We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - D4A5U5 (D4A5U5_RAT)
Protein
Submitted name:
Ovo-like zinc finger 2
Gene
Ovol2
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- chromatin binding Source: RGD
- DNA binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- angiogenesis Source: RGD
- cellular response to transforming growth factor beta stimulus Source: RGD
- dorsal/ventral pattern formation Source: RGD
- embryonic digestive tract morphogenesis Source: RGD
- endocardium formation Source: RGD
- epidermal cell differentiation Source: RGD
- epidermis development Source: RGD
- heart development Source: RGD
- heart looping Source: RGD
- heart trabecula formation Source: RGD
- labyrinthine layer blood vessel development Source: RGD
- negative regulation of cell population proliferation Source: RGD
- negative regulation of epithelial to mesenchymal transition Source: RGD
- negative regulation of gene expression Source: RGD
- negative regulation of stem cell proliferation Source: RGD
- neural crest cell migration Source: RGD
- neural fold formation Source: RGD
- positive regulation of gene expression Source: RGD
- positive regulation of keratinocyte differentiation Source: RGD
- regulation of keratinocyte proliferation Source: RGD
- regulation of SMAD protein signal transduction Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Ovo-like zinc finger 2ImportedSubmitted name: Zinc finger protein 339 (Predicted), isoform CRA_bImported |
Gene namesi | ORF Names:rCG_27483Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1306130, Ovol2 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000006850, Expressed in duodenum and 16 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 85 – 112 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 113 – 140 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 141 – 169 | C2H2-typeInterPro annotationAdd BLAST | 29 | |
Domaini | 180 – 208 | C2H2-typeInterPro annotationAdd BLAST | 29 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 55 | DisorderedSequence analysisAdd BLAST | 55 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 18 – 34 | Polar residuesSequence analysisAdd BLAST | 17 |
Keywords - Domaini
RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG3576, Eukaryota |
GeneTreei | ENSGT00940000159359 |
HOGENOMi | CLU_087964_0_0_1 |
OMAi | RHLCAFC |
OrthoDBi | 1419156at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR027756, Ovo-like IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR10032, PTHR10032, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
i Sequence
Sequence statusi: Complete.
D4A5U5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLGCLLRDP PEDCRSDGGS SSGCSCSAGE PGGAESSSSP RAPEPETPEL
60 70 80 90 100
HDAEGTDGHL AAMQRPVARS KIKFTTGTCN DSVIHNCDLC GKSFRLQRML
110 120 130 140 150
NRHLKCHNQV KRHLCTFCGK GFNDTFDLKR HVRTHTGIRP YKCEVCYKAF
160 170 180 190 200
TQRCSLESHL KKIHGVQQQY AYKQRRDKLY VCEDCGYTGP TQEDLYLHVN
210 220 230 240
SAHPGSTFLK KTSKKLAALM QNKLTSPLQE NSTLSEEEEK K
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07054062 Genomic DNA No translation available. CH474026 Genomic DNA Translation: EDL95169.1 |
RefSeqi | NP_001099989.1, NM_001106519.1 |
Genome annotation databases
Ensembli | ENSRNOT00000065553; ENSRNOP00000061477; ENSRNOG00000006850 |
GeneIDi | 296201 |
KEGGi | rno:296201 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07054062 Genomic DNA No translation available. CH474026 Genomic DNA Translation: EDL95169.1 |
RefSeqi | NP_001099989.1, NM_001106519.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000061477 |
Genome annotation databases
Ensembli | ENSRNOT00000065553; ENSRNOP00000061477; ENSRNOG00000006850 |
GeneIDi | 296201 |
KEGGi | rno:296201 |
Organism-specific databases
CTDi | 58495 |
RGDi | 1306130, Ovol2 |
Phylogenomic databases
eggNOGi | KOG3576, Eukaryota |
GeneTreei | ENSGT00940000159359 |
HOGENOMi | CLU_087964_0_0_1 |
OMAi | RHLCAFC |
OrthoDBi | 1419156at2759 |
Gene expression databases
Bgeei | ENSRNOG00000006850, Expressed in duodenum and 16 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR027756, Ovo-like IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR10032, PTHR10032, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | D4A5U5_RAT | |
Accessioni | D4A5U5Primary (citable) accession number: D4A5U5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | January 19, 2022 | |
This is version 88 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |