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Entry version 84 (02 Jun 2021)
Sequence version 2 (03 Apr 2013)
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Protein
Submitted name:

ATP-binding cassette, subfamily A (ABC1), member 15

Gene

Abca15

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi558 – 565ATPPROSITE-ProRule annotation8
Nucleotide bindingi1389 – 1396ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ATP-binding cassette, subfamily A (ABC1), member 15Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Abca15Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
1305981, Abca15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei24 – 43HelicalSequence analysisAdd BLAST20
Transmembranei259 – 281HelicalSequence analysisAdd BLAST23
Transmembranei302 – 328HelicalSequence analysisAdd BLAST27
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Transmembranei367 – 386HelicalSequence analysisAdd BLAST20
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Transmembranei442 – 465HelicalSequence analysisAdd BLAST24
Transmembranei904 – 922HelicalSequence analysisAdd BLAST19
Transmembranei1068 – 1088HelicalSequence analysisAdd BLAST21
Transmembranei1108 – 1130HelicalSequence analysisAdd BLAST23
Transmembranei1151 – 1171HelicalSequence analysisAdd BLAST21
Transmembranei1177 – 1199HelicalSequence analysisAdd BLAST23
Transmembranei1276 – 1294HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D4ACN5

PRoteomics IDEntifications database

More...
PRIDEi
D4ACN5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D4ACN5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D4ACN5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000027505, Expressed in testis and 3 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000033528

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D4ACN5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini522 – 755ABC transporterInterPro annotationAdd BLAST234
Domaini1354 – 1587ABC transporterInterPro annotationAdd BLAST234

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni835 – 862DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi841 – 856Polar residuesSequence analysisAdd BLAST16

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0059, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162242

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000604_19_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D4ACN5

Identification of Orthologs from Complete Genome Data

More...
OMAi
IVMVKEP

Database of Orthologous Groups

More...
OrthoDBi
131191at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105191

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR026082, ABCA
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR19229, PTHR19229, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D4ACN5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPASKKLL LLLWKNFTLK RRKFGALVTE IILMLAFSIV LLTTRHLLSI
60 70 80 90 100
NKMESLHFPD QPVGAVPFFF RVSANSSRPW ELAYVPSNIT VVHNIVENVK
110 120 130 140 150
KDLNFPMAVI GFPSESDFED YARSSVNSRN ILAAIVFDHN FANSRDPLPK
160 170 180 190 200
KIKYNLRFSD IKKNIHGMAY YQGHTWLTKF LFPPLRIVGP RNPQEADGGS
210 220 230 240 250
PGYITEGFLA VQHALDKAIM LHHGGAAATA LFNDVSLFIQ RFPYPAYYHD
260 270 280 290 300
HFYLFANTFV PLTVASIFFL NHLILVWSIV WEKENRLKEY QLMIGLRNWM
310 320 330 340 350
FWIAYFFTFF CLYFINIIFM CIVLFVKIDP APIFQYNDPI LVFILLLFYA
360 370 380 390 400
ISSIFFSFMI STLFNRVSFA VSLGSFLFFL TYLPAITMNQ SFEHMPPRQK
410 420 430 440 450
LIWSFDFNVG MAFGFRFLVN AETRKTGMKW NNIFLPTDSD SLLFTYVLGM
460 470 480 490 500
LLVDAFIYGL VAWYIEAVFP GEYGVPKPWN FFLMHSYWFG ESRQQKPEIT
510 520 530 540 550
QFCKRVESKY FEVEPTDLTA GIQIKHLHKV FQENNITKVA INDLSLNVYE
560 570 580 590 600
GQITVLLGHN GAGKSTTLSI LSGLYPPTSG EAYVHGEDIS QHMDQIRNFL
610 620 630 640 650
GLCPQQNLLF DHLTVSEHLY FYCRVKGVPQ NMCLEETNNM LSAFNLTEKR
660 670 680 690 700
DAFSKSLSGG MKRKLAIIIA LIGGSKVVIL DEPTSGMDPA SRRSTWDVVQ
710 720 730 740 750
TYKQNRTILL TTHYMDEADM LGDRIAIMVQ GTLRCCGSSV FLKRLYGVGS
760 770 780 790 800
HIVMVKEPVC DVDEISKLIH YYIPTATLKT NVGNELSFIL PKEYTHKFEA
810 820 830 840 850
LLTALEENQE NLGISSFGMS ITTMEEVFLR VSKMEDSKPD MEATQSPSAG
860 870 880 890 900
SKGNRNRDVE SSMRAGFPTQ SEDQTIVFNT GCPLYLQQFH AMFMKRLMYN
910 920 930 940 950
WRNWRVLSVQ ILGLVISTFL LLKSHEFRHK RIRQMNLDDY GQTIVPFSIL
960 970 980 990 1000
GKSNLTTSLL IHLENMLKPG NHQLKEVQGD LLKYLEGNEE CIHLCIVALS
1010 1020 1030 1040 1050
IKVAAGRAKL TVLFNNEAYH SPSLSLAVLD NILFMSLSGA NASITVFHKP
1060 1070 1080 1090 1100
QPRPTSKEWP RSTYGKIVAF KIQLGMALLV SGFCILTVTE RITKAKHMQF
1110 1120 1130 1140 1150
LSGASVLVYW LSALVFDFII FFISCCFLLV MFKYYKIDIY VTDYHILETM
1160 1170 1180 1190 1200
LILILFGWSA IPLTYLMSFL FSKSIPAYIQ LLVFYYLSGT SGLLIDTIIE
1210 1220 1230 1240 1250
AGLSTIISNS TQTFLLSSLL FFPTYNLGKC ISEYTVIYQR KILCIQQKNV
1260 1270 1280 1290 1300
LKYLNCSKEY TKKNIYSLKK PMIGKYLIAM SIAGFVYLLF IFFWENISWK
1310 1320 1330 1340 1350
LRMLIHQHIY FGVCKKYKSD IISNELSGTS EDNDVENERR EILYQPEKFL
1360 1370 1380 1390 1400
NCPVLIKQLT KIYFKSPLIL AVKNISLAIQ ERECFGLLGF NGAGKTTTFQ
1410 1420 1430 1440 1450
ILTGEITPTA GDVFIDGISI TKDVLKVRSK IGYCPQFDAL LEYLTGWEIM
1460 1470 1480 1490 1500
VMYARIWGIS ERQIRPYVNT YLNSLELEPH ANSLISTYSE GNKRRLSTAI
1510 1520 1530 1540 1550
AMMGKPSVIF LDEPSTGMDP RARRLLWDAV IKIRESGKAI IITSHSMEEC
1560 1570 1580 1590 1600
EALCTRLSIM VHGKLTCLGS PQYLKNKFGD IYILKTKVKS GETLKEFKNF
1610 1620 1630 1640 1650
ITLTFPGSEL KQENQGILNY YIPSKDNSWG KVFGILEKAK EQYDLEDYSI
1660
SQITLDQVFL AFADQDRK
Length:1,668
Mass (Da):190,598
Last modified:April 3, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF9F12277E49F95B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07005604 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001099763.2, NM_001106293.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000037026; ENSRNOP00000033528; ENSRNOG00000027505

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
293442

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:293442

UCSC genome browser

More...
UCSCi
RGD:1305981, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07005604 Genomic DNA No translation available.
RefSeqiNP_001099763.2, NM_001106293.2

3D structure databases

SMRiD4ACN5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033528

PTM databases

iPTMnetiD4ACN5
PhosphoSitePlusiD4ACN5

Proteomic databases

PaxDbiD4ACN5
PRIDEiD4ACN5

Genome annotation databases

EnsembliENSRNOT00000037026; ENSRNOP00000033528; ENSRNOG00000027505
GeneIDi293442
KEGGirno:293442
UCSCiRGD:1305981, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
320631
RGDi1305981, Abca15

Phylogenomic databases

eggNOGiKOG0059, Eukaryota
GeneTreeiENSGT00940000162242
HOGENOMiCLU_000604_19_1_1
InParanoidiD4ACN5
OMAiIVMVKEP
OrthoDBi131191at2759
TreeFamiTF105191

Gene expression databases

BgeeiENSRNOG00000027505, Expressed in testis and 3 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR026082, ABCA
IPR027417, P-loop_NTPase
PANTHERiPTHR19229, PTHR19229, 1 hit
PfamiView protein in Pfam
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD4ACN5_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4ACN5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: June 2, 2021
This is version 84 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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