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UniProtKB - D4ANG0 (SED2_ARTBC)
Protein
Probable tripeptidyl-peptidase SED2
Gene
SED2
Organism
Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Status
Functioni
Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.
By similarityCatalytic activityi
- Release of an N-terminal tripeptide from a polypeptide. EC:3.4.14.10
Cofactori
Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 286 | Charge relay systemBy similarity | 1 | |
Active sitei | 290 | Charge relay systemBy similarity | 1 | |
Active sitei | 501 | Charge relay systemBy similarity | 1 | |
Metal bindingi | 543 | CalciumBy similarity | 1 | |
Metal bindingi | 544 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 576 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 578 | CalciumBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- serine-type endopeptidase activity Source: InterPro
- tripeptidyl-peptidase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Biological process | Virulence |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:SED2 ORF Names:ARB_05765 |
Organismi | Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes) |
Taxonomic identifieri | 663331 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › Arthrodermataceae › Trichophyton › |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- extracellular space 1 Publication
Extracellular region or secreted
- extracellular space Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
PropeptideiPRO_0000397829 | 17 – 203 | Removed in mature formBy similarityAdd BLAST | 187 | |
ChainiPRO_0000397830 | 204 – 596 | Probable tripeptidyl-peptidase SED2Add BLAST | 393 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 265 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 403 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 572 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, ZymogenProteomic databases
PRIDEi | D4ANG0 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 210 – 596 | Peptidase S53Add BLAST | 387 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QR6D, Eukaryota |
HOGENOMi | CLU_013783_3_0_1 |
OMAi | CDMIGQL |
Family and domain databases
CDDi | cd04056, Peptidases_S53, 1 hit cd11377, Pro-peptidase_S53, 1 hit |
Gene3Di | 3.40.50.200, 1 hit |
InterProi | View protein in InterPro IPR000209, Peptidase_S8/S53_dom IPR036852, Peptidase_S8/S53_dom_sf IPR023828, Peptidase_S8_Ser-AS IPR015366, S53_propep IPR030400, Sedolisin_dom |
Pfami | View protein in Pfam PF00082, Peptidase_S8, 1 hit PF09286, Pro-kuma_activ, 1 hit |
SMARTi | View protein in SMART SM00944, Pro-kuma_activ, 1 hit |
SUPFAMi | SSF52743, SSF52743, 1 hit |
PROSITEi | View protein in PROSITE PS51695, SEDOLISIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
D4ANG0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLLKFVCLL ASVAAAKPTP GASHKVIEHL DFVPEGWQMV GAADPAAIID
60 70 80 90 100
FWLAIERENP EKLYDTIYDV STPGRAQYGK HLKREELDDL LRPRAETSES
110 120 130 140 150
IINWLTNGGV NPQHIRDEGD WVRFSTNVKT AETLMNTRFN VFKDNLNSVS
160 170 180 190 200
KIRTLEYSVP VAISAHVQMI QPTTLFGRQK PQNSLILNPL TKDLESMSVE
210 220 230 240 250
EFAASQCRSL VTTACLRELY GLGDRVTQAR DDNRIGVSGF LEEYAQYRDL
260 270 280 290 300
ELFLSRFEPS AKGFNFSEGL IAGGKNTQGG PGSSTEANLD MQYVVGLSHK
310 320 330 340 350
AKVTYYSTAG RGPLIPDLSQ PSQASNNNEP YLEQLRYLVK LPKNQLPSVL
360 370 380 390 400
TTSYGDTEQS LPASYTKATC DLFAQLGTMG VSVIFSSGDT GPGSSCQTND
410 420 430 440 450
GKNATRFNPI YPASCPFVTS IGGTVGTGPE RAVSFSSGGF SDRFPRPQYQ
460 470 480 490 500
DNAVKDYLKI LGNQWSGLFD PNGRAFPDIA AQGSNYAVYD KGRMTGVSGT
510 520 530 540 550
SASAPAMAAI IAQLNDFRLA KGSPVLGFLN PWIYSKGFSG FTDIVDGGSR
560 570 580 590
GCTGYDIYSG LKAKKVPYAS WNATKGWDPV TGFGTPNFQA LTKVLP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | ABSU01000003 Genomic DNA Translation: EFE35721.1 |
RefSeqi | XP_003016366.1, XM_003016320.1 |
Genome annotation databases
EnsemblFungii | EFE35721; EFE35721; ARB_05765 |
GeneIDi | 9521849 |
KEGGi | abe:ARB_05765 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | ABSU01000003 Genomic DNA Translation: EFE35721.1 |
RefSeqi | XP_003016366.1, XM_003016320.1 |
3D structure databases
SMRi | D4ANG0 |
ModBasei | Search... |
Proteomic databases
PRIDEi | D4ANG0 |
Genome annotation databases
EnsemblFungii | EFE35721; EFE35721; ARB_05765 |
GeneIDi | 9521849 |
KEGGi | abe:ARB_05765 |
Phylogenomic databases
eggNOGi | ENOG502QR6D, Eukaryota |
HOGENOMi | CLU_013783_3_0_1 |
OMAi | CDMIGQL |
Family and domain databases
CDDi | cd04056, Peptidases_S53, 1 hit cd11377, Pro-peptidase_S53, 1 hit |
Gene3Di | 3.40.50.200, 1 hit |
InterProi | View protein in InterPro IPR000209, Peptidase_S8/S53_dom IPR036852, Peptidase_S8/S53_dom_sf IPR023828, Peptidase_S8_Ser-AS IPR015366, S53_propep IPR030400, Sedolisin_dom |
Pfami | View protein in Pfam PF00082, Peptidase_S8, 1 hit PF09286, Pro-kuma_activ, 1 hit |
SMARTi | View protein in SMART SM00944, Pro-kuma_activ, 1 hit |
SUPFAMi | SSF52743, SSF52743, 1 hit |
PROSITEi | View protein in PROSITE PS51695, SEDOLISIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SED2_ARTBC | |
Accessioni | D4ANG0Primary (citable) accession number: D4ANG0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 5, 2010 |
Last sequence update: | May 18, 2010 | |
Last modified: | September 29, 2021 | |
This is version 48 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |