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UniProtKB - D4A7M5 (D4A7M5_RAT)
Protein
Neurogenic differentiation factor
Gene
Neurod4
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- amacrine cell differentiation Source: RGD
- camera-type eye development Source: RGD
- cell fate commitment Source: RGD
- glial cell differentiation Source: RGD
- neuroblast proliferation Source: RGD
- neuron development Source: RGD
- neuron differentiation Source: GO_Central
- neuron migration Source: RGD
- Notch signaling pathway Source: RGD
- positive regulation of cell differentiation Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- retina development in camera-type eye Source: RGD
Keywordsi
Molecular function | ActivatorARBA annotation, Developmental proteinUniRule annotationARBA annotation, DNA-bindingUniRule annotationARBA annotation |
Biological process | DifferentiationUniRule annotation, NeurogenesisUniRule annotationARBA annotation, Transcription, Transcription regulationUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Neurogenic differentiation factorUniRule annotation |
Gene namesi | Name:Neurod4Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1310434, Neurod4 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000008449, Expressed in brain and 15 other tissues |
Interactioni
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000011167 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 87 – 139 | BHLHInterPro annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 23 – 80 | DisorderedSequence analysisAdd BLAST | 58 |
Phylogenomic databases
eggNOGi | KOG3898, Eukaryota |
GeneTreei | ENSGT00940000160217 |
HOGENOMi | CLU_055134_0_0_1 |
InParanoidi | D4A7M5 |
OMAi | MAHYPSV |
OrthoDBi | 1096531at2759 |
PhylomeDBi | D4A7M5 |
TreeFami | TF315153 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032651, Neurod4 IPR022575, Neurogenic_DUF IPR016637, TF_bHLH_NeuroD |
PANTHERi | PTHR19290:SF86, PTHR19290:SF86, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF12533, Neuro_bHLH, 1 hit |
PIRSFi | PIRSF015618, bHLH_NeuroD, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
D4A7M5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKMYMKSKD MVELVNTQSW MDKGLSSQNE MEEQERRPGS YGMLGTLMEE
60 70 80 90 100
HDSIEEEEEE EEDGDKPKRR GPKKKKMTKA RLERFRARRV KANARERTRM
110 120 130 140 150
HGLNDALDNL RRVMPCYSKT QKLSKIETLR LARNYIWALS EVLETGQTLE
160 170 180 190 200
GKGFVEMLCK GLSQPTSNLV AGCLQLGPQS ALLEKREEKS PICDSTVSVH
210 220 230 240 250
SFNYQSPGLP SPPYGHMETH PLHLKPQPFK SLGDSFGSHP PDCSTPPYEG
260 270 280 290 300
PLTPPLSISG NFSLKQEGSP DLEKSYNFMP HYTSASVSSG HVHSTPFQTG
310 320 330
TPRYDVPVDL TYDSYPHHGI GTQINTIFSD
Sequence databases
RefSeqi | XP_006240880.1, XM_006240818.3 XP_006240881.1, XM_006240819.3 XP_006240882.1, XM_006240820.3 XP_006240884.1, XM_006240822.3 XP_006240885.1, XM_006240823.3 XP_017450179.1, XM_017594690.1 |
Genome annotation databases
Ensembli | ENSRNOT00000011167.7; ENSRNOP00000011167.3; ENSRNOG00000008449.7 |
GeneIDi | 288821 |
UCSCi | RGD:1310434, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_006240880.1, XM_006240818.3 XP_006240881.1, XM_006240819.3 XP_006240882.1, XM_006240820.3 XP_006240884.1, XM_006240822.3 XP_006240885.1, XM_006240823.3 XP_017450179.1, XM_017594690.1 |
3D structure databases
AlphaFoldDBi | D4A7M5 |
SMRi | D4A7M5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000011167 |
Proteomic databases
PaxDbi | D4A7M5 |
Genome annotation databases
Ensembli | ENSRNOT00000011167.7; ENSRNOP00000011167.3; ENSRNOG00000008449.7 |
GeneIDi | 288821 |
UCSCi | RGD:1310434, rat |
Organism-specific databases
CTDi | 58158 |
RGDi | 1310434, Neurod4 |
Phylogenomic databases
eggNOGi | KOG3898, Eukaryota |
GeneTreei | ENSGT00940000160217 |
HOGENOMi | CLU_055134_0_0_1 |
InParanoidi | D4A7M5 |
OMAi | MAHYPSV |
OrthoDBi | 1096531at2759 |
PhylomeDBi | D4A7M5 |
TreeFami | TF315153 |
Gene expression databases
Bgeei | ENSRNOG00000008449, Expressed in brain and 15 other tissues |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032651, Neurod4 IPR022575, Neurogenic_DUF IPR016637, TF_bHLH_NeuroD |
PANTHERi | PTHR19290:SF86, PTHR19290:SF86, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF12533, Neuro_bHLH, 1 hit |
PIRSFi | PIRSF015618, bHLH_NeuroD, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | D4A7M5_RAT | |
Accessioni | D4A7M5Primary (citable) accession number: D4A7M5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | May 25, 2022 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |