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UniProtKB - D4AK75 (SED3_ARTBC)
Protein
Probable tripeptidyl-peptidase SED3
Gene
SED3
Organism
Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Status
Functioni
Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.
By similarityCatalytic activityi
- Release of an N-terminal tripeptide from a polypeptide. EC:3.4.14.10
Cofactori
Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 282 | Charge relay systemBy similarity | 1 | |
Active sitei | 286 | Charge relay systemBy similarity | 1 | |
Active sitei | 496 | Charge relay systemBy similarity | 1 | |
Metal bindingi | 538 | CalciumBy similarity | 1 | |
Metal bindingi | 539 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 570 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 572 | CalciumBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- serine-type endopeptidase activity Source: InterPro
- tripeptidyl-peptidase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Biological process | Virulence |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:SED3 ORF Names:ARB_04677/ARB_04678 |
Organismi | Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes) |
Taxonomic identifieri | 663331 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › Arthrodermataceae › Trichophyton › |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- extracellular space By similarity
Extracellular region or secreted
- extracellular space Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
PropeptideiPRO_0000406412 | 19 – 198 | Removed in mature formBy similarityAdd BLAST | 180 | |
ChainiPRO_0000406413 | 199 – 593 | Probable tripeptidyl-peptidase SED3Add BLAST | 395 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 204 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 261 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 275 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 295 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 554 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 566 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, ZymogenFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 206 – 592 | Peptidase S53Add BLAST | 387 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QR6D, Eukaryota |
HOGENOMi | CLU_1730971_0_0_1 |
Family and domain databases
CDDi | cd04056, Peptidases_S53, 1 hit cd11377, Pro-peptidase_S53, 1 hit |
Gene3Di | 3.40.50.200, 1 hit |
InterProi | View protein in InterPro IPR036852, Peptidase_S8/S53_dom_sf IPR015366, S53_propep IPR030400, Sedolisin_dom |
Pfami | View protein in Pfam PF09286, Pro-kuma_activ, 1 hit |
SMARTi | View protein in SMART SM00944, Pro-kuma_activ, 1 hit |
SUPFAMi | SSF52743, SSF52743, 1 hit |
PROSITEi | View protein in PROSITE PS51695, SEDOLISIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
D4AK75-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLRWHSVIP LFLAMTVAFP NTYRTVVEDL PAIPEGWVQG NPPSPETSVR
60 70 80 90 100
MNLAVGQQNT RTFEQIVLDI STPGHRNYGK HLSRRDLKGL LRPRRETSNL
110 120 130 140 150
ILSWLEKSGV PKRSIVDDGD WIHFVISISQ AERMLQTRFY HFHDVQDPGI
160 170 180 190 200
SMIRTLKYSV PSRLARHVYM IQPTTKFGKP KKHANSIANL QAIYLSTNAT
210 220 230 240 250
ENCNATITPR CLRELYKMGD YVAKPDCRNV IGVSGYLDQY ARYSDFYKFL
260 270 280 290 300
ELYAPEMKGA NFSVAHIGNG QNLQNSTRNS IEASLDIEYA LGLSNASAVF
310 320 330 340 350
YTTSGRGPLV PDLDQPEQEH NSNEPYLDQL HYLLSLPQEA LPAVLSTSYG
360 370 380 390 400
ENEQSVPERF SHATCNLFAQ LGARGVSVIF SSGDSGVGSS CLTNDKKKIT
410 420 430 440 450
RFNPTFPASC PFVTSVGATF KINPERATGF SSGGFSDRHS RPGYQNDAVQ
460 470 480 490 500
HYLDKLGDRW KGLYNPKGRG IPDVSAQGAN FAIYDHGKVI IVSGTSASAP
510 520 530 540 550
AFAAIIANLN AIRLRANKPV LGYLNPFIYG KGREGFTDIV HGGSKGCVGY
560 570 580 590
SSTNRSTPAV PYASWNATEG WDPVTGVGTP NFRILAKIVQ HME
Sequence cautioni
The sequence EFE37148 differs from that shown. Reason: Frameshift. The predicted genes ARB_04677 and ARB_04678 have been merged.Curated
The sequence EFE37149 differs from that shown. Reason: Frameshift. The predicted genes ARB_04677 and ARB_04678 have been merged.Curated
The sequence EFE37149 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | ABSU01000001 Genomic DNA Translation: EFE37148.1 Frameshift. ABSU01000001 Genomic DNA Translation: EFE37149.1 Sequence problems. |
RefSeqi | XP_003017793.1, XM_003017747.1 XP_003017794.1, XM_003017748.1 |
Genome annotation databases
EnsemblFungii | EFE37148; EFE37148; ARB_04677 EFE37149; EFE37149; ARB_04678 |
GeneIDi | 9522640 9522641 |
KEGGi | abe:ARB_04677 abe:ARB_04678 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | ABSU01000001 Genomic DNA Translation: EFE37148.1 Frameshift. ABSU01000001 Genomic DNA Translation: EFE37149.1 Sequence problems. |
RefSeqi | XP_003017793.1, XM_003017747.1 XP_003017794.1, XM_003017748.1 |
3D structure databases
SMRi | D4AK75 |
ModBasei | Search... |
Genome annotation databases
EnsemblFungii | EFE37148; EFE37148; ARB_04677 EFE37149; EFE37149; ARB_04678 |
GeneIDi | 9522640 9522641 |
KEGGi | abe:ARB_04677 abe:ARB_04678 |
Phylogenomic databases
eggNOGi | ENOG502QR6D, Eukaryota |
HOGENOMi | CLU_1730971_0_0_1 |
Family and domain databases
CDDi | cd04056, Peptidases_S53, 1 hit cd11377, Pro-peptidase_S53, 1 hit |
Gene3Di | 3.40.50.200, 1 hit |
InterProi | View protein in InterPro IPR036852, Peptidase_S8/S53_dom_sf IPR015366, S53_propep IPR030400, Sedolisin_dom |
Pfami | View protein in Pfam PF09286, Pro-kuma_activ, 1 hit |
SMARTi | View protein in SMART SM00944, Pro-kuma_activ, 1 hit |
SUPFAMi | SSF52743, SSF52743, 1 hit |
PROSITEi | View protein in PROSITE PS51695, SEDOLISIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SED3_ARTBC | |
Accessioni | D4AK75Primary (citable) accession number: D4AK75 Secondary accession number(s): D4AK76 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | February 23, 2022 | |
This is version 47 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |