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Protein

Basic leucine zipper transcriptional factor ATF-like

Gene

Batf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8+ dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8+ dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8+ T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper transcriptional factor ATF-like
Alternative name(s):
B-cell-activating transcription factor
Short name:
B-ATF
Gene namesi
Name:Batf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1304923 Batf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004204641 – 125Basic leucine zipper transcriptional factor ATF-likeAdd BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43PhosphoserineBy similarity1
Modified residuei48PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated on serine and threonine residues and at least one tyrosine residue. Phosphorylation at Ser-43 inhibit DNA binding activity and transforms it as a negative regulator of AP-1 mediated transcription (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiD4A7E1

Expressioni

Gene expression databases

BgeeiENSRNOG00000008588
GenevisibleiD4A7E1 RN

Interactioni

Subunit structurei

Heterodimer; mainly heterodimerizes with JUNB. The BATF-JUNB heterodimer interacts with IRF4 and IRF8. Interacts (via bZIP domain) with IRF4 and IRF8; the interaction is direct. Also forms heterodimers with JUN and JUND. Also Interacts with IFI35 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011563

Structurei

3D structure databases

ProteinModelPortaliD4A7E1
SMRiD4A7E1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 89bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni28 – 50Basic motifAdd BLAST23
Regioni54 – 75Leucine-zipperAdd BLAST22

Sequence similaritiesi

Belongs to the bZIP family.Curated

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
GeneTreeiENSGT00390000016869
InParanoidiD4A7E1
KOiK09034
OMAiDSNDTSY
OrthoDBiEOG091G0YSM
PhylomeDBiD4A7E1
TreeFamiTF332340

Family and domain databases

InterProiView protein in InterPro
IPR000837 AP-1
IPR029820 BATF
IPR004827 bZIP
PANTHERiPTHR23351 PTHR23351, 1 hit
PTHR23351:SF14 PTHR23351:SF14, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PRINTSiPR00042 LEUZIPPRFOS
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequencei

Sequence statusi: Complete.

D4A7E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHSSDSSDS SFSRSPPPGK QDSSDDVRKV QRREKNRIAA QKSRQRQTQK
60 70 80 90 100
ADTLHLESED LEKQNAALRK EIKQLTEELK YFTSVLSSHE PLCSVLASGT
110 120
PSPPEVVYSA HAFHQPHISS PRFQP
Length:125
Mass (Da):14,065
Last modified:April 20, 2010 - v1
Checksum:iA23B00D6E0827938
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473982 Genomic DNA Translation: EDL81581.1
RefSeqiNP_001100218.1, NM_001106748.1
XP_008762980.1, XM_008764758.2
UniGeneiRn.16670

Genome annotation databases

EnsembliENSRNOT00000011563; ENSRNOP00000011563; ENSRNOG00000008588
GeneIDi299206
KEGGirno:299206
UCSCiRGD:1304923 rat

Similar proteinsi

Entry informationi

Entry nameiBATF_RAT
AccessioniPrimary (citable) accession number: D4A7E1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2012
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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