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Entry version 63 (16 Oct 2019)
Sequence version 2 (03 Apr 2013)
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Protein
Submitted name:

Apoptosis-associated tyrosine kinase

Gene

Aatk

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Apoptosis-associated tyrosine kinaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AatkImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Rat genome database

More...
RGDi
1590980 Aatk

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500305336221 – 1370Sequence analysisAdd BLAST1350

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D4ABZ3

PRoteomics IDEntifications database

More...
PRIDEi
D4ABZ3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D4ABZ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D4ABZ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000004392 Expressed in 10 organ(s), highest expression level in brain

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000005839

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini135 – 405Protein kinaseInterPro annotationAdd BLAST271

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni556 – 629DisorderedSequence analysisAdd BLAST74
Regioni642 – 736DisorderedSequence analysisAdd BLAST95
Regioni797 – 897DisorderedSequence analysisAdd BLAST101
Regioni909 – 1194DisorderedSequence analysisAdd BLAST286
Regioni1243 – 1298DisorderedSequence analysisAdd BLAST56
Regioni1331 – 1370DisorderedSequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi566 – 581PolarSequence analysisAdd BLAST16
Compositional biasi676 – 695PolarSequence analysisAdd BLAST20
Compositional biasi702 – 722PolarSequence analysisAdd BLAST21
Compositional biasi850 – 889PolarSequence analysisAdd BLAST40
Compositional biasi956 – 972PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1100 – 1114PolarSequence analysisAdd BLAST15
Compositional biasi1156 – 1170AcidicSequence analysisAdd BLAST15
Compositional biasi1337 – 1354PolarSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGQE Eukaryota
ENOG410XQFM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154244

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D4ABZ3

KEGG Orthology (KO)

More...
KOi
K17480

Identification of Orthologs from Complete Genome Data

More...
OMAi
ELRCYNI

Database of Orthologous Groups

More...
OrthoDBi
53680at2759

TreeFam database of animal gene trees

More...
TreeFami
TF332280

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07714 Pkinase_Tyr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00109 TYRKINASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D4ABZ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPIALLALAM SSSFFNPSFA FSSHFDPDGA PLSELSWSSS LAVVAVSFSG
60 70 80 90 100
IFTVIVLMLA CLCCKKGGIG FKEFENAEGE EYVADFSEQG SPAATVQNGP
110 120 130 140 150
DVYVLPLTEV SLPMAKQPGR SVQLLKSTDL GRHSLLYLKE IGHGWFGKVF
160 170 180 190 200
LGEVHSGVSG TQVVVKELKA SASVQEQMQF LEEAQPYRAL QHSNLLQCLA
210 220 230 240 250
QCAEVTPYLL VMEFCPLGDL KGYLRSCRVT ESMAPDPLTL QRMACEVACG
260 270 280 290 300
VLHLHRHNYV HSDLALRNCL LTADLTVKVG DYGLAHCKYR EDYLVTADQL
310 320 330 340 350
WVPLRWIAPE LVDEVHGNLL VVDQTKTSNV WSLGVTIWEL FELGAQPYPQ
360 370 380 390 400
HSDRQVLAYA VREQQLKLPK PQLQLTLSDR WYEVMQFCWL QPEQRPTAEE
410 420 430 440 450
VHLLLSYLCA KGTTELEEEF ERRWRSLRPG GSAGLGSAST VPAAAASELT
460 470 480 490 500
AASSFPLLEQ FTSDGFHVDS DDVLTVTETS HGLNFEYKWE AGCGAEAYPP
510 520 530 540 550
PGAAFSPGSA GRLQELCAPD SSPPGVVPVL SAHSPSVGSE YFIRLEGAVP
560 570 580 590 600
AAGHDPDCAG CAPSPQAVSE QDNNSEESTA ASLVMEPLLG HAPPTGGLWG
610 620 630 640 650
PCDHHSRRRQ EPPCPSRSPS PGTPMLPAED IDWGVATFCP PFFDDPLGTS
660 670 680 690 700
PSGSPGAQPS PSDEELEEGK TGRAAQCGHW SSNMSANNNS GSRDPESWDP
710 720 730 740 750
GYVSSFTDSY RDDCSSLEQT PRASPELGHP LSQEDSRDFL PGLVAASPGQ
760 770 780 790 800
ESSRCFNLLP LCPAKGLAPA ACLVPPPWTE AAVGGAENPI VEPKLAQEAE
810 820 830 840 850
GSAEPQLPLP SVPSPSHEGA SLPSEEASAP DIQPASPTPA AGSWVTVPEP
860 870 880 890 900
APTLDSSSSS LGQEVPSSED EDTTEVTSGV FTDLSSDGPH TEKSGIVPAL
910 920 930 940 950
RCLQKQVGTP DSLDSLDIPS SASDGGCEVL SPSAAGPAGG QPRAMDSGYD
960 970 980 990 1000
TENYESPEFV LKEAHESSEP EAFGEPASEG ESPGPDTLLS VSLGDLSRKN
1010 1020 1030 1040 1050
PYRDSAYFSD LDAESEPNFG PEKHSGIQDS QKEQDLRSPP SPGHESVQAF
1060 1070 1080 1090 1100
PRPEVSSEVL PPPQQSEEPM PEGPGSEPLE AQGPVEVEPV PGPSHSKCLL
1110 1120 1130 1140 1150
LTSAPLSSEG NGTESRGPPG PLSGPAQTGR MGNPSTSRSP LCLALPGHPG
1160 1170 1180 1190 1200
TSEGRPEDDE DTEDSEESDE ELRCYSVQEP SEDSEEEPSA VPVVVAESQS
1210 1220 1230 1240 1250
ARNLRSLLKM PSLLSEAFCD DLERKKKAVS FFDDVTVYLF DQESPTREAG
1260 1270 1280 1290 1300
EPFPSTKECP TFLEGSPGSP SATGVPLRAG HSPDSSAPEP GSRFEWDGDF
1310 1320 1330 1340 1350
PLVPGKAALV TALDPADPVL AAPPTPAAPF SRFTVSPAPP SRFSITQVSD
1360 1370
SDAQSMGGPA ADAEGRCTKA
Length:1,370
Mass (Da):145,526
Last modified:April 3, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i94C6E932E0D7B1A2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07030916 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001162174.1, NM_001168703.1
XP_006247988.1, XM_006247926.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000005839; ENSRNOP00000005839; ENSRNOG00000004392

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
690853

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:690853

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07030916 Genomic DNA No translation available.
RefSeqiNP_001162174.1, NM_001168703.1
XP_006247988.1, XM_006247926.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005839

PTM databases

iPTMnetiD4ABZ3
PhosphoSitePlusiD4ABZ3

Proteomic databases

PaxDbiD4ABZ3
PRIDEiD4ABZ3

Genome annotation databases

EnsembliENSRNOT00000005839; ENSRNOP00000005839; ENSRNOG00000004392
GeneIDi690853
KEGGirno:690853

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9625
RGDi1590980 Aatk

Phylogenomic databases

eggNOGiENOG410IGQE Eukaryota
ENOG410XQFM LUCA
GeneTreeiENSGT00940000154244
InParanoidiD4ABZ3
KOiK17480
OMAiELRCYNI
OrthoDBi53680at2759
TreeFamiTF332280

Gene expression databases

BgeeiENSRNOG00000004392 Expressed in 10 organ(s), highest expression level in brain

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD4ABZ3_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4ABZ3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: October 16, 2019
This is version 63 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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