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Protein
Submitted name:

Iron-sulfur cluster assembly 2

Gene

Isca2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • 2 iron, 2 sulfur cluster binding Source: GO_Central
  • 4 iron, 4 sulfur cluster binding Source: GO_Central
  • iron ion binding Source: GO_Central
  • structural molecule activity Source: InterPro

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-1362409 Mitochondrial iron-sulfur cluster biogenesis

Names & Taxonomyi

Protein namesi
Submitted name:
Iron-sulfur cluster assembly 2Imported
Submitted name:
RCG20978, isoform CRA_eImported
Gene namesi
Name:Isca2Imported
Synonyms:RGD1563216Imported
ORF Names:rCG_20978Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1563216 Isca2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiD4A4L5

PTM databases

SwissPalmiD4A4L5

Expressioni

Gene expression databases

BgeeiENSRNOG00000012085 Expressed in 9 organ(s), highest expression level in heart

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016089

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 147Fe-S_biosynInterPro annotationAdd BLAST99

Phylogenomic databases

eggNOGiKOG1119 Eukaryota
COG0316 LUCA
GeneTreeiENSGT00390000005700
KOiK22072
OMAiMEKGEYL
OrthoDBiEOG091G0XVD
TreeFamiTF314519

Family and domain databases

Gene3Di2.60.300.12, 1 hit
InterProiView protein in InterPro
IPR000361 FeS_biogenesis
IPR016092 FeS_cluster_insertion
IPR017870 FeS_cluster_insertion_CS
IPR035903 HesB-like_dom_sf
PfamiView protein in Pfam
PF01521 Fe-S_biosyn, 1 hit
SUPFAMiSSF89360 SSF89360, 1 hit
TIGRFAMsiTIGR00049 TIGR00049, 1 hit
PROSITEiView protein in PROSITE
PS01152 HESB, 1 hit

Sequencei

Sequence statusi: Complete.

D4A4L5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAARALSLT AEAFGAAIPR RQGRLLAAFP RLLTRWETTS SIPEAGEGQI
60 70 80 90 100
RLTDSCVQRL LEITEGSEFL RLQVEGGGCS GFQYKFSLDT VINPDDRVFE
110 120 130 140 150
QGGARVVVDS DSLAYVKGAQ VDFSQELIRS SFQVLNNPQA QQGCSCGSSF

SIKI
Length:154
Mass (Da):16,680
Last modified:April 20, 2010 - v1
Checksum:i9D8A27CB34E6E383
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113727 Genomic DNA No translation available.
CH473982 Genomic DNA Translation: EDL81531.1
RefSeqiNP_001102748.1, NM_001109278.2
UniGeneiRn.36341

Genome annotation databases

EnsembliENSRNOT00000016089; ENSRNOP00000016089; ENSRNOG00000012085
GeneIDi500694
KEGGirno:500694
UCSCiRGD:1563216 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113727 Genomic DNA No translation available.
CH473982 Genomic DNA Translation: EDL81531.1
RefSeqiNP_001102748.1, NM_001109278.2
UniGeneiRn.36341

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016089

PTM databases

SwissPalmiD4A4L5

Proteomic databases

PRIDEiD4A4L5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016089; ENSRNOP00000016089; ENSRNOG00000012085
GeneIDi500694
KEGGirno:500694
UCSCiRGD:1563216 rat

Organism-specific databases

CTDi122961
RGDi1563216 Isca2

Phylogenomic databases

eggNOGiKOG1119 Eukaryota
COG0316 LUCA
GeneTreeiENSGT00390000005700
KOiK22072
OMAiMEKGEYL
OrthoDBiEOG091G0XVD
TreeFamiTF314519

Enzyme and pathway databases

ReactomeiR-RNO-1362409 Mitochondrial iron-sulfur cluster biogenesis

Gene expression databases

BgeeiENSRNOG00000012085 Expressed in 9 organ(s), highest expression level in heart

Family and domain databases

Gene3Di2.60.300.12, 1 hit
InterProiView protein in InterPro
IPR000361 FeS_biogenesis
IPR016092 FeS_cluster_insertion
IPR017870 FeS_cluster_insertion_CS
IPR035903 HesB-like_dom_sf
PfamiView protein in Pfam
PF01521 Fe-S_biosyn, 1 hit
SUPFAMiSSF89360 SSF89360, 1 hit
TIGRFAMsiTIGR00049 TIGR00049, 1 hit
PROSITEiView protein in PROSITE
PS01152 HESB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD4A4L5_RAT
AccessioniPrimary (citable) accession number: D4A4L5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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