UniProtKB - D4AC20 (D4AC20_RAT)
Protein
Cytidine deaminase
Gene
Cda
Organism
Rattus norvegicus (Rat)
Status
Functioni
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.UniRule annotationARBA annotation
Catalytic activityi
Cofactori
Zn2+UniRule annotationARBA annotation
GO - Molecular functioni
- cytidine deaminase activity Source: RGD
- identical protein binding Source: RGD
- nucleoside binding Source: RGD
- protein homodimerization activity Source: RGD
- zinc ion binding Source: RGD
GO - Biological processi
- cellular response to external biotic stimulus Source: RGD
- cytidine deamination Source: RGD
- negative regulation of cell growth Source: RGD
- negative regulation of nucleotide metabolic process Source: RGD
- response to cycloheximide Source: RGD
Keywordsi
Molecular function | HydrolaseUniRule annotation |
Ligand | Metal-bindingUniRule annotationARBA annotation, ZincUniRule annotationARBA annotation |
Enzyme and pathway databases
Reactomei | R-RNO-6798695, Neutrophil degranulation R-RNO-73614, Pyrimidine salvage |
Names & Taxonomyi
Protein namesi | Recommended name: Cytidine deaminaseUniRule annotation (EC:3.5.4.5UniRule annotation)Alternative name(s): Cytidine aminohydrolaseUniRule annotation |
Gene namesi | ORF Names:rCG_31070Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1311101, Cda 6501229, LOC100909857 |
Subcellular locationi
Cytosol
- cytosol Source: RGD
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000015677, Expressed in jejunum and 18 other tissues |
Interactioni
GO - Molecular functioni
- identical protein binding Source: RGD
- protein homodimerization activity Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000065378 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 140 | CMP/dCMP-type deaminaseInterPro annotationAdd BLAST | 128 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0833, Eukaryota |
GeneTreei | ENSGT00390000000911 |
HOGENOMi | CLU_097262_1_2_1 |
OMAi | LTHFTCV |
OrthoDBi | 1400471at2759 |
TreeFami | TF314486 |
Family and domain databases
InterProi | View protein in InterPro IPR016192, APOBEC/CMP_deaminase_Zn-bd IPR002125, CMP_dCMP_dom IPR006262, Cyt_deam_tetra IPR016193, Cytidine_deaminase-like |
Pfami | View protein in Pfam PF00383, dCMP_cyt_deam_1, 1 hit |
SUPFAMi | SSF53927, SSF53927, 1 hit |
TIGRFAMsi | TIGR01354, cyt_deam_tetra, 1 hit |
PROSITEi | View protein in PROSITE PS00903, CYT_DCMP_DEAMINASES_1, 1 hit PS51747, CYT_DCMP_DEAMINASES_2, 1 hit |
i Sequence
Sequence statusi: Complete.
D4AC20-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQERPSCAV EPEHVQRLLL SSREAKKSAY CPYSRFPVGA ALLTGDGRIF
60 70 80 90 100
SGCNVENACY PLGVCAERTA IQKAISEGYK DFRAIAIASD LQEEFISPCG
110 120 130 140
ACRQVMREFG TNWAVYMTKP DGTFVVRTVQ ELLPASFGPE DLQKIH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07050212 Genomic DNA No translation available. AABR07050213 Genomic DNA No translation available. AABR07050214 Genomic DNA No translation available. AABR07050218 Genomic DNA No translation available. AABR07050219 Genomic DNA No translation available. CH473968 Genomic DNA Translation: EDL80875.1 |
RefSeqi | NP_001102158.1, NM_001108688.1 XP_003750114.1, XM_003750066.4 |
Genome annotation databases
Ensembli | ENSRNOT00000021036; ENSRNOP00000021036; ENSRNOG00000015677 ENSRNOT00000075128; ENSRNOP00000065378; ENSRNOG00000049700 |
GeneIDi | 100909857 362638 |
KEGGi | rno:100909857 rno:362638 |
UCSCi | RGD:1311101, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07050212 Genomic DNA No translation available. AABR07050213 Genomic DNA No translation available. AABR07050214 Genomic DNA No translation available. AABR07050218 Genomic DNA No translation available. AABR07050219 Genomic DNA No translation available. CH473968 Genomic DNA Translation: EDL80875.1 |
RefSeqi | NP_001102158.1, NM_001108688.1 XP_003750114.1, XM_003750066.4 |
3D structure databases
SMRi | D4AC20 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000065378 |
Proteomic databases
PRIDEi | D4AC20 |
Genome annotation databases
Ensembli | ENSRNOT00000021036; ENSRNOP00000021036; ENSRNOG00000015677 ENSRNOT00000075128; ENSRNOP00000065378; ENSRNOG00000049700 |
GeneIDi | 100909857 362638 |
KEGGi | rno:100909857 rno:362638 |
UCSCi | RGD:1311101, rat |
Organism-specific databases
CTDi | 978 |
RGDi | 1311101, Cda 6501229, LOC100909857 |
Phylogenomic databases
eggNOGi | KOG0833, Eukaryota |
GeneTreei | ENSGT00390000000911 |
HOGENOMi | CLU_097262_1_2_1 |
OMAi | LTHFTCV |
OrthoDBi | 1400471at2759 |
TreeFami | TF314486 |
Enzyme and pathway databases
Reactomei | R-RNO-6798695, Neutrophil degranulation R-RNO-73614, Pyrimidine salvage |
Gene expression databases
Bgeei | ENSRNOG00000015677, Expressed in jejunum and 18 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR016192, APOBEC/CMP_deaminase_Zn-bd IPR002125, CMP_dCMP_dom IPR006262, Cyt_deam_tetra IPR016193, Cytidine_deaminase-like |
Pfami | View protein in Pfam PF00383, dCMP_cyt_deam_1, 1 hit |
SUPFAMi | SSF53927, SSF53927, 1 hit |
TIGRFAMsi | TIGR01354, cyt_deam_tetra, 1 hit |
PROSITEi | View protein in PROSITE PS00903, CYT_DCMP_DEAMINASES_1, 1 hit PS51747, CYT_DCMP_DEAMINASES_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D4AC20_RAT | |
Accessioni | D4AC20Primary (citable) accession number: D4AC20 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | February 10, 2021 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |