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UniProtKB - D4A6Z4 (D4A6Z4_RAT)
Protein
Submitted name:
Zic family member 4
Gene
Zic4
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- central nervous system development Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Zic family member 4Imported |
Gene namesi | Name:Zic4Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1307298, Zic4 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nucleus Source: RGD
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000014871, Expressed in cerebellum and 4 other tissues |
ExpressionAtlasi | D4A6Z4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 168 – 195 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 196 – 225 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 226 – 255 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 256 – 285 | C2H2-typeInterPro annotationAdd BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 52 | DisorderedSequence analysisAdd BLAST | 52 |
Sequence similaritiesi
Belongs to the GLI C2H2-type zinc-finger protein family.ARBA annotation
Keywords - Domaini
RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000154200 |
HOGENOMi | CLU_002678_37_0_1 |
InParanoidi | D4A6Z4 |
OMAi | MNLAAPH |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type IPR041643, Znf_ZIC |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits PF18366, zf_ZIC, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
D4A6Z4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRKRLRLYRN TLKESSSSCG HHGPQLAAAS NPSVFPGLHE QPPQASHSRP
60 70 80 90 100
LNGLLRLGIP GDMYARSEPF APGPMARGDT LATATALHGY GGMNLTMNLT
110 120 130 140 150
APHGPGAFFR YMRQPIKQEL ICKWLGDDSP ISPRPCSKTF STMHELVTHV
160 170 180 190 200
TVEHVGGPEQ ANHICFWEEC PRQGKPFKAK YKLVNHIRVH TGEKPFPCPF
210 220 230 240 250
PGCGKVFARS ENLKIHKRTH TGEKPFRCEF EGCERRFANS SDRKKHSHVH
260 270 280 290 300
TSDKPYMCKV RGCDKCYTHP SSLRKHMKVH GRSPPPSSGY DSAITSALTS
310 320
TSLESGREPS VACSAAVVVR GTDVSE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3ZMJ5 | D3ZMJ5_RAT | Zic family member 4 | Zic4 Zic4_predicted, rCG_25168 | 74 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07071064 Genomic DNA No translation available. AABR07071065 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSRNOT00000019938; ENSRNOP00000019938; ENSRNOG00000014871 |
UCSCi | RGD:1307298, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07071064 Genomic DNA No translation available. AABR07071065 Genomic DNA No translation available. |
3D structure databases
SMRi | D4A6Z4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000019938 |
Proteomic databases
PaxDbi | D4A6Z4 |
Genome annotation databases
Ensembli | ENSRNOT00000019938; ENSRNOP00000019938; ENSRNOG00000014871 |
UCSCi | RGD:1307298, rat |
Organism-specific databases
RGDi | 1307298, Zic4 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000154200 |
HOGENOMi | CLU_002678_37_0_1 |
InParanoidi | D4A6Z4 |
OMAi | MNLAAPH |
Gene expression databases
Bgeei | ENSRNOG00000014871, Expressed in cerebellum and 4 other tissues |
ExpressionAtlasi | D4A6Z4, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type IPR041643, Znf_ZIC |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits PF18366, zf_ZIC, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | D4A6Z4_RAT | |
Accessioni | D4A6Z4Primary (citable) accession number: D4A6Z4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | July 22, 2015 | |
Last modified: | September 29, 2021 | |
This is version 69 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |