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UniProtKB - D4A505 (D4A505_RAT)
Protein
Submitted name:
Transcription factor AP-2 beta
Gene
Tfap2b
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- chromatin binding Source: RGD
- cis-regulatory region sequence-specific DNA binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKB
- protein heterodimerization activity Source: RGD
- protein homodimerization activity Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- anatomical structure development Source: GO_Central
- aorta morphogenesis Source: UniProtKB
- calcium ion homeostasis Source: UniProtKB
- cellular ammonium homeostasis Source: UniProtKB
- cellular creatinine homeostasis Source: UniProtKB
- cellular urea homeostasis Source: UniProtKB
- collecting duct development Source: UniProtKB
- distal tubule development Source: UniProtKB
- ductus arteriosus closure Source: UniProtKB
- fat cell differentiation Source: RGD
- forelimb morphogenesis Source: UniProtKB
- gene expression Source: RGD
- glucose homeostasis Source: UniProtKB
- glucose metabolic process Source: UniProtKB
- hindlimb morphogenesis Source: UniProtKB
- kidney development Source: UniProtKB
- magnesium ion homeostasis Source: UniProtKB
- metanephric nephron development Source: RGD
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of neuron apoptotic process Source: RGD
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- phosphate ion homeostasis Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of neuron apoptotic process Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of urine volume Source: UniProtKB
- potassium ion homeostasis Source: UniProtKB
- regulation of BMP signaling pathway Source: UniProtKB
- regulation of cell differentiation Source: UniProtKB
- regulation of cell population proliferation Source: GO_Central
- regulation of insulin secretion Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: UniProtKB
- renal water homeostasis Source: UniProtKB
- response to xenobiotic stimulus Source: RGD
- retina layer formation Source: RGD
- sensory organ development Source: RGD
- skin development Source: RGD
- smooth muscle tissue development Source: RGD
- sodium ion homeostasis Source: UniProtKB
- sympathetic nervous system development Source: UniProtKB
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Transcription factor AP-2 beta |
Gene namesi | Name:Tfap2bImported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1306321, Tfap2b |
Subcellular locationi
Nucleus
- nucleus Source: RGD
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000011823, Expressed in kidney and 8 other tissues |
ExpressionAtlasi | D4A505, baseline and differential |
Interactioni
GO - Molecular functioni
- protein heterodimerization activity Source: RGD
- protein homodimerization activity Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000030726 |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the AP-2 family.ARBA annotation
Phylogenomic databases
eggNOGi | KOG3811, Eukaryota |
GeneTreei | ENSGT00950000182848 |
InParanoidi | D4A505 |
OrthoDBi | 641707at2759 |
TreeFami | TF313718 |
Family and domain databases
InterProi | View protein in InterPro IPR004979, TF_AP2 IPR008122, TF_AP2_beta IPR013854, TF_AP2_C |
PANTHERi | PTHR10812, PTHR10812, 1 hit PTHR10812:SF14, PTHR10812:SF14, 1 hit |
Pfami | View protein in Pfam PF03299, TF_AP-2, 1 hit |
PRINTSi | PR01750, AP2BTNSCPFCT PR01748, AP2TNSCPFCT |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
D4A505-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLVHTYSSMD RHDGVPSHSS RLSQLGSVSQ GPYSSAPPLS HTPSSDFQPP
60 70 80 90 100
YFPPPYQPLP YHQSQDPYSH VNDPYSLNPL HQPQQHPWGQ RQRQEVGSEA
110 120 130 140 150
GSLLPQPRAA LPQLSGLDPR RDYHSVRRPD VLLHSAHHGL DAGMGDSLSL
160 170 180 190 200
HGLGHPGMED VQSVEDANNS GMNLLDQSVI KKVPVPPKSV TSLMMNKDGF
210 220 230 240 250
LGGMSVNTGE VFCSVPGRLS LLSSTSKYKV TVGEVQRRLS PPECLNASLL
260 270 280 290 300
GGVLRRAKSK NGGRSLRERL EKIGLNLPAG RRKAANVTLL TSLVEGEAVH
310 320 330 340 350
LARDFGYICE TEFPAKAVSE YLNRQHTDPS DLHSRKNMLL ATKQLCKEFT
360 370 380 390 400
DLLAQDRTPI GNSRPSPILE PGIQSCLTHF SLITHGFGAP AICAALTALQ
410 420 430 440
NYLTEALKGM DKMFLNNTTN RHTSGEGPGS KTGDKEEKHR K
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2KAT2 | A0A0G2KAT2_RAT | Transcription factor AP-2 beta | Tfap2b | 459 | Annotation score: |
Sequence databases
RefSeqi | NP_001100366.2, NM_001106896.2 |
Genome annotation databases
Ensembli | ENSRNOT00000030912.5; ENSRNOP00000030726.4; ENSRNOG00000011823.8 |
GeneIDi | 301285 |
KEGGi | rno:301285 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001100366.2, NM_001106896.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000030726 |
Proteomic databases
PaxDbi | D4A505 |
Genome annotation databases
Ensembli | ENSRNOT00000030912.5; ENSRNOP00000030726.4; ENSRNOG00000011823.8 |
GeneIDi | 301285 |
KEGGi | rno:301285 |
Organism-specific databases
CTDi | 7021 |
RGDi | 1306321, Tfap2b |
Phylogenomic databases
eggNOGi | KOG3811, Eukaryota |
GeneTreei | ENSGT00950000182848 |
InParanoidi | D4A505 |
OrthoDBi | 641707at2759 |
TreeFami | TF313718 |
Gene expression databases
Bgeei | ENSRNOG00000011823, Expressed in kidney and 8 other tissues |
ExpressionAtlasi | D4A505, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR004979, TF_AP2 IPR008122, TF_AP2_beta IPR013854, TF_AP2_C |
PANTHERi | PTHR10812, PTHR10812, 1 hit PTHR10812:SF14, PTHR10812:SF14, 1 hit |
Pfami | View protein in Pfam PF03299, TF_AP-2, 1 hit |
PRINTSi | PR01750, AP2BTNSCPFCT PR01748, AP2TNSCPFCT |
MobiDBi | Search... |
Entry informationi
Entry namei | D4A505_RAT | |
Accessioni | D4A505Primary (citable) accession number: D4A505 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | May 25, 2022 | |
Last modified: | May 25, 2022 | |
This is version 84 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |