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Entry version 85 (29 Sep 2021)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

Intercellular adhesion molecule 5

Gene

Icam5

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • integrin binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesionARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-RNO-216083, Integrin cell surface interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Intercellular adhesion molecule 5Imported
Submitted name:
RCG31795Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Icam5Imported
ORF Names:rCG_31795Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Rat genome database

More...
RGDi
1305039, Icam5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 31HelicalSequence analysisAdd BLAST20
Transmembranei833 – 858HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
D4A435

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
D4A435, 1 site, 11 N-linked glycans (1 site)

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
D4A435

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000020694, Expressed in frontal cortex and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000028096

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D4A435

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini408 – 486Ig-likeInterPro annotationAdd BLAST79
Domaini491 – 567Ig-likeInterPro annotationAdd BLAST77
Domaini665 – 738Ig-likeInterPro annotationAdd BLAST74
Domaini745 – 828Ig-likeInterPro annotationAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni883 – 908DisorderedSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QS16, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162184

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014560_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
PGIYVCN

Database of Orthologous Groups

More...
OrthoDBi
731140at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D4A435

TreeFam database of animal gene trees

More...
TreeFami
TF333745

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003988, ICAM
IPR013768, ICAM_N
IPR003987, ICAM_VCAM_N
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03921, ICAM_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01473, ICAM
PR01472, ICAMVCAM1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 6 hits
SM00408, IGc2, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835, IG_LIKE, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D4A435-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGPSPGLRR TLLGLWAALG LGILGISAVA LEPFWADLQP RVALVERGGS
60 70 80 90 100
LWLNCSTNCP RPERGGLETS LRRNGTQRGL RWLARQLVDI REPETQPVCF
110 120 130 140 150
FRCARRTLQA RGLIRTFQRP DRVELVPLPP WQPVGENFTL SCRVPGAGPR
160 170 180 190 200
ASLTLTLLRG GQELIRRSFV GEPPRARGAM LTATVLARRE DHRANFSCLA
210 220 230 240 250
ELDLRPHGLG LFANSSAPRQ LRTFAMPPLS PSLIAPRFLE VGSERPVTCT
260 270 280 290 300
LDGLFPAPEA GVYLSLGDQR LHPNVTLDGE SLVATATATA SEEQEGTKQL
310 320 330 340 350
MCIVTLGGES RETQENLTVY SFPAPLLTLS EPEAPEGKMV TVSCWAGARA
360 370 380 390 400
LVTLEGIPAA VPGQPAELQL NVTKNDDKRG FFCDAALDVD GETLRKNQSS
410 420 430 440 450
ELRVLYAPRL DDLDCPRSWT WPEGPEQTLH CEARGNPEPS VHCARPDGGA
460 470 480 490 500
VLALGLLGPV TRALAGTYRC TAINGQGQAV KDVTLTVEYA PALDSVGCPE
510 520 530 540 550
RITWLEGTEA SLSCVAHGVP PPSVSCVRSG KEEVMEGPLR VAREHAGTYR
560 570 580 590 600
CEAINARGSA AKNVAVTVEY GPSFEELGCP SNWTWVEGSG KLFSCEVDGK
610 620 630 640 650
PEPRVECVGS EGASEGVVLP LVSSNSGSRN SMTPGNLSPG IYLCNATNRH
660 670 680 690 700
GSTVKTVVVS AESPPQMDES SCPSHQTWLE GAEATALACS ARGRPSPRVR
710 720 730 740 750
CSREGAARLE RLQVSREDAG TYLCVATNAH GTDSRTVTVG VEYRPVVAEL
760 770 780 790 800
AASPPSVRPG GNFTLTCRAE AWPPAQISWR APPGALNLGL SSNNSTLSVA
810 820 830 840 850
GAMGSHGGEY ECAATNAHGR HARRITVRVA GPWLWVAVGG AAGGAALLAA
860 870 880 890 900
GAGLAFYVQS TACKKGEYNV QEAESSGEAV CLNGAGGTPG AEGGAETPGT
910
AESPADGEVF AIQLTSS
Length:917
Mass (Da):96,905
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5A68490995BD1448
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC118115 Genomic DNA No translation available.
AC135310 Genomic DNA No translation available.
CH473993 Genomic DNA Translation: EDL78332.1

NCBI Reference Sequences

More...
RefSeqi
NP_001165550.1, NM_001172079.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000028096; ENSRNOP00000028096; ENSRNOG00000020694

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
313785

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:313785

UCSC genome browser

More...
UCSCi
RGD:1305039, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118115 Genomic DNA No translation available.
AC135310 Genomic DNA No translation available.
CH473993 Genomic DNA Translation: EDL78332.1
RefSeqiNP_001165550.1, NM_001172079.1

3D structure databases

SMRiD4A435
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028096

PTM databases

GlyGeniD4A435, 1 site, 11 N-linked glycans (1 site)
SwissPalmiD4A435

Proteomic databases

PRIDEiD4A435

Genome annotation databases

EnsembliENSRNOT00000028096; ENSRNOP00000028096; ENSRNOG00000020694
GeneIDi313785
KEGGirno:313785
UCSCiRGD:1305039, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7087
RGDi1305039, Icam5

Phylogenomic databases

eggNOGiENOG502QS16, Eukaryota
GeneTreeiENSGT00940000162184
HOGENOMiCLU_014560_0_0_1
OMAiPGIYVCN
OrthoDBi731140at2759
PhylomeDBiD4A435
TreeFamiTF333745

Enzyme and pathway databases

ReactomeiR-RNO-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-RNO-216083, Integrin cell surface interactions

Gene expression databases

BgeeiENSRNOG00000020694, Expressed in frontal cortex and 20 other tissues

Family and domain databases

Gene3Di2.60.40.10, 9 hits
InterProiView protein in InterPro
IPR003988, ICAM
IPR013768, ICAM_N
IPR003987, ICAM_VCAM_N
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
PfamiView protein in Pfam
PF03921, ICAM_N, 1 hit
PRINTSiPR01473, ICAM
PR01472, ICAMVCAM1
SMARTiView protein in SMART
SM00409, IG, 6 hits
SM00408, IGc2, 4 hits
SUPFAMiSSF48726, SSF48726, 9 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD4A435_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4A435
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 29, 2021
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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