Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Caspase recruitment domain family, member 15 (Predicted)

Gene

Nod2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • muramyl dipeptide binding Source: RGD

GO - Biological processi

Keywordsi

LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-168638 NOD1/2 Signaling Pathway
R-RNO-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-RNO-450302 activated TAK1 mediates p38 MAPK activation
R-RNO-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-RNO-5689896 Ovarian tumor domain proteases
R-RNO-9020702 Interleukin-1 signaling

Names & Taxonomyi

Protein namesi
Submitted name:
Caspase recruitment domain family, member 15 (Predicted)Imported
Submitted name:
Nucleotide-binding oligomerization domain-containing 2Imported
Gene namesi
Name:Nod2Imported
Synonyms:Card15_predictedImported
ORF Names:rCG_63140Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1306368 Nod2

Subcellular locationi

Expressioni

Gene expression databases

BgeeiENSRNOG00000014124 Expressed in 9 organ(s), highest expression level in spleen
ExpressionAtlasiD4A5W3 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061463

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 82CARDInterPro annotationAdd BLAST82
Domaini107 – 191CARDInterPro annotationAdd BLAST85
Domaini266 – 402NACHTInterPro annotationAdd BLAST137

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG4308 Eukaryota
ENOG410ZBX3 LUCA
GeneTreeiENSGT00860000133673
KOiK10165

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00619 CARD, 2 hits
PF13516 LRR_6, 3 hits
PF05729 NACHT, 1 hit
SUPFAMiSSF47986 SSF47986, 2 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 2 hits
PS50837 NACHT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

D4A5W3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCSQEDFQAQ RSQLVALLVS GSLEGFESIL DWLLSWDVLS REDYEGLSLP
60 70 80 90 100
GQPLSHSARR LLDTVCNKGV WGCQKLFEAV QEAQANSHTF ELQGCWDVHS
110 120 130 140 150
LHPTRDLQSH RPAIVRRLCS HVEAILELAR DEGFLSQYEC EEIRLPIFTS
160 170 180 190 200
SQRARRLLDL AAVKANGLAA FLLQHVRKLP ASLSLPYEAA ECQKFTAKLR
210 220 230 240 250
TMVSAQSRFL STYDGSENLC LEDIYTENTL ELRTEVGTAG ALQKSPATLG
260 270 280 290 300
LEELFGTHGH LNKDADTILV VGEAGSGKST LLQRLHLLWA SGQNFREFLF
310 320 330 340 350
IFPFSCRQLQ CMTKPLSLRT LLFEHCCWPD VGQDDVFQFL LDHPDRVLLT
360 370 380 390 400
FDGLDEFKFR FTDRERHCSP LDPTSVQTLL FNLLQGNLLK NACKVLTSRP
410 420 430 440 450
DAVSALLRKF VRTECHLKGF SEEGIKLYLR KHHREPGVAD RLIHLIQATS
460 470 480 490 500
ALHGLCHLPV FSWMVSRCHR ELLLQNRGFP TTSTDMYLLI LQHFLLHASP
510 520 530 540 550
PDSFPLGLGP GLLQSRLSTL LHLGHLALQG LAMSCYVFSA QQLQAAQVDS
560 570 580 590 600
EDISLGFLVR AQSVVPGSKA PLEFLHITFQ CFFAAFYLAV SADTSAASLK
610 620 630 640 650
HLFSCGRPGN SLLLRLLPNL CIQGSRVKGG QAALLQKAEP HNLQITAAFL
660 670 680 690 700
AGLLSQQHRD LLAACQVPER VLLQRQARAR SCLAHSLREH FHSIPPAVPG
710 720 730 740 750
ETKSMHAMPG FIWLIRSLYE MQEVQLAREA VRRLDIGHLK LTFCRVGPAE
760 770 780 790 800
CAALAFVLQH LQRPVALQLD HNSVGDVGVE QLLPCLGVCT ALYLRDNNIS
810 820 830 840 850
DRGARTLVEC ALRCEQLQKL ALFNNKLTDG CASSVAKLLA HKQNFLSLRV
860 870 880 890 900
GNNHITAAGA EVLAQGLKSN TSLQFLGFWG NSVGDKGSQA LAEVVADHQR
910 920 930
LKWLSLVGNN IGSVGAHALA LMLEKNKSLE EL
Length:932
Mass (Da):103,398
Last modified:April 20, 2010 - v1
Checksum:iC0A7A4271FF7DEA9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K4Z7A0A0G2K4Z7_RAT
Nucleotide-binding oligomerization ...
Nod2
989Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07043075 Genomic DNA No translation available.
AABR07043076 Genomic DNA No translation available.
CH474037 Genomic DNA Translation: EDL87529.1
RefSeqiNP_001099642.1, NM_001106172.1
UniGeneiRn.218600

Genome annotation databases

EnsembliENSRNOT00000065103; ENSRNOP00000061463; ENSRNOG00000014124
GeneIDi291912
KEGGirno:291912

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07043075 Genomic DNA No translation available.
AABR07043076 Genomic DNA No translation available.
CH474037 Genomic DNA Translation: EDL87529.1
RefSeqiNP_001099642.1, NM_001106172.1
UniGeneiRn.218600

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061463

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000065103; ENSRNOP00000061463; ENSRNOG00000014124
GeneIDi291912
KEGGirno:291912

Organism-specific databases

CTDi64127
RGDi1306368 Nod2

Phylogenomic databases

eggNOGiKOG4308 Eukaryota
ENOG410ZBX3 LUCA
GeneTreeiENSGT00860000133673
KOiK10165

Enzyme and pathway databases

ReactomeiR-RNO-168638 NOD1/2 Signaling Pathway
R-RNO-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-RNO-450302 activated TAK1 mediates p38 MAPK activation
R-RNO-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-RNO-5689896 Ovarian tumor domain proteases
R-RNO-9020702 Interleukin-1 signaling

Gene expression databases

BgeeiENSRNOG00000014124 Expressed in 9 organ(s), highest expression level in spleen
ExpressionAtlasiD4A5W3 baseline and differential

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00619 CARD, 2 hits
PF13516 LRR_6, 3 hits
PF05729 NACHT, 1 hit
SUPFAMiSSF47986 SSF47986, 2 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 2 hits
PS50837 NACHT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD4A5W3_RAT
AccessioniPrimary (citable) accession number: D4A5W3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: October 10, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again