Nuclear receptor coactivator

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• aryl hydrocarbon receptor binding Source: RGD
• chromatin binding Source: RGD
• DNA binding Source: RGD
• enzyme binding Source: RGD
• estrogen receptor binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Expression of estrogen receptor co-regulators SRC-1, RIP140 and NCoR and their interaction with estrogen receptor in rat uterus, under the influence of ormeloxifene."
    Daverey A., Saxena R., Tewari S., Goel S.K., Dwivedi A.
    J Steroid Biochem Mol Biol 116:93-101(2009) [PubMed] [Europe PMC] [Abstract]
• nuclear receptor binding Source: RGDInferred from physical interactionⁱ
  • "Steroid receptor coactivator-1 from brain physically interacts differentially with steroid receptor subtypes."
    Molenda-Figueira H.A., Murphy S.D., Shea K.L., Siegal N.K., Zhao Y., Chadwick J.G. Jr., Denner L.A., Tetel M.J.
    Endocrinology 149:5272-5279(2008) [PubMed] [Europe PMC] [Abstract]
• nuclear receptor coactivator activity Source: RGD
• progesterone receptor binding Source: RGDInferred from physical interactionⁱ
  • "Steroid receptor coactivator-1 from brain physically interacts differentially with steroid receptor subtypes."
    Molenda-Figueira H.A., Murphy S.D., Shea K.L., Siegal N.K., Zhao Y., Chadwick J.G. Jr., Denner L.A., Tetel M.J.
    Endocrinology 149:5272-5279(2008) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: RGDInferred from physical interactionⁱ
  • "Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors."
    Wang L., Tankersley L.R., Tang M., Potter J.J., Mezey E.
    Arch Biochem Biophys 428:92-98(2004) [PubMed] [Europe PMC] [Abstract]
• protein dimerization activity Source: InterPro
• protein N-terminus binding Source: RGD
• retinoic acid receptor binding Source: RGDInferred from physical interactionⁱ
  • "Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors."
    Wang L., Tankersley L.R., Tang M., Potter J.J., Mezey E.
    Arch Biochem Biophys 428:92-98(2004) [PubMed] [Europe PMC] [Abstract]
• retinoid X receptor binding Source: RGDInferred from physical interactionⁱ
  • "Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors."
    Wang L., Tankersley L.R., Tang M., Potter J.J., Mezey E.
    Arch Biochem Biophys 428:92-98(2004) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The synergistic effect of dexamethasone and all-trans-retinoic acid on hepatic phosphoenolpyruvate carboxykinase gene expression involves the coactivator p300."
    Wang X.L., Herzog B., Waltner-Law M., Hall R.K., Shiota M., Granner D.K.
    J Biol Chem 279:34191-34200(2004) [PubMed] [Europe PMC] [Abstract]
• transcription coactivator activity Source: RGD

GO - Biological processⁱ

• cellular response to hormone stimulus Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation."
    McInerney E.M., Rose D.W., Flynn S.E., Westin S., Mullen T.M., Krones A., Inostroza J., Torchia J., Nolte R.T., Assa-Munt N., Milburn M.V., Glass C.K., Rosenfeld M.G.
    Genes Dev 12:3357-3368(1998) [PubMed] [Europe PMC] [Abstract]
• cellular response to Thyroglobulin triiodothyronine Source: RGD
• cerebellum development Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Coactivator and corepressor gene expression in rat cerebellum during postnatal development and the effect of altered thyroid status."
    Martinez de Arrieta C., Koibuchi N., Chin W.W.
    Endocrinology 141:1693-1698(2000) [PubMed] [Europe PMC] [Abstract]
  • "Postnatal changes of steroid receptor coactivator-1 immunoreactivity in rat cerebellar cortex."
    Yousefi B., Jingu H., Ohta M., Umezu M., Koibuchi N.
    Thyroid 15:314-319(2005) [PubMed] [Europe PMC] [Abstract]
• cerebral cortex development Source: RGDInferred from expression patternⁱ
  • "Developmental expression profiles and distinct regional estrogen responsiveness suggest a novel role for the steroid receptor coactivator SRC-1 as discriminative amplifier of estrogen signaling in the rat brain."
    Mitev Y.A., Wolf S.S., Almeida O.F., Patchev V.K.
    FASEB J 17:518-519(2003) [PubMed] [Europe PMC] [Abstract]
• estrous cycle Source: RGDInferred from expression patternⁱ
  • "Changes in the content of steroid receptor coactivator-1 and silencing mediator for retinoid and thyroid hormone receptors in the rat brain during the estrous cycle."
    Camacho-Arroyo I., Neri-Gomez T., Gonzalez-Arenas A., Guerra-Araiza C.
    J Steroid Biochem Mol Biol 94:267-272(2005) [PubMed] [Europe PMC] [Abstract]
• hippocampus development Source: RGDInferred from expression patternⁱ
  • "Sex differences and synchronous development of steroid receptor coactivator-1 and synaptic proteins in the hippocampus of postnatal female and male C57BL/6 mice."
    Bian C., Zhu K., Guo Q., Xiong Y., Cai W., Zhang J.
    Steroids 77:149-156(2012) [PubMed] [Europe PMC] [Abstract]
• histone H4 acetylation Source: RGD
• hypothalamus development Source: RGDInferred from expression patternⁱ
  • "Developmental expression profiles and distinct regional estrogen responsiveness suggest a novel role for the steroid receptor coactivator SRC-1 as discriminative amplifier of estrogen signaling in the rat brain."
    Mitev Y.A., Wolf S.S., Almeida O.F., Patchev V.K.
    FASEB J 17:518-519(2003) [PubMed] [Europe PMC] [Abstract]
• labyrinthine layer morphogenesis Source: RGD
• lactation Source: RGDInferred from expression patternⁱ
  • "Expression of nuclear hormone receptors, their coregulators and type I iodothyronine 5'-deiodinase gene in mammary tissue of nonlactating and postlactating rats."
    Macejova D., Baranova M., Liska J., Brtko J.
    Life Sci 77:2584-2593(2005) [PubMed] [Europe PMC] [Abstract]
• male gonad development Source: RGDInferred from expression patternⁱ
  • "Differential expression of p160 steroid receptor coactivators in the rat testis and epididymis."
    Igarashi-Migitaka J., Takeshita A., Koibuchi N., Yamada S., Ohtani-Kaneko R., Hirata K.
    Eur J Endocrinol 153:595-604(2005) [PubMed] [Europe PMC] [Abstract]
• male mating behavior Source: RGDInferred from mutant phenotypeⁱ
  • "Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior."
    Auger A.P., Tetel M.J., McCarthy M.M.
    Proc Natl Acad Sci U S A 97:7551-7555(2000) [PubMed] [Europe PMC] [Abstract]
• mRNA transcription by RNA polymerase II Source: RGD
• positive regulation of apoptotic process Source: RGD
• positive regulation of female receptivity Source: RGDInferred from mutant phenotypeⁱ
  • "Nuclear receptor coactivators function in estrogen receptor- and progestin receptor-dependent aspects of sexual behavior in female rats."
    Molenda-Figueira H.A., Williams C.A., Griffin A.L., Rutledge E.M., Blaustein J.D., Tetel M.J.
    Horm Behav 50:383-392(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neuron differentiation Source: RGD
• positive regulation of transcription, DNA-templated Source: RGD
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from mutant phenotypeⁱ
  • "Recruitment of the p160 coactivators by the glucocorticoid receptor: dependence on the promoter context and cell type but not hypoxic conditions."
    Trousson A., Grenier J., Fonte C., Massaad-Massade L., Schumacher M., Massaad C.
    J Steroid Biochem Mol Biol 104:305-311(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter by galactose Source: RGD
• regulation of thyroid hormone mediated signaling pathway Source: RGD
• response to estradiol Source: RGDInferred from mutant phenotypeⁱ
  • "Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation."
    McInerney E.M., Rose D.W., Flynn S.E., Westin S., Mullen T.M., Krones A., Inostroza J., Torchia J., Nolte R.T., Assa-Munt N., Milburn M.V., Glass C.K., Rosenfeld M.G.
    Genes Dev 12:3357-3368(1998) [PubMed] [Europe PMC] [Abstract]
• response to hormone Source: RGDInferred from expression patternⁱ
  • "Expression and hormonal regulation of coactivator and corepressor genes."
    Misiti S., Schomburg L., Yen P.M., Chin W.W.
    Endocrinology 139:2493-2500(1998) [PubMed] [Europe PMC] [Abstract]
• response to progesterone Source: RGDInferred from mutant phenotypeⁱ
  • "Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation."
    McInerney E.M., Rose D.W., Flynn S.E., Westin S., Mullen T.M., Krones A., Inostroza J., Torchia J., Nolte R.T., Assa-Munt N., Milburn M.V., Glass C.K., Rosenfeld M.G.
    Genes Dev 12:3357-3368(1998) [PubMed] [Europe PMC] [Abstract]
• response to retinoic acid Source: RGDInferred from mutant phenotypeⁱ
  • "Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation."
    McInerney E.M., Rose D.W., Flynn S.E., Westin S., Mullen T.M., Krones A., Inostroza J., Torchia J., Nolte R.T., Assa-Munt N., Milburn M.V., Glass C.K., Rosenfeld M.G.
    Genes Dev 12:3357-3368(1998) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Keywords - PTMⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• aryl hydrocarbon receptor binding Source: RGD
• enzyme binding Source: RGD
• estrogen receptor binding Source: RGDInferred from physical interactionⁱ
  • "Expression of estrogen receptor co-regulators SRC-1, RIP140 and NCoR and their interaction with estrogen receptor in rat uterus, under the influence of ormeloxifene."
    Daverey A., Saxena R., Tewari S., Goel S.K., Dwivedi A.
    J Steroid Biochem Mol Biol 116:93-101(2009) [PubMed] [Europe PMC] [Abstract]
• nuclear receptor binding Source: RGDInferred from physical interactionⁱ
  • "Steroid receptor coactivator-1 from brain physically interacts differentially with steroid receptor subtypes."
    Molenda-Figueira H.A., Murphy S.D., Shea K.L., Siegal N.K., Zhao Y., Chadwick J.G. Jr., Denner L.A., Tetel M.J.
    Endocrinology 149:5272-5279(2008) [PubMed] [Europe PMC] [Abstract]
• progesterone receptor binding Source: RGDInferred from physical interactionⁱ
  • "Steroid receptor coactivator-1 from brain physically interacts differentially with steroid receptor subtypes."
    Molenda-Figueira H.A., Murphy S.D., Shea K.L., Siegal N.K., Zhao Y., Chadwick J.G. Jr., Denner L.A., Tetel M.J.
    Endocrinology 149:5272-5279(2008) [PubMed] [Europe PMC] [Abstract]
• protein dimerization activity Source: InterPro
• protein N-terminus binding Source: RGD
• retinoic acid receptor binding Source: RGDInferred from physical interactionⁱ
  • "Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors."
    Wang L., Tankersley L.R., Tang M., Potter J.J., Mezey E.
    Arch Biochem Biophys 428:92-98(2004) [PubMed] [Europe PMC] [Abstract]
• retinoid X receptor binding Source: RGDInferred from physical interactionⁱ
  • "Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors."
    Wang L., Tankersley L.R., Tang M., Potter J.J., Mezey E.
    Arch Biochem Biophys 428:92-98(2004) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSGLGDSSSD PANPDSHKRK GSPCDTLASS TEKRRREQEN KYLEELAELL 
        60         70         80         90        100
SANISDIDSL SVKPDKCKIL KKTVDQIQLM KRMEQEKSTT DDDVQKSDIS 
       110        120        130        140        150
SSSQGVIEKE SLGPLLLEAL DGFFFVVNCE GRIVFVSENV TSYLGYNQEE 
       160        170        180        190        200
LMNTSVYSIL HVGDHAEFVK NLLPKSLGTE NQEACQRYEV MQCFTVSQPK 
       210        220        230        240        250
SIQEDGEGKI ISIDTSSLRA AGRTGWEDLV RKCIYAFFQP QGREPSYARQ 
       260        270        280        290        300
LFQEVMTRGT ASSPSYRFIL NDGTMLSAHT KCKLCYPQSP DMQPFIMGIH 
       310        320        330        340        350
IIDREHSGLS PQDDTNSGMS IPRINPSVNP GISPAHGVTR SSTLPPSNNN 
       360        370        380        390        400
MVSARANRQQ STDLNSGSSH SNSSSSQGSF GCSPGNQIVA SVALSQGQAG 
       410        420        430        440        450
SQSSNPSLNL NNSPMEGTGI SLAQFMSPRR QANSGLATRA RMSNNSFPPN 
       460        470        480        490        500
IPTLSSPVGI TSGACSNNNR SYSNIPVTSL QGMNEGPNNS VGFSAGSPVL 
       510        520        530        540        550
RQMSSQNSPS RLSMQPAKAE SKDNKEIASI LNEMIQSDNS ANEGKPLDSG 
       560        570        580        590        600
LLHNNDRLSD GDSKYSQTSH KLVQLLTTTA EQQLRHADID TSCKDVLSCT 
       610        620        630        640        650
GTSSSASSNP SGGTCPSSHS SLTERHKILH RLLQEGSPSD ITTLSVEPEK 
       660        670        680        690        700
KDSASASTAM SVSGQAQGSA SIKLELDASK KKESKDHQLL RYLLDKDEKD 
       710        720        730        740        750
LRSTPNLSLD DVKVKVEKKE QMDPCNTNPA PVTKPAPEEV KLESQSQFSA 
       760        770        780        790        800
DLDQFDQLLP TLEKAAQLPG LCETDRMDGA VPGVNIKSEI LPASLQPTPA 
       810        820        830        840        850
RSAPRLNRLP ELELEAIDNQ FGQPGAGDQI PWANNTVTAI NQSKPEDQCI 
       860        870        880        890        900
SSQLDELLCP PTTVEGRNDE KALLEQLVSF LSGKDETELA ELDRALGIDK 
       910        920        930        940        950
LVQGGGLDVL SERFPPQQAT PPLMMEDRPT LYPQPYSSPS PTAGLSGPFQ 
       960        970        980        990       1000
GMVRQKPSLG TMPVQVTPPR GTFSPNMGMQ PRQTLNRPPA APNQLRLQLQ 
      1010       1020       1030       1040       1050
QRLQGQQQLM HQNRQAILNQ FAANAPVGMN MRSGMQQQIT PQPPLNAQML 
      1060       1070       1080       1090       1100
AQRQRELYSQ QHRQRQIIQQ QRAMLMRHQS FGNNIPPSSG LPVQMGNPRL 
      1110       1120       1130       1140       1150
PQGAPQQFPY PPNYGTNPGT PPASTSPFSQ LAANPEASLA TRSSMVNRGM 
      1160       1170       1180       1190       1200
AGNMGGQFGT GISPQMQQNV FQYPGSGLVP QAEANFAPSL SPGSSMVPMP 
      1210       1220       1230       1240       1250
IPPQSSLLQQ TPPTSGYQSP DMKAWQQGTM GNNNVFSQAV QSQPAPAQPG 
      1260       1270       1280       1290       1300
VYNNMSITVS MAGGNANVQN MNPMMGQMQM SSLQMPGMNT VCSEQMNDPA 
      1310       1320       1330       1340       1350
LRHTGLYCNQ LSSTDLLKTE ADGNQDKKTE EFFSVQVQQL QVFADVQCTV 
      1360       1370       1380       1390       1400
NLKGASKPTL VLAVLLQEKA IRTNADEEHG LKTSRKKPFP QVLPSASHRP 
      1410 
WYKQLHKNSI YSETTGL                                     

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ