UniProtKB - D4ABP9 (FBX3_RAT)
Protein
F-box only protein 3
Gene
Fbxo3
Organism
Rattus norvegicus (Rat)
Status
Functioni
Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2, and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity).By similarity
Keywordsi
Biological process | Ubl conjugation pathway |
Names & Taxonomyi
Protein namesi | Recommended name: F-box only protein 3 |
Gene namesi | Name:Fbxo3 Synonyms:Fbx3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1593433, Fbxo3 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Note: Colocalizes with PML at the peripheries of nuclear bodies.By similarity
Cytosol
- cytosol Source: Ensembl
Nucleus
- nucleoplasm Source: Ensembl
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000396824 | 1 – 480 | F-box only protein 3Add BLAST | 480 |
Proteomic databases
jPOSTi | D4ABP9 |
PaxDbi | D4ABP9 |
PeptideAtlasi | D4ABP9 |
PRIDEi | D4ABP9 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000009549, Expressed in liver and 21 other tissues |
Genevisiblei | D4ABP9, RN |
Interactioni
Subunit structurei
Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO3, SKP1, CUL1 and RBX1. Directly interacts with PML, either alone or within the SCF complex (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000014478 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 56 | F-boxPROSITE-ProRule annotationAdd BLAST | 47 | |
Domaini | 278 – 408 | ApaGPROSITE-ProRule annotationAdd BLAST | 131 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 414 – 461 | Glu-richAdd BLAST | 48 |
Phylogenomic databases
eggNOGi | KOG4408, Eukaryota |
GeneTreei | ENSGT00940000153571 |
HOGENOMi | CLU_056869_0_0_1 |
InParanoidi | D4ABP9 |
OMAi | YRDLVSC |
OrthoDBi | 506060at2759 |
PhylomeDBi | D4ABP9 |
TreeFami | TF329795 |
Family and domain databases
Gene3Di | 2.60.40.1470, 1 hit 3.40.1580.10, 1 hit |
InterProi | View protein in InterPro IPR007474, ApaG_domain IPR036767, ApaG_sf IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR018958, Knr4/Smi1-like_dom IPR037883, Knr4/Smi1-like_sf |
Pfami | View protein in Pfam PF04379, DUF525, 1 hit PF12937, F-box-like, 1 hit PF09346, SMI1_KNR4, 1 hit |
SMARTi | View protein in SMART SM00256, FBOX, 1 hit SM00860, SMI1_KNR4, 1 hit |
SUPFAMi | SSF110069, SSF110069, 1 hit SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS51087, APAG, 1 hit PS50181, FBOX, 1 hit |
i Sequence
Sequence statusi: Complete.
D4ABP9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAVEAETGL LTLESLPTDP LLLILSFVDY RDLINCCYVS RRLSQLSTHD
60 70 80 90 100
PLWRRHCKKY WLITEEEKAR KNQCWKSLFI ATYSDVGRYI NHYAAIKKAW
110 120 130 140 150
DDLKKYLEPR CPRMVLSLKE GAREEDLDAV EAQIGCKLPD DYRCSYRIHN
160 170 180 190 200
GQKLVVPGLL GSMALSNHYR SEDLLDVDTA AGGFQQRQGL KYCLPLTFCI
210 220 230 240 250
HTGLSQYIAV EAAEGRNKNE VFYQCPDQMA RNPAAIDMFI IGATFTDWFT
260 270 280 290 300
SYVNNVVSGG FPIIRDQIFR YIHDPECVAT TGDITVSVST SFLPELSSVH
310 320 330 340 350
PPHYFFTYRI RIEMSRDALP EKACQLDSRY WRITNAKGDV EEVQGPGVVG
360 370 380 390 400
EFPIISPGRI YEYTSCTTFS TTSGYMEGYY TFHFLYFKDK VFNVAIPRFH
410 420 430 440 450
MACPTFRVSI ARLEMGPDEY EEMEEEAEEE EEEENDDSAD MDESDESDED
460 470 480
ENESDEGEGE ERRRRVFDVP IRRRRCSRLF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473949 Genomic DNA Translation: EDL79684.1 |
RefSeqi | NP_001103076.1, NM_001109606.1 |
Genome annotation databases
Ensembli | ENSRNOT00000014478; ENSRNOP00000014478; ENSRNOG00000009549 |
GeneIDi | 690634 |
KEGGi | rno:690634 |
UCSCi | RGD:1593433, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473949 Genomic DNA Translation: EDL79684.1 |
RefSeqi | NP_001103076.1, NM_001109606.1 |
3D structure databases
SMRi | D4ABP9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000014478 |
Proteomic databases
jPOSTi | D4ABP9 |
PaxDbi | D4ABP9 |
PeptideAtlasi | D4ABP9 |
PRIDEi | D4ABP9 |
Genome annotation databases
Ensembli | ENSRNOT00000014478; ENSRNOP00000014478; ENSRNOG00000009549 |
GeneIDi | 690634 |
KEGGi | rno:690634 |
UCSCi | RGD:1593433, rat |
Organism-specific databases
CTDi | 26273 |
RGDi | 1593433, Fbxo3 |
Phylogenomic databases
eggNOGi | KOG4408, Eukaryota |
GeneTreei | ENSGT00940000153571 |
HOGENOMi | CLU_056869_0_0_1 |
InParanoidi | D4ABP9 |
OMAi | YRDLVSC |
OrthoDBi | 506060at2759 |
PhylomeDBi | D4ABP9 |
TreeFami | TF329795 |
Miscellaneous databases
PROi | PR:D4ABP9 |
Gene expression databases
Bgeei | ENSRNOG00000009549, Expressed in liver and 21 other tissues |
Genevisiblei | D4ABP9, RN |
Family and domain databases
Gene3Di | 2.60.40.1470, 1 hit 3.40.1580.10, 1 hit |
InterProi | View protein in InterPro IPR007474, ApaG_domain IPR036767, ApaG_sf IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR018958, Knr4/Smi1-like_dom IPR037883, Knr4/Smi1-like_sf |
Pfami | View protein in Pfam PF04379, DUF525, 1 hit PF12937, F-box-like, 1 hit PF09346, SMI1_KNR4, 1 hit |
SMARTi | View protein in SMART SM00256, FBOX, 1 hit SM00860, SMI1_KNR4, 1 hit |
SUPFAMi | SSF110069, SSF110069, 1 hit SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS51087, APAG, 1 hit PS50181, FBOX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FBX3_RAT | |
Accessioni | D4ABP9Primary (citable) accession number: D4ABP9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 10, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | December 2, 2020 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |