Neurod4

Functionⁱ

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

amacrine cell differentiation Source: Ensembl
cell fate commitment Source: Ensembl
glial cell differentiation Source: Ensembl
neuroblast proliferation Source: Ensembl
neuron development Source: Ensembl
neuron migration Source: Ensembl
Notch signaling pathway Source: Ensembl
positive regulation of cell differentiation
Source: RGD
Inferred from mutant phenotypeⁱ
- 15345241
regulation of transcription, DNA-templated Source: InterPro
retina development in camera-type eye
Source: RGD
Inferred from expression patternⁱ
- 15345241

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental proteinUniRule annotation, DNA-bindingUniRule annotation
Biological process	DifferentiationUniRule annotation, NeurogenesisUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neurogenic differentiation factorUniRule annotation
Gene namesⁱ	Name:Neurod4Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 7

Organism-specific databases

Rat genome database More...RGDⁱ	1310434 Neurod4

RGDⁱ

1310434 Neurod4

Keywords - Cellular componentⁱ

NucleusUniRule annotation

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	D4A7M5
PRIDEⁱ	D4A7M5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000008449 Expressed in 6 organ(s), highest expression level in skeletal muscle tissue

Bgeeⁱ

ENSRNOG00000008449 Expressed in 6 organ(s), highest expression level in skeletal muscle tissue

Interactionⁱ

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000011167

STRINGⁱ

10116.ENSRNOP00000011167

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	87 – 139	BHLHInterPro annotationAdd BLAST		53

Phylogenomic databases

eggNOGⁱ	ENOG410KD2S Eukaryota ENOG410Z6FG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00680000099860
InParanoidⁱ	D4A7M5
OMAⁱ	PPYGHME
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G15AI
PhylomeDBⁱ	D4A7M5
TreeFamⁱ	TF315153

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR032651 Neurod4 IPR022575 Neurogenic_DUF IPR016637 TF_bHLH_NeuroD
PANTHERⁱ	PTHR19290:SF86 PTHR19290:SF86, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF12533 Neuro_bHLH, 1 hit
PIRSFⁱ	PIRSF015618 bHLH_NeuroD, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

D4A7M5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAKMYMKSKD MVELVNTQSW MDKGLSSQNE MEEQERRPGS YGMLGTLMEE 
        60         70         80         90        100
HDSIEEEEEE EEDGDKPKRR GPKKKKMTKA RLERFRARRV KANARERTRM 
       110        120        130        140        150
HGLNDALDNL RRVMPCYSKT QKLSKIETLR LARNYIWALS EVLETGQTLE 
       160        170        180        190        200
GKGFVEMLCK GLSQPTSNLV AGCLQLGPQS ALLEKREEKS PICDSTVSVH 
       210        220        230        240        250
SFNYQSPGLP SPPYGHMETH PLHLKPQPFK SLGDSFGSHP PDCSTPPYEG 
       260        270        280        290        300
PLTPPLSISG NFSLKQEGSP DLEKSYNFMP HYTSASVSSG HVHSTPFQTG 
       310        320        330
TPRYDVPVDL TYDSYPHHGI GTQINTIFSD

Length:330

Mass (Da):37,167

Last modified:April 20, 2010 - v1

Checksum:ⁱ89D4E9FE2136A953

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07055767 Genomic DNA No translation available. AABR07073276 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	XP_006240880.1, XM_006240818.3 XP_006240881.1, XM_006240819.3 XP_006240882.1, XM_006240820.3 XP_006240884.1, XM_006240822.3 XP_006240885.1, XM_006240823.3 XP_017450179.1, XM_017594690.1
UniGeneⁱ	Rn.120002

Genome annotation databases

Ensemblⁱ	ENSRNOT00000011167; ENSRNOP00000011167; ENSRNOG00000008449
GeneIDⁱ	288821
UCSC genome browser More...UCSCⁱ	RGD:1310434 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
D4A7M5	Neurogenic differentiation factor 4		MOUSE		330	UniRef90_O09105
UPI0004ED0365		NANGA		331
UPI000A304902		MUSPA		330
UPI000A314FC4		MUSCR		330
Neurogenic differentiation factor		MOUSE		330

Protein	Similar proteins		Species	Score	Length	Source
D4A7M5	Neurogenic differentiation factor 4		MOUSE		330	UniRef50_O09105
Neurogenic differentiation factor 4		XENLA		315
Neurogenic differentiation factor		ORENI		352
Uncharacterized protein		FICAL		327
neurogenic differentiation factor 4-like		SALSA		328
+131

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07055767 Genomic DNA No translation available. AABR07073276 Genomic DNA No translation available.
RefSeqⁱ	XP_006240880.1, XM_006240818.3 XP_006240881.1, XM_006240819.3 XP_006240882.1, XM_006240820.3 XP_006240884.1, XM_006240822.3 XP_006240885.1, XM_006240823.3 XP_017450179.1, XM_017594690.1
UniGeneⁱ	Rn.120002

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000011167

STRINGⁱ

10116.ENSRNOP00000011167

Proteomic databases

PaxDbⁱ	D4A7M5
PRIDEⁱ	D4A7M5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000011167; ENSRNOP00000011167; ENSRNOG00000008449
GeneIDⁱ	288821
UCSCⁱ	RGD:1310434 rat

Organism-specific databases

CTDⁱ	58158
RGDⁱ	1310434 Neurod4

Phylogenomic databases

eggNOGⁱ	ENOG410KD2S Eukaryota ENOG410Z6FG LUCA
GeneTreeⁱ	ENSGT00680000099860
InParanoidⁱ	D4A7M5
OMAⁱ	PPYGHME
OrthoDBⁱ	EOG091G15AI
PhylomeDBⁱ	D4A7M5
TreeFamⁱ	TF315153

Gene expression databases

Bgeeⁱ	ENSRNOG00000008449 Expressed in 6 organ(s), highest expression level in skeletal muscle tissue

Bgeeⁱ

ENSRNOG00000008449 Expressed in 6 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR032651 Neurod4 IPR022575 Neurogenic_DUF IPR016637 TF_bHLH_NeuroD
PANTHERⁱ	PTHR19290:SF86 PTHR19290:SF86, 1 hit
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF12533 Neuro_bHLH, 1 hit
PIRSFⁱ	PIRSF015618 bHLH_NeuroD, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D4A7M5_RAT
Accessionⁱ	D4A7M5Primary (citable) accession number: D4A7M5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 20, 2010
	Last sequence update:	April 20, 2010
	Last modified:	November 7, 2018
	This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

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Proteomes

Annotation systems

Supporting data

UniProtKB - D4A7M5 (D4A7M5_RAT)

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Neurogenic differentiation factor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ