Tyrosinase

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• copper ion binding Source: RGD
• identical protein binding Source: RGD
• monophenol monooxygenase activity Source: RGD
• protein homodimerization activity Source: RGD

GO - Biological processⁱ

• cell population proliferation Source: RGD
• melanin biosynthetic process Source: RGD
• pigmentation Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "A Tyrosinase missense mutation causes albinism in the Wistar rat."
    Blaszczyk W.M., Arning L., Hoffmann K.P., Epplen J.T.
    Pigment Cell Res 18:144-145(2005) [PubMed] [Europe PMC] [Abstract]
• response to blue light Source: Ensembl
• response to cAMP Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Vitamin D nutrition increases skin tyrosinase response to exposure to ultraviolet radiation."
    Pavlovitch J.H., Rizk M., Balsan S.
    Mol Cell Endocrinol 25:295-302(1982) [PubMed] [Europe PMC] [Abstract]
• response to UV Source: RGDInferred from expression patternⁱ
  • "Vitamin D nutrition increases skin tyrosinase response to exposure to ultraviolet radiation."
    Pavlovitch J.H., Rizk M., Balsan S.
    Mol Cell Endocrinol 25:295-302(1982) [PubMed] [Europe PMC] [Abstract]
• response to vitamin D Source: RGDInferred from expression patternⁱ
  • "Vitamin D nutrition increases skin tyrosinase response to exposure to ultraviolet radiation."
    Pavlovitch J.H., Rizk M., Balsan S.
    Mol Cell Endocrinol 25:295-302(1982) [PubMed] [Europe PMC] [Abstract]
• thymus development Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• identical protein binding Source: RGD
• protein homodimerization activity Source: RGD

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MFLAVLYYLL WSFQTSAGHF PRDCASSKNL MAKECCPPWM GDGSPCGHLS 
        60         70         80         90        100
GRGSCQDILL SNAPSGPQFP FKGVDDRESW PSVFYNRTCQ CSGNFMGFNC 
       110        120        130        140        150
GNCKFGFGGP NCTEKRLLIR RNIFDLSASE KNKFFSYLTL AKHTISSVYV 
       160        170        180        190        200
IPTGTYGQMN NGSTPMFKDI NIYDLFVWMH YYVSRDTLLG GSEIWRDIDF 
       210        220        230        240        250
AHEAPGFLPW HRLFLLLWEQ EMQELTGDEN FTIPYWDWRD AENCDICTDE 
       260        270        280        290        300
YLGGRHPENP NLLSPASFFS SWEIICSRSE EYNSHQVLCD GTPEGPLLRN 
       310        320        330        340        350
PGNHDKAKTP RLPSSADVEF CLSLTQYESG SMDRTANFSF RNTLEGFASP 
       360        370        380        390        400
LTGIADSSQS SMHNALHIYM NGTMSQVQGS ANDPIFLLHH AFVDSIFEQW 
       410        420        430        440        450
LRRHRPLLEV YPEANAPIGH NRESYMVPFI PLYRNGDFFI SSKDLGYDYS 
       460        470        480        490        500
YLQESDPGFY RNYIEPYLEQ ASRIWPWLLG AALVGAVVAT ALAGLSSRLC 
       510        520        530
HQKKKQPQEE RQPLLMDKDD YHSLLYQSHL                       

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ