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Entry version 77 (11 Dec 2019)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

TBC1 domain family member 1

Gene

Tbc1d1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TBC1 domain family member 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tbc1d1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Rat genome database

More...
RGDi
1304562 Tbc1d1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
D4AC16

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D4AC16

PRoteomics IDEntifications database

More...
PRIDEi
D4AC16

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D4AC16

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D4AC16

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000002180 Expressed in 9 organ(s), highest expression level in testis

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000033018

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D4AC16

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini287 – 368PIDInterPro annotationAdd BLAST82
Domaini889 – 1083Rab-GAP TBCInterPro annotationAdd BLAST195

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni509 – 545DisorderedSequence analysisAdd BLAST37
Regioni622 – 683DisorderedSequence analysisAdd BLAST62
Regioni767 – 788DisorderedSequence analysisAdd BLAST22
Regioni1238 – 1257DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili823 – 846Sequence analysisAdd BLAST24
Coiled coili1169 – 1210Sequence analysisAdd BLAST42
Coiled coili1218 – 1238Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi520 – 540PolarSequence analysisAdd BLAST21
Compositional biasi622 – 636PolyampholyteSequence analysisAdd BLAST15
Compositional biasi645 – 659Pro-richSequence analysisAdd BLAST15
Compositional biasi660 – 683PolarSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4436 Eukaryota
ENOG410YWJY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157949

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D4AC16

KEGG Orthology (KO)

More...
KOi
K18341

Identification of Orthologs from Complete Genome Data

More...
OMAi
TLIWEKM

Database of Orthologous Groups

More...
OrthoDBi
323342at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D4AC16

TreeFam database of animal gene trees

More...
TreeFami
TF317184

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021785 DUF3350
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11830 DUF3350, 1 hit
PF00640 PID, 1 hit
PF00566 RabGAP-TBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00462 PTB, 2 hits
SM00164 TBC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47923 SSF47923, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01179 PID, 1 hit
PS50086 TBC_RABGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D4AC16-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAITFTARK HPFPNEVSVD FGLQLVGSLP VHSLTTMPML PWVVAEVRRL
60 70 80 90 100
SGQCSKKEPG MKQVRLWVSP SGLRCEPDLR KSQPWDPLIC SSIFECKPQR
110 120 130 140 150
VHKLIHNSQD PSYFACLIKE DAAHQQSLCY VFKADDQTKV PEIISSIRQA
160 170 180 190 200
GKIARQEELR CPSEFDDTFA KKFEVLFCGR VTVAHKKAPP ALIDECIEKF
210 220 230 240 250
NHVSCGRRID WDAPTGQPSA PGARPMRKSF SQPGLRSLAF RKEFQDASLR
260 270 280 290 300
SSTFSSFDND IENHLIGGHN VVQPTDMEEN RTMLFTIGQS EVYLISPDTK
310 320 330 340 350
KIALEKNFKE ISFCSQGIRH VDHFGFICRE CSGGGGAGFH FVCYVFQCTN
360 370 380 390 400
EALVDEIMMT LKQAFTVAAV QQTAKAPAQL CEGCPLQGLH KLCERIEGMN
410 420 430 440 450
SSKTKLELQK HLTTLTNQEQ AMIFEEVQKL RPRNEQRENE LIISFLRCLY
460 470 480 490 500
EEKQKEHSHT GEPKQTLQVA AENIGSELPP SASRFRLDSL KNRAKRSLTE
510 520 530 540 550
SLESILSRGN KARGLQDHSA SVDLDSSTSS TLSNTSKELS MGDKEALPIS
560 570 580 590 600
ESSFKLLGSS DDLSSDSESH IAEESALLSP QQAFRRRANT LSHFPVECPA
610 620 630 640 650
PPEPAQTSPG VSQRKLMRYH SVSTETPHER NVDHLPGGES RCCPGQPSDP
660 670 680 690 700
PPLPPRLNPS ASSPNFFKYL KHNSSGEQSG NAVPKSVSYR NALRKKLHSS
710 720 730 740 750
SSVPNFLKFL APVDENNTCD FKNTNRDFES KANHLGDTDG TPVKARRHSW
760 770 780 790 800
RQQIFLRVAT PQKACDSPSR YEDYSELGEL PPRSPLEPVC EDGPFGPVQE
810 820 830 840 850
EKKKTSRELR ELWKKAILQQ ILLLRMEKEN QKLQASENDL LNKRLKLDYE
860 870 880 890 900
EITPCLKEVT TVWEKMLSTP GRSKIKFDME KVHSAVGQGV PRHHRGEIWK
910 920 930 940 950
FLAEQFHLKH PFPSKQQPKD VPYKELLKKL TSQQHAILID LGRTFPTHPY
960 970 980 990 1000
FSAQLGAGQL SLYNILKAYS LLDQEVGYCQ GLSFVAGILL LHMSEEEAFK
1010 1020 1030 1040 1050
MLKFLMFDMG LRKQYRPDMI ILQIQMYQLS RLLHDYHRDL YNHLEEYEIG
1060 1070 1080 1090 1100
PSLYAAPWFL TVFASQFPLG FVARVFDMIF LQGSEVIFKV ALSLLGSHKP
1110 1120 1130 1140 1150
LILQHENLET IVDFIKNTLP NLGLVQMEKT ISQVFEMDIA KQLQAYEVEY
1160 1170 1180 1190 1200
HVLQEELIDS SPLSDNQRMD KLEKTNSSLR KQNLDLLEQL QVANARIQSL
1210 1220 1230 1240 1250
EVTVEKLLTS ESKLKQAVLT LEMERSALLQ MVEELRRQMA QPSTAEPDCT

RLEPTGD
Length:1,257
Mass (Da):142,331
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE6A2D449C250FBE8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07015023 Genomic DNA No translation available.
AABR07015024 Genomic DNA No translation available.
AABR07015025 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_001071842.3, XM_001071842.6
XP_006251066.1, XM_006251004.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000029209; ENSRNOP00000033018; ENSRNOG00000002180

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
360937

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:360937

UCSC genome browser

More...
UCSCi
RGD:1304562 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07015023 Genomic DNA No translation available.
AABR07015024 Genomic DNA No translation available.
AABR07015025 Genomic DNA No translation available.
RefSeqiXP_001071842.3, XM_001071842.6
XP_006251066.1, XM_006251004.3

3D structure databases

SMRiD4AC16
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033018

PTM databases

iPTMnetiD4AC16
PhosphoSitePlusiD4AC16

Proteomic databases

jPOSTiD4AC16
PaxDbiD4AC16
PRIDEiD4AC16

Genome annotation databases

EnsembliENSRNOT00000029209; ENSRNOP00000033018; ENSRNOG00000002180
GeneIDi360937
KEGGirno:360937
UCSCiRGD:1304562 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23216
RGDi1304562 Tbc1d1

Phylogenomic databases

eggNOGiKOG4436 Eukaryota
ENOG410YWJY LUCA
GeneTreeiENSGT00940000157949
InParanoidiD4AC16
KOiK18341
OMAiTLIWEKM
OrthoDBi323342at2759
PhylomeDBiD4AC16
TreeFamiTF317184

Gene expression databases

BgeeiENSRNOG00000002180 Expressed in 9 organ(s), highest expression level in testis

Family and domain databases

Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR021785 DUF3350
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF11830 DUF3350, 1 hit
PF00640 PID, 1 hit
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 2 hits
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS01179 PID, 1 hit
PS50086 TBC_RABGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD4AC16_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4AC16
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: December 11, 2019
This is version 77 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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