SIM bHLH transcription factor 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors."
    Woods S.L., Whitelaw M.L.
    J. Biol. Chem. 277:10236-10243(2002) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis."
    Ema M., Morita M., Ikawa S., Tanaka M., Matsuda Y., Gotoh O., Saijoh Y., Fujii H., Hamada H., Kikuchi Y., Fujii-Kuriyama Y.
    Mol. Cell. Biol. 16:5865-5875(1996) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• embryonic pattern specification Source: RGDInferred from sequence orthologyⁱ
  • "Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants."
    Goshu E., Jin H., Fasnacht R., Sepenski M., Michaud J.L., Fan C.M.
    Mol. Cell. Biol. 22:4147-4157(2002) [PubMed] [Europe PMC] [Abstract]
• lung development Source: RGDInferred from sequence orthologyⁱ
  • "Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants."
    Goshu E., Jin H., Fasnacht R., Sepenski M., Michaud J.L., Fan C.M.
    Mol. Cell. Biol. 22:4147-4157(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors."
    Woods S.L., Whitelaw M.L.
    J. Biol. Chem. 277:10236-10243(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression."
    Ooe N., Saito K., Mikami N., Nakatuka I., Kaneko H.
    Mol. Cell. Biol. 24:608-616(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• protein heterodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis."
    Ema M., Morita M., Ikawa S., Tanaka M., Matsuda Y., Gotoh O., Saijoh Y., Fujii H., Hamada H., Kikuchi Y., Fujii-Kuriyama Y.
    Mol. Cell. Biol. 16:5865-5875(1996) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MKEKSKNAAK TRREKENGEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL 
        60         70         80         90        100
KMRAVFPEGL GDAWGQPSRT GPLDSVAKEL GSHLLQTLDG FVFVVASDGK 
       110        120        130        140        150
IMYISETASV HLGLSQVELT GNSIYEYIHP SDHDEMTAVL TAHPPLHHHL 
       160        170        180        190        200
LQEYEIERSF FLRMKCVLAK RNAGLTCSGY KVIHCSGYLK IRQYMLDMSL 
       210        220        230        240        250
YDSCYQIVGL VAVGQSLPPS AITEIKLHNN MFMFRASLDL KLIFLDSRVT 
       260        270        280        290        300
ELTGYEPQDL IEKTLYHHVH GCDTFHLRYA HHLLLVKGQV TTKYYRLLSK 
       310        320        330        340        350
LGGWVWVQSY ATVVHNSRSS RPHCIVSVNY VLTEVEYKEL QLSLDQVSTS 
       360        370        380        390        400
KSQESWRTTL STSQETRKSA KPKTTKMRTK LRTNPYPSQQ YSSFQMDKLE 
       410        420        430        440        450
CSQAGNWRTS PPTSAVAPPE QQLHSEASDL LYGPPYSLPF SYRYGHFPLD 
       460        470        480        490        500
SHVFSSKKPG LPAKFGQPQG SPCEVARFFL STLPASSECQ WHYANSLMPS 
       510        520        530        540        550
SPSPAKNLSE SPVNAARHGL VPNYEAPAAT ARRFGEDPAP SSFPSCGHYR 
       560        570        580        590        600
EEPTLGSAKA ARQASRDTAR LALARATPEC CAPPAPEPQA PAQLPFVLLN 
       610        620        630        640        650
YHRVLARRGP LGSAAPGAPE AAGSLRPRHP GPVAASAPGA PRPHYLGASV 

IITNGR                                                 

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ