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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