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Entry version 89 (02 Jun 2021)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

Pseudopodium-enriched atypical kinase 1

Gene

Peak1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Pseudopodium-enriched atypical kinase 1Imported
Submitted name:
Similar to RIKEN cDNA C230081A13 (Predicted)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Peak1Imported
Synonyms:RGD1312026Imported, RGD1312026_predictedImported
ORF Names:rCG_58069Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Rat genome database

More...
RGDi
1312026, Peak1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000042519, Expressed in lung and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000061695

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1300 – 1662Protein kinaseInterPro annotationAdd BLAST363

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni42 – 66DisorderedSequence analysisAdd BLAST25
Regioni322 – 410DisorderedSequence analysisAdd BLAST89
Regioni489 – 513DisorderedSequence analysisAdd BLAST25
Regioni543 – 579DisorderedSequence analysisAdd BLAST37
Regioni662 – 918DisorderedSequence analysisAdd BLAST257
Regioni930 – 964DisorderedSequence analysisAdd BLAST35
Regioni1020 – 1092DisorderedSequence analysisAdd BLAST73
Regioni1392 – 1443DisorderedSequence analysisAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi42 – 58Polar residuesSequence analysisAdd BLAST17
Compositional biasi323 – 407Polar residuesSequence analysisAdd BLAST85
Compositional biasi493 – 513Polar residuesSequence analysisAdd BLAST21
Compositional biasi561 – 579Polar residuesSequence analysisAdd BLAST19
Compositional biasi693 – 760Polar residuesSequence analysisAdd BLAST68
Compositional biasi803 – 857Polar residuesSequence analysisAdd BLAST55
Compositional biasi858 – 873Pro residuesSequence analysisAdd BLAST16
Compositional biasi874 – 904Polar residuesSequence analysisAdd BLAST31
Compositional biasi930 – 951Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi1038 – 1053Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1420 – 1443Polar residuesSequence analysisAdd BLAST24

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVUZ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157591

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002882_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
LPPSCMI

Database of Orthologous Groups

More...
OrthoDBi
49921at2759

TreeFam database of animal gene trees

More...
TreeFami
TF333340

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR008266, Tyr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D4A563-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSACNTFTEH VWKPGECKNC FKPKSLHQLP PDSEKAPITH GSVKTNANHS
60 70 80 90 100
NNHRVRNTGN FRPPVAKKPT IAVKPTMMVA DGQSVCGELS IQEHCENKPV
110 120 130 140 150
ILGWNQNRTS LSQKPLNNNS EGDTEGFGSV PQQCANNDRA KTIPNNNGLT
160 170 180 190 200
EVLKEIAGLD ASPPVRGNET NSRETFLGRI NDCYKRSLER KIPPSCMTGS
210 220 230 240 250
TKDSQGKHVI LSGSTEVISN EGGRFCYPEF SSGEESEEDV LFSNMEEEHE
260 270 280 290 300
SWDESDEELL AMEIRMRGQP RFANFRANTL SPVRFFVSKK WNTIPLRNKS
310 320 330 340 350
LQRICAVDYD DSYDEILNGY EENSGVSYGQ GSIQSTVSSD STSPDSSFTE
360 370 380 390 400
ESRSETASSL SQKICNGGIS PGNPGNSKDM AETESNSESP PPNNEEKDSS
410 420 430 440 450
LTSKSPVKVP ETHKAVLALR LQEKDGKIAV QTEKPENKAS TDIAGQAVTI
460 470 480 490 500
SLVPVEEQTK PYRVVNLEQP LCKPYTVVDV SAAMASEHLG RPKVKGSSST
510 520 530 540 550
PNSPVTSPAL TPGQINAHLK KSSAIRYQEV WTSSTSPRQK IPKIELSTGG
560 570 580 590 600
TGPNVPPRKN CHKSAPTSPT ATNISSKTIP VKSPNLSEIK FNSYNNAGMP
610 620 630 640 650
PFPIIIHDEP SYARSSKNAI KVPIVINPNA YDNLAIYKSF LGTSGELSVK
660 670 680 690 700
EKTTSVISHT YEEIETESKV SDSTPSKLAD GPPAKGFSSS AERKRGSVAQ
710 720 730 740 750
KVQEFNNCLN RGQSSPQRSY SSTHSSPAKI QRPTQEPVGK TESAQGSQVP
760 770 780 790 800
GSSGSTREKA SAVLCQIVAS IQPPQTPPEA PQSSPKACSV DELYAIPPDA
810 820 830 840 850
DTTKNIPKNT PVRPKSLFTS QSSGEGEAHQ TTESPTTKTQ KDPSTKPVTS
860 870 880 890 900
PPSKLVTSTQ SEPPPPFPPP RSTSSPYHAS NLLQRHFTNW TKPTSPTRST
910 920 930 940 950
EAESILHSEG SRRAADAKPK RWISFKSFFR RRKTDEEEEK EKEREKGKLV
960 970 980 990 1000
GLDGTVIHML PPPPVQRHHW FTEAKGESSE KPAIVFMYRC DPDQGHLSVD
1010 1020 1030 1040 1050
QSKAGADNGR TEDVLLRNLE EKKNSHPPSQ IPDKACSRVT HEVAEELSPR
1060 1070 1080 1090 1100
DPRTPAVKQD GTSVTPTLPP PDLEREEEKD ATSDPTDVSP CSATYSNLGQ
1110 1120 1130 1140 1150
SRAAMIPPKH PRHPKGALDD AIAFGEKTDQ EVLNASQPTP PPLPKKMIRA
1160 1170 1180 1190 1200
NTEPIPKDLQ KSMESSLCVV ANPTYDIDPN WDASSAGSSV SYELKGLDVE
1210 1220 1230 1240 1250
SYESLERPLH KERPVPSTAN SISSLATLSI KDRFSNSMES LSSRRGLSCR
1260 1270 1280 1290 1300
QARSIQKPQR QALYRGLDSR EEVVGKLRSL HTDALKRLAV KCEDLFMAGQ
1310 1320 1330 1340 1350
KDQLRFGVDS WSDFRLTSDK PCCEAGDAVY YTASYAKDPL SNYAVKICKS
1360 1370 1380 1390 1400
KAKESQQYYH SLAVRQSLPV HFNIQQDCGH FLAEVPNRLL PWEDPNAPEK
1410 1420 1430 1440 1450
AEDGNEDSEE EVKAETSGGN PEPCSESESS QKENQQVTNR KQRSHVVVIT
1460 1470 1480 1490 1500
REVPHLTVAD FVRDSLAHHG KSPDLYERQV CLLLLQLCSG LEHLKPYHVT
1510 1520 1530 1540 1550
HCDLRLENLL LVQHQPGGAT QCPSPADPCP TSACPTRLIV SNFSQAKQKS
1560 1570 1580 1590 1600
HLMDPQILRD QSRLAPEIIT ATQYKKCDEF QTGILIYEML HLPNPFDENP
1610 1620 1630 1640 1650
ELKEKEYTRT DLPRIPLRSP YSWGLQQLAS CLLNPNPSER ILISDAKGIL
1660 1670 1680 1690 1700
QCLLWGPRED LFQIFTTSAT LVQKNALLQN WLDIKRTLLM IKFAEKSLDR
1710 1720 1730
EGGISLEDWL CAQYLAFATT DSLSYIVKIL QYR
Length:1,733
Mass (Da):191,112
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7681D83E90880764
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07070240 Genomic DNA No translation available.
AABR07070241 Genomic DNA No translation available.
AABR07070242 Genomic DNA No translation available.
AABR07070243 Genomic DNA No translation available.
CH473975 Genomic DNA Translation: EDL95581.1

NCBI Reference Sequences

More...
RefSeqi
NP_001101619.1, NM_001108149.1
XP_006243177.1, XM_006243115.3
XP_006243178.1, XM_006243116.3
XP_017451132.1, XM_017595643.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000068658; ENSRNOP00000061695; ENSRNOG00000042519

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
315686

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:315686

UCSC genome browser

More...
UCSCi
RGD:1312026, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07070240 Genomic DNA No translation available.
AABR07070241 Genomic DNA No translation available.
AABR07070242 Genomic DNA No translation available.
AABR07070243 Genomic DNA No translation available.
CH473975 Genomic DNA Translation: EDL95581.1
RefSeqiNP_001101619.1, NM_001108149.1
XP_006243177.1, XM_006243115.3
XP_006243178.1, XM_006243116.3
XP_017451132.1, XM_017595643.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061695

Genome annotation databases

EnsembliENSRNOT00000068658; ENSRNOP00000061695; ENSRNOG00000042519
GeneIDi315686
KEGGirno:315686
UCSCiRGD:1312026, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79834
RGDi1312026, Peak1

Phylogenomic databases

eggNOGiENOG502QVUZ, Eukaryota
GeneTreeiENSGT00940000157591
HOGENOMiCLU_002882_0_0_1
OMAiLPPSCMI
OrthoDBi49921at2759
TreeFamiTF333340

Gene expression databases

BgeeiENSRNOG00000042519, Expressed in lung and 20 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR008266, Tyr_kinase_AS
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD4A563_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4A563
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: June 2, 2021
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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