Sim2

Functionⁱ

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein heterodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

embryonic pattern specification Source: Ensembl
lung development Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription, DNA-templated Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-bindingSAAS annotation
Biological process	Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: SIM bHLH transcription factor 2Imported Submitted name: Single-minded 2 (Predicted)Imported
Gene namesⁱ	Name:Sim2Imported Synonyms:Sim2_predictedImported ORF Names:rCG_53059Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 11

Organism-specific databases

Rat genome database More...RGDⁱ	1308016 Sim2

RGDⁱ

1308016 Sim2

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotationSAAS annotation

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	D4AA36

PRIDEⁱ

D4AA36

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000054203 Expressed in 7 organ(s), highest expression level in adult mammalian kidney

Bgeeⁱ

ENSRNOG00000054203 Expressed in 7 organ(s), highest expression level in adult mammalian kidney

Interactionⁱ

GO - Molecular functionⁱ

protein heterodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000002294

STRINGⁱ

10116.ENSRNOP00000002294

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 53	BHLHInterPro annotationAdd BLAST	53
Domainⁱ	77 – 140	PASInterPro annotationAdd BLAST	64
Domainⁱ	233 – 288	PASInterPro annotationAdd BLAST	56
Domainⁱ	336 – 656	Single-minded C-terminalInterPro annotationAdd BLAST	321

Keywords - Domainⁱ

RepeatSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG3559 Eukaryota ENOG410XY57 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118788
KEGG Orthology (KO) More...KOⁱ	K09100
OMAⁱ	SDLLYAP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06FQ

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit cd00130 PAS, 2 hits
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR001610 PAC IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold IPR013655 PAS_fold_3 IPR010578 SIM_C
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF00989 PAS, 1 hit PF08447 PAS_3, 1 hit PF06621 SIM_C, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00086 PAC, 1 hit SM00091 PAS, 2 hits
SUPFAMⁱ	SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 2 hits PS51302 SIM_C, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

D4AA36-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKEKSKNAAK TRREKENGEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL 
        60         70         80         90        100
KMRAVFPEGL GDAWGQPSRT GPLDSVAKEL GSHLLQTLDG FVFVVASDGK 
       110        120        130        140        150
IMYISETASV HLGLSQVELT GNSIYEYIHP SDHDEMTAVL TAHPPLHHHL 
       160        170        180        190        200
LQEYEIERSF FLRMKCVLAK RNAGLTCSGY KVIHCSGYLK IRQYMLDMSL 
       210        220        230        240        250
YDSCYQIVGL VAVGQSLPPS AITEIKLHNN MFMFRASLDL KLIFLDSRVT 
       260        270        280        290        300
ELTGYEPQDL IEKTLYHHVH GCDTFHLRYA HHLLLVKGQV TTKYYRLLSK 
       310        320        330        340        350
LGGWVWVQSY ATVVHNSRSS RPHCIVSVNY VLTEVEYKEL QLSLDQVSTS 
       360        370        380        390        400
KSQESWRTTL STSQETRKSA KPKTTKMRTK LRTNPYPSQQ YSSFQMDKLE 
       410        420        430        440        450
CSQAGNWRTS PPTSAVAPPE QQLHSEASDL LYGPPYSLPF SYRYGHFPLD 
       460        470        480        490        500
SHVFSSKKPG LPAKFGQPQG SPCEVARFFL STLPASSECQ WHYANSLMPS 
       510        520        530        540        550
SPSPAKNLSE SPVNAARHGL VPNYEAPAAT ARRFGEDPAP SSFPSCGHYR 
       560        570        580        590        600
EEPTLGSAKA ARQASRDTAR LALARATPEC CAPPAPEPQA PAQLPFVLLN 
       610        620        630        640        650
YHRVLARRGP LGSAAPGAPE AAGSLRPRHP GPVAASAPGA PRPHYLGASV 

IITNGR

Length:656

Mass (Da):72,514

Last modified:April 20, 2010 - v1

Checksum:ⁱ4F4A0058B3DE1A14

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07033666 Genomic DNA No translation available. CH474083 Genomic DNA Translation: EDL76725.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001100578.1, NM_001107108.3

Genome annotation databases

Ensemblⁱ	ENSRNOT00000081834; ENSRNOP00000069809; ENSRNOG00000054203
GeneIDⁱ	304071
KEGGⁱ	rno:304071
UCSC genome browser More...UCSCⁱ	RGD:1308016 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
D4AA36	Single-minded homolog 2		MOUSE		657	UniRef90_Q61079
Uncharacterized protein (Fragment)		NEOLE		612
UPI000A30776D		MUSPA		656
UPI000A31AFBD		MUSCR		656
Single-minded 2 short splice variant (Fragment)		MOUSE		198
+3

Protein	Similar proteins		Species	Score	Length	Source
D4AA36	Isoform SIM2S of Single-minded homolog 2		HUMAN		570	UniRef50_Q14190-2
Single-minded homolog 2		MOUSE		657
Uncharacterized protein		MACFA		667
Class E basic helix-loop-helix protein 15 (Fragment)		MACMU		525
Uncharacterized protein		AOTNA		663
+57

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07033666 Genomic DNA No translation available. CH474083 Genomic DNA Translation: EDL76725.1
RefSeqⁱ	NP_001100578.1, NM_001107108.3

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000002294

STRINGⁱ

10116.ENSRNOP00000002294

Proteomic databases

PRIDEⁱ	D4AA36

PRIDEⁱ

D4AA36

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000081834; ENSRNOP00000069809; ENSRNOG00000054203
GeneIDⁱ	304071
KEGGⁱ	rno:304071
UCSCⁱ	RGD:1308016 rat

Organism-specific databases

CTDⁱ	6493
RGDⁱ	1308016 Sim2

Phylogenomic databases

eggNOGⁱ	KOG3559 Eukaryota ENOG410XY57 LUCA
GeneTreeⁱ	ENSGT00760000118788
KOⁱ	K09100
OMAⁱ	SDLLYAP
OrthoDBⁱ	EOG091G06FQ

Gene expression databases

Bgeeⁱ	ENSRNOG00000054203 Expressed in 7 organ(s), highest expression level in adult mammalian kidney

Bgeeⁱ

ENSRNOG00000054203 Expressed in 7 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit cd00130 PAS, 2 hits
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR001610 PAC IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold IPR013655 PAS_fold_3 IPR010578 SIM_C
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF00989 PAS, 1 hit PF08447 PAS_3, 1 hit PF06621 SIM_C, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00086 PAC, 1 hit SM00091 PAS, 2 hits
SUPFAMⁱ	SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 2 hits PS51302 SIM_C, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D4AA36_RAT
Accessionⁱ	D4AA36Primary (citable) accession number: D4AA36
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 20, 2010
	Last sequence update:	April 20, 2010
	Last modified:	November 7, 2018
	This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D4AA36 (D4AA36_RAT)

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SIM bHLH transcription factor 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ