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Entry version 55 (12 Aug 2020)
Sequence version 1 (20 Apr 2010)
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Protein

Cysteine and histidine-rich domain-containing protein 1

Gene

Chordc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (By similarity). Involved in stress response. Prevents tumorigenesis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi5Zinc 1PROSITE-ProRule annotation1
Metal bindingi10Zinc 1PROSITE-ProRule annotation1
Metal bindingi24Zinc 1PROSITE-ProRule annotation1
Metal bindingi27Zinc 2PROSITE-ProRule annotation1
Metal bindingi42Zinc 2PROSITE-ProRule annotation1
Metal bindingi43Zinc 2PROSITE-ProRule annotation1
Metal bindingi59Zinc 2PROSITE-ProRule annotation1
Metal bindingi64Zinc 1PROSITE-ProRule annotation1
Metal bindingi157Zinc 3PROSITE-ProRule annotation1
Metal bindingi162Zinc 3PROSITE-ProRule annotation1
Metal bindingi176Zinc 3PROSITE-ProRule annotation1
Metal bindingi179Zinc 4PROSITE-ProRule annotation1
Metal bindingi194Zinc 4PROSITE-ProRule annotation1
Metal bindingi195Zinc 4PROSITE-ProRule annotation1
Metal bindingi211Zinc 4PROSITE-ProRule annotation1
Metal bindingi216Zinc 3PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processStress response
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cysteine and histidine-rich domain-containing protein 1
Alternative name(s):
CHORD domain-containing protein 1
Short name:
CHP-1
Morgana
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Chordc1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8
  • UP000234681 Componentsi: Chromosome 8, Unassembled WGS sequence

Organism-specific databases

Rat genome database

More...
RGDi
1304679, Chordc1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004028022 – 331Cysteine and histidine-rich domain-containing protein 1Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei47PhosphothreonineBy similarity1
Modified residuei51PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
D4A4T9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D4A4T9

PeptideAtlas

More...
PeptideAtlasi
D4A4T9

PRoteomics IDEntifications database

More...
PRIDEi
D4A4T9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D4A4T9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D4A4T9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000026643, Expressed in quadriceps femoris and 21 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
D4A4T9, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HSP90AA1, HSP90AB1, PPP5C, ROCK1 and ROCK2.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000030171

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D4A4T9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 64CHORD 1PROSITE-ProRule annotationAdd BLAST60
Domaini157 – 216CHORD 2PROSITE-ProRule annotationAdd BLAST60
Domaini227 – 316CSPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 77Interaction with PPP5CBy similarityAdd BLAST76
Regioni65 – 316Interaction with HSP90AA1 and HSP90AB1By similarityAdd BLAST252

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1667, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154174

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_040079_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D4A4T9

KEGG Orthology (KO)

More...
KOi
K16729

Identification of Orthologs from Complete Genome Data

More...
OMAi
MAQKCVH

Database of Orthologous Groups

More...
OrthoDBi
1163528at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D4A4T9

TreeFam database of animal gene trees

More...
TreeFami
TF105394

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.790, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007051, CHORD_dom
IPR039790, CHORD_protein
IPR007052, CS_dom
IPR008978, HSP20-like_chaperone

The PANTHER Classification System

More...
PANTHERi
PTHR12621, PTHR12621, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04968, CHORD, 2 hits
PF04969, CS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49764, SSF49764, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51401, CHORD, 2 hits
PS51203, CS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

D4A4T9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLCYNRGC GQRFDPEANA DDACTYHPGV PVFHDALKGW SCCKRRTTDF
60 70 80 90 100
SDFLSIVGCT KGRHNSEKPP EPVKPEVKTT EKKELSELKP KFQEHIIQAP
110 120 130 140 150
KPVEAIKRPS PDEPMTNLEL KISASLKQAL DKLKLSSGNE EDKKEEDSDE
160 170 180 190 200
IKIGTSCKNG GCSKTYQGLQ SLEEVCVYHS GVPIFHEGMK YWSCCRRKTS
210 220 230 240 250
DFNTFLAQEG CTRGKHVWTK KDAGKKVVPC RHDWHQTGGE VTISVYAKNS
260 270 280 290 300
LPELSQVEAN STLLNVHIVF EGEKEFHQNV KLWGVIDVKR SYVTMTATKI
310 320 330
EITMRKAEPM QWASLELPTT KKQEKQKDIA D
Length:331
Mass (Da):37,362
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i88100248DC1061C5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH473993 Genomic DNA Translation: EDL78419.1

NCBI Reference Sequences

More...
RefSeqi
NP_001101598.1, NM_001108128.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000030569; ENSRNOP00000030171; ENSRNOG00000026643

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
315447

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:315447

UCSC genome browser

More...
UCSCi
RGD:1304679, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473993 Genomic DNA Translation: EDL78419.1
RefSeqiNP_001101598.1, NM_001108128.1

3D structure databases

SMRiD4A4T9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030171

PTM databases

iPTMnetiD4A4T9
PhosphoSitePlusiD4A4T9

Proteomic databases

jPOSTiD4A4T9
PaxDbiD4A4T9
PeptideAtlasiD4A4T9
PRIDEiD4A4T9

Genome annotation databases

EnsembliENSRNOT00000030569; ENSRNOP00000030171; ENSRNOG00000026643
GeneIDi315447
KEGGirno:315447
UCSCiRGD:1304679, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26973
RGDi1304679, Chordc1

Phylogenomic databases

eggNOGiKOG1667, Eukaryota
GeneTreeiENSGT00940000154174
HOGENOMiCLU_040079_0_0_1
InParanoidiD4A4T9
KOiK16729
OMAiMAQKCVH
OrthoDBi1163528at2759
PhylomeDBiD4A4T9
TreeFamiTF105394

Miscellaneous databases

Protein Ontology

More...
PROi
PR:D4A4T9

Gene expression databases

BgeeiENSRNOG00000026643, Expressed in quadriceps femoris and 21 other tissues
GenevisibleiD4A4T9, RN

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR007051, CHORD_dom
IPR039790, CHORD_protein
IPR007052, CS_dom
IPR008978, HSP20-like_chaperone
PANTHERiPTHR12621, PTHR12621, 1 hit
PfamiView protein in Pfam
PF04968, CHORD, 2 hits
PF04969, CS, 1 hit
SUPFAMiSSF49764, SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51401, CHORD, 2 hits
PS51203, CS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHRD1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4A4T9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: April 20, 2010
Last modified: August 12, 2020
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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