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Entry version 87 (12 Aug 2020)
Sequence version 3 (22 Jul 2015)
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Protein
Submitted name:

SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily c, member 2

Gene

Smarcc2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-3214858, RMTs methylate histone arginines
R-RNO-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily c, member 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Smarcc2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Rat genome database

More...
RGDi
1597704, Smarcc2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Isopeptide bondARBA annotation, Ubl conjugationARBA annotation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
D4A510

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D4A510

PeptideAtlas

More...
PeptideAtlasi
D4A510

PRoteomics IDEntifications database

More...
PRIDEi
D4A510

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D4A510

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D4A510

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000031135, Expressed in frontal cortex and 20 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
D4A510, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
D4A510, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000058649

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D4A510

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini424 – 521SWIRMInterPro annotationAdd BLAST98
Domaini627 – 678SANTInterPro annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni256 – 412DisorderedSequence analysisAdd BLAST157
Regioni544 – 570DisorderedSequence analysisAdd BLAST27
Regioni761 – 884DisorderedSequence analysisAdd BLAST124
Regioni978 – 1135DisorderedSequence analysisAdd BLAST158

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi258 – 292PolyampholyteSequence analysisAdd BLAST35
Compositional biasi303 – 317PolyampholyteSequence analysisAdd BLAST15
Compositional biasi326 – 348PolyampholyteSequence analysisAdd BLAST23
Compositional biasi393 – 412PolyampholyteSequence analysisAdd BLAST20
Compositional biasi556 – 570PolyampholyteSequence analysisAdd BLAST15
Compositional biasi777 – 884PolyampholyteSequence analysisAdd BLAST108
Compositional biasi986 – 1010Pro-richSequence analysisAdd BLAST25
Compositional biasi1047 – 1066PolarSequence analysisAdd BLAST20
Compositional biasi1067 – 1095Pro-richSequence analysisAdd BLAST29
Compositional biasi1111 – 1135Pro-richSequence analysisAdd BLAST25

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1279, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155746

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004447_0_1_1

KEGG Orthology (KO)

More...
KOi
K11649

Identification of Orthologs from Complete Genome Data

More...
OMAi
AGAMANF

Database of Orthologous Groups

More...
OrthoDBi
683891at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D4A510

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036420, BRCT_dom_sf
IPR000953, Chromo/chromo_shadow_dom
IPR009057, Homeobox-like_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR038044, SMARCC2
IPR032451, SMARCC_C
IPR032450, SMARCC_N
IPR007526, SWIRM
IPR032448, SWIRM-assoc
IPR036388, WH-like_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12802:SF105, PTHR12802:SF105, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00249, Myb_DNA-binding, 1 hit
PF04433, SWIRM, 1 hit
PF16495, SWIRM-assoc_1, 1 hit
PF16496, SWIRM-assoc_2, 1 hit
PF16498, SWIRM-assoc_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00298, CHROMO, 1 hit
SM00717, SANT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 2 hits
SSF52113, SSF52113, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51293, SANT, 1 hit
PS50934, SWIRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D4A510-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVRKKDGGP NVKYYEAADT VTQFDNVRLW LGKNYKKYIQ AEPPTNKSLS
60 70 80 90 100
SLVVQLLQFQ EEVFGKHVSN APLTKLPIKC FLDFKAGGSL CHILAAAYKF
110 120 130 140 150
KSDQGWRRYD FQNPSRMDRN VEMFMTIEKS LVQNNCLSRP NIFLCPEIEP
160 170 180 190 200
KLLGKLKDIV KRHQGTISED KSNASHVVYP APGNLEEEEW VRPVMKRDKQ
210 220 230 240 250
VLLHWGYYPD SYDTWIPASE IEASVEDAPT PEKPRKVHAK WILDTDTFNE
260 270 280 290 300
WMNEEDYEVS DDKSPVSRRK KISAKTLTDE VNSPDADRRD KKGGNYKKRK
310 320 330 340 350
RSPSPSPTPE AKKKNAKKGP STPYTKSKRG HREEEQEDLT KDMDEPSPVP
360 370 380 390 400
NVEEVTLPKT VNTKKDSESA PVKGGTMTDL DEQDDESMET TGKDEDENST
410 420 430 440 450
GNKGEQTKSA DLHEDNVTEQ THHIIVPSYA AWFDYNSVHA IERRALPEFF
460 470 480 490 500
NGKNKSKTPE IYLAYRNFMI DTYRLNPQEY LTSTACRRNL AGDVCAIMRV
510 520 530 540 550
HAFLEQWGLI NYQVDAESRP TPMGPPPTSH FHVLADTPSG LVPLQPKPPQ
560 570 580 590 600
GRQVDADTKA GRKGKELDDL VPEAAKGKPE LQGSASQQML NFPDKGKEKP
610 620 630 640 650
ADMQNFGLRT DMYTKKNIPS KSKAAASATR EWTEQETLLL LEALEMYKDD
660 670 680 690 700
WNKVSEHVGS RTQDECILHF LRLPIEDPYL EDSEASLGPL AYQPIPFSQS
710 720 730 740 750
GNPVMSTVAF LASVVDPRVA SAAAKSALEE FSKMKEEVPT ALVEAHVRKV
760 770 780 790 800
EEAAKVTGKA DPAFGLESSG IAGTASDEPE RIEESGTEEA RAESQAADEK
810 820 830 840 850
KEPKEPREGG GAVEEEAKEE ISEAPKKDEE KGKEADSEKE SEKSDGDPIV
860 870 880 890 900
DPEKDKEPTE GQEEGLKEVA EPEGERKAKV ERDIGEGNLS TAAAAALAAA
910 920 930 940 950
AVKAKHLAAV EERKIKSLVA LLVETQMKKL EIKLRHFEEL ETIMDREREA
960 970 980 990 1000
LEYQRQQLLA DRQAFHMEQL KYAEMRARQQ HFQQMQQQPP PPPPPPPPPA
1010 1020 1030 1040 1050
LPPGSQPIPP TGAAAPATVH GLAVAPASVA SAPPGGGAPP GTLGPSEQIG
1060 1070 1080 1090 1100
QAGTTAGPQQ PQQAGAPQPG AVPPGVPPPG PHGPSPFPNQ QTPPSMMPGA
1110 1120 1130
VPGSGHPGVA DPGTPLPPDP TAPSPGTVTP VPPPQ
Length:1,135
Mass (Da):124,739
Last modified:July 22, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD095EED146B7C67C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07073271 Genomic DNA No translation available.
AC128207 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_001055673.1, XM_001055673.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000028244; ENSRNOP00000028244; ENSRNOG00000031135

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
685179

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:685179

UCSC genome browser

More...
UCSCi
RGD:1597704, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07073271 Genomic DNA No translation available.
AC128207 Genomic DNA No translation available.
RefSeqiXP_001055673.1, XM_001055673.6

3D structure databases

SMRiD4A510
ModBaseiSearch...

Protein-protein interaction databases

IntActiD4A510, 3 interactors
STRINGi10116.ENSRNOP00000058649

PTM databases

iPTMnetiD4A510
PhosphoSitePlusiD4A510

Proteomic databases

jPOSTiD4A510
PaxDbiD4A510
PeptideAtlasiD4A510
PRIDEiD4A510

Genome annotation databases

EnsembliENSRNOT00000028244; ENSRNOP00000028244; ENSRNOG00000031135
GeneIDi685179
KEGGirno:685179
UCSCiRGD:1597704, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6601
RGDi1597704, Smarcc2

Phylogenomic databases

eggNOGiKOG1279, Eukaryota
GeneTreeiENSGT00940000155746
HOGENOMiCLU_004447_0_1_1
KOiK11649
OMAiAGAMANF
OrthoDBi683891at2759
PhylomeDBiD4A510

Enzyme and pathway databases

ReactomeiR-RNO-3214858, RMTs methylate histone arginines
R-RNO-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Gene expression databases

BgeeiENSRNOG00000031135, Expressed in frontal cortex and 20 other tissues
GenevisibleiD4A510, RN

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR036420, BRCT_dom_sf
IPR000953, Chromo/chromo_shadow_dom
IPR009057, Homeobox-like_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR038044, SMARCC2
IPR032451, SMARCC_C
IPR032450, SMARCC_N
IPR007526, SWIRM
IPR032448, SWIRM-assoc
IPR036388, WH-like_DNA-bd_sf
PANTHERiPTHR12802:SF105, PTHR12802:SF105, 1 hit
PfamiView protein in Pfam
PF00249, Myb_DNA-binding, 1 hit
PF04433, SWIRM, 1 hit
PF16495, SWIRM-assoc_1, 1 hit
PF16496, SWIRM-assoc_2, 1 hit
PF16498, SWIRM-assoc_3, 1 hit
SMARTiView protein in SMART
SM00298, CHROMO, 1 hit
SM00717, SANT, 1 hit
SUPFAMiSSF46689, SSF46689, 2 hits
SSF52113, SSF52113, 1 hit
PROSITEiView protein in PROSITE
PS51293, SANT, 1 hit
PS50934, SWIRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD4A510_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4A510
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: August 12, 2020
This is version 87 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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