UniProtKB - D4A7E1 (BATF_RAT)
Basic leucine zipper transcriptional factor ATF-like
Batf
Functioni
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8+ dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8+ dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8+ T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity).
By similarityGO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- cellular response to DNA damage stimulus Source: UniProtKB
- defense response to protozoan Source: UniProtKB
- DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
- hematopoietic stem cell differentiation Source: UniProtKB
- isotype switching Source: UniProtKB
- lymphoid progenitor cell differentiation Source: UniProtKB
- myeloid dendritic cell differentiation Source: UniProtKB
- positive regulation of cytokine production Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- T-helper 17 cell differentiation Source: UniProtKB
- T-helper 17 cell lineage commitment Source: UniProtKB
- T-helper 2 cell differentiation Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Differentiation, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Basic leucine zipper transcriptional factor ATF-likeAlternative name(s): B-cell-activating transcription factor Short name: B-ATF |
Gene namesi | Name:Batf |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1304923, Batf |
Subcellular locationi
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: UniProtKB
- RNA polymerase II transcription regulator complex Source: RGD
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000420464 | 1 – 125 | Basic leucine zipper transcriptional factor ATF-likeAdd BLAST | 125 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 43 | PhosphoserineBy similarity | 1 | |
Modified residuei | 48 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | D4A7E1 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000008588, Expressed in thymus and 19 other tissues |
Genevisiblei | D4A7E1, RN |
Interactioni
Subunit structurei
Heterodimer; mainly heterodimerizes with JUNB. The BATF-JUNB heterodimer interacts with IRF4 and IRF8.
Interacts (via bZIP domain) with IRF4 and IRF8; the interaction is direct. Also forms heterodimers with JUN and JUND.
Interacts with IFI35 (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000011563 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 89 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 59 | DisorderedSequence analysisAdd BLAST | 59 | |
Regioni | 28 – 50 | Basic motifAdd BLAST | 23 | |
Regioni | 54 – 75 | Leucine-zipperAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 20 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 21 – 41 | Basic and acidic residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1414, Eukaryota |
GeneTreei | ENSGT00940000159745 |
HOGENOMi | CLU_088612_4_0_1 |
InParanoidi | D4A7E1 |
OMAi | CTGLTPQ |
OrthoDBi | 1544557at2759 |
PhylomeDBi | D4A7E1 |
TreeFami | TF332340 |
Family and domain databases
InterProi | View protein in InterPro IPR000837, AP-1 IPR029820, BATF IPR004827, bZIP IPR046347, bZIP_sf |
PANTHERi | PTHR23351, PTHR23351, 1 hit PTHR23351:SF14, PTHR23351:SF14, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
PRINTSi | PR00042, LEUZIPPRFOS |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MPHSSDSSDS SFSRSPPPGK QDSSDDVRKV QRREKNRIAA QKSRQRQTQK
60 70 80 90 100
ADTLHLESED LEKQNAALRK EIKQLTEELK YFTSVLSSHE PLCSVLASGT
110 120
PSPPEVVYSA HAFHQPHISS PRFQP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473982 Genomic DNA Translation: EDL81581.1 |
RefSeqi | NP_001100218.1, NM_001106748.1 XP_008762980.1, XM_008764758.2 |
Genome annotation databases
Ensembli | ENSRNOT00000011563; ENSRNOP00000011563; ENSRNOG00000008588 |
GeneIDi | 299206 |
KEGGi | rno:299206 |
UCSCi | RGD:1304923, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473982 Genomic DNA Translation: EDL81581.1 |
RefSeqi | NP_001100218.1, NM_001106748.1 XP_008762980.1, XM_008764758.2 |
3D structure databases
AlphaFoldDBi | D4A7E1 |
SMRi | D4A7E1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000011563 |
Proteomic databases
PaxDbi | D4A7E1 |
Genome annotation databases
Ensembli | ENSRNOT00000011563; ENSRNOP00000011563; ENSRNOG00000008588 |
GeneIDi | 299206 |
KEGGi | rno:299206 |
UCSCi | RGD:1304923, rat |
Organism-specific databases
CTDi | 10538 |
RGDi | 1304923, Batf |
Phylogenomic databases
eggNOGi | KOG1414, Eukaryota |
GeneTreei | ENSGT00940000159745 |
HOGENOMi | CLU_088612_4_0_1 |
InParanoidi | D4A7E1 |
OMAi | CTGLTPQ |
OrthoDBi | 1544557at2759 |
PhylomeDBi | D4A7E1 |
TreeFami | TF332340 |
Miscellaneous databases
PROi | PR:D4A7E1 |
Gene expression databases
Bgeei | ENSRNOG00000008588, Expressed in thymus and 19 other tissues |
Genevisiblei | D4A7E1, RN |
Family and domain databases
InterProi | View protein in InterPro IPR000837, AP-1 IPR029820, BATF IPR004827, bZIP IPR046347, bZIP_sf |
PANTHERi | PTHR23351, PTHR23351, 1 hit PTHR23351:SF14, PTHR23351:SF14, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
PRINTSi | PR00042, LEUZIPPRFOS |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BATF_RAT | |
Accessioni | D4A7E1Primary (citable) accession number: D4A7E1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2012 |
Last sequence update: | April 20, 2010 | |
Last modified: | May 25, 2022 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families