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Entry version 78 (05 Jun 2019)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

5-azacytidine induced gene 1 (Predicted), isoform CRA_a

Gene

Cep131

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-2565942 Regulation of PLK1 Activity at G2/M Transition
R-RNO-380259 Loss of Nlp from mitotic centrosomes
R-RNO-380270 Recruitment of mitotic centrosome proteins and complexes
R-RNO-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-RNO-380320 Recruitment of NuMA to mitotic centrosomes
R-RNO-5620912 Anchoring of the basal body to the plasma membrane
R-RNO-8854518 AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
5-azacytidine induced gene 1 (Predicted), isoform CRA_aImported
Submitted name:
Centrosomal protein 131Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cep131Imported
Synonyms:Azi1Imported, Azi1_predictedImported
ORF Names:rCG_33168Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Rat genome database

More...
RGDi
1307745 Cep131

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
D4AEL8

PRoteomics IDEntifications database

More...
PRIDEi
D4AEL8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000004430 Expressed in 9 organ(s), highest expression level in testis

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000005977

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D4AEL8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 95DisorderedSequence analysisAdd BLAST95
Regioni129 – 155DisorderedSequence analysisAdd BLAST27
Regioni218 – 249DisorderedSequence analysisAdd BLAST32
Regioni297 – 427DisorderedSequence analysisAdd BLAST131
Regioni1040 – 1069DisorderedSequence analysisAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili439 – 459Sequence analysisAdd BLAST21
Coiled coili559 – 615Sequence analysisAdd BLAST57
Coiled coili620 – 640Sequence analysisAdd BLAST21
Coiled coili649 – 676Sequence analysisAdd BLAST28
Coiled coili721 – 824Sequence analysisAdd BLAST104
Coiled coili831 – 865Sequence analysisAdd BLAST35
Coiled coili890 – 971Sequence analysisAdd BLAST82
Coiled coili987 – 1014Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi34 – 48PolarSequence analysisAdd BLAST15
Compositional biasi71 – 91PolarSequence analysisAdd BLAST21
Compositional biasi136 – 150PolarSequence analysisAdd BLAST15
Compositional biasi228 – 244PolarSequence analysisAdd BLAST17
Compositional biasi311 – 330PolyampholyteSequence analysisAdd BLAST20
Compositional biasi340 – 363PolyampholyteSequence analysisAdd BLAST24
Compositional biasi409 – 426PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1040 – 1062PolyampholyteSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEUN Eukaryota
ENOG410YVPU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001758

KEGG Orthology (KO)

More...
KOi
K16540

Identification of Orthologs from Complete Genome Data

More...
OMAi
NSATQVN

Database of Orthologous Groups

More...
OrthoDBi
918776at2759

TreeFam database of animal gene trees

More...
TreeFami
TF328914

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030465 CEP131

The PANTHER Classification System

More...
PANTHERi
PTHR31540 PTHR31540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D4AEL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGSRTISAT PEGSPEGMDL SLIGLPLPMS QRPGSASAAK SIFRSVSVAT
60 70 80 90 100
GSEPRKKALE ATGPGGPRAI NNLRRSNSTT QVNQSWTGSP RPAEPTDFLM
110 120 130 140 150
LFEGSTSGRR RVASFSKVSS EKGATWNVLD DQPRDFASPA NSQSPSTLDS
160 170 180 190 200
ALGPRRKECS LAPSFTANNR SNKGAVGNCV TTMVHNHYAS SKKVSPPKSS
210 220 230 240 250
NQTAPSLNNI VKAAAREGGE GSDFGKPRKN FSSVSQSTRG TTGLLRRKEV
260 270 280 290 300
TEEEAERFIQ QVNQAAVTIQ RWYRCQVQRR RTGAASLEHL LASKREGQRQ
310 320 330 340 350
RLGSGNLLDL HRQEEAARKK AREEKARQAR QAAIQELQQK RAQKAREVEH
360 370 380 390 400
RPPKERPETR ALEQPRPTQE PPSMPSSVTH PKANNAGASL YPTGPADPCP
410 420 430 440 450
PASESFPERQ PSLEDKPQDA HSQVEAREDL AALASTRSKT RARATLDDLL
460 470 480 490 500
DTLKLLEEEP EPLLHPKAYR QDRYAWMDEE EDTNPLTADN LEKFGKLSAA
510 520 530 540 550
PGPPDDGTLL SEAKLQSIMT FLDEMEKSGQ ERPAPWRESL VLEAGPRSLE
560 570 580 590 600
LGSEGTTSVM RLKLELEEKK QAMVLLQRAL AQQRDLATRR VKETEKELSR
610 620 630 640 650
QLRQQKEQYE ATIQRHLSFI DQLIEDKKVL SEKCEAVVAE LKQGDQRCRE
660 670 680 690 700
RVAQVQEQHE LEIKKLKELM SATEKIRREK WINEKTKKIK EITVRGLEPE
710 720 730 740 750
IQKLIAKHKQ EVRRLRGLHE AELQQREEQA AQRHLRQAEE LREHLERERE
760 770 780 790 800
ALGQQERERA QQRLEQHLEQ EQRALEQQRR RLYTEVAEEK ERLGQQAARQ
810 820 830 840 850
RVELEELRQQ LEESSAALTR ALRAEFERSR EEQERRHQME LKALKDQLEA
860 870 880 890 900
ERQAWVASCA KKEEAWLLTR ERELKEEIRK GRDQEIELVI HRLEADMTLA
910 920 930 940 950
KEESERAAEN RVKRVRDKYE TELSELEQSE RKLQERCTEL KGRLGEAEGE
960 970 980 990 1000
KERLQSLLRQ KEKELDDLRV VNTQMCSERA SLAQVVRQEF AEQLAASQEE
1010 1020 1030 1040 1050
TQRVKAELAE LRARQQMELD EVHRRVKTAL ARKEAAVNSL RKQHEAAEKR
1060
ADHLEELLEQ HKGPSLSSK
Length:1,069
Mass (Da):121,845
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7748A30DC75AA9A5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07030916 Genomic DNA No translation available.
CH473948 Genomic DNA Translation: EDM06812.1

NCBI Reference Sequences

More...
RefSeqi
NP_001101780.1, NM_001108310.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000005977; ENSRNOP00000005977; ENSRNOG00000004430

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
360672

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:360672

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07030916 Genomic DNA No translation available.
CH473948 Genomic DNA Translation: EDM06812.1
RefSeqiNP_001101780.1, NM_001108310.1

3D structure databases

SMRiD4AEL8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005977

Proteomic databases

jPOSTiD4AEL8
PRIDEiD4AEL8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005977; ENSRNOP00000005977; ENSRNOG00000004430
GeneIDi360672
KEGGirno:360672

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22994
RGDi1307745 Cep131

Phylogenomic databases

eggNOGiENOG410IEUN Eukaryota
ENOG410YVPU LUCA
GeneTreeiENSGT00390000001758
KOiK16540
OMAiNSATQVN
OrthoDBi918776at2759
TreeFamiTF328914

Enzyme and pathway databases

ReactomeiR-RNO-2565942 Regulation of PLK1 Activity at G2/M Transition
R-RNO-380259 Loss of Nlp from mitotic centrosomes
R-RNO-380270 Recruitment of mitotic centrosome proteins and complexes
R-RNO-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-RNO-380320 Recruitment of NuMA to mitotic centrosomes
R-RNO-5620912 Anchoring of the basal body to the plasma membrane
R-RNO-8854518 AURKA Activation by TPX2

Gene expression databases

BgeeiENSRNOG00000004430 Expressed in 9 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR030465 CEP131
PANTHERiPTHR31540 PTHR31540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD4AEL8_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4AEL8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: June 5, 2019
This is version 78 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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