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UniProtKB - D4A9W3 (D4A9W3_RAT)

Entry version 73 (02 Dec 2020)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

D-glutamate cyclase

Gene

Dglucy

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyaseARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
D-glutamate cyclaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DglucyImported
Synonyms:RGD1311756Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Rat genome database

More...RGDi		1311756, Dglucy

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		D4A9W3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		D4A9W3

PeptideAtlas

More...PeptideAtlasi		D4A9W3

PRoteomics IDEntifications database

More...PRIDEi		D4A9W3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000004442, Expressed in adult mammalian kidney and 21 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		D4A9W3, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000005903

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		D4A9W3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini300 – 610DUF4392InterPro annotationAdd BLAST311

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the D-glutamate cyclase family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QV7A, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000002237

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_033607_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		D4A9W3

Identification of Orthologs from Complete Genome Data

More...OMAi		HERYLRK

Database of Orthologous Groups

More...OrthoDBi		351128at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		D4A9W3

TreeFam database of animal gene trees

More...TreeFami		TF300254

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009906, D-Glu_cyclase
IPR017135, D-Glu_cyclase_mito
IPR025504, DUF4392
IPR038021, Putative_hydro-lyase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07286, DUF1445, 1 hit
PF14336, DUF4392, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037204, UCP037204, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF160920, SSF160920, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D4A9W3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPFSLLLRS CLPSAIRSLP KAAHIRNISS MTGGLQPASV VVLPRSLAPA 
        60         70         80         90        100
FESFCQGNHG PLPLLGQSEP EKTFPQLSAV PDIRTICPQF QKYEFGTCTG 
       110        120        130        140        150
ILTSLEEYSE QLKDMVTFIM DCSFSIEEAL EQAGIPRRDL TGSGHAGAYK 
       160        170        180        190        200
TAVPCATIAG FCCPLVVTMR PVPKDKLERL LLATHSLGGQ QGQPIHIGDP 
       210        220        230        240        250
ELLGIKPLSK PDYGSYVECR PGDVPVFWPS HLTSLEAVIG CKAPLAFASP 
       260        270        280        290        300
PGCTVMIPRD TVSPASRPTP QMVPEVHAIS KDPLHYSIVS APAAQKIREL 
       310        320        330        340        350
ESTIATDPGN RGIGHLLLKD ELLLAALSLS HAHSVLVTTG FPTHFSHEPP 
       360        370        380        390        400
EETDGPPGAI ALAAFLQALG KEAAMVVDRR ALNLHTKIVE DAVKQGVLKT 
       410        420        430        440        450
PIPILTYRGG SVEDARAFLC KDGDPKSPRF DHLVAVERAG RAADGNYYNA 
       460        470        480        490        500
RKVNIKHLVD PIDDIFLAAQ KIPGISSTGV GDGGNELGMG RVKEAVKKHI 
       510        520        530        540        550
RNGDVIACDV EADFAVIAGV SNWGGYALAC ALYILNSCPV HERYLRRATG 
       560        570        580        590        600
PSGEAGEQSW IQALPSVAKE EKMLGILVQN QVRSGVSGIV GMEVDGLPFH 
       610 
GVHAEMIQKL VDVTTVPM
Length:618
Mass (Da):66,056
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E4930979EA1E78A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AABR07065366 Genomic DNA No translation available.
AABR07065367 Genomic DNA No translation available.
AABR07065368 Genomic DNA No translation available.
AABR07065369 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_001167028.1, NM_001173557.1
XP_006240503.1, XM_006240441.3
XP_006240504.1, XM_006240442.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000005903; ENSRNOP00000005903; ENSRNOG00000004442

Database of genes from NCBI RefSeq genomes

More...GeneIDi		362769

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:362769

UCSC genome browser

More...UCSCi		RGD:1311756, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07065366 Genomic DNA No translation available.
AABR07065367 Genomic DNA No translation available.
AABR07065368 Genomic DNA No translation available.
AABR07065369 Genomic DNA No translation available.
RefSeqiNP_001167028.1, NM_001173557.1
XP_006240503.1, XM_006240441.3
XP_006240504.1, XM_006240442.2

3D structure databases

SMRiD4A9W3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005903

Proteomic databases

jPOSTiD4A9W3
PaxDbiD4A9W3
PeptideAtlasiD4A9W3
PRIDEiD4A9W3

Genome annotation databases

EnsembliENSRNOT00000005903; ENSRNOP00000005903; ENSRNOG00000004442
GeneIDi362769
KEGGirno:362769
UCSCiRGD:1311756, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		80017
RGDi1311756, Dglucy

Phylogenomic databases

eggNOGiENOG502QV7A, Eukaryota
GeneTreeiENSGT00390000002237
HOGENOMiCLU_033607_0_0_1
InParanoidiD4A9W3
OMAiHERYLRK
OrthoDBi351128at2759
PhylomeDBiD4A9W3
TreeFamiTF300254

Gene expression databases

BgeeiENSRNOG00000004442, Expressed in adult mammalian kidney and 21 other tissues
GenevisibleiD4A9W3, RN

Family and domain databases

InterProiView protein in InterPro
IPR009906, D-Glu_cyclase
IPR017135, D-Glu_cyclase_mito
IPR025504, DUF4392
IPR038021, Putative_hydro-lyase
PfamiView protein in Pfam
PF07286, DUF1445, 1 hit
PF14336, DUF4392, 1 hit
PIRSFiPIRSF037204, UCP037204, 1 hit
SUPFAMiSSF160920, SSF160920, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD4A9W3_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4A9W3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: December 2, 2020
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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