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UniProtKB - D4A3Q3 (D4A3Q3_RAT)
Protein
Nuclear receptor coactivator
Gene
Ncoa1
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- aryl hydrocarbon receptor binding Source: RGD
- chromatin binding Source: RGD
- DNA binding Source: RGD
- enzyme binding Source: RGD
- estrogen receptor binding Source: RGD
- nuclear receptor binding Source: RGD
- nuclear receptor coactivator activity Source: RGD
- progesterone receptor binding Source: RGD
- protein-containing complex binding Source: RGD
- protein dimerization activity Source: InterPro
- protein N-terminus binding Source: RGD
- retinoic acid receptor binding Source: RGD
- retinoid X receptor binding Source: RGD
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
- transcription coactivator activity Source: RGD
GO - Biological processi
- cellular response to hormone stimulus Source: RGD
- cellular response to Thyroglobulin triiodothyronine Source: RGD
- cerebellum development Source: RGD
- cerebral cortex development Source: RGD
- estrous cycle Source: RGD
- hippocampus development Source: RGD
- histone H4 acetylation Source: RGD
- hypothalamus development Source: RGD
- labyrinthine layer morphogenesis Source: RGD
- lactation Source: RGD
- male gonad development Source: RGD
- male mating behavior Source: RGD
- mRNA transcription by RNA polymerase II Source: RGD
- positive regulation of apoptotic process Source: RGD
- positive regulation of female receptivity Source: RGD
- positive regulation of neuron differentiation Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of transcription from RNA polymerase II promoter by galactose Source: RGD
- regulation of thyroid hormone mediated signaling pathway Source: RGD
- response to estradiol Source: RGD
- response to hormone Source: RGD
- response to progesterone Source: RGD
- response to retinoic acid Source: RGD
Keywordsi
Molecular function | ActivatorUniRule annotationARBA annotation, ReceptorImported |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Enzyme and pathway databases
Reactomei | R-RNO-159418, Recycling of bile acids and salts R-RNO-192105, Synthesis of bile acids and bile salts R-RNO-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-RNO-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-RNO-211976, Endogenous sterols R-RNO-3214847, HATs acetylate histones R-RNO-3899300, SUMOylation of transcription cofactors R-RNO-400206, Regulation of lipid metabolism by PPARalpha R-RNO-9018519, Estrogen-dependent gene expression R-RNO-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-RNO-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-RNO-9707564, Cytoprotection by HMOX1 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear receptor coactivatorUniRule annotation |
Gene namesi | ORF Names:rCG_61821Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1309046, Ncoa1 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- nucleus Source: RGD
- RNA polymerase II transcription regulator complex Source: RGD
Other locations
- chromatin Source: RGD
- cytoplasm Source: RGD
- neuron projection Source: RGD
- protein-containing complex Source: RGD
- transcription regulator complex Source: RGD
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000004068, Expressed in Ammon's horn and 20 other tissues |
Interactioni
GO - Molecular functioni
- aryl hydrocarbon receptor binding Source: RGD
- enzyme binding Source: RGD
- estrogen receptor binding Source: RGD
- nuclear receptor binding Source: RGD
- progesterone receptor binding Source: RGD
- protein dimerization activity Source: InterPro
- protein N-terminus binding Source: RGD
- retinoic acid receptor binding Source: RGD
- retinoid X receptor binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000061906 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 80 | BHLHInterPro annotationAdd BLAST | 58 | |
Domaini | 109 – 180 | PASInterPro annotationAdd BLAST | 72 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 39 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 83 – 105 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 306 – 382 | DisorderedSequence analysisAdd BLAST | 77 | |
Regioni | 394 – 416 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 431 – 450 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 486 – 523 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 537 – 565 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 599 – 670 | DisorderedSequence analysisAdd BLAST | 72 | |
Regioni | 1099 – 1130 | DisorderedSequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 311 – 382 | Polar residuesSequence analysisAdd BLAST | 72 | |
Compositional biasi | 486 – 517 | Polar residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 599 – 622 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 636 – 670 | Polar residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 1104 – 1118 | Pro residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
eggNOGi | KOG3561, Eukaryota |
GeneTreei | ENSGT00950000183021 |
OMAi | GVQGQFN |
OrthoDBi | 59971at2759 |
Family and domain databases
CDDi | cd00130, PAS, 1 hit |
Gene3Di | 4.10.280.10, 1 hit 6.10.140.410, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR010011, NCO_DUF1518 IPR028819, NCOA1 IPR009110, Nuc_rcpt_coact IPR014920, Nuc_rcpt_coact_Ncoa-typ IPR037077, Nuc_rcpt_coact_Ncoa_int_sf IPR017426, Nuclear_rcpt_coactivator IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR014935, SRC/p160_LXXLL |
PANTHERi | PTHR10684, PTHR10684, 3 hits PTHR10684:SF1, PTHR10684:SF1, 3 hits |
Pfami | View protein in Pfam PF07469, DUF1518, 2 hits PF00010, HLH, 1 hit PF08815, Nuc_rec_co-act, 1 hit PF00989, PAS, 1 hit PF08832, SRC-1, 1 hit |
PIRSFi | PIRSF038181, Nuclear_receptor_coactivator, 4 hits |
SMARTi | View protein in SMART SM01151, DUF1518, 2 hits SM00353, HLH, 1 hit SM00091, PAS, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits SSF69125, SSF69125, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
D4A3Q3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGLGDSSSD PANPDSHKRK GSPCDTLASS TEKRRREQEN KYLEELAELL
60 70 80 90 100
SANISDIDSL SVKPDKCKIL KKTVDQIQLM KRMEQEKSTT DDDVQKSDIS
110 120 130 140 150
SSSQGVIEKE SLGPLLLEAL DGFFFVVNCE GRIVFVSENV TSYLGYNQEE
160 170 180 190 200
LMNTSVYSIL HVGDHAEFVK NLLPKSLGTE NQEACQRYEV MQCFTVSQPK
210 220 230 240 250
SIQEDGEGKI ISIDTSSLRA AGRTGWEDLV RKCIYAFFQP QGREPSYARQ
260 270 280 290 300
LFQEVMTRGT ASSPSYRFIL NDGTMLSAHT KCKLCYPQSP DMQPFIMGIH
310 320 330 340 350
IIDREHSGLS PQDDTNSGMS IPRINPSVNP GISPAHGVTR SSTLPPSNNN
360 370 380 390 400
MVSARANRQQ STDLNSGSSH SNSSSSQGSF GCSPGNQIVA SVALSQGQAG
410 420 430 440 450
SQSSNPSLNL NNSPMEGTGI SLAQFMSPRR QANSGLATRA RMSNNSFPPN
460 470 480 490 500
IPTLSSPVGI TSGACSNNNR SYSNIPVTSL QGMNEGPNNS VGFSAGSPVL
510 520 530 540 550
RQMSSQNSPS RLSMQPAKAE SKDNKEIASI LNEMIQSDNS ANEGKPLDSG
560 570 580 590 600
LLHNNDRLSD GDSKYSQTSH KLVQLLTTTA EQQLRHADID TSCKDVLSCT
610 620 630 640 650
GTSSSASSNP SGGTCPSSHS SLTERHKILH RLLQEGSPSD ITTLSVEPEK
660 670 680 690 700
KDSASASTAM SVSGQAQGSA SIKLELDASK KKESKDHQLL RYLLDKDEKD
710 720 730 740 750
LRSTPNLSLD DVKVKVEKKE QMDPCNTNPA PVTKPAPEEV KLESQSQFSA
760 770 780 790 800
DLDQFDQLLP TLEKAAQLPG LCETDRMDGA VPGVNIKSEI LPASLQPTPA
810 820 830 840 850
RSAPRLNRLP ELELEAIDNQ FGQPGAGDQI PWANNTVTAI NQSKPEDQCI
860 870 880 890 900
SSQLDELLCP PTTVEGRNDE KALLEQLVSF LSGKDETELA ELDRALGIDK
910 920 930 940 950
LVQGGGLDVL SERFPPQQAT PPLMMEDRPT LYPQPYSSPS PTAGLSGPFQ
960 970 980 990 1000
GMVRQKPSLG TMPVQVTPPR GTFSPNMGMQ PRQTLNRPPA APNQLRLQLQ
1010 1020 1030 1040 1050
QRLQGQQQLM HQNRQAILNQ FAANAPVGMN MRSGMQQQIT PQPPLNAQML
1060 1070 1080 1090 1100
AQRQRELYSQ QHRQRQIIQQ QRAMLMRHQS FGNNIPPSSG LPVQMGNPRL
1110 1120 1130 1140 1150
PQGAPQQFPY PPNYGTNPGT PPASTSPFSQ LAANPEASLA TRSSMVNRGM
1160 1170 1180 1190 1200
AGNMGGQFGT GISPQMQQNV FQYPGSGLVP QAEANFAPSL SPGSSMVPMP
1210 1220 1230 1240 1250
IPPQSSLLQQ TPPTSGYQSP DMKAWQQGTM GNNNVFSQAV QSQPAPAQPG
1260 1270 1280 1290 1300
VYNNMSITVS MAGGNANVQN MNPMMGQMQM SSLQMPGMNT VCSEQMNDPA
1310 1320 1330 1340 1350
LRHTGLYCNQ LSSTDLLKTE ADGNQDKKTE EFFSVQVQQL QVFADVQCTV
1360 1370 1380 1390 1400
NLKGASKPTL VLAVLLQEKA IRTNADEEHG LKTSRKKPFP QVLPSASHRP
1410
WYKQLHKNSI YSETTGL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JZG4 | A0A0G2JZG4_RAT | Nuclear receptor coactivator | Ncoa1 | 1,401 | Annotation score: | ||
A0A8I6APA0 | A0A8I6APA0_RAT | Nuclear receptor coactivator 1 | Ncoa1 | 1,460 | Annotation score: | ||
A0A8I6GLM3 | A0A8I6GLM3_RAT | Nuclear receptor coactivator 1 | Ncoa1 | 1,443 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473947 Genomic DNA Translation: EDM03032.1 |
RefSeqi | NP_001101482.1, NM_001108012.1 |
Genome annotation databases
Ensembli | ENSRNOT00000068531.3; ENSRNOP00000061906.2; ENSRNOG00000004068.8 |
GeneIDi | 313929 |
KEGGi | rno:313929 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473947 Genomic DNA Translation: EDM03032.1 |
RefSeqi | NP_001101482.1, NM_001108012.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000061906 |
Genome annotation databases
Ensembli | ENSRNOT00000068531.3; ENSRNOP00000061906.2; ENSRNOG00000004068.8 |
GeneIDi | 313929 |
KEGGi | rno:313929 |
Organism-specific databases
CTDi | 8648 |
RGDi | 1309046, Ncoa1 |
Phylogenomic databases
eggNOGi | KOG3561, Eukaryota |
GeneTreei | ENSGT00950000183021 |
OMAi | GVQGQFN |
OrthoDBi | 59971at2759 |
Enzyme and pathway databases
Reactomei | R-RNO-159418, Recycling of bile acids and salts R-RNO-192105, Synthesis of bile acids and bile salts R-RNO-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-RNO-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-RNO-211976, Endogenous sterols R-RNO-3214847, HATs acetylate histones R-RNO-3899300, SUMOylation of transcription cofactors R-RNO-400206, Regulation of lipid metabolism by PPARalpha R-RNO-9018519, Estrogen-dependent gene expression R-RNO-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-RNO-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-RNO-9707564, Cytoprotection by HMOX1 |
Gene expression databases
Bgeei | ENSRNOG00000004068, Expressed in Ammon's horn and 20 other tissues |
Family and domain databases
CDDi | cd00130, PAS, 1 hit |
Gene3Di | 4.10.280.10, 1 hit 6.10.140.410, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR010011, NCO_DUF1518 IPR028819, NCOA1 IPR009110, Nuc_rcpt_coact IPR014920, Nuc_rcpt_coact_Ncoa-typ IPR037077, Nuc_rcpt_coact_Ncoa_int_sf IPR017426, Nuclear_rcpt_coactivator IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR014935, SRC/p160_LXXLL |
PANTHERi | PTHR10684, PTHR10684, 3 hits PTHR10684:SF1, PTHR10684:SF1, 3 hits |
Pfami | View protein in Pfam PF07469, DUF1518, 2 hits PF00010, HLH, 1 hit PF08815, Nuc_rec_co-act, 1 hit PF00989, PAS, 1 hit PF08832, SRC-1, 1 hit |
PIRSFi | PIRSF038181, Nuclear_receptor_coactivator, 4 hits |
SMARTi | View protein in SMART SM01151, DUF1518, 2 hits SM00353, HLH, 1 hit SM00091, PAS, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits SSF69125, SSF69125, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | D4A3Q3_RAT | |
Accessioni | D4A3Q3Primary (citable) accession number: D4A3Q3 Secondary accession number(s): D4AB68 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 3, 2013 | |
Last modified: | May 25, 2022 | |
This is version 107 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |