Zic4

Functionⁱ

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Zic family member 4Imported
Gene namesⁱ	Name:Zic4Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 8

Organism-specific databases

Rat genome database More...RGDⁱ	1307298 Zic4

RGDⁱ

1307298 Zic4

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	D4A6Z4
PRIDEⁱ	D4A6Z4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000014871 Expressed in 2 organ(s), highest expression level in brain
ExpressionAtlasⁱ	D4A6Z4 baseline and differential

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000019938

STRINGⁱ

10116.ENSRNOP00000019938

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	168 – 195	C2H2-typeInterPro annotationAdd BLAST	28
Domainⁱ	196 – 225	C2H2-typeInterPro annotationAdd BLAST	30
Domainⁱ	226 – 255	C2H2-typeInterPro annotationAdd BLAST	30
Domainⁱ	256 – 285	C2H2-typeInterPro annotationAdd BLAST	30

Keywords - Domainⁱ

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140802
InParanoidⁱ	D4A6Z4
OMAⁱ	PSSDFGR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0M59

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

D4A6Z4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRKRLRLYRN TLKESSSSCG HHGPQLAAAS NPSVFPGLHE QPPQASHSRP 
        60         70         80         90        100
LNGLLRLGIP GDMYARSEPF APGPMARGDT LATATALHGY GGMNLTMNLT 
       110        120        130        140        150
APHGPGAFFR YMRQPIKQEL ICKWLGDDSP ISPRPCSKTF STMHELVTHV 
       160        170        180        190        200
TVEHVGGPEQ ANHICFWEEC PRQGKPFKAK YKLVNHIRVH TGEKPFPCPF 
       210        220        230        240        250
PGCGKVFARS ENLKIHKRTH TGEKPFRCEF EGCERRFANS SDRKKHSHVH 
       260        270        280        290        300
TSDKPYMCKV RGCDKCYTHP SSLRKHMKVH GRSPPPSSGY DSAITSALTS 
       310        320 
TSLESGREPS VACSAAVVVR GTDVSE

Length:326

Mass (Da):36,032

Last modified:July 22, 2015 - v3

Checksum:ⁱ44F76A2BA20AF3FA

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D3ZMJ5	D3ZMJ5_RAT		Zic family member 4 Zic family member 4 (Zic family member 4 (Predicted), isoform CRA_a)	Zic4 Zic4_predicted, rCG_25168	74	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07071064 Genomic DNA No translation available. AABR07071065 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AABR07071064 Genomic DNA No translation available.
AABR07071065 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENSRNOT00000019938; ENSRNOP00000019938; ENSRNOG00000014871
UCSC genome browser More...UCSCⁱ	RGD:1307298 rat

Protein	Similar proteins		Species	Score	Length	Source
D4A6Z4	Zinc finger protein ZIC 4		MOUSE		341	UniRef90_Q61467
UPI00077DBFF4		PERMB		366
UPI000A306A15		MUSPA		353
UPI000A3168EA		MUSCR		353
Zinc finger protein ZIC 4		MOUSE		334
+12

Protein	Similar proteins		Species	Score	Length	Source
D4A6Z4	Zinc finger protein ZIC 4		MOUSE		341	UniRef50_Q61467
zinc finger protein ZIC 5-like		URSMA		500
UPI00077DBFF4		PERMB		366
UPI000A3168EA		MUSCR		353
UPI000A306A15		MUSPA		353
+17

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07071064 Genomic DNA No translation available. AABR07071065 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AABR07071064 Genomic DNA No translation available.
AABR07071065 Genomic DNA No translation available.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000019938

STRINGⁱ

10116.ENSRNOP00000019938

Proteomic databases

PaxDbⁱ	D4A6Z4
PRIDEⁱ	D4A6Z4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000019938; ENSRNOP00000019938; ENSRNOG00000014871
UCSCⁱ	RGD:1307298 rat

Organism-specific databases

RGDⁱ	1307298 Zic4

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00900000140802
InParanoidⁱ	D4A6Z4
OMAⁱ	PSSDFGR
OrthoDBⁱ	EOG091G0M59

Gene expression databases

Bgeeⁱ	ENSRNOG00000014871 Expressed in 2 organ(s), highest expression level in brain
ExpressionAtlasⁱ	D4A6Z4 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D4A6Z4_RAT
Accessionⁱ	D4A6Z4Primary (citable) accession number: D4A6Z4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 20, 2010
	Last sequence update:	July 22, 2015
	Last modified:	November 7, 2018
	This is version 55 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D4A6Z4 (D4A6Z4_RAT)

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Zic family member 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ