Zbtb7b

Functionⁱ

GO - Molecular functionⁱ

enhancer sequence-specific DNA binding Source: Ensembl
histone deacetylase binding Source: Ensembl
protein homodimerization activity Source: Ensembl
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive thermogenesis Source: Ensembl
interleukin-17 secretion Source: Ensembl
lactation Source: Ensembl
negative regulation of CD8-positive, alpha-beta T cell differentiation Source: Ensembl
negative regulation of NK T cell proliferation Source: Ensembl
negative regulation of T-helper 17 cell differentiation Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
NK T cell differentiation Source: Ensembl
positive regulation of brown fat cell differentiation Source: Ensembl
positive regulation of CD4-positive, alpha-beta T cell differentiation Source: Ensembl
positive regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from sequence or structural similarityⁱ
- 28784777
positive regulation of gene expression
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of histone deacetylation Source: Ensembl
positive regulation of insulin receptor signaling pathway Source: Ensembl
positive regulation of SREBP signaling pathway Source: Ensembl
regulation of transcription involved in cell fate commitment Source: Ensembl
response to insulin Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Zinc finger and BTB domain-containing 7BImported
Gene namesⁱ	Name:Zbtb7bImported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 2

Organism-specific databases

Rat genome database More...RGDⁱ	1305963 Zbtb7b

RGDⁱ

1305963 Zbtb7b

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	D4A579
PeptideAtlas More...PeptideAtlasⁱ	D4A579
PRIDEⁱ	D4A579

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000020640 Expressed in 9 organ(s), highest expression level in liver

Bgeeⁱ

ENSRNOG00000020640 Expressed in 9 organ(s), highest expression level in liver

Interactionⁱ

GO - Molecular functionⁱ

histone deacetylase binding Source: Ensembl
protein homodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000028010

STRINGⁱ

10116.ENSRNOP00000028010

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	34 – 115	BTBInterPro annotationAdd BLAST	82
Domainⁱ	350 – 377	C2H2-typeInterPro annotationAdd BLAST	28
Domainⁱ	378 – 405	C2H2-typeInterPro annotationAdd BLAST	28
Domainⁱ	406 – 433	C2H2-typeInterPro annotationAdd BLAST	28
Domainⁱ	434 – 467	C2H2-typeInterPro annotationAdd BLAST	34

Keywords - Domainⁱ

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150939
OMAⁱ	SRGARYP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08VI
PhylomeDBⁱ	D4A579
TreeFamⁱ	TF331824

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

D4A579-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGSPEDDLIG IPFPDHSSEL LSCLNEQRQL GHLCDLTIRT QGLEYRTHRA 
        60         70         80         90        100
VLAACSHYFK KLFTEGGGGT VMGTGGGGTA AGGAGAGVCE LDFVGPEALG 
       110        120        130        140        150
ALLEFAYTAT LTTSSANMPA VLQAARLLEI PCVIAACMEI LQGSGLEAPS 
       160        170        180        190        200
PDEDDCERAR QYLEAFATAT TTASTSGMPN GEDSPPQVPL LPPPPPPPRP 
       210        220        230        240        250
VARRSRKPRK AFLQTKGARA NHLVPEAPTV LTHPLAYEEE EMVGRVGNSG 
       260        270        280        290        300
GSGLGDNYSP PAGATSPAEG PLNYEVFEGE EEEEELVYPP AYGLAQSNEP 
       310        320        330        340        350
SLSPEELGSD EDPIDPDLMA YLSSLHQDAL APGLDGQDKL VRKRRSQMPQ 
       360        370        380        390        400
ECPVCHKIIH GAGKLPRHMR THTGEKPFAC EVCGVRFTRN DKLKIHMRKH 
       410        420        430        440        450
TGERPYSCPH CPARFLHSYD LKNHMHLHTG DRPYECHLCH KAFAKEDHLQ 
       460        470        480        490        500
RHLKGQNCLE VRTRRRRKDD APPHYPPPST TTSSPAGLDL SNGHLDTFRL 
       510        520        530        540 
SLARFWEQSA TTGPPVTTQG PPEEEEEEGT PTTPQAESAM ESS

Length:543

Mass (Da):58,855

Last modified:July 22, 2015 - v3

Checksum:ⁱF3B4B24C4DF4C3D5

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC098750 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	XP_006232676.1, XM_006232614.3 XP_008759358.1, XM_008761136.2 XP_008759359.1, XM_008761137.2 XP_017446253.1, XM_017590764.1
UniGeneⁱ	Rn.73830

Genome annotation databases

Ensemblⁱ	ENSRNOT00000028010; ENSRNOP00000028010; ENSRNOG00000020640
GeneIDⁱ	295248
UCSC genome browser More...UCSCⁱ	RGD:1305963 rat

Protein	Similar proteins		Species	Score	Length	Source
D4A579	Zinc finger and BTB domain-containing protein 7B		HUMAN		539	UniRef90_O15156
ZBTB7B isoform 1		PANTR		539
Uncharacterized protein		MACMU		636
Zinc finger and BTB domain-containing protein 7B (Fragment)		MOUSE		29
zinc finger and BTB domain-containing protein 7B		TARSY		586
+129

Protein	Similar proteins		Species	Score	Length	Source
D4A579	Zinc finger and BTB domain-containing protein 7B		MOUSE		544	UniRef50_Q64321
Zinc finger and BTB domain-containing protein 7B		HUMAN		539
Zinc finger and BTB domain-containing protein 7B		MYOBR		516
Zinc finger and BTB domain containing 7B		MONDO		527
Uncharacterized protein		SARHA		529
+166

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC098750 Genomic DNA No translation available.
RefSeqⁱ	XP_006232676.1, XM_006232614.3 XP_008759358.1, XM_008761136.2 XP_008759359.1, XM_008761137.2 XP_017446253.1, XM_017590764.1
UniGeneⁱ	Rn.73830

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000028010

STRINGⁱ

10116.ENSRNOP00000028010

Proteomic databases

PaxDbⁱ	D4A579
PeptideAtlasⁱ	D4A579
PRIDEⁱ	D4A579

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000028010; ENSRNOP00000028010; ENSRNOG00000020640
GeneIDⁱ	295248
UCSCⁱ	RGD:1305963 rat

Organism-specific databases

CTDⁱ	51043
RGDⁱ	1305963 Zbtb7b

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00930000150939
OMAⁱ	SRGARYP
OrthoDBⁱ	EOG091G08VI
PhylomeDBⁱ	D4A579
TreeFamⁱ	TF331824

Gene expression databases

Bgeeⁱ	ENSRNOG00000020640 Expressed in 9 organ(s), highest expression level in liver

Bgeeⁱ

ENSRNOG00000020640 Expressed in 9 organ(s), highest expression level in liver

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D4A579_RAT
Accessionⁱ	D4A579Primary (citable) accession number: D4A579
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 20, 2010
	Last sequence update:	July 22, 2015
	Last modified:	November 7, 2018
	This is version 76 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

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UniParc

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Supporting data

UniProtKB - D4A579 (D4A579_RAT)

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Zinc finger and BTB domain-containing 7B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ