Zinc finger and BTB domain-containing 7B

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin."
    Galera P., Musso M., Ducy P., Karsenty G.
    Proc. Natl. Acad. Sci. U.S.A. 91:9372-9376(1994) [PubMed] [Europe PMC] [Abstract]
  • "c-Krox binds to several sites in the promoter of both mouse type I collagen genes. Structure/function study and developmental expression analysis."
    Galera P., Park R.W., Ducy P., Mattei M.G., Karsenty G.
    J. Biol. Chem. 271:21331-21339(1996) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin."
    Galera P., Musso M., Ducy P., Karsenty G.
    Proc. Natl. Acad. Sci. U.S.A. 91:9372-9376(1994) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: RGDInferred from sequence orthologyⁱ
  • "c-Krox binds to several sites in the promoter of both mouse type I collagen genes. Structure/function study and developmental expression analysis."
    Galera P., Park R.W., Ducy P., Mattei M.G., Karsenty G.
    J. Biol. Chem. 271:21331-21339(1996) [PubMed] [Europe PMC] [Abstract]
• histone deacetylase binding Source: RGDInferred from sequence orthologyⁱ
  • "Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation."
    Rui J., Liu H., Zhu X., Cui Y., Liu X.
    J. Immunol. 189:1380-1390(2012) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation."
    Rui J., Liu H., Zhu X., Cui Y., Liu X.
    J. Immunol. 189:1380-1390(2012) [PubMed] [Europe PMC] [Abstract]
  • "c-Krox binds to several sites in the promoter of both mouse type I collagen genes. Structure/function study and developmental expression analysis."
    Galera P., Park R.W., Ducy P., Mattei M.G., Karsenty G.
    J. Biol. Chem. 271:21331-21339(1996) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin."
    Galera P., Musso M., Ducy P., Karsenty G.
    Proc. Natl. Acad. Sci. U.S.A. 91:9372-9376(1994) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• adaptive thermogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis."
    Li S., Mi L., Yu L., Yu Q., Liu T., Wang G.X., Zhao X.Y., Wu J., Lin J.D.
    Proc. Natl. Acad. Sci. U.S.A. 114:E7111-E7120(2017) [PubMed] [Europe PMC] [Abstract]
• interleukin-17 secretion Source: RGDInferred from sequence orthologyⁱ
  • "ZBTB7B (Th-POK) regulates the development of IL-17-producing CD1d-restricted mouse NKT cells."
    Enders A., Stankovic S., Teh C., Uldrich A.P., Yabas M., Juelich T., Altin J.A., Frankenreiter S., Bergmann H., Roots C.M., Kyparissoudis K., Goodnow C.C., Godfrey D.I.
    J. Immunol. 189:5240-5249(2012) [PubMed] [Europe PMC] [Abstract]
• lactation Source: RGDInferred from sequence orthologyⁱ
  • "Th-POK regulates mammary gland lactation through mTOR-SREBP pathway."
    Zhang R., Ma H., Gao Y., Wu Y., Qiao Y., Geng A., Cai C., Han Y., Zeng Y.A., Liu X., Ge G.
    PLoS Genet. 14:E1007211-E1007211(2018) [PubMed] [Europe PMC] [Abstract]
• negative regulation of CD8-positive, alpha-beta T cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation."
    Rui J., Liu H., Zhu X., Cui Y., Liu X.
    J. Immunol. 189:1380-1390(2012) [PubMed] [Europe PMC] [Abstract]
  • "The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling."
    Luckey M.A., Kimura M.Y., Waickman A.T., Feigenbaum L., Singer A., Park J.H.
    Nat. Immunol. 15:638-645(2014) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: RGDInferred from sequence orthologyⁱ
  • "Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation."
    Rui J., Liu H., Zhu X., Cui Y., Liu X.
    J. Immunol. 189:1380-1390(2012) [PubMed] [Europe PMC] [Abstract]
  • "The transcription factor Th-POK negatively regulates Th17 differentiation in Valpha14i NKT cells."
    Engel I., Zhao M., Kappes D., Taniuchi I., Kronenberg M.
    Blood 120:4524-4532(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of NK T cell proliferation Source: RGDInferred from sequence orthologyⁱ
  • "ZBTB7B (Th-POK) regulates the development of IL-17-producing CD1d-restricted mouse NKT cells."
    Enders A., Stankovic S., Teh C., Uldrich A.P., Yabas M., Juelich T., Altin J.A., Frankenreiter S., Bergmann H., Roots C.M., Kyparissoudis K., Goodnow C.C., Godfrey D.I.
    J. Immunol. 189:5240-5249(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of T-helper 17 cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "The transcription factor Th-POK negatively regulates Th17 differentiation in Valpha14i NKT cells."
    Engel I., Zhao M., Kappes D., Taniuchi I., Kronenberg M.
    Blood 120:4524-4532(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation."
    Rui J., Liu H., Zhu X., Cui Y., Liu X.
    J. Immunol. 189:1380-1390(2012) [PubMed] [Europe PMC] [Abstract]
• NK T cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "ZBTB7B (Th-POK) regulates the development of IL-17-producing CD1d-restricted mouse NKT cells."
    Enders A., Stankovic S., Teh C., Uldrich A.P., Yabas M., Juelich T., Altin J.A., Frankenreiter S., Bergmann H., Roots C.M., Kyparissoudis K., Goodnow C.C., Godfrey D.I.
    J. Immunol. 189:5240-5249(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of brown fat cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis."
    Li S., Mi L., Yu L., Yu Q., Liu T., Wang G.X., Zhao X.Y., Wu J., Lin J.D.
    Proc. Natl. Acad. Sci. U.S.A. 114:E7111-E7120(2017) [PubMed] [Europe PMC] [Abstract]
• positive regulation of CD4-positive, alpha-beta T cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling."
    Luckey M.A., Kimura M.Y., Waickman A.T., Feigenbaum L., Singer A., Park J.H.
    Nat. Immunol. 15:638-645(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cold-induced thermogenesis Source: YuBioLab <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis."
    Li S., Mi L., Yu L., Yu Q., Liu T., Wang G.X., Zhao X.Y., Wu J., Lin J.D.
    Proc. Natl. Acad. Sci. U.S.A. 114:E7111-E7120(2017) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: RGDInferred from sequence orthologyⁱ
  • "Regulation of GATA-3 expression during CD4 lineage differentiation."
    Gimferrer I., Hu T., Simmons A., Wang C., Souabni A., Busslinger M., Bender T.P., Hernandez-Hoyos G., Alberola-Ila J.
    J. Immunol. 186:3892-3898(2011) [PubMed] [Europe PMC] [Abstract]
  • "The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling."
    Luckey M.A., Kimura M.Y., Waickman A.T., Feigenbaum L., Singer A., Park J.H.
    Nat. Immunol. 15:638-645(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of histone deacetylation Source: RGDInferred from sequence orthologyⁱ
  • "Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation."
    Rui J., Liu H., Zhu X., Cui Y., Liu X.
    J. Immunol. 189:1380-1390(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of insulin receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Th-POK regulates mammary gland lactation through mTOR-SREBP pathway."
    Zhang R., Ma H., Gao Y., Wu Y., Qiao Y., Geng A., Cai C., Han Y., Zeng Y.A., Liu X., Ge G.
    PLoS Genet. 14:E1007211-E1007211(2018) [PubMed] [Europe PMC] [Abstract]
• positive regulation of SREBP signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Th-POK regulates mammary gland lactation through mTOR-SREBP pathway."
    Zhang R., Ma H., Gao Y., Wu Y., Qiao Y., Geng A., Cai C., Han Y., Zeng Y.A., Liu X., Ge G.
    PLoS Genet. 14:E1007211-E1007211(2018) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin."
    Galera P., Musso M., Ducy P., Karsenty G.
    Proc. Natl. Acad. Sci. U.S.A. 91:9372-9376(1994) [PubMed] [Europe PMC] [Abstract]
  • "c-Krox binds to several sites in the promoter of both mouse type I collagen genes. Structure/function study and developmental expression analysis."
    Galera P., Park R.W., Ducy P., Mattei M.G., Karsenty G.
    J. Biol. Chem. 271:21331-21339(1996) [PubMed] [Europe PMC] [Abstract]
• regulation of CD4-positive, alpha-beta T cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells."
    Wang L., Wildt K.F., Zhu J., Zhang X., Feigenbaum L., Tessarollo L., Paul W.E., Fowlkes B.J., Bosselut R.
    Nat. Immunol. 9:1122-1130(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of CD8-positive, alpha-beta T cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells."
    Wang L., Wildt K.F., Zhu J., Zhang X., Feigenbaum L., Tessarollo L., Paul W.E., Fowlkes B.J., Bosselut R.
    Nat. Immunol. 9:1122-1130(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of gene expression Source: RGDInferred from sequence orthologyⁱ
  • "The transcription factor Th-POK negatively regulates Th17 differentiation in Valpha14i NKT cells."
    Engel I., Zhao M., Kappes D., Taniuchi I., Kronenberg M.
    Blood 120:4524-4532(2012) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription involved in cell fate commitment Source: RGDInferred from sequence orthologyⁱ
  • "Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation."
    Rui J., Liu H., Zhu X., Cui Y., Liu X.
    J. Immunol. 189:1380-1390(2012) [PubMed] [Europe PMC] [Abstract]
• response to insulin Source: RGDInferred from sequence orthologyⁱ
  • "Th-POK regulates mammary gland lactation through mTOR-SREBP pathway."
    Zhang R., Ma H., Gao Y., Wu Y., Qiao Y., Geng A., Cai C., Han Y., Zeng Y.A., Liu X., Ge G.
    PLoS Genet. 14:E1007211-E1007211(2018) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• histone deacetylase binding Source: RGDInferred from sequence orthologyⁱ
  • "Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation."
    Rui J., Liu H., Zhu X., Cui Y., Liu X.
    J. Immunol. 189:1380-1390(2012) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation."
    Rui J., Liu H., Zhu X., Cui Y., Liu X.
    J. Immunol. 189:1380-1390(2012) [PubMed] [Europe PMC] [Abstract]
  • "c-Krox binds to several sites in the promoter of both mouse type I collagen genes. Structure/function study and developmental expression analysis."
    Galera P., Park R.W., Ducy P., Mattei M.G., Karsenty G.
    J. Biol. Chem. 271:21331-21339(1996) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MGSPEDDLIG IPFPDHSSEL LSCLNEQRQL GHLCDLTIRT QGLEYRTHRA 
        60         70         80         90        100
VLAACSHYFK KLFTEGGGGT VMGTGGGGTA AGGAGAGVCE LDFVGPEALG 
       110        120        130        140        150
ALLEFAYTAT LTTSSANMPA VLQAARLLEI PCVIAACMEI LQGSGLEAPS 
       160        170        180        190        200
PDEDDCERAR QYLEAFATAT TTASTSGMPN GEDSPPQVPL LPPPPPPPRP 
       210        220        230        240        250
VARRSRKPRK AFLQTKGARA NHLVPEAPTV LTHPLAYEEE EMVGRVGNSG 
       260        270        280        290        300
GSGLGDNYSP PAGATSPAEG PLNYEVFEGE EEEEELVYPP AYGLAQSNEP 
       310        320        330        340        350
SLSPEELGSD EDPIDPDLMA YLSSLHQDAL APGLDGQDKL VRKRRSQMPQ 
       360        370        380        390        400
ECPVCHKIIH GAGKLPRHMR THTGEKPFAC EVCGVRFTRN DKLKIHMRKH 
       410        420        430        440        450
TGERPYSCPH CPARFLHSYD LKNHMHLHTG DRPYECHLCH KAFAKEDHLQ 
       460        470        480        490        500
RHLKGQNCLE VRTRRRRKDD APPHYPPPST TTSSPAGLDL SNGHLDTFRL 
       510        520        530        540 
SLARFWEQSA TTGPPVTTQG PPEEEEEEGT PTTPQAESAM ESS        

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ