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UniProtKB - D4AA26 (D4AA26_RAT)
Protein
Submitted name:
Atonal bHLH transcription factor 8
Gene
Atoh8
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription factor binding Source: RGD
- E-box binding Source: RGD
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- formation of primary germ layer Source: RGD
- myoblast proliferation Source: RGD
- negative regulation of endothelial cell proliferation Source: RGD
- negative regulation of gene expression Source: RGD
- negative regulation of transcription, DNA-templated Source: RGD
- neuron differentiation Source: GO_Central
- positive regulation of endothelial cell differentiation Source: RGD
- positive regulation of endothelial cell migration Source: RGD
- positive regulation of miRNA transcription Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- SMAD protein signal transduction Source: RGD
- tube formation Source: RGD
Names & Taxonomyi
Protein namesi | Submitted name: Atonal bHLH transcription factor 8Submitted name: Similar to bHLH factor Math6 (Predicted)Imported |
Gene namesi | ORF Names:rCG_56155Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1561512, Atoh8 |
Subcellular locationi
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: RGD
Other locations
- cytoplasm Source: RGD
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000010716, Expressed in testis and 21 other tissues |
Interactioni
GO - Molecular functioni
- DNA-binding transcription factor binding Source: RGD
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000014277 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 231 – 283 | BHLHInterPro annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 59 – 140 | DisorderedSequence analysisAdd BLAST | 82 | |
Regioni | 158 – 222 | DisorderedSequence analysisAdd BLAST | 65 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 121 – 135 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 158 – 186 | Pro residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 188 – 209 | Polar residuesSequence analysisAdd BLAST | 22 |
Phylogenomic databases
eggNOGi | KOG3898, Eukaryota |
GeneTreei | ENSGT00940000161151 |
HOGENOMi | CLU_057987_0_0_1 |
OMAi | VCVQELH |
OrthoDBi | 1014108at2759 |
TreeFami | TF324848 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR032660, ATOH8 IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
PANTHERi | PTHR19290:SF102, PTHR19290:SF102, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
D4AA26-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKHIPVLEDG PWKTVCVKEL NGLKKLKRKG KEPVRRANGY KTFRLDLEAP
60 70 80 90 100
EFGATASATA ATNGLRDRTQ PFPIATPVPA SVAPAVPPGG GTDTAREFRG
110 120 130 140 150
IRAPEVSDAR KRGFALGTVG PGLPTPPPPP ASQSLAPGDP EVQPLREQAL
160 170 180 190 200
RPRILLCAPP ARPTPSAPLA PPAVPQESPV RPAPPTRPGE SSYSSISHVI
210 220 230 240 250
YNNHPDSSAS PRKRPGEATA ASTEIKALQQ TRRLLANARE RTRVHTISAA
260 270 280 290 300
FEALRKQVPC YSYGQKLSKL AILRIACNYI LSLARLADLD YSADHSNLSF
310 320
SECVQRCTRT LQAEGRAKKR KE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473957 Genomic DNA Translation: EDL91017.1 |
RefSeqi | NP_001102711.1, NM_001109241.1 |
Genome annotation databases
Ensembli | ENSRNOT00000014277.4; ENSRNOP00000014277.3; ENSRNOG00000010716.4 |
GeneIDi | 500200 |
KEGGi | rno:500200 |
UCSCi | RGD:1561512, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473957 Genomic DNA Translation: EDL91017.1 |
RefSeqi | NP_001102711.1, NM_001109241.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000014277 |
Genome annotation databases
Ensembli | ENSRNOT00000014277.4; ENSRNOP00000014277.3; ENSRNOG00000010716.4 |
GeneIDi | 500200 |
KEGGi | rno:500200 |
UCSCi | RGD:1561512, rat |
Organism-specific databases
CTDi | 84913 |
RGDi | 1561512, Atoh8 |
Phylogenomic databases
eggNOGi | KOG3898, Eukaryota |
GeneTreei | ENSGT00940000161151 |
HOGENOMi | CLU_057987_0_0_1 |
OMAi | VCVQELH |
OrthoDBi | 1014108at2759 |
TreeFami | TF324848 |
Gene expression databases
Bgeei | ENSRNOG00000010716, Expressed in testis and 21 other tissues |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR032660, ATOH8 IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
PANTHERi | PTHR19290:SF102, PTHR19290:SF102, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | D4AA26_RAT | |
Accessioni | D4AA26Primary (citable) accession number: D4AA26 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | May 25, 2022 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |