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UniProtKB - D4ADJ5 (D4ADJ5_RAT)
Protein
Submitted name:
Helt bHLH transcription factor
Gene
Helt
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- identical protein binding Source: RGD
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
GO - Biological processi
- anterior/posterior pattern specification Source: GO_Central
- central nervous system development Source: RGD
- GABAergic neuron differentiation in basal ganglia Source: RGD
- gene expression Source: RGD
- multicellular organism aging Source: RGD
- multicellular organism growth Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- neuron differentiation Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- post-embryonic development Source: RGD
- regulation of neurogenesis Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
- suckling behavior Source: RGD
Keywordsi
Molecular function | RepressorARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Helt bHLH transcription factor |
Gene namesi | |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1564073, Helt |
Subcellular locationi
Nucleus
- nucleus Source: RGD
Other locations
- transcription regulator complex Source: RGD
PTM / Processingi
Proteomic databases
PaxDbi | D4ADJ5 |
PTM databases
iPTMneti | D4ADJ5 |
PhosphoSitePlusi | D4ADJ5 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000010785, Expressed in female gonad and 6 other tissues |
Interactioni
GO - Molecular functioni
- identical protein binding Source: RGD
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000014360 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 65 | BHLHInterPro annotationAdd BLAST | 56 | |
Domaini | 86 – 121 | OrangeInterPro annotationAdd BLAST | 36 |
Phylogenomic databases
eggNOGi | KOG4304, Eukaryota |
GeneTreei | ENSGT00940000160388 |
HOGENOMi | CLU_084227_0_0_1 |
InParanoidi | D4ADJ5 |
OMAi | FAWPHGA |
OrthoDBi | 1054305at2759 |
PhylomeDBi | D4ADJ5 |
TreeFami | TF323617 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
Pfami | View protein in Pfam PF07527, Hairy_orange, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
i Sequence
Sequence statusi: Complete.
D4ADJ5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDRLKERKR TPVSHKVIEK RRRDRINRCL NELGKTVPMA LAKQSSGKLE
60 70 80 90 100
KAEILEMTVQ YLRALHSADF PRGREKELLA EFANYFHYGY HECMKNLVHY
110 120 130 140 150
LTTVERMETK DTKYARILAF LQSKARLGAE PAFPPLSLPE PDFSYQLHPA
160 170 180 190 200
GPEFPGHSPG EATVFPQGAT PGSFPWPPGA ARSPALPYLS SATVPLPTPA
210 220 230 240
QPHSPFLAPM QGLDRHYLNL IGHGHPNTLN LHTPQHPPVL
Sequence databases
RefSeqi | XP_003751648.1, XM_003751600.3 XP_003752951.1, XM_003752903.3 |
Genome annotation databases
Ensembli | ENSRNOT00000014360.6; ENSRNOP00000014360.4; ENSRNOG00000010785.6 |
GeneIDi | 498633 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_003751648.1, XM_003751600.3 XP_003752951.1, XM_003752903.3 |
3D structure databases
AlphaFoldDBi | D4ADJ5 |
SMRi | D4ADJ5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000014360 |
PTM databases
iPTMneti | D4ADJ5 |
PhosphoSitePlusi | D4ADJ5 |
Proteomic databases
PaxDbi | D4ADJ5 |
Genome annotation databases
Ensembli | ENSRNOT00000014360.6; ENSRNOP00000014360.4; ENSRNOG00000010785.6 |
GeneIDi | 498633 |
Organism-specific databases
CTDi | 391723 |
RGDi | 1564073, Helt |
Phylogenomic databases
eggNOGi | KOG4304, Eukaryota |
GeneTreei | ENSGT00940000160388 |
HOGENOMi | CLU_084227_0_0_1 |
InParanoidi | D4ADJ5 |
OMAi | FAWPHGA |
OrthoDBi | 1054305at2759 |
PhylomeDBi | D4ADJ5 |
TreeFami | TF323617 |
Gene expression databases
Bgeei | ENSRNOG00000010785, Expressed in female gonad and 6 other tissues |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
Pfami | View protein in Pfam PF07527, Hairy_orange, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | D4ADJ5_RAT | |
Accessioni | D4ADJ5Primary (citable) accession number: D4ADJ5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | May 25, 2022 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |