Nuclear receptor coactivator

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: Ensembl
• estrogen receptor binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 19460436
• nuclear hormone receptor binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• nuclear receptor binding Source: RGDInferred from physical interactionⁱ
  • 18566116
• nuclear receptor transcription coactivator activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• progesterone receptor binding Source: RGDInferred from physical interactionⁱ
  • 18566116
• protein-containing complex binding Source: RGDInferred from physical interactionⁱ
  • 15234273
• protein dimerization activity Source: InterPro
• retinoic acid receptor binding Source: RGDInferred from physical interactionⁱ
  • 15234273
• retinoid X receptor binding Source: RGDInferred from physical interactionⁱ
  • 15234273
• RNA polymerase II regulatory region DNA binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 15166231
• transcription factor binding Source: RGDInferred from physical interactionⁱ
  • 19485965

GO - Biological processⁱ

• cellular response to hormone stimulus Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 9808623
• cellular response to Thyroglobulin triiodothyronine Source: Ensembl
• cerebellum development Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 10803578
  • 15876152
• cerebral cortex development Source: RGDInferred from expression patternⁱ
  • 12551846
• estrous cycle Source: RGDInferred from expression patternⁱ
  • 15862975
• hippocampus development Source: RGDInferred from expression patternⁱ
  • 22085911
• histone H4 acetylation Source: Ensembl
• hypothalamus development Source: RGDInferred from expression patternⁱ
  • 12551846
• labyrinthine layer morphogenesis Source: Ensembl
• lactation Source: RGDInferred from expression patternⁱ
  • 15946693
• male gonad development Source: RGDInferred from expression patternⁱ
  • 16189181
• male mating behavior Source: RGDInferred from mutant phenotypeⁱ
  • 10861018
• positive regulation of apoptotic process Source: Ensembl
• positive regulation of female receptivity Source: RGDInferred from mutant phenotypeⁱ
  • 16769066
• positive regulation of neuron differentiation Source: Ensembl
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from mutant phenotypeⁱ
  • 17481888
• positive regulation of transcription from RNA polymerase II promoter by galactose Source: Ensembl
• regulation of cellular response to drug Source: Ensembl
• regulation of thyroid hormone mediated signaling pathway Source: Ensembl
• response to estradiol Source: RGDInferred from mutant phenotypeⁱ
  • 9808623
• response to hormone Source: RGDInferred from expression patternⁱ
  • 9564863
• response to progesterone Source: RGDInferred from mutant phenotypeⁱ
  • 9808623
• response to retinoic acid Source: RGDInferred from mutant phenotypeⁱ
  • 9808623

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• estrogen receptor binding Source: RGDInferred from physical interactionⁱ
  • 19460436
• nuclear hormone receptor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• nuclear receptor binding Source: RGDInferred from physical interactionⁱ
  • 18566116
• progesterone receptor binding Source: RGDInferred from physical interactionⁱ
  • 18566116
• protein dimerization activity Source: InterPro
• retinoic acid receptor binding Source: RGDInferred from physical interactionⁱ
  • 15234273
• retinoid X receptor binding Source: RGDInferred from physical interactionⁱ
  • 15234273
• transcription factor binding Source: RGDInferred from physical interactionⁱ
  • 19485965

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MSGLGDSSSD PANPDSHKRK GSPCDTLASS TEKRRREQEN KYLEELAELL 
        60         70         80         90        100
SANISDIDSL SVKPDKCKIL KKTVDQIQLM KRMEQEKSTT DDDVQKSDIS 
       110        120        130        140        150
SSSQGVIEKE SLGPLLLEAL DGFFFVVNCE GRIVFVSENV TSYLGYNQEE 
       160        170        180        190        200
LMNTSVYSIL HVGDHAEFVK NLLPKSLGTE NQEACQRYEV MQCFTVSQPK 
       210        220        230        240        250
SIQEDGEGKI ISIDTSSLRA AGRTGWEDLV RKCIYAFFQP QGREPSYARQ 
       260        270        280        290        300
LFQEVMTRGT ASSPSYRFIL NDGTMLSAHT KCKLCYPQSP DMQPFIMGIH 
       310        320        330        340        350
IIDREHSGLS PQDDTNSGMS IPRINPSVNP GISPAHGVTR SSTLPPSNNN 
       360        370        380        390        400
MVSARANRQQ STDLNSGSSH SNSSSSQGSF GCSPGNQIVA SVALSQGQAG 
       410        420        430        440        450
SQSSNPSLNL NNSPMEGTGI SLAQFMSPRR QANSGLATRA RMSNNSFPPN 
       460        470        480        490        500
IPTLSSPVGI TSGACSNNNR SYSNIPVTSL QGMNEGPNNS VGFSAGSPVL 
       510        520        530        540        550
RQMSSQNSPS RLSMQPAKAE SKDNKEIASI LNEMIQSDNS ANEGKPLDSG 
       560        570        580        590        600
LLHNNDRLSD GDSKYSQTSH KLVQLLTTTA EQQLRHADID TSCKDVLSCT 
       610        620        630        640        650
GTSSSASSNP SGGTCPSSHS SLTERHKILH RLLQEGSPSD ITTLSVEPEK 
       660        670        680        690        700
KDSASASTAM SVSGQAQGSA SIKLELDASK KKESKDHQLL RYLLDKDEKD 
       710        720        730        740        750
LRSTPNLSLD DVKVKVEKKE QMDPCNTNPA PVTKPAPEEV KLESQSQFSA 
       760        770        780        790        800
DLDQFDQLLP TLEKAAQLPG LCETDRMDGA VPGVNIKSEI LPASLQPTPA 
       810        820        830        840        850
RSAPRLNRLP ELELEAIDNQ FGQPGAGDQI PWANNTVTAI NQSKPEDQCI 
       860        870        880        890        900
SSQLDELLCP PTTVEGRNDE KALLEQLVSF LSGKDETELA ELDRALGIDK 
       910        920        930        940        950
LVQGGGLDVL SERFPPQQAT PPLMMEDRPT LYPQPYSSPS PTAGLSGPFQ 
       960        970        980        990       1000
GMVRQKPSLG TMPVQVTPPR GTFSPNMGMQ PRQTLNRPPA APNQLRLQLQ 
      1010       1020       1030       1040       1050
QRLQGQQQLM HQNRQAILNQ FAANAPVGMN MRSGMQQQIT PQPPLNAQML 
      1060       1070       1080       1090       1100
AQRQRELYSQ QHRQRQIIQQ QRAMLMRHQS FGNNIPPSSG LPVQMGNPRL 
      1110       1120       1130       1140       1150
PQGAPQQFPY PPNYGTNPGT PPASTSPFSQ LAANPEASLA TRSSMVNRGM 
      1160       1170       1180       1190       1200
AGNMGGQFGT GISPQMQQNV FQYPGSGLVP QAEANFAPSL SPGSSMVPMP 
      1210       1220       1230       1240       1250
IPPQSSLLQQ TPPTSGYQSP DMKAWQQGTM GNNNVFSQAV QSQPAPAQPG 
      1260       1270       1280       1290       1300
VYNNMSITVS MAGGNANVQN MNPMMGQMQM SSLQMPGMNT VCSEQMNDPA 
      1310       1320       1330       1340       1350
LRHTGLYCNQ LSSTDLLKTE ADGNQDKKTE EFFSVQVQQL QVFADVQCTV 
      1360       1370       1380       1390       1400
NLKGASKPTL VLAVLLQEKA IRTNADEEHG LKTSRKKPFP QVLPSASHRP 
      1410 
WYKQLHKNSI YSETTGL                                     

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ