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Entry version 94 (05 Jun 2019)
Sequence version 1 (20 Apr 2010)
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Protein

Serine-protein kinase ATM

Gene

Atm

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
Biological processDNA damageUniRule annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-2559586 DNA Damage/Telomere Stress Induced Senescence
R-RNO-3371453 Regulation of HSF1-mediated heat shock response
R-RNO-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-RNO-5685938 HDR through Single Strand Annealing (SSA)
R-RNO-5685942 HDR through Homologous Recombination (HRR)
R-RNO-5693548 Sensing of DNA Double Strand Breaks
R-RNO-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-RNO-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-RNO-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-RNO-5693571 Nonhomologous End-Joining (NHEJ)
R-RNO-5693579 Homologous DNA Pairing and Strand Exchange
R-RNO-5693607 Processing of DNA double-strand break ends
R-RNO-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-RNO-6804757 Regulation of TP53 Degradation
R-RNO-69473 G2/M DNA damage checkpoint
R-RNO-69541 Stabilization of p53

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine-protein kinase ATMUniRule annotation (EC:2.7.11.1UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AtmImported
Synonyms:Atm_mappedImported
ORF Names:rCG_58300Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Rat genome database

More...
RGDi
1593265 Atm

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicleUniRule annotation, NucleusUniRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
D4ACL8

PRoteomics IDEntifications database

More...
PRIDEi
D4ACL8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000029773 Expressed in 10 organ(s), highest expression level in spleen

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000045529

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1967 – 2574FATInterPro annotationAdd BLAST608
Domaini2720 – 3064PI3K/PI4KInterPro annotationAdd BLAST345
Domaini3032 – 3064FATCInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni833 – 862DisorderedSequence analysisAdd BLAST30
Regioni1975 – 2001DisorderedSequence analysisAdd BLAST27
Regioni2984 – 3005DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1618 – 1641Sequence analysisAdd BLAST24
Coiled coili3011 – 3031Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1984 – 2001PolarSequence analysisAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. ATM subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0892 Eukaryota
ENOG410XNPY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00670000098061

KEGG Orthology (KO)

More...
KOi
K04728

Identification of Orthologs from Complete Genome Data

More...
OMAi
LDPFPDH

Database of Orthologous Groups

More...
OrthoDBi
80538at2759

TreeFam database of animal gene trees

More...
TreeFami
TF101182

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR015519 ATM/Tel1
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
IPR021668 TAN

The PANTHER Classification System

More...
PANTHERi
PTHR11139:SF72 PTHR11139:SF72, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF11640 TAN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit
SM01342 TAN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

D4ACL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLALNDLLI CCRQLEHDRA TERRKEVDKF KRLIQDPETV QHLDRHSDSK
60 70 80 90 100
QGKYLNWDAV FRFLQKYIQK ETESLRTAKS NVSASTQTSR QKKMQEISSL
110 120 130 140 150
VRFFIKCANK RAPRLKCQDL LNYVMDTVKD SSNGATYGAD CSNILLKDIL
160 170 180 190 200
SVRKYWCEVS QQQWLELFSL YIRLYLKPSQ DINRVLVARI IHAVTRGCCS
210 220 230 240 250
QTDGLPSKFL DLFSKAIQYA RQEKSSPGLS HILAALNIFL KTLAVNFRKR
260 270 280 290 300
VCEIGDEILP TLLYIWTQHR LNDSLKEVII ELIHLQIYIH HPQGAKAPEE
310 320 330 340 350
GAYESMKWKR ILYNLYDLLV NEISHIGSRG KYSSGSRNIA VKENLIDLMA
360 370 380 390 400
DVCYQLFNAD TRSVEISQSY ATQRESTDYS VPCKRRKIDI GWEVIKDYLQ
410 420 430 440 450
KSQNDFDLVP WLQITTRLIS KYPSSLPNCE LSPLILILYQ LLPQQRRGER
460 470 480 490 500
IPHVLRCLTE VALCQGKKSN LESSQKSDLL KLWIKIWSIT FRGISSEQTQ
510 520 530 540 550
TENFGLLGAI IQGSLVELDR EFWKLFTGSA CKPSSPSVRC LTLALSMCVV
560 570 580 590 600
PDAIKMGTEQ SVCDANRSFS VKESIMRWLL FYQLEGDLED SAEPPPILQS
610 620 630 640 650
NFPHLILEKI LVSLTMKNSK AAMKFFQSAP ECEQHCEDTE EPSFSEAEEL
660 670 680 690 700
FLQTTFDKMD FLTPVKEDTV EKFQSRVGFS VHQNLKESLD HYLLGLSEQL
710 720 730 740 750
LSNYSSEITS SETLVRCSSL LVGVLGCYCY MGVITEDEAY KSELFQKAKS
760 770 780 790 800
LMQCAGESIS LFKNKTNEES RVGSLRSVIH LCTSCLCRHT KHTLNKIASG
810 820 830 840 850
FFLRLLTSKL MNDIADICKS LASCTKKPFD YGEEHSLRDD DDDGDGGDGG
860 870 880 890 900
ESLMETQGSS STDLFSDYSA STVSDANDYG ENQNAVGAAN PLTADWLSRQ
910 920 930 940 950
DHLLLDMLRF LCLSVTACQS RTASFRGADI RRKLLMLLDP STLDLTKSLH
960 970 980 990 1000
LHMYLVLLKD LPGKEHLLPM EDVVELLQPL SLVCSLYRRD QDVCKTILSN
1010 1020 1030 1040 1050
VLHIVTNLGQ GSVDTESTRN AQGQFLTVMG AFWHLTKEKK CIFSVRMALV
1060 1070 1080 1090 1100
KCLQTLLEAD PYSKWAILNV KGQDFPVREA FPQFLADGHH HVRMLAAGSI
1110 1120 1130 1140 1150
SRLFQDMRQG DSSRSLKALP LKFQQTSFNS AYMIAEAGIR ELLCDSQNPD
1160 1170 1180 1190 1200
LLDEIYNRKS VLLTVIAVVL HCSPICEKQA LFALCKSVKE NGLEPHLVKK
1210 1220 1230 1240 1250
VLEKVSESFG CRCLEDFMAS HLDYLVLEWL NLQDAKYSLS SFPFTLLNYM
1260 1270 1280 1290 1300
SVEDFYRSCY KILIPHLVIR KHFDEVKSIA NQIQRCWKSL LIDCFPKMLV
1310 1320 1330 1340 1350
HILPYFACEG TGDSSSAQKR ETATEVYDTL KGEDFLGKQI DQVFISNLPE
1360 1370 1380 1390 1400
IVVELLMTLH ETADSDSGQS PDLCDFSGDL DPAPNPPYFP SHVIKATFAY
1410 1420 1430 1440 1450
ISSCHKTKFK SILEILSKIP DSYQKILLAI CEQAAETNNV FKKHRILKIY
1460 1470 1480 1490 1500
HLFVSLLLKD IQSGLGGAWA FVLRDVIYTL IHYINKRSSH FTDVSLRSFS
1510 1520 1530 1540 1550
LCCDLLSRVC RTAVTHCKDA LENHLHVIVG TLIPLVDYQE VQEQVLDLLK
1560 1570 1580 1590 1600
YLVIDNKDNK NLFVTIKLLD PFPDHVVFKD LRLTQQKIKY SGGPFTLLEE
1610 1620 1630 1640 1650
INHFLSVSAY NPLPLTRLEG LKDLRRQLEQ HKDQMLDLVR ASQDNPQDGI
1660 1670 1680 1690 1700
VVKLVVSLLQ LSKMAVNQTG EREVLEAVGR CLGEIGPLDF STIAVQHSKD
1710 1720 1730 1740 1750
TPYTKAYGLP EDRELQWTLI MLTALNNTLV EDSVKIRSAA ATCLKNILAT
1760 1770 1780 1790 1800
KTGHIFWENH KTSADPMLTY LQPFRASRKK FLELPQFVKE DALEGLDDVN
1810 1820 1830 1840 1850
LWVPQSESHD IWIKTLTCAF LDSGGIKSEI LQLLKPMCEV KTDFCQMVLP
1860 1870 1880 1890 1900
YLIHDVLLQD THESWRTLLS THVRGFFTNC FKHSSQASRS ATPANSDSES
1910 1920 1930 1940 1950
ENFLRCCLDK KSQRTMLAVV DYLRRQKRPS SGTAFEDAFW LDLNYLEVAK
1960 1970 1980 1990 2000
VAQSCAAHFT ALLYAEIYSD KKNMDEQEKR SPTFEEGSQG TTISSLSEKS
2010 2020 2030 2040 2050
KEETGISLQD LLLEIYRSIG EPDSLYGCGG GKVLQPLTRI RTYEHEATWE
2060 2070 2080 2090 2100
KALVTYDLET TISSSTRQSG IIQALQNLGL SHILSIYLKG LDHERREWCG
2110 2120 2130 2140 2150
ELQELHYQAA WRNMQWDLCT SANQELEGTS YHESLYNALQ CLRNREFSTF
2160 2170 2180 2190 2200
YDSLRHARVK EVEELSKGSL ESVYSLYPTL SRLQAVGELE NSGELFSRSV
2210 2220 2230 2240 2250
TDRERSEVYL KWQKHSQLLK DSDFSFQEPL MALRTVILEI LVQKEMENSQ
2260 2270 2280 2290 2300
GGCSKDILTK HLVEFSVLAR TFKNTQLPER AIFKIKQYNP AICGISEWHL
2310 2320 2330 2340 2350
EEAQVFWAKK EQSLALSILK QMIKKLDSSF REVCNEAGLK GLHAECLRVC
2360 2370 2380 2390 2400
GNWLAETCLE NPAVIMQTYL EKAVKVAGSY DGDSRELRNG QMKAFLSLAR
2410 2420 2430 2440 2450
FSDTQYQRIE NYMKSSEFEN KQALLKRAKE EVGLIREHKI QTNRYTIKVQ
2460 2470 2480 2490 2500
RELELDECAL RALKEDRKRF LCKAVENYIS CLLSGEEHDL WVFRLCSLWL
2510 2520 2530 2540 2550
ENSGVSEVNG MMKRDGMKIS SYKFLPLMYQ LAARMGTKMT GGLGFHEVLN
2560 2570 2580 2590 2600
NLISRISMDH PHHTLFIILA LANANKDEFL SKPETARRGR ITKNAPKESS
2610 2620 2630 2640 2650
QLDEDRAEAA SRIIHTIRSA RRTMVKDMEA LCDAYIILAN LDASQWRNQR
2660 2670 2680 2690 2700
KGISIPANQP ITKLKNLEDV VVPTMEIKVD PTGEYEKLVT IKSFKTEFRL
2710 2720 2730 2740 2750
AGGLNLPKII DCVGSDGKER RQLVKGRDDL RQDAVMQQVF QMCNMLLQRN
2760 2770 2780 2790 2800
TETRKRKLTI CTYKVVPLSQ RSGVLEWCTG TIPIGEYLVN NEEGAHKRYR
2810 2820 2830 2840 2850
PNDLSANQCQ KKMMEVQKKS FEEKYETFMT ICQNFEPVFR YFCMEKFLDP
2860 2870 2880 2890 2900
AVWFEKRLAY TRSVATSSIV GYILGLGDRH VQNILINEQS AELVHIDLGV
2910 2920 2930 2940 2950
AFEQGKILPT PETVPFRLSR DIVDGMGITG VEGVFRRCCE KTMEVMRSSQ
2960 2970 2980 2990 3000
EALLTIVEVL LYDPLFDWTM NPLKALYLQQ RPEDETDLQS TPSADDQECK
3010 3020 3030 3040 3050
RSLSDTDQSF NKVAERVLMR LQEKLKGVEE GTVLSVGGQV NLLIQQAMDP
3060
KNLSRLFPGW KAWV
Length:3,064
Mass (Da):349,119
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9CF0EA4F19E65F0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K3I0A0A0G2K3I0_RAT
Serine-protein kinase ATM
Atm
3,062Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07073407 Genomic DNA No translation available.
AC133262 Genomic DNA No translation available.
CH473975 Genomic DNA Translation: EDL95516.1
CH473975 Genomic DNA Translation: EDL95517.1

NCBI Reference Sequences

More...
RefSeqi
NP_001100291.1, NM_001106821.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000050555; ENSRNOP00000045529; ENSRNOG00000029773

Database of genes from NCBI RefSeq genomes

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GeneIDi
300711

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:300711

UCSC genome browser

More...
UCSCi
RGD:1593265 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07073407 Genomic DNA No translation available.
AC133262 Genomic DNA No translation available.
CH473975 Genomic DNA Translation: EDL95516.1
CH473975 Genomic DNA Translation: EDL95517.1
RefSeqiNP_001100291.1, NM_001106821.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045529

Proteomic databases

jPOSTiD4ACL8
PRIDEiD4ACL8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000050555; ENSRNOP00000045529; ENSRNOG00000029773
GeneIDi300711
KEGGirno:300711
UCSCiRGD:1593265 rat

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
472
RGDi1593265 Atm

Phylogenomic databases

eggNOGiKOG0892 Eukaryota
ENOG410XNPY LUCA
GeneTreeiENSGT00670000098061
KOiK04728
OMAiLDPFPDH
OrthoDBi80538at2759
TreeFamiTF101182

Enzyme and pathway databases

ReactomeiR-RNO-2559586 DNA Damage/Telomere Stress Induced Senescence
R-RNO-3371453 Regulation of HSF1-mediated heat shock response
R-RNO-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-RNO-5685938 HDR through Single Strand Annealing (SSA)
R-RNO-5685942 HDR through Homologous Recombination (HRR)
R-RNO-5693548 Sensing of DNA Double Strand Breaks
R-RNO-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-RNO-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-RNO-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-RNO-5693571 Nonhomologous End-Joining (NHEJ)
R-RNO-5693579 Homologous DNA Pairing and Strand Exchange
R-RNO-5693607 Processing of DNA double-strand break ends
R-RNO-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-RNO-6804757 Regulation of TP53 Degradation
R-RNO-69473 G2/M DNA damage checkpoint
R-RNO-69541 Stabilization of p53

Gene expression databases

BgeeiENSRNOG00000029773 Expressed in 10 organ(s), highest expression level in spleen

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR015519 ATM/Tel1
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
IPR021668 TAN
PANTHERiPTHR11139:SF72 PTHR11139:SF72, 1 hit
PfamiView protein in Pfam
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF11640 TAN, 1 hit
SMARTiView protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit
SM01342 TAN, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD4ACL8_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4ACL8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: June 5, 2019
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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