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Entry version 68 (12 Aug 2020)
Sequence version 2 (03 Apr 2013)
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Protein

Protocadherin-16

Gene

Dchs1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protocadherin-16
Alternative name(s):
Protein dachsous homolog 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dchs1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
1309878, Dchs1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini36 – 2933ExtracellularSequence analysisAdd BLAST2898
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2934 – 2954HelicalSequence analysisAdd BLAST21
Topological domaini2955 – 3291CytoplasmicSequence analysisAdd BLAST337

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35Sequence analysisAdd BLAST35
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000042904636 – 3291Protocadherin-16Add BLAST3256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi396N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1711N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2354N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2562N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei3048PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
D4ACX8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D4ACX8

PeptideAtlas

More...
PeptideAtlasi
D4ACX8

PRoteomics IDEntifications database

More...
PRIDEi
D4ACX8

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
D4ACX8, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D4ACX8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D4ACX8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000031643, Expressed in brain and 20 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
D4ACX8, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterophilic interaction with FAT4; this interaction affects their respective protein levels.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000040147

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D4ACX8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 137Cadherin 1PROSITE-ProRule annotationAdd BLAST101
Domaini138 – 249Cadherin 2PROSITE-ProRule annotationAdd BLAST112
Domaini250 – 356Cadherin 3PROSITE-ProRule annotationAdd BLAST107
Domaini369 – 466Cadherin 4PROSITE-ProRule annotationAdd BLAST98
Domaini476 – 572Cadherin 5PROSITE-ProRule annotationAdd BLAST97
Domaini573 – 679Cadherin 6PROSITE-ProRule annotationAdd BLAST107
Domaini680 – 784Cadherin 7PROSITE-ProRule annotationAdd BLAST105
Domaini785 – 888Cadherin 8PROSITE-ProRule annotationAdd BLAST104
Domaini889 – 994Cadherin 9PROSITE-ProRule annotationAdd BLAST106
Domaini995 – 1105Cadherin 10PROSITE-ProRule annotationAdd BLAST111
Domaini1100 – 1205Cadherin 11PROSITE-ProRule annotationAdd BLAST106
Domaini1218 – 1317Cadherin 12PROSITE-ProRule annotationAdd BLAST100
Domaini1326 – 1429Cadherin 13PROSITE-ProRule annotationAdd BLAST104
Domaini1430 – 1539Cadherin 14PROSITE-ProRule annotationAdd BLAST110
Domaini1539 – 1642Cadherin 15PROSITE-ProRule annotationAdd BLAST104
Domaini1643 – 1744Cadherin 16PROSITE-ProRule annotationAdd BLAST102
Domaini1745 – 1848Cadherin 17PROSITE-ProRule annotationAdd BLAST104
Domaini1849 – 1953Cadherin 18PROSITE-ProRule annotationAdd BLAST105
Domaini1976 – 2061Cadherin 19PROSITE-ProRule annotationAdd BLAST86
Domaini2062 – 2164Cadherin 20PROSITE-ProRule annotationAdd BLAST103
Domaini2165 – 2270Cadherin 21PROSITE-ProRule annotationAdd BLAST106
Domaini2270 – 2369Cadherin 22PROSITE-ProRule annotationAdd BLAST100
Domaini2370 – 2475Cadherin 23PROSITE-ProRule annotationAdd BLAST106
Domaini2476 – 2595Cadherin 24PROSITE-ProRule annotationAdd BLAST120
Domaini2596 – 2699Cadherin 25PROSITE-ProRule annotationAdd BLAST104
Domaini2700 – 2806Cadherin 26PROSITE-ProRule annotationAdd BLAST107
Domaini2807 – 2926Cadherin 27PROSITE-ProRule annotationAdd BLAST120

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3594, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161822

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000265_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D4ACX8

KEGG Orthology (KO)

More...
KOi
K16507

Identification of Orthologs from Complete Genome Data

More...
OMAi
TGHIRLM

Database of Orthologous Groups

More...
OrthoDBi
34489at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316403

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028, Cadherin, 23 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205, CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112, CA, 27 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313, SSF49313, 27 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232, CADHERIN_1, 18 hits
PS50268, CADHERIN_2, 27 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

D4ACX8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQEELSVALS CPGMKSLGTL LPLLVLLGTT VPGIRGQAGS LDLQIDEEQP
60 70 80 90 100
AGTLIGDISA GLPPGTAPPP MYFISAQEGS GVGTDLDIDE HSGVVCTARV
110 120 130 140 150
LDRERRDRYR FTAVTPDGAT VEVTVRVADI NDHAPAFPQA RAALQIPEHT
160 170 180 190 200
ALGTRYPLEP AHDADAGRLG TQGYALSGDG AGETFRLETR PGPGGAPVPE
210 220 230 240 250
LVIAGELDRE NRSHYMLQLE AYDGGSPPRR AQALLDVTLL DINDHAPAFN
260 270 280 290 300
QSRYHAVVSE SLAPGSPVLQ VFASDADAGA NGAVTYEINR RQSEGDGPFS
310 320 330 340 350
IDAHTGFLKL ERPLDFEQRR VHELVVQARD GGAHPELGSA FVTVHVRDAN
360 370 380 390 400
DNQPSMTVIF LSADGSPRVS EAAPPGQLVA RISVSDPDDG DFAHVNVSLE
410 420 430 440 450
GGEGHFALST QDSVIYLVCV ARRLDREERD VYNLRVTATD SGSPPLRAEA
460 470 480 490 500
AFVLHVTDVN DNAPAFDRQL YRPEPLPEVA LPGSFVVRVT ARDPDQGTNG
510 520 530 540 550
QVTYSLAPGT HTHWFSIDPT SGIITTAATL DYELEPQPQL IVVATDGGLP
560 570 580 590 600
PLVSSATVSV ALQDVNDNEP QFQRTFYNAS LPEGTQPGTC FLQVTATDAD
610 620 630 640 650
SGPFGLLSYS LGAGLGASGS PPFRIDAHSG EVCTTRILDR DQGPSSFDFT
660 670 680 690 700
VTAIDGGGLK SMVYVKVFVA DENDNPPQFY PREYAASLSA QSTPGTAVLR
710 720 730 740 750
VHAHDPDQGP HGRLSYHILA GNSPPLFALD AHSGLLTVAW PLGRRANSVV
760 770 780 790 800
QLEIGAQDGG GLQAEPIARV NISIVPGTPT PPIFEQLQYV FSVPEDVAPG
810 820 830 840 850
TSVGVVQAHN PPGRLGPVTL TLSGGDPRGL FSLDSASGLL KTLRPLDREL
860 870 880 890 900
LGPVLELEVR AGSGTPPVFS AARIRVLLDD VNDNSPAFPA PEDTVLLPQN
910 920 930 940 950
TAPGTPVYTL RALDPDSGAN SRVTFSLLAG GDGLFTVDPT TGHVRLMGPL
960 970 980 990 1000
GPPGGPPHEL EVEAQDGGSP PRTSHFRLRV VIQDLGIHGL APRFDSPTYR
1010 1020 1030 1040 1050
VDLPSGTTTG TQILQVQAQA PDGSPVTYHL AADGASNPFG LESQSGWLWV
1060 1070 1080 1090 1100
RAALDRESQE LYTLKVMAVS GSKAELGQQT GTATVRVVIL NQNDHSPRLS
1110 1120 1130 1140 1150
EEPTFLAVAE NQPPGTSVGR VFATDKDSGP NGRLTYSLQQ LSEDSKAFRI
1160 1170 1180 1190 1200
HPQTGEVTTL QTLDREQQSS FQLLVQVQDA GSPPRSATGT VHVAVLDLND
1210 1220 1230 1240 1250
NSPTFLQASG AAGGGLPIQV PDRVPPGTLV TTLQAKDPDE GENGTILYTL
1260 1270 1280 1290 1300
TGSGSELFSL HPHTGELHTA ASLIRAERPH YVLTLSAHDQ GSPPRSASLQ
1310 1320 1330 1340 1350
LLVQVLPSTR MVESPDLVEA DSAATVPVVL TVTAAEGLRP GSLLGSVAPQ
1360 1370 1380 1390 1400
EPASMGVLTY TLVGGADPEG TFALDSASGR LYLARVLDFE SGPAWRALTV
1410 1420 1430 1440 1450
RAEGPGGAGA RLMRVQVRVQ DENEHAPAFA RDPLALALPE NPEPGATLYT
1460 1470 1480 1490 1500
FRASDADGPG PNSDVRYRLL RQEPPVPALR LDARTGALSA PRGLDRETTP
1510 1520 1530 1540 1550
ALLLIVEATD RPANASRRKA TRVSARVFVT DENDNAPVFA SPSRMRLPED
1560 1570 1580 1590 1600
QPPGPAALHV VARDPDLGEA ARVSYRLAAG GDGHFRLHAT TGALSVVRPL
1610 1620 1630 1640 1650
DREQRAEHVL TVVASDHGSP PRSSTQLLTV SVVDVNDEAP AFPQQEYNVI
1660 1670 1680 1690 1700
LRENSPPGTS LLTLKATDPD LGANGQVTYG GVSGESFSLD PNSGVLTTLR
1710 1720 1730 1740 1750
ALDREEQEEI NLTVYARDRG LPPLLTHITV RVTVEDENDH SPTFGNTHLS
1760 1770 1780 1790 1800
LEVPEGQDPQ TLTTLRASDP DGGLNGQLQY RILGGDPSGA FALDLTSGEF
1810 1820 1830 1840 1850
GTTRPLDREV EPAFQLQIEA RDGGQPALSA TLLVTVTVLD ANDHAPAFPV
1860 1870 1880 1890 1900
PSYSVEVPED APVGTLLLQL QAHDPDEGDN GRVMYYLGAG TAGAFLLEPT
1910 1920 1930 1940 1950
SGELSTATAL DREHCASYAF SVTAVDGAAA GPLSTTVPIT VTVRDVNDHA
1960 1970 1980 1990 2000
PAFPTSPLRL RLPRPGPSLN KPTLALATLR AEDRDAGANA SILYRLAGTP
2010 2020 2030 2040 2050
PPGTTVDSYT GEIRVARSPA ALGPRDRVLF IVATDLGRPA RSATGVVIVG
2060 2070 2080 2090 2100
IQGEPERGPR FPRANNEAVL RENAPPGTPV ISPKAVHSGG SNGPITYSIL
2110 2120 2130 2140 2150
SGNERGIFSI QPSTGTITVQ SAEGLDFETN PRLRLVLQAE SGGAFAFSVL
2160 2170 2180 2190 2200
TLTLQDANDN APRFLQPHYV AFLPESRPLE GPLLQVEADD LDQGSGGQIS
2210 2220 2230 2240 2250
YSLAASQPAR GLFHVDPATG TITTTAILDR EIWAETRLVL MATDRGSPAL
2260 2270 2280 2290 2300
VGSATLTVMV IDTNDNRPTI PQPWELRVSE DALLGSEIAQ VTGNDVDSGP
2310 2320 2330 2340 2350
VLWYVLSPSG PQDPFSIGRY GGRVSLTGPL DFEQCDHYHL QLLAHDGPHE
2360 2370 2380 2390 2400
GHANLTVLVE DVNDNVPIFS QSLYQVMMLE HTPPGSAILS VSATDRDSGA
2410 2420 2430 2440 2450
NGHISYHLAS PAEGFSVDTN NGTLFTTVGA MALGHEGPGV VDVVLEARDH
2460 2470 2480 2490 2500
GAPGRSAQAT VHVQLKDQND HAPSFTLPHY RVAVSEDLPP GSTLLTLEAI
2510 2520 2530 2540 2550
DADGSRSHAT VDYSIISGNR GRVFQLEPRL AEVGDGVGPG PQALGCLVLL
2560 2570 2580 2590 2600
EPLDFESLTQ YNLTVTAADR GQPPRSSAVP VTVTVLDVND NPPVFTRASY
2610 2620 2630 2640 2650
RVTVPEDMPV GAELLHVEAS DADPGPHGLV HFTLSSGDPL GLFELDENSG
2660 2670 2680 2690 2700
ALRLAHPLDC ETQAQHQLVV QAADPAGTHF ALVPVTVEVQ DVNDHGPAFP
2710 2720 2730 2740 2750
LSLLSTSLAE NQPPGTLVTT LHAMDGDAGT FGRLRYTLLE AVPGPEGREA
2760 2770 2780 2790 2800
FSLNSSTGEL RARVPFDYEH TGSFRLLVGA ADAGNLSASV TVSVLITGED
2810 2820 2830 2840 2850
EYDPVFLAPS FHFQVPEGAQ RGHSLGHVQA TDEDGGADGL VLYSLATSSP
2860 2870 2880 2890 2900
YFGINQTTGA LYLRVDSRAP GSGTATSGGG GRTRREAPRE LRLEVVARGP
2910 2920 2930 2940 2950
LPGSRSATVP VTVDITHTAL GLAPDLNLLL VGAVAASLGV VVVLALAALV
2960 2970 2980 2990 3000
LGLVRARSRK AEAAPGPMSQ TAPIASSSLQ KLGREPPSPP PSEHLYHQTL
3010 3020 3030 3040 3050
PSYGGPGAGG PYPRGGSLDP SHSSGRGSAE AAEDDEIRMI NEFPRVASVA
3060 3070 3080 3090 3100
SSLAARGPDS GIQQDADGLS DTSCEPPAPD TWYKGRKAGL LLPGAGATLY
3110 3120 3130 3140 3150
REEGPPATAT AFLGGCGLSP APTGDYGFPA DGKPCVAGAL TAIVAGEEEL
3160 3170 3180 3190 3200
RGSYNWDYLL SWCPQFQPLA SVFTEIARLK DEARPCPPAP RIDPPPLITA
3210 3220 3230 3240 3250
VAHPGAKSVP PKPASTAATR AIFPPASHRS PISHEGSLSS AAMSPSFSPS
3260 3270 3280 3290
LSPLAARSPV VSPFGVAQGP SASALSTESG LEPPDDTELR I
Length:3,291
Mass (Da):345,981
Last modified:April 3, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2C15E55E42CE503
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AABR06007653 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
NP_001101014.2, NM_001107544.2
XP_006230004.1, XM_006229942.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSRNOT00000042865; ENSRNOP00000040147; ENSRNOG00000031643

Database of genes from NCBI RefSeq genomes

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GeneIDi
308912

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:308912

UCSC genome browser

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UCSCi
RGD:1309878, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06007653 Genomic DNA No translation available.
RefSeqiNP_001101014.2, NM_001107544.2
XP_006230004.1, XM_006229942.2

3D structure databases

SMRiD4ACX8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040147

PTM databases

GlyGeniD4ACX8, 4 sites
iPTMnetiD4ACX8
PhosphoSitePlusiD4ACX8

Proteomic databases

jPOSTiD4ACX8
PaxDbiD4ACX8
PeptideAtlasiD4ACX8
PRIDEiD4ACX8

Genome annotation databases

EnsembliENSRNOT00000042865; ENSRNOP00000040147; ENSRNOG00000031643
GeneIDi308912
KEGGirno:308912
UCSCiRGD:1309878, rat

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8642
RGDi1309878, Dchs1

Phylogenomic databases

eggNOGiKOG3594, Eukaryota
GeneTreeiENSGT00940000161822
HOGENOMiCLU_000265_2_0_1
InParanoidiD4ACX8
KOiK16507
OMAiTGHIRLM
OrthoDBi34489at2759
TreeFamiTF316403

Miscellaneous databases

Protein Ontology

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PROi
PR:D4ACX8

Gene expression databases

BgeeiENSRNOG00000031643, Expressed in brain and 20 other tissues
GenevisibleiD4ACX8, RN

Family and domain databases

InterProiView protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
PfamiView protein in Pfam
PF00028, Cadherin, 23 hits
PRINTSiPR00205, CADHERIN
SMARTiView protein in SMART
SM00112, CA, 27 hits
SUPFAMiSSF49313, SSF49313, 27 hits
PROSITEiView protein in PROSITE
PS00232, CADHERIN_1, 18 hits
PS50268, CADHERIN_2, 27 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCD16_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4ACX8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 14, 2014
Last sequence update: April 3, 2013
Last modified: August 12, 2020
This is version 68 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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