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Entry version 57 (12 Aug 2020)
Sequence version 1 (18 May 2010)
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Protein

Nonribosomal peptide synthase sidC

Gene

sidC

Organism
Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonribosomal peptide synthase; part of the siderophore biosynthetic pathway (PubMed:26960149). Arthroderma benhamiae produces 2 types of extracellular siderophores, ferrichrome C and ferricrocin (PubMed:26960149). The biosynthesis of these siderophores depends on the hydroxylation of ornithine to N5-hydroxyornithine, catalyzed by the monooxygenase sidA (PubMed:26960149). The structure of ferricrocin differs from ferrichrome C only by a serine for alanine substitution and the assembly of both siderophores is suggested to be performed by the nonribosomal peptide synthase (NRPS) sidC (PubMed:26960149).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Siderophore biosynthesis

This protein is involved in Siderophore biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Siderophore biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nonribosomal peptide synthase sidC1 Publication (EC:6.3.2.-1 Publication)
Short name:
NPRS sidC1 Publication
Alternative name(s):
Siderophore peptide synthetase C1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sidC1 Publication
ORF Names:ARB_07686
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri663331 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeTrichophyton
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008866 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004443791 – 5087Nonribosomal peptide synthase sidCAdd BLAST5087

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei705O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1777O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2339O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3424O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3980O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei4530O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is under the control of the iron acquisition regulator hapX (PubMed:26960149).1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
63400.XP_003013966.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D4AU56

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini671 – 744Carrier 1PROSITE-ProRule annotationAdd BLAST74
Domaini1740 – 1817Carrier 2PROSITE-ProRule annotationAdd BLAST78
Domaini2302 – 2378Carrier 3PROSITE-ProRule annotationAdd BLAST77
Domaini3387 – 3464Carrier 4PROSITE-ProRule annotationAdd BLAST78
Domaini3943 – 4019Carrier 5PROSITE-ProRule annotationAdd BLAST77
Domaini4496 – 4569Carrier 6PROSITE-ProRule annotationAdd BLAST74

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni165 – 563Adenylation 1Sequence analysisAdd BLAST399
Regioni782 – 1112Condensation 1Sequence analysisAdd BLAST331
Regioni1217 – 1611Adenylation 2Sequence analysisAdd BLAST395
Regioni1855 – 2272Condensation 2Sequence analysisAdd BLAST418
Regioni2419 – 2831Condensation 3Sequence analysisAdd BLAST413
Regioni2860 – 3258Adenylation 3Sequence analysisAdd BLAST399
Regioni3506 – 3910Condensation 4Sequence analysisAdd BLAST405
Regioni4051 – 4416Condensation 5Sequence analysisAdd BLAST366
Regioni4610 – 4913Condensation 6Sequence analysisAdd BLAST304

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module (By similarity). Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product (By similarity). Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme (By similarity). Occasionally, methyltransferase domains (responsible for amino acid methylation) are present within the NRP synthetase (By similarity). SidC has the following architecture: A-T-C-A-T-C-T-C-A-T-C-T-C-T-C.Sequence analysisBy similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1178, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000092_2_0_1

KEGG Orthology (KO)

More...
KOi
K22148

Identification of Orthologs from Complete Genome Data

More...
OMAi
GPSETTN

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 6 hits
3.30.559.10, 5 hits
3.40.50.12780, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 3 hits
PF13193, AMP-binding_C, 1 hit
PF00668, Condensation, 6 hits
PF00550, PP-binding, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823, PKS_PP, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 6 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733, AA-adenyl-dom, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 1 hit
PS50075, CARRIER, 6 hits
PS00012, PHOSPHOPANTETHEINE, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D4AU56-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSFLCDRYT QFPSLNYGAE DVPSQASATW ELDNVTDLNR LILAWASILS
60 70 80 90 100
RLSEEESPVI QIDGAAARIH LESGRIESVQ IEKSGNSGSR TAILTSDTPI
110 120 130 140 150
TSERCQLEIR YTPHQLHGSI TSRGCTSVRY LDQLARNLES LLREPLPLSI
160 170 180 190 200
VNPTPLILPG PRLFHEMVRH TGNEPAISFL NESGEVEDLS YEMLHSLSEQ
210 220 230 240 250
LASHLVHILA SLPPPGQHGK IIPVLLPQSL DLYVAWLAIL KAGAAVCPLN
260 270 280 290 300
LDTPSERLNF IVGDVDARVV VTNEGLTSAF QNIETSITIV KMEEIKTFAP
310 320 330 340 350
GCLSSVDVCN EDLAYVMYTS GSTGLPKGVG ISHQAAVQAL LAHDEIIPGF
360 370 380 390 400
RRFLQFAAPT FDVSVFEIFF PLFRGVTLVG CNRRLMLNDL PGIINQLNID
410 420 430 440 450
AAELTPTVCG ELLQSRDAVP CLKLLLTIGE MLTRHVVDEF GSSKDRPGLL
460 470 480 490 500
HGMYGPTEAT IHCTAVSSVR AGSLVGNIGT PFKTVSAFII SMDHIVGQEP
510 520 530 540 550
VILPVGHVGE LVVGGPQLAR YYLNRPTENR NAFIDSKTYG RLYRTGDKAR
560 570 580 590 600
LHPNGELQCM GRISTGQVKL RGQRIELGEI ENVLLKNQYV RNVAACVIQG
610 620 630 640 650
ALVAFLSADV AHCTSRDLQL TCRRSLPKFM IPGNFVILNK LPRLPSGKID
660 670 680 690 700
RKGLEAEYIL SKGVDQTDLA EPAGDIEQKI SVSLNLLLES SLTPTASLAS
710 720 730 740 750
AGLDSLRAIH LASSLRKEGV FLNALDILEA DSIRKMAALV LKSQPEVTVI
760 770 780 790 800
PTESEPLKMW NTIIQQGHEM LKLTENLQQP TDIIPCSPIQ TGMLLETKLN
810 820 830 840 850
PKAYFNSVEL QFDRGISLED VKSAFLSTAL QNEVLRSGFI EIDFPGFPYA
860 870 880 890 900
QVVWESLHPD QIIESKIFDH NLELQNQWDI LHPLRVQLCV IDGQPKALVH
910 920 930 940 950
IHHSLYDGWS WDQIMRDLVS ALENKQLTQR PQYRLFTLFH INNHSSEIRE
960 970 980 990 1000
QALNYWRSHL QGSTPCLWPN FQDRSDLPKV TQVVERQFNV DIDQLDSFVR
1010 1020 1030 1040 1050
DFRISRQTIF QAAIGYLLSA YNGTSDIILG NVSAGRTLPI DGIESIVGPC
1060 1070 1080 1090 1100
ISTLPLRLNL QKARTVRDLL AILHGLNRKS LVHGFVPLRD VKQVSGINTA
1110 1120 1130 1140 1150
DQLFDTLFVW QDNFTTVCGP IAQVTSRDFL EFTLTTELGI QDGKIWAKAT
1160 1170 1180 1190 1200
FEESILPESH VVIFLKQIES IAMTFLESAD RLLEDIPFHL PESLLSMENN
1210 1220 1230 1240 1250
FPPPLKSVPG LSDSVEELAK TDSERIAVEF LDSLDPETGD RAIKTLTYSE
1260 1270 1280 1290 1300
LDAQSNKLAG QLRNLGVVEG NLVAICLEKS LELYISILAV IKAGAGYVPI
1310 1320 1330 1340 1350
TPQTPIMRMK HIIQQASCRI CIADSEIQAE LSDVPNTTAM LAKPQILVEN
1360 1370 1380 1390 1400
ALYEFPKAPG SCPAYAVFTS GTTGTPKGVL ISRFNLESNI AVLSALYPDF
1410 1420 1430 1440 1450
PESRLLQACS HAFDVSVFEI FFAWSRGMTL CSAKNDVLFR DIELAIRKMR
1460 1470 1480 1490 1500
ITHLSMTPTV AALVRANNVP LVKFLVTAGE ALTPKVRMDW AGKGLWQGYG
1510 1520 1530 1540 1550
PSETTNICTV KPNICMSHFI SNIGRPLPNT SVFVLAEGER FSLVPRGAVG
1560 1570 1580 1590 1600
ELCFGGDQVG IGYLNMEDLT RQKFLIHEAY GRIYKSGDYG RLLPDGSIAF
1610 1620 1630 1640 1650
VGRRDDLVKI RGQRIELGEI TSVLMTHENV KDCATIVCDS NNGDSGDSKQ
1660 1670 1680 1690 1700
LISFWVPDNI NIDGLGQHEN SHIFQQLFDY IGDHLPSYMI PSFLIPISHI
1710 1720 1730 1740 1750
PMTTIGRKID KEALKYMYLS ANPTLLDVYS RGKEEEHTQE NLTDNEAKVA
1760 1770 1780 1790 1800
GLVAQVTGVS TKEIGRHTSF YRLGFDSVIA IALSRELKLA GFGQIDISVI
1810 1820 1830 1840 1850
MKNDSIARLT RKISQSIEAQ MPSLESIPTF DHLFSRELIR KIKDEASSHG
1860 1870 1880 1890 1900
VNVTKILPCT SLQEGMLSGI STGNDASYYN HLVFEINRNI ELLKTAWMKM
1910 1920 1930 1940 1950
VARHDILRTW FRQTDDARFP FVQVVLERLD IAWQSIECPI ADAPSTLEKS
1960 1970 1980 1990 2000
KLAVAVKEGP HSLYSFTVLQ CVDSPKVFLL LSIHHALYDG EAMEVLLQEV
2010 2020 2030 2040 2050
QECLLEHQLP PVVPFDLYLH EMIKVNSDST DQFWSNYLKD FTPTLFTSPS
2060 2070 2080 2090 2100
SLVKGSPKMS RSTSHIPSSS FTEVCNACKS SSVTTLSLLQ AAWSRLICLL
2110 2120 2130 2140 2150
SGSPDICFGD VVNCRSIPID GAQRIVGPCF NTLPVRTSLN GNMTNIDLMR
2160 2170 2180 2190 2200
NLQSNRAATL PYQLSSMRRI QSRFSQRGQR IFDSLLLLQG RPLQLNESLW
2210 2220 2230 2240 2250
RMVSENGVMD FPIIFEIIPH PESDSLQFIF HFDEGLVPTT DIDTITACYH
2260 2270 2280 2290 2300
AILNHTLRFP EARVMDFSLV ESDGQVSGGL SVFRKLGEAN GDHKSNGYGK
2310 2320 2330 2340 2350
SEEWSAESLE IRNLLSAMSK IDKKRINMDT TIFELGLDSI NAIQIAGHFR
2360 2370 2380 2390 2400
KVGYEISAAD ILEGPSIREI ASVLQGSKSS PCVGLALHNF DFDSFQSLHL
2410 2420 2430 2440 2450
PSICDKLGLL ESSVEAIRPC TTPQAGMLAS FINSEGLLYF NSFTLKSPTP
2460 2470 2480 2490 2500
LNLIALRFVW ESVMERNEML RTGFCEVKDD IFPFAMVTYR PGIIELPWNE
2510 2520 2530 2540 2550
CLSPSKRMSD ARHEQHLNGK SILNQLHRPP WFLTVKPCSD STLMQLSAHH
2560 2570 2580 2590 2600
ALYDAHSMNL ILSEVINVYN GSTLPPAIPV SSVLGFIVEK FQSPESESYW
2610 2620 2630 2640 2650
SEVGPSFSAT KFPDMNPLHA KVNDTRFLSR DCSFTMEKLQ KGCRELGVTL
2660 2670 2680 2690 2700
QAVGQAAWSR ILSSYVGESN VTYGLVLSGR DISEQAQDTA FPCLTTVPAH
2710 2720 2730 2740 2750
QNVEATNREL LQQIMKSNAM AVKYQFTSLT KIQRLSKADS PLFDTLFVFQ
2760 2770 2780 2790 2800
KLASTDKQQP LWDVVEESSQ TEYSVSLELI PSSDTLKLAL TYQNHILPDG
2810 2820 2830 2840 2850
QASLLLDELD WLLTHILQYP DSTSSSLDTA SRSIVSVLPR KDSKIDCPTQ
2860 2870 2880 2890 2900
LLHEFVEVGA TRHPSRVALE FAERINGKLI TQSWTYKDLD EQGNRYANLL
2910 2920 2930 2940 2950
HHLGVKQGTL VGVSFQKCPE AYFSILGVLK VGCAFLAIDP SAPIARKQFI
2960 2970 2980 2990 3000
LDDSKADILM CGMEQQDELK SLTGIRLVPV NEEGLLDGVN STPPTLSFPL
3010 3020 3030 3040 3050
HGDATCYCLY TSGSTGTPKG CEITHDNAVQ AMLSFQRLFG GHWDESSRWF
3060 3070 3080 3090 3100
QFASFHFDVS VLEQYWTWSV GICLTSCPRD TLFEDFAGTL RDLSITHIDL
3110 3120 3130 3140 3150
TPSLAQLIQP EDVPSLCRGV FITGGEKLKQ EILEQWGPHE VIYNGYGPTE
3160 3170 3180 3190 3200
VTIGCTMLPR VTSSDKPTNI GPQFDNVSGY VFKQGTNTPV LRGGIGELCV
3210 3220 3230 3240 3250
SGPLVGKGYL NRPQLTAEKF QYIETYGERV YRTGDLVRMM HDESFCFLGR
3260 3270 3280 3290 3300
IDDQVKLRGQ RLEINEINHV IKNSTEEVGD VVTMVLKHPT ATKEQIVSFT
3310 3320 3330 3340 3350
TVVTSASTAA CPEVDFSPEA GRVLEAIRSE CRSHLPGYMI PTHIIPLTRF
3360 3370 3380 3390 3400
PLSSNNKIDN GQLRGIFASM LLSEMQALSS HEQESPTEDT DTIRKIIPIL
3410 3420 3430 3440 3450
SRFTKVEEKT ISSSSNIFEL GLDSILVISF SRALREAGCP AAHPSVVMKC
3460 3470 3480 3490 3500
STLSLLAKAV ESPDNNVEGE RRQYEDAKQK IAAFAHMHMS HLANELEVAP
3510 3520 3530 3540 3550
QDIEAITPCT SLQDGMLYQC LRNESHPYLT SFTFQLAPHT DIPMLKEAWK
3560 3570 3580 3590 3600
RAQVSFQLLR TKFPLTDDGY ALVVLKEAAL PWFEFAISKD DELESTAESY
3610 3620 3630 3640 3650
FKEWNLGFNN FMGRVWEIGI ISSPKRRWMC LNIFHGLYDG ISLPIILDAV
3660 3670 3680 3690 3700
KHVYNGGQMP RSMPFTEVLP LGPLRTVPAA KSFWAKHLEN LSQTTIPRRS
3710 3720 3730 3740 3750
LPEPGSRTST IRIEGFHCIE ETRRSLNVTE KAMFHACWVY TFERYFNYIP
3760 3770 3780 3790 3800
TMGIVVSGRS FDSEDADVAV GPLFNTIPCN IPKFSFSTFS ELIQACHDYS
3810 3820 3830 3840 3850
VSALPFQHTP LRSIMKWIGR SSQRPLFDVL FVFQKQENIT SQSGESLWEP
3860 3870 3880 3890 3900
VASFTEADYP LALEVQSQGS GSFQVTAACQ GDILTSDGIS DLLEQFRLSL
3910 3920 3930 3940 3950
RSLVEEPFSN LSFSGNSTSL EASSKQIANK VIGGPSPNVT TSFQWSQAAS
3960 3970 3980 3990 4000
LLRQEIAKLA NLDVSEINED SSVLEVGLDS IDAIKLSSRL KRDHIDLSVG
4010 4020 4030 4040 4050
NIMRNRTIRT MMAEVTVNGS ATKADLTYLK SLESQLRRSL EEDGKDLGDI
4060 4070 4080 4090 4100
EHIYPATPLQ EGMINEMLSS DGLHYFNHDI LQISEDVDVT MLKNAWETIA
4110 4120 4130 4140 4150
KRHPILRTSF ATVSDPNLPF SYAQLIHKSS IKIDWDIVDI AENSIESILQ
4160 4170 4180 4190 4200
EERARALSLV MSKPLFNLRL IRDGAKLLLI LSLPHAMYDG WSLTLLHQDV
4210 4220 4230 4240 4250
ASAYSGQFSA RPSYQHVLED IISSSRDEGL QFWKGVLSDA EPSIFPPQPG
4260 4270 4280 4290 4300
AGDQGALVHR DETASDIPLS HVLNFCKAHG VTAQALGLTC WTIVLASYLG
4310 4320 4330 4340 4350
QLDVLFGTVM LGRDTEEASK VAFPTMNTVA VRGILHGSVS EMLEYVQRNL
4360 4370 4380 4390 4400
GNMLAHQHYP LRKIKSMMGV GNKDLFDTLF IYQKSPSSQE GQDKPLYKSI
4410 4420 4430 4440 4450
NSSSSVEYSI CVELEAIDDS AVWRVACKDT ILGKKDTSQL VLQLLQVFKT
4460 4470 4480 4490 4500
IIQSPEIPTA GFVEVRERPT LDSVTQNGGS LPDGPGGIAI EPVVWSLLEE
4510 4520 4530 4540 4550
RIRDTLSLVA AVPKEEITRN TTIFHFGIDS ISAIKVSSLL RRQSVLISVR
4560 4570 4580 4590 4600
DILRAETVGK MAEIVNSARE KKPTTATSRE KLLSLQTLKN SNIDLQLRKY
4610 4620 4630 4640 4650
GMKREDVEVF LPATAGQVYM LETWKNSHGK LFFPDFFYRV TGRITQSQLD
4660 4670 4680 4690 4700
NAWKVMTAKL PILRTTILSI GDTGMPYVLA ELKQVSNPII WRSDLRVKSN
4710 4720 4730 4740 4750
RRHVAARQGS GLVYLYASQT ETETLLMLHI HHALYDAVAL QHLINILESL
4760 4770 4780 4790 4800
FQDVSTPVNT PVDIAEFIQY GKAMSSEAQQ EAFWKGYLGN DITPVAKKGS
4810 4820 4830 4840 4850
GPVMDVQAGA GKYQPGLLDN TDWLNKICQA EGLSVQAVFL AAYSKVHVRE
4860 4870 4880 4890 4900
FHVRGADLTV GVYLANRSHD LVGLPELVAP TLNIVPLRIQ DPGSRSVFEL
4910 4920 4930 4940 4950
ARIIQSDLHE IGSAENCTVS LAQIAEWTGI RLDTTVNFIK LPEVAAQVST
4960 4970 4980 4990 5000
ATSGAPQLVQ VTEEEVLEWL SKESCNSNGS EQVDAAAKGS SSKLWLEEML
5010 5020 5030 5040 5050
GIESGVGLEN AGDVYKVSPP GSQLSQDSPE KQEANNKPSP QPSVDIEAAV
5060 5070 5080
RNNTLDVGVF GPSSDKALGV LDGVRRELLA LQTSSAR
Length:5,087
Mass (Da):564,032
Last modified:May 18, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B065B8C2B4C9ABD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
ABSU01000010 Genomic DNA Translation: EFE33326.1

NCBI Reference Sequences

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RefSeqi
XP_003013966.1, XM_003013920.1

Genome annotation databases

Ensembl fungal genome annotation project

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EnsemblFungii
EFE33326; EFE33326; ARB_07686

Database of genes from NCBI RefSeq genomes

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GeneIDi
9521384

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
abe:ARB_07686

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABSU01000010 Genomic DNA Translation: EFE33326.1
RefSeqiXP_003013966.1, XM_003013920.1

3D structure databases

SMRiD4AU56
ModBaseiSearch...

Protein-protein interaction databases

STRINGi63400.XP_003013966.1

Genome annotation databases

EnsemblFungiiEFE33326; EFE33326; ARB_07686
GeneIDi9521384
KEGGiabe:ARB_07686

Phylogenomic databases

eggNOGiKOG1178, Eukaryota
HOGENOMiCLU_000092_2_0_1
KOiK22148
OMAiGPSETTN

Family and domain databases

Gene3Di1.10.1200.10, 6 hits
3.30.559.10, 5 hits
3.40.50.12780, 3 hits
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501, AMP-binding, 3 hits
PF13193, AMP-binding_C, 1 hit
PF00668, Condensation, 6 hits
PF00550, PP-binding, 6 hits
SMARTiView protein in SMART
SM00823, PKS_PP, 5 hits
SUPFAMiSSF47336, SSF47336, 6 hits
TIGRFAMsiTIGR01733, AA-adenyl-dom, 2 hits
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 1 hit
PS50075, CARRIER, 6 hits
PS00012, PHOSPHOPANTETHEINE, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIDC_ARTBC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4AU56
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2018
Last sequence update: May 18, 2010
Last modified: August 12, 2020
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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