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UniProtKB - D4A579 (D4A579_RAT)
Protein
Submitted name:
Zinc finger and BTB domain-containing 7B
Gene
Zbtb7b
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- cis-regulatory region sequence-specific DNA binding Source: RGD
- DNA binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- histone deacetylase binding Source: RGD
- identical protein binding Source: RGD
- protein homodimerization activity Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- adaptive thermogenesis Source: RGD
- lactation Source: RGD
- negative regulation of CD8-positive, alpha-beta T cell differentiation Source: RGD
- negative regulation of gene expression Source: RGD
- negative regulation of NK T cell proliferation Source: RGD
- negative regulation of T-helper 17 cell differentiation Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- NK T cell differentiation Source: RGD
- positive regulation of brown fat cell differentiation Source: RGD
- positive regulation of CD4-positive, alpha-beta T cell differentiation Source: RGD
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of gene expression Source: RGD
- positive regulation of histone deacetylation Source: RGD
- positive regulation of insulin receptor signaling pathway Source: RGD
- positive regulation of interleukin-17 production Source: RGD
- positive regulation of SREBP signaling pathway Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of CD4-positive, alpha-beta T cell differentiation Source: RGD
- regulation of CD8-positive, alpha-beta T cell differentiation Source: RGD
- regulation of gene expression Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to insulin Source: RGD
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Zinc finger and BTB domain-containing 7BImported |
Gene namesi | Name:Zbtb7bImported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1305963, Zbtb7b |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000020640, Expressed in jejunum and 19 other tissues |
Interactioni
GO - Molecular functioni
- histone deacetylase binding Source: RGD
- identical protein binding Source: RGD
- protein homodimerization activity Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000028010 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 115 | BTBInterPro annotationAdd BLAST | 82 | |
Domaini | 350 – 377 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 378 – 405 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 406 – 433 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 434 – 467 | C2H2-typeInterPro annotationAdd BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 171 – 220 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 246 – 271 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 460 – 492 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 506 – 543 | DisorderedSequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 185 – 201 | Pro residuesSequence analysisAdd BLAST | 17 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160219 |
HOGENOMi | CLU_025627_0_0_1 |
OMAi | EEDLVYP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | D4A579 |
TreeFami | TF331824 |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
i Sequence
Sequence statusi: Complete.
D4A579-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSPEDDLIG IPFPDHSSEL LSCLNEQRQL GHLCDLTIRT QGLEYRTHRA
60 70 80 90 100
VLAACSHYFK KLFTEGGGGT VMGTGGGGTA AGGAGAGVCE LDFVGPEALG
110 120 130 140 150
ALLEFAYTAT LTTSSANMPA VLQAARLLEI PCVIAACMEI LQGSGLEAPS
160 170 180 190 200
PDEDDCERAR QYLEAFATAT TTASTSGMPN GEDSPPQVPL LPPPPPPPRP
210 220 230 240 250
VARRSRKPRK AFLQTKGARA NHLVPEAPTV LTHPLAYEEE EMVGRVGNSG
260 270 280 290 300
GSGLGDNYSP PAGATSPAEG PLNYEVFEGE EEEEELVYPP AYGLAQSNEP
310 320 330 340 350
SLSPEELGSD EDPIDPDLMA YLSSLHQDAL APGLDGQDKL VRKRRSQMPQ
360 370 380 390 400
ECPVCHKIIH GAGKLPRHMR THTGEKPFAC EVCGVRFTRN DKLKIHMRKH
410 420 430 440 450
TGERPYSCPH CPARFLHSYD LKNHMHLHTG DRPYECHLCH KAFAKEDHLQ
460 470 480 490 500
RHLKGQNCLE VRTRRRRKDD APPHYPPPST TTSSPAGLDL SNGHLDTFRL
510 520 530 540
SLARFWEQSA TTGPPVTTQG PPEEEEEEGT PTTPQAESAM ESS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC098750 Genomic DNA No translation available. |
RefSeqi | XP_006232676.1, XM_006232614.3 XP_008759358.1, XM_008761136.2 XP_008759359.1, XM_008761137.2 XP_017446253.1, XM_017590764.1 |
Genome annotation databases
Ensembli | ENSRNOT00000028010; ENSRNOP00000028010; ENSRNOG00000020640 |
GeneIDi | 295248 |
UCSCi | RGD:1305963, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC098750 Genomic DNA No translation available. |
RefSeqi | XP_006232676.1, XM_006232614.3 XP_008759358.1, XM_008761136.2 XP_008759359.1, XM_008761137.2 XP_017446253.1, XM_017590764.1 |
3D structure databases
SMRi | D4A579 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000028010 |
Proteomic databases
PaxDbi | D4A579 |
PeptideAtlasi | D4A579 |
Genome annotation databases
Ensembli | ENSRNOT00000028010; ENSRNOP00000028010; ENSRNOG00000020640 |
GeneIDi | 295248 |
UCSCi | RGD:1305963, rat |
Organism-specific databases
CTDi | 51043 |
RGDi | 1305963, Zbtb7b |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160219 |
HOGENOMi | CLU_025627_0_0_1 |
OMAi | EEDLVYP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | D4A579 |
TreeFami | TF331824 |
Gene expression databases
Bgeei | ENSRNOG00000020640, Expressed in jejunum and 19 other tissues |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | D4A579_RAT | |
Accessioni | D4A579Primary (citable) accession number: D4A579 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | July 22, 2015 | |
Last modified: | September 29, 2021 | |
This is version 91 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |