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Protein

Nuclear receptor coactivator

Gene

Ncoa1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation, ReceptorImported
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-159418 Recycling of bile acids and salts
R-RNO-192105 Synthesis of bile acids and bile salts
R-RNO-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-RNO-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-RNO-211976 Endogenous sterols
R-RNO-3214847 HATs acetylate histones
R-RNO-3899300 SUMOylation of transcription cofactors
R-RNO-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-RNO-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor coactivatorUniRule annotation
Gene namesi
Name:Ncoa1Imported
Synonyms:Ncoa1_predictedImported
ORF Names:rCG_61821Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1309046 Ncoa1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiD4A3Q3

Expressioni

Gene expression databases

BgeeiENSRNOG00000004068 Expressed in 9 organ(s), highest expression level in Ammon's horn
ExpressionAtlasiD4A3Q3 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061906

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 80BHLHInterPro annotationAdd BLAST58
Domaini109 – 180PASInterPro annotationAdd BLAST72

Sequence similaritiesi

Belongs to the SRC/p160 nuclear receptor coactivator family.UniRule annotation

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiENOG410IQ5S Eukaryota
ENOG410XPF9 LUCA
GeneTreeiENSGT00530000063109
KOiK09101
OMAiQSMNEGP
OrthoDBiEOG091G00US

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 1 hit
Gene3Di1.10.287.1070, 1 hit
4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR010011 DUF1518
IPR036638 HLH_DNA-bd_sf
IPR028819 NCOA1
IPR009110 Nuc_rcpt_coact
IPR014920 Nuc_rcpt_coact_Ncoa-typ
IPR037077 Nuc_rcpt_coact_Ncoa_int_sf
IPR017426 Nuclear_rcpt_coactivator
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR014935 SRC/p160_LXXLL
PANTHERiPTHR10684 PTHR10684, 3 hits
PTHR10684:SF1 PTHR10684:SF1, 3 hits
PfamiView protein in Pfam
PF07469 DUF1518, 2 hits
PF00010 HLH, 1 hit
PF08815 Nuc_rec_co-act, 1 hit
PF00989 PAS, 1 hit
PF08832 SRC-1, 1 hit
PIRSFiPIRSF038181 Nuclear_receptor_coactivator, 4 hits
SMARTiView protein in SMART
SM01151 DUF1518, 2 hits
SM00353 HLH, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
SSF69125 SSF69125, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

D4A3Q3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGLGDSSSD PANPDSHKRK GSPCDTLASS TEKRRREQEN KYLEELAELL
60 70 80 90 100
SANISDIDSL SVKPDKCKIL KKTVDQIQLM KRMEQEKSTT DDDVQKSDIS
110 120 130 140 150
SSSQGVIEKE SLGPLLLEAL DGFFFVVNCE GRIVFVSENV TSYLGYNQEE
160 170 180 190 200
LMNTSVYSIL HVGDHAEFVK NLLPKSLGTE NQEACQRYEV MQCFTVSQPK
210 220 230 240 250
SIQEDGEGKI ISIDTSSLRA AGRTGWEDLV RKCIYAFFQP QGREPSYARQ
260 270 280 290 300
LFQEVMTRGT ASSPSYRFIL NDGTMLSAHT KCKLCYPQSP DMQPFIMGIH
310 320 330 340 350
IIDREHSGLS PQDDTNSGMS IPRINPSVNP GISPAHGVTR SSTLPPSNNN
360 370 380 390 400
MVSARANRQQ STDLNSGSSH SNSSSSQGSF GCSPGNQIVA SVALSQGQAG
410 420 430 440 450
SQSSNPSLNL NNSPMEGTGI SLAQFMSPRR QANSGLATRA RMSNNSFPPN
460 470 480 490 500
IPTLSSPVGI TSGACSNNNR SYSNIPVTSL QGMNEGPNNS VGFSAGSPVL
510 520 530 540 550
RQMSSQNSPS RLSMQPAKAE SKDNKEIASI LNEMIQSDNS ANEGKPLDSG
560 570 580 590 600
LLHNNDRLSD GDSKYSQTSH KLVQLLTTTA EQQLRHADID TSCKDVLSCT
610 620 630 640 650
GTSSSASSNP SGGTCPSSHS SLTERHKILH RLLQEGSPSD ITTLSVEPEK
660 670 680 690 700
KDSASASTAM SVSGQAQGSA SIKLELDASK KKESKDHQLL RYLLDKDEKD
710 720 730 740 750
LRSTPNLSLD DVKVKVEKKE QMDPCNTNPA PVTKPAPEEV KLESQSQFSA
760 770 780 790 800
DLDQFDQLLP TLEKAAQLPG LCETDRMDGA VPGVNIKSEI LPASLQPTPA
810 820 830 840 850
RSAPRLNRLP ELELEAIDNQ FGQPGAGDQI PWANNTVTAI NQSKPEDQCI
860 870 880 890 900
SSQLDELLCP PTTVEGRNDE KALLEQLVSF LSGKDETELA ELDRALGIDK
910 920 930 940 950
LVQGGGLDVL SERFPPQQAT PPLMMEDRPT LYPQPYSSPS PTAGLSGPFQ
960 970 980 990 1000
GMVRQKPSLG TMPVQVTPPR GTFSPNMGMQ PRQTLNRPPA APNQLRLQLQ
1010 1020 1030 1040 1050
QRLQGQQQLM HQNRQAILNQ FAANAPVGMN MRSGMQQQIT PQPPLNAQML
1060 1070 1080 1090 1100
AQRQRELYSQ QHRQRQIIQQ QRAMLMRHQS FGNNIPPSSG LPVQMGNPRL
1110 1120 1130 1140 1150
PQGAPQQFPY PPNYGTNPGT PPASTSPFSQ LAANPEASLA TRSSMVNRGM
1160 1170 1180 1190 1200
AGNMGGQFGT GISPQMQQNV FQYPGSGLVP QAEANFAPSL SPGSSMVPMP
1210 1220 1230 1240 1250
IPPQSSLLQQ TPPTSGYQSP DMKAWQQGTM GNNNVFSQAV QSQPAPAQPG
1260 1270 1280 1290 1300
VYNNMSITVS MAGGNANVQN MNPMMGQMQM SSLQMPGMNT VCSEQMNDPA
1310 1320 1330 1340 1350
LRHTGLYCNQ LSSTDLLKTE ADGNQDKKTE EFFSVQVQQL QVFADVQCTV
1360 1370 1380 1390 1400
NLKGASKPTL VLAVLLQEKA IRTNADEEHG LKTSRKKPFP QVLPSASHRP
1410
WYKQLHKNSI YSETTGL
Length:1,417
Mass (Da):153,761
Last modified:April 3, 2013 - v2
Checksum:i51190E264BC3AE31
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JZG4A0A0G2JZG4_RAT
Nuclear receptor coactivator
Ncoa1 Ncoa1_predicted, rCG_61821
1,401Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07063325 Genomic DNA No translation available.
AABR07063326 Genomic DNA No translation available.
AABR07063327 Genomic DNA No translation available.
AABR07063328 Genomic DNA No translation available.
AABR07063329 Genomic DNA No translation available.
AABR07063330 Genomic DNA No translation available.
AABR07063331 Genomic DNA No translation available.
AABR07063332 Genomic DNA No translation available.
CH473947 Genomic DNA Translation: EDM03032.1
RefSeqiNP_001101482.1, NM_001108012.1
UniGeneiRn.165307

Genome annotation databases

EnsembliENSRNOT00000068531; ENSRNOP00000061906; ENSRNOG00000004068
GeneIDi313929
KEGGirno:313929

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07063325 Genomic DNA No translation available.
AABR07063326 Genomic DNA No translation available.
AABR07063327 Genomic DNA No translation available.
AABR07063328 Genomic DNA No translation available.
AABR07063329 Genomic DNA No translation available.
AABR07063330 Genomic DNA No translation available.
AABR07063331 Genomic DNA No translation available.
AABR07063332 Genomic DNA No translation available.
CH473947 Genomic DNA Translation: EDM03032.1
RefSeqiNP_001101482.1, NM_001108012.1
UniGeneiRn.165307

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061906

Proteomic databases

PRIDEiD4A3Q3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000068531; ENSRNOP00000061906; ENSRNOG00000004068
GeneIDi313929
KEGGirno:313929

Organism-specific databases

CTDi8648
RGDi1309046 Ncoa1

Phylogenomic databases

eggNOGiENOG410IQ5S Eukaryota
ENOG410XPF9 LUCA
GeneTreeiENSGT00530000063109
KOiK09101
OMAiQSMNEGP
OrthoDBiEOG091G00US

Enzyme and pathway databases

ReactomeiR-RNO-159418 Recycling of bile acids and salts
R-RNO-192105 Synthesis of bile acids and bile salts
R-RNO-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-RNO-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-RNO-211976 Endogenous sterols
R-RNO-3214847 HATs acetylate histones
R-RNO-3899300 SUMOylation of transcription cofactors
R-RNO-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-RNO-9018519 Estrogen-dependent gene expression

Gene expression databases

BgeeiENSRNOG00000004068 Expressed in 9 organ(s), highest expression level in Ammon's horn
ExpressionAtlasiD4A3Q3 baseline and differential

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 1 hit
Gene3Di1.10.287.1070, 1 hit
4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR010011 DUF1518
IPR036638 HLH_DNA-bd_sf
IPR028819 NCOA1
IPR009110 Nuc_rcpt_coact
IPR014920 Nuc_rcpt_coact_Ncoa-typ
IPR037077 Nuc_rcpt_coact_Ncoa_int_sf
IPR017426 Nuclear_rcpt_coactivator
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR014935 SRC/p160_LXXLL
PANTHERiPTHR10684 PTHR10684, 3 hits
PTHR10684:SF1 PTHR10684:SF1, 3 hits
PfamiView protein in Pfam
PF07469 DUF1518, 2 hits
PF00010 HLH, 1 hit
PF08815 Nuc_rec_co-act, 1 hit
PF00989 PAS, 1 hit
PF08832 SRC-1, 1 hit
PIRSFiPIRSF038181 Nuclear_receptor_coactivator, 4 hits
SMARTiView protein in SMART
SM01151 DUF1518, 2 hits
SM00353 HLH, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
SSF69125 SSF69125, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD4A3Q3_RAT
AccessioniPrimary (citable) accession number: D4A3Q3
Secondary accession number(s): D4AB68
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: November 7, 2018
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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