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Entry version 95 (10 Feb 2021)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

Nuclear transcription factor, X-box-binding 1

Gene

Nfx1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulationARBA annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nuclear transcription factor, X-box-binding 1Imported
Submitted name:
RCG55154Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nfx1Imported
ORF Names:rCG_55154Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Rat genome database

More...
RGDi
1310277, Nfx1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
D4AE50

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000009015, Expressed in skeletal muscle tissue and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
D4AE50, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000057423

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D4AE50

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini349 – 405PHD-typeInterPro annotationAdd BLAST57
Domaini352 – 403RING-typeInterPro annotationAdd BLAST52
Domaini988 – 1056R3HInterPro annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni20 – 325DisorderedSequence analysisAdd BLAST306
Regioni1069 – 1098DisorderedSequence analysisAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili931 – 951Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi27 – 48PolarSequence analysisAdd BLAST22
Compositional biasi76 – 106PolarSequence analysisAdd BLAST31
Compositional biasi118 – 142PolarSequence analysisAdd BLAST25
Compositional biasi143 – 161PolyampholyteSequence analysisAdd BLAST19
Compositional biasi181 – 205PolyampholyteSequence analysisAdd BLAST25
Compositional biasi224 – 257PolyampholyteSequence analysisAdd BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NFX1 family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1952, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156325

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005714_1_2_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
HPCEHPP

Database of Orthologous Groups

More...
OrthoDBi
299100at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105889

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02643, R3H_NF-X1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1370.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034078, NFX1_fam
IPR001374, R3H_dom
IPR036867, R3H_dom_sf
IPR034076, R3H_NF-X1
IPR019786, Zinc_finger_PHD-type_CS
IPR000967, Znf_NFX1
IPR019787, Znf_PHD-finger
IPR001841, Znf_RING

The PANTHER Classification System

More...
PANTHERi
PTHR12360, PTHR12360, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01424, R3H, 1 hit
PF01422, zf-NF-X1, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00393, R3H, 1 hit
SM00438, ZnF_NFX, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82708, SSF82708, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51061, R3H, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

D4AE50-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEAPPVSGT FKFNTDAAEF IPQERKNSGL NCGTQRRLDS NRIGRRNYSS
60 70 80 90 100
SPPCHLPRHI PYDDVSAVHQ HGYASGSKPK SPQGFFQSSN KSLKNHGLQN
110 120 130 140 150
QPWQKLRNEK HQNRIKKAQG LTEQTSDTSS LESVARSESG TNPREHSPSE
160 170 180 190 200
SEKEVVIADP RGAKPKKATQ LTYNYGRGPK AKGRLRSEWG NRMSPKSEDE
210 220 230 240 250
NARPVAISHS DSSEASCRKP VVDPCVCRRS EQRRYPQKRP PWEVEGARPR
260 270 280 290 300
PGRNPPKQES QRHINAGPKN NMPPLPKDNL RERPTKSACD TGNLAVVTKS
310 320 330 340 350
SRRVDQEKNA GRRQDPQVLS PFPRGKQNHM LKNVETHTGS LIEQLTTEKY
360 370 380 390 400
ECMVCCELVQ VTAPVWSCQS CFHVFHLNCI KKWARSPASH ADGQSGWRCP
410 420 430 440 450
ACQNVSAHVP STYTCFCGKV KNPEWSRNEI PHSCGEVCRK KQPGQDCPHS
460 470 480 490 500
CNLLCHPGPC PPCPAFTTKT CECGRTRHTV RCGQPVSVHC SNVCENILNC
510 520 530 540 550
GQHRCAELCH AGQCQPCRII LNQVCYCGST SRDVLCGTDV GKSDGFGDFS
560 570 580 590 600
CLKICGKDLK CGSHTCSQVC HPQPCQPCPR LPHLVRYCPC GQTPLSQLLE
610 620 630 640 650
HGSNGRKTCM DPVPSCGKVC GKPLSCGSSD FIHTCEKLCH EGDCGPCSRT
660 670 680 690 700
SVISCRCSFR TKELPCTSLK SEDATFMCDK RCNKKRLCGR HKCNEICCVD
710 720 730 740 750
KEHKCPLICG RKLRCGLHRC EEPCHRGNCQ TCWQASFDEL TCHCGASVIY
760 770 780 790 800
PPVPCGTRPP ECTQTCARIH ECDHPVYHSC HSEEKCPPCT FLTQKWCMGK
810 820 830 840 850
HELRSNIPCH LVDISCGLPC SAMLPCGMHK CQRLCHKGEC LVDEACKQPC
860 870 880 890 900
TTPRADCGHP CMAPCHPSLP CPVTACKAKV ELQCECGRRK EMVICSEASG
910 920 930 940 950
TYQRIAAISM ASKITDMQLG DSVEISKFIT KKEVQQARLQ CDEECAALER
960 970 980 990 1000
KKRLAEAFDI TDDSDPFNVR SSASKFSDSL KDDARKDFKF VSDIEKEMEA
1010 1020 1030 1040 1050
LVEAVNKGKS NKKSYCFPPM NRDHRRIIHD LAQVYGLESV SYDSEPKRNV
1060 1070 1080 1090 1100
VVTAIRGKSI CPPTTLTSVI ERETQTRPPP PIPHHRHQAD KNPGSSNLQK
1110
IVKEPVIDYF DVQD
Length:1,114
Mass (Da):123,971
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAAAB8B11722A672F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q4V7B3Q4V7B3_RAT
Nuclear transcription factor, X-box...
Nfx1
818Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07048017 Genomic DNA No translation available.
AABR07048018 Genomic DNA No translation available.
AABR07048019 Genomic DNA No translation available.
AABR07073103 Genomic DNA No translation available.
AC121205 Genomic DNA No translation available.
CH473962 Genomic DNA Translation: EDL98652.1

NCBI Reference Sequences

More...
RefSeqi
NP_001019955.2, NM_001024784.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000060692; ENSRNOP00000057423; ENSRNOG00000009015

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
313166

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:313166

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07048017 Genomic DNA No translation available.
AABR07048018 Genomic DNA No translation available.
AABR07048019 Genomic DNA No translation available.
AABR07073103 Genomic DNA No translation available.
AC121205 Genomic DNA No translation available.
CH473962 Genomic DNA Translation: EDL98652.1
RefSeqiNP_001019955.2, NM_001024784.2

3D structure databases

SMRiD4AE50
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057423

Proteomic databases

PRIDEiD4AE50

Genome annotation databases

EnsembliENSRNOT00000060692; ENSRNOP00000057423; ENSRNOG00000009015
GeneIDi313166
KEGGirno:313166

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4799
RGDi1310277, Nfx1

Phylogenomic databases

eggNOGiKOG1952, Eukaryota
GeneTreeiENSGT00940000156325
HOGENOMiCLU_005714_1_2_1
OMAiHPCEHPP
OrthoDBi299100at2759
TreeFamiTF105889

Gene expression databases

BgeeiENSRNOG00000009015, Expressed in skeletal muscle tissue and 20 other tissues
ExpressionAtlasiD4AE50, baseline and differential

Family and domain databases

CDDicd02643, R3H_NF-X1, 1 hit
Gene3Di3.30.1370.50, 1 hit
InterProiView protein in InterPro
IPR034078, NFX1_fam
IPR001374, R3H_dom
IPR036867, R3H_dom_sf
IPR034076, R3H_NF-X1
IPR019786, Zinc_finger_PHD-type_CS
IPR000967, Znf_NFX1
IPR019787, Znf_PHD-finger
IPR001841, Znf_RING
PANTHERiPTHR12360, PTHR12360, 1 hit
PfamiView protein in Pfam
PF01424, R3H, 1 hit
PF01422, zf-NF-X1, 7 hits
SMARTiView protein in SMART
SM00393, R3H, 1 hit
SM00438, ZnF_NFX, 9 hits
SUPFAMiSSF82708, SSF82708, 1 hit
PROSITEiView protein in PROSITE
PS51061, R3H, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD4AE50_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4AE50
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 10, 2021
This is version 95 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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