Helt

Functionⁱ

GO - Molecular functionⁱ

microsatellite binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein homodimerization activity Source: Ensembl
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific double-stranded DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription corepressor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blood vessel development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
central nervous system development Source: Ensembl
GABAergic neuron differentiation in basal ganglia Source: Ensembl
heart development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
multicellular organism aging Source: Ensembl
multicellular organism growth Source: Ensembl
Notch signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
post-embryonic development Source: Ensembl
regulation of neurogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
suckling behavior Source: Ensembl
transcription, DNA-templated Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation

Biological process

Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Helt bHLH transcription factorImported
Gene namesⁱ	Name:HeltImported Synonyms:Helt-ps1Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 16

Organism-specific databases

Rat genome database More...RGDⁱ	1564073 Helt

RGDⁱ

1564073 Helt

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotationSAAS annotation

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	D4ADJ5
PRIDEⁱ	D4ADJ5

PTM databases

iPTMnetⁱ	D4ADJ5
PhosphoSitePlusⁱ	D4ADJ5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000010785 Expressed in 1 organ(s), highest expression level in brain

Bgeeⁱ

ENSRNOG00000010785 Expressed in 1 organ(s), highest expression level in brain

Interactionⁱ

GO - Molecular functionⁱ

protein homodimerization activity Source: Ensembl
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000014360

STRINGⁱ

10116.ENSRNOP00000014360

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	10 – 65	BHLHInterPro annotationAdd BLAST		56
Domainⁱ	86 – 121	OrangeInterPro annotationAdd BLAST		36

Phylogenomic databases

eggNOGⁱ	KOG4304 Eukaryota ENOG4111F0X LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00700000104130
InParanoidⁱ	D4ADJ5
OMAⁱ	HAHPNAL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G115T
PhylomeDBⁱ	D4ADJ5
TreeFamⁱ	TF323617

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR003650 Orange_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07527 Hairy_orange, 1 hit PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS51054 ORANGE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

D4ADJ5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSDRLKERKR TPVSHKVIEK RRRDRINRCL NELGKTVPMA LAKQSSGKLE 
        60         70         80         90        100
KAEILEMTVQ YLRALHSADF PRGREKELLA EFANYFHYGY HECMKNLVHY 
       110        120        130        140        150
LTTVERMETK DTKYARILAF LQSKARLGAE PAFPPLSLPE PDFSYQLHPA 
       160        170        180        190        200
GPEFPGHSPG EATVFPQGAT PGSFPWPPGA ARSPALPYLS SATVPLPTPA 
       210        220        230        240
QPHSPFLAPM QGLDRHYLNL IGHGHPNTLN LHTPQHPPVL

Length:240

Mass (Da):26,934

Last modified:April 20, 2010 - v1

Checksum:ⁱBEA36A0E33DE9BAC

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07072511 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	XP_003751648.1, XM_003751600.3 XP_003752951.1, XM_003752903.3

Genome annotation databases

Ensemblⁱ	ENSRNOT00000014360; ENSRNOP00000014360; ENSRNOG00000010785
GeneIDⁱ	498633
KEGGⁱ	rno:498633

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
D4ADJ5	Hairy and enhancer of split-related protein HELT		MOUSE		240	UniRef90_Q7TS99
Uncharacterized protein		PROCO		242
Uncharacterized protein		CALJA		242
Uncharacterized protein		Cebus capucinus imitator		242
HELT isoform 2		PONAB		242
+66

Protein	Similar proteins		Species	Score	Length	Source
D4ADJ5	Hairy and enhancer of split-related protein HELT		MOUSE		240	UniRef50_Q7TS99
HELT isoform 2		PONAB		242
Uncharacterized protein		PROCO		242
hairy and enhancer of split-related protein HELT isoform X1		DIPOR		242
Uncharacterized protein		AOTNA		242
+127

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07072511 Genomic DNA No translation available.
RefSeqⁱ	XP_003751648.1, XM_003751600.3 XP_003752951.1, XM_003752903.3

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000014360

STRINGⁱ

10116.ENSRNOP00000014360

PTM databases

iPTMnetⁱ	D4ADJ5
PhosphoSitePlusⁱ	D4ADJ5

Proteomic databases

PaxDbⁱ	D4ADJ5
PRIDEⁱ	D4ADJ5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000014360; ENSRNOP00000014360; ENSRNOG00000010785
GeneIDⁱ	498633
KEGGⁱ	rno:498633

Organism-specific databases

CTDⁱ	391723
RGDⁱ	1564073 Helt

Phylogenomic databases

eggNOGⁱ	KOG4304 Eukaryota ENOG4111F0X LUCA
GeneTreeⁱ	ENSGT00700000104130
InParanoidⁱ	D4ADJ5
OMAⁱ	HAHPNAL
OrthoDBⁱ	EOG091G115T
PhylomeDBⁱ	D4ADJ5
TreeFamⁱ	TF323617

Gene expression databases

Bgeeⁱ	ENSRNOG00000010785 Expressed in 1 organ(s), highest expression level in brain

Bgeeⁱ

ENSRNOG00000010785 Expressed in 1 organ(s), highest expression level in brain

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR003650 Orange_dom
Pfamⁱ	View protein in Pfam PF07527 Hairy_orange, 1 hit PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS51054 ORANGE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D4ADJ5_RAT
Accessionⁱ	D4ADJ5Primary (citable) accession number: D4ADJ5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 20, 2010
	Last sequence update:	April 20, 2010
	Last modified:	November 7, 2018
	This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D4ADJ5 (D4ADJ5_RAT)

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Helt bHLH transcription factor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ