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UniProtKB - D4AD15 (D4AD15_RAT)

Entry version 88 (02 Dec 2020)
Sequence version 2 (22 Jul 2015)
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Protein
Submitted name:

Eukaryotic translation initiation factor 4 gamma, 1

Gene

Eif4g1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factorARBA annotation
Biological processProtein biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Eukaryotic translation initiation factor 4 gamma, 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Eif4g1Imported
Synonyms:LOC100911431Imported, LOC680559Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Rat genome database

More...RGDi		1306144, Eif4g1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		D4AD15

PRoteomics IDEntifications database

More...PRIDEi		D4AD15

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000001738, Expressed in skeletal muscle tissue and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		D4AD15, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		D4AD15, 7 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		D4AD15

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1233 – 1355MIInterPro annotationAdd BLAST123
Domaini1421 – 1591W2InterPro annotationAdd BLAST171

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 82DisorderedSequence analysisAdd BLAST82
Regioni166 – 223DisorderedSequence analysisAdd BLAST58
Regioni236 – 319DisorderedSequence analysisAdd BLAST84
Regioni338 – 517DisorderedSequence analysisAdd BLAST180
Regioni532 – 595DisorderedSequence analysisAdd BLAST64
Regioni650 – 711DisorderedSequence analysisAdd BLAST62
Regioni726 – 752DisorderedSequence analysisAdd BLAST27
Regioni1021 – 1109DisorderedSequence analysisAdd BLAST89
Regioni1121 – 1227DisorderedSequence analysisAdd BLAST107

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 26Pro-richSequence analysisAdd BLAST26
Compositional biasi30 – 67PolarSequence analysisAdd BLAST38
Compositional biasi174 – 190PolyampholyteSequence analysisAdd BLAST17
Compositional biasi198 – 221PolarSequence analysisAdd BLAST24
Compositional biasi260 – 274Pro-richSequence analysisAdd BLAST15
Compositional biasi338 – 357PolarSequence analysisAdd BLAST20
Compositional biasi455 – 473AcidicSequence analysisAdd BLAST19
Compositional biasi541 – 555PolarSequence analysisAdd BLAST15
Compositional biasi565 – 581PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1055 – 1083PolarSequence analysisAdd BLAST29
Compositional biasi1095 – 1109PolarSequence analysisAdd BLAST15
Compositional biasi1121 – 1135PolarSequence analysisAdd BLAST15
Compositional biasi1136 – 1215PolyampholyteSequence analysisAdd BLAST80

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic initiation factor 4G family.ARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154648

Database of Orthologous Groups

More...OrthoDBi		594395at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.180, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR037584, EIF4G1
IPR003891, Initiation_fac_eIF4g_MI
IPR016021, MIF4-like_sf
IPR003890, MIF4G-like_typ-3
IPR003307, W2_domain

The PANTHER Classification System

More...PANTHERi		PTHR23253:SF10, PTHR23253:SF10, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02847, MA3, 1 hit
PF02854, MIF4G, 1 hit
PF02020, W2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00515, eIF5C, 1 hit
SM00544, MA3, 1 hit
SM00543, MIF4G, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51366, MI, 1 hit
PS51363, W2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

D4AD15-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKAPQPTGP PPARSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQH 
        60         70         80         90        100
FYPSRAQPPS SAASRVQSAA PARPGPAPHV YPAGSQVMMI PSQISYSASQ 
       110        120        130        140        150
GAYYIPGQGR STYVVPTQQY PVQPGAPGFY PGASPTEFGT YAGAYYPAQS 
       160        170        180        190        200
VQQFPASVAP APVLMNQPPQ IAPKRERKTI RIRDPNQGGK DITEEIMSGA 
       210        220        230        240        250
RTASTPTPPQ TGGSLEPQPN GESPQVAVII RPDDRSQGAA IGGRPGLPGP 
       260        270        280        290        300
EHSPGTESQP SSPSPTPSPP PILEPGSESN LGVLSIPGDT MTTGMIPISV 
       310        320        330        340        350
EESTPISCES GEPYCLSPEP TLAEPILEVE VTLSKPIPES EFSSSPLQVS 
       360        370        380        390        400
TSLVPHRAET HEPNGVIPSE DLEPEVESST EPAPPPLSAC ASESLVPIAP 
       410        420        430        440        450
TAQPEELLNG APSPPAVDLS PVSEPEEQAK EVPSAALASI VSPTPPVAPS 
       460        470        480        490        500
DTSAAQEEEI EEDEDEDGEA ESEKGGEDLP LDSTPVPAQL SQNLEVAAAP 
       510        520        530        540        550
QVAVSVPKRR RKIKELNKKE AVGDLLDAFK EVDPAVPEVE NQPPTGSNPS 
       560        570        580        590        600
PESEGSAALP QPEEAEETWD SKEDKIHNAE NIQPGEQKYE YKSDQWKPLN 
       610        620        630        640        650
LEEKKRYDRE FLLGFQFIFA SMQKPEGLPH ITDVVLDKAN KTPLRSLDPS 
       660        670        680        690        700
RLPGINCGPD FTPSFANLGR PTLSSRGPPR GGPGGELPRG PQAGLGPRRS 
       710        720        730        740        750
QQGPRKETRK IISSVIMTED IKLNKAEKAW KPSSKRTAAD KDRGEEDADG 
       760        770        780        790        800
SKTQDLFRRV RSILNKLTPQ MFQQLMKQVT QLAIDTEERL KGVIDLIFEK 
       810        820        830        840        850
AISEPNFSVA YANMCRCLMA LKVPTTEKPT VTVNFRKLLL NRCQKEFEKD 
       860        870        880        890        900
KDDDEVFEKK QKEMDEAATA EERGRLKEEL EEARDIARRR SLGNIKFIGE 
       910        920        930        940        950
LFKLKMLTEA IMHDCVVKLL KNHDEESLEC LCRLLTTIGK DLDFAKAKPR 
       960        970        980        990       1000
MDQYFNQMEK IIKEKKTSSR IRFMLQDVLD LRQSNWVPRR GDQGPKTIDQ 
      1010       1020       1030       1040       1050
IHKEAEMEEH REHIKVQQLM AKGGDKRRGG PPGPPVNRGL PLVDDGGWNT 
      1060       1070       1080       1090       1100
VPISKGSRPI DTSRLTKITK PGSIDSNNQL FAPGGRLSWG KGSSGGSGAK 
      1110       1120       1130       1140       1150
PSDTASEATR PATLNRFSAL QQTLPVENTD NRRVVQRSSL SRERGEKAGD 
      1160       1170       1180       1190       1200
RGDRLERSER GGDRGDRLDR ARTPATKRSF SKEVEERSRE RPSQPEGLRK 
      1210       1220       1230       1240       1250
AASLTEDRGR DPVKREATLP PVSPPKAALA VDEVERKSKA IIEEYLHLND 
      1260       1270       1280       1290       1300
MKEAVQCVQE LASPSLLFIF VRLGIESTLE RSTIAREHMG RLLHQLLCAG 
      1310       1320       1330       1340       1350
HLSTAQYYQG LYETLELAED MEIDIPHVWL YLAELITPIL QEDGVPMGEL 
      1360       1370       1380       1390       1400
FREITKPLRP MGKATSLLLE ILGLLCKSMG PKKVGMLWRE AGLSWREFLA 
      1410       1420       1430       1440       1450
EGQDVGSFVA EKKVEYTLGE ESEAPGQRAL AFEELRRQLE KLLKDGGSNQ 
      1460       1470       1480       1490       1500
RVFDWIEANL NEQQIASNTL VRALMTTVCY SAIIFETPLR VDVQVLKVRA 
      1510       1520       1530       1540       1550
RLLQKYLSDE QKELQALYAL QALVVTLEQP ANLLRMFFDA LYDEDVVKED 
      1560       1570       1580       1590 
AFYSWESSKD PAEQQGKGVA LKSVTAFFNW LREAEDEESD HN
Length:1,592
Mass (Da):175,088
Last modified:July 22, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44778C3DC6B1A7B9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3ZU13D3ZU13_RAT
Eukaryotic translation initiation f...
Eif4g1
1,598Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC110855 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_006221256.1, XM_006221194.2
XP_006221257.1, XM_006221195.3
XP_006248646.1, XM_006248584.3
XP_006248647.1, XM_006248585.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000040029; ENSRNOP00000040698; ENSRNOG00000001738

Database of genes from NCBI RefSeq genomes

More...GeneIDi		287986

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:287986

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110855 Genomic DNA No translation available.
RefSeqiXP_006221256.1, XM_006221194.2
XP_006221257.1, XM_006221195.3
XP_006248646.1, XM_006248584.3
XP_006248647.1, XM_006248585.3

3D structure databases

SMRiD4AD15
ModBaseiSearch...

Protein-protein interaction databases

IntActiD4AD15, 7 interactors

Proteomic databases

jPOSTiD4AD15
PRIDEiD4AD15

Genome annotation databases

EnsembliENSRNOT00000040029; ENSRNOP00000040698; ENSRNOG00000001738
GeneIDi287986
KEGGirno:287986

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1981
RGDi1306144, Eif4g1

Phylogenomic databases

GeneTreeiENSGT00940000154648
OrthoDBi594395at2759

Gene expression databases

BgeeiENSRNOG00000001738, Expressed in skeletal muscle tissue and 20 other tissues
ExpressionAtlasiD4AD15, baseline and differential

Family and domain databases

Gene3Di1.25.40.180, 3 hits
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR037584, EIF4G1
IPR003891, Initiation_fac_eIF4g_MI
IPR016021, MIF4-like_sf
IPR003890, MIF4G-like_typ-3
IPR003307, W2_domain
PANTHERiPTHR23253:SF10, PTHR23253:SF10, 1 hit
PfamiView protein in Pfam
PF02847, MA3, 1 hit
PF02854, MIF4G, 1 hit
PF02020, W2, 1 hit
SMARTiView protein in SMART
SM00515, eIF5C, 1 hit
SM00544, MA3, 1 hit
SM00543, MIF4G, 1 hit
SUPFAMiSSF48371, SSF48371, 3 hits
PROSITEiView protein in PROSITE
PS51366, MI, 1 hit
PS51363, W2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD4AD15_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4AD15
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: December 2, 2020
This is version 88 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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