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Protein
Submitted name:

SIM bHLH transcription factor 2

Gene

Sim2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingSAAS annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
SIM bHLH transcription factor 2Imported
Submitted name:
Single-minded 2 (Predicted)Imported
Gene namesi
Name:Sim2Imported
Synonyms:Sim2_predictedImported
ORF Names:rCG_53059Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1308016 Sim2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiD4AA36

Expressioni

Gene expression databases

BgeeiENSRNOG00000054203 Expressed in 7 organ(s), highest expression level in adult mammalian kidney

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002294

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 53BHLHInterPro annotationAdd BLAST53
Domaini77 – 140PASInterPro annotationAdd BLAST64
Domaini233 – 288PASInterPro annotationAdd BLAST56
Domaini336 – 656Single-minded C-terminalInterPro annotationAdd BLAST321

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG3559 Eukaryota
ENOG410XY57 LUCA
GeneTreeiENSGT00760000118788
KOiK09100
OMAiSDLLYAP
OrthoDBiEOG091G06FQ

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR001610 PAC
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR013655 PAS_fold_3
IPR010578 SIM_C
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF00989 PAS, 1 hit
PF08447 PAS_3, 1 hit
PF06621 SIM_C, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00086 PAC, 1 hit
SM00091 PAS, 2 hits
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits
PS51302 SIM_C, 1 hit

Sequencei

Sequence statusi: Complete.

D4AA36-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKEKSKNAAK TRREKENGEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL
60 70 80 90 100
KMRAVFPEGL GDAWGQPSRT GPLDSVAKEL GSHLLQTLDG FVFVVASDGK
110 120 130 140 150
IMYISETASV HLGLSQVELT GNSIYEYIHP SDHDEMTAVL TAHPPLHHHL
160 170 180 190 200
LQEYEIERSF FLRMKCVLAK RNAGLTCSGY KVIHCSGYLK IRQYMLDMSL
210 220 230 240 250
YDSCYQIVGL VAVGQSLPPS AITEIKLHNN MFMFRASLDL KLIFLDSRVT
260 270 280 290 300
ELTGYEPQDL IEKTLYHHVH GCDTFHLRYA HHLLLVKGQV TTKYYRLLSK
310 320 330 340 350
LGGWVWVQSY ATVVHNSRSS RPHCIVSVNY VLTEVEYKEL QLSLDQVSTS
360 370 380 390 400
KSQESWRTTL STSQETRKSA KPKTTKMRTK LRTNPYPSQQ YSSFQMDKLE
410 420 430 440 450
CSQAGNWRTS PPTSAVAPPE QQLHSEASDL LYGPPYSLPF SYRYGHFPLD
460 470 480 490 500
SHVFSSKKPG LPAKFGQPQG SPCEVARFFL STLPASSECQ WHYANSLMPS
510 520 530 540 550
SPSPAKNLSE SPVNAARHGL VPNYEAPAAT ARRFGEDPAP SSFPSCGHYR
560 570 580 590 600
EEPTLGSAKA ARQASRDTAR LALARATPEC CAPPAPEPQA PAQLPFVLLN
610 620 630 640 650
YHRVLARRGP LGSAAPGAPE AAGSLRPRHP GPVAASAPGA PRPHYLGASV

IITNGR
Length:656
Mass (Da):72,514
Last modified:April 20, 2010 - v1
Checksum:i4F4A0058B3DE1A14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07033666 Genomic DNA No translation available.
CH474083 Genomic DNA Translation: EDL76725.1
RefSeqiNP_001100578.1, NM_001107108.3

Genome annotation databases

EnsembliENSRNOT00000081834; ENSRNOP00000069809; ENSRNOG00000054203
GeneIDi304071
KEGGirno:304071
UCSCiRGD:1308016 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07033666 Genomic DNA No translation available.
CH474083 Genomic DNA Translation: EDL76725.1
RefSeqiNP_001100578.1, NM_001107108.3

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002294

Proteomic databases

PRIDEiD4AA36

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000081834; ENSRNOP00000069809; ENSRNOG00000054203
GeneIDi304071
KEGGirno:304071
UCSCiRGD:1308016 rat

Organism-specific databases

CTDi6493
RGDi1308016 Sim2

Phylogenomic databases

eggNOGiKOG3559 Eukaryota
ENOG410XY57 LUCA
GeneTreeiENSGT00760000118788
KOiK09100
OMAiSDLLYAP
OrthoDBiEOG091G06FQ

Gene expression databases

BgeeiENSRNOG00000054203 Expressed in 7 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR001610 PAC
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR013655 PAS_fold_3
IPR010578 SIM_C
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF00989 PAS, 1 hit
PF08447 PAS_3, 1 hit
PF06621 SIM_C, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00086 PAC, 1 hit
SM00091 PAS, 2 hits
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits
PS51302 SIM_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD4AA36_RAT
AccessioniPrimary (citable) accession number: D4AA36
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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