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Entry version 85 (29 Sep 2021)
Sequence version 3 (22 Jul 2015)
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Protein
Submitted name:

Seizure-related 6 homolog-like

Gene

Sez6l

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Seizure-related 6 homolog-likeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sez6lImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Rat genome database

More...
RGDi
1563628, Sez6l

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei896 – 918HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500305366032 – 963Sequence analysisAdd BLAST932

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi221 ↔ 248PROSITE-ProRule annotation
Disulfide bondi392 ↔ 419PROSITE-ProRule annotation
Disulfide bondi713 ↔ 740PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
D4AD89

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D4AD89

PRoteomics IDEntifications database

More...
PRIDEi
D4AD89

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D4AD89

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
D4AD89

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000025612, Expressed in frontal cortex and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000038097

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini221 – 329CUBInterPro annotationAdd BLAST109
Domaini331 – 390SushiInterPro annotationAdd BLAST60
Domaini392 – 502CUBInterPro annotationAdd BLAST111
Domaini505 – 566SushiInterPro annotationAdd BLAST62
Domaini568 – 679CUBInterPro annotationAdd BLAST112
Domaini683 – 742SushiInterPro annotationAdd BLAST60
Domaini744 – 807SushiInterPro annotationAdd BLAST64
Domaini811 – 872SushiInterPro annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni113 – 150DisorderedSequence analysisAdd BLAST38
Regioni164 – 210DisorderedSequence analysisAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi113 – 138Polar residuesSequence analysisAdd BLAST26

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVYR, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158873

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011474_1_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
QGEPQLT

Database of Orthologous Groups

More...
OrthoDBi
126806at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D4AD89

TreeFam database of animal gene trees

More...
TreeFami
TF330037

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033, CCP, 5 hits
cd00041, CUB, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859, CUB_dom
IPR035914, Sperma_CUB_dom_sf
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431, CUB, 3 hits
PF00084, Sushi, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032, CCP, 5 hits
SM00042, CUB, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854, SSF49854, 3 hits
SSF57535, SSF57535, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180, CUB, 3 hits
PS50923, SUSHI, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D4AD89-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVAPPQAAG PDRISLLLVA LLLGSPVAAR AEDGGPEGDM HPSTAYLLPS
60 70 80 90 100
ALLEGSLEEG VTSAAPGPLP SREALEALEG SLPPLFPDEA RVQHTPSLRK
110 120 130 140 150
ALPSLKQLNS ARRQLRPLAT PTTLQRLGSP SSATTKPREP GDPEQPTAPA
160 170 180 190 200
PLQIAPFTAL ATTLPHSPQP AQAPDDSSLS SPLDKGDNEL TGSASEESQE
210 220 230 240 250
TTTSTIVTTT IITTEQAPAL CGVSFSDPEG YIDSSDFPPQ PSSSFLECTY
260 270 280 290 300
NVTVYTGYGV ELQVKSVNLS EGELLSIRGV DGPTLTVLAN QTLLVEGQVI
310 320 330 340 350
RSPTNTISVY FRTFQDDNLG TFQLHYQAFM LSCNFPRRPD AGDVTVMDLH
360 370 380 390 400
SGGVAHFHCH LGYELQGAKT LTCINASKPH WSSQEPVCSA PCGGAVHNAT
410 420 430 440 450
IGRVLSPSYP GNTNGSQLCV WTIEAPEGQK LHLHLERLLL HEKDRMVVYS
460 470 480 490 500
GRTNTSALLY DSLRTESVPF EGLLSEGSNI RIEFTSDQGQ AASAFNIRFE
510 520 530 540 550
AFEKGHCYEP YIQNGNFTTS DPTYNIGTIV EFTCDPGHSL EQGPAVIECV
560 570 580 590 600
NVRDPYWNDT EPLCRAMCGG ELSAVAGVVL SPNWPEPYAE GEDCVWKIHV
610 620 630 640 650
GEEKRIFLDI QFLNLSNSDI LTIYDGDEVV PHVLGQYFGN SSPQKLYSST
660 670 680 690 700
PDLTIQFHSD PAGLIFGKGQ GFIMNYIEVS RNDSCSDLPE IQNGWKTTSH
710 720 730 740 750
TELVRGARIT YQCDPGYDIV GSDTLTCQWD LSWSSDPPFC EKIMYCTDPG
760 770 780 790 800
EVEHSTRLIS DPVLLVGTTI QYTCSPGFVL EGSSLLTCYS RETGTPIWTS
810 820 830 840 850
RLPHCVSEES LACDNPGLPE NGYQILYKRL YLPGESLTFM CYEGFELMGE
860 870 880 890 900
VTIRCILGQP SHWSGPLPIC KVNQDSFEHA LEAEAAAESS LEGGNMALAI
910 920 930 940 950
FIPVLLISLL LGGAYIYVTR CRQYSSLRLP LMYSHPYSQI TVETEFDNPI
960
YETGETREYE VSI
Length:963
Mass (Da):104,846
Last modified:July 22, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i700737ECE400EC2F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07036620 Genomic DNA No translation available.
AABR07036621 Genomic DNA No translation available.
AABR07072308 Genomic DNA No translation available.
AC123358 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_006249603.1, XM_006249541.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000032193; ENSRNOP00000038097; ENSRNOG00000025612

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
304554

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07036620 Genomic DNA No translation available.
AABR07036621 Genomic DNA No translation available.
AABR07072308 Genomic DNA No translation available.
AC123358 Genomic DNA No translation available.
RefSeqiXP_006249603.1, XM_006249541.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038097

PTM databases

PhosphoSitePlusiD4AD89
SwissPalmiD4AD89

Proteomic databases

jPOSTiD4AD89
PaxDbiD4AD89
PRIDEiD4AD89

Genome annotation databases

EnsembliENSRNOT00000032193; ENSRNOP00000038097; ENSRNOG00000025612
GeneIDi304554

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23544
RGDi1563628, Sez6l

Phylogenomic databases

eggNOGiENOG502QVYR, Eukaryota
GeneTreeiENSGT00940000158873
HOGENOMiCLU_011474_1_0_1
OMAiQGEPQLT
OrthoDBi126806at2759
PhylomeDBiD4AD89
TreeFamiTF330037

Gene expression databases

BgeeiENSRNOG00000025612, Expressed in frontal cortex and 20 other tissues

Family and domain databases

CDDicd00033, CCP, 5 hits
cd00041, CUB, 3 hits
Gene3Di2.60.120.290, 3 hits
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR035914, Sperma_CUB_dom_sf
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00431, CUB, 3 hits
PF00084, Sushi, 5 hits
SMARTiView protein in SMART
SM00032, CCP, 5 hits
SM00042, CUB, 3 hits
SUPFAMiSSF49854, SSF49854, 3 hits
SSF57535, SSF57535, 5 hits
PROSITEiView protein in PROSITE
PS01180, CUB, 3 hits
PS50923, SUSHI, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD4AD89_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4AD89
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: September 29, 2021
This is version 85 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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