Nfe2l1

Functionⁱ

GO - Molecular functionⁱ

DNA-binding transcription factor activity Source: GO_Central
protein-containing complex binding Source: Ensembl
protein domain specific binding Source: Ensembl
RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
transcriptional activator activity, RNA polymerase II transcription factor binding Source: Ensembl
transcription regulatory region sequence-specific DNA binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to oxidative stress Source: InterPro
erythrocyte differentiation Source: Ensembl
positive regulation of transcription, DNA-templated Source: GO_Central
regulation of transcription by RNA polymerase II Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-bindingSAAS annotation
Biological process	Transcription, Transcription regulationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Nuclear factor, erythroid 2-like 1Imported
Gene namesⁱ	Name:Nfe2l1Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 10

Organism-specific databases

Rat genome database More...RGDⁱ	1311972 Nfe2l1

RGDⁱ

1311972 Nfe2l1

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	D4A349

PaxDbⁱ

D4A349

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000008830 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue

Bgeeⁱ

ENSRNOG00000008830 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue

Interactionⁱ

GO - Molecular functionⁱ

protein domain specific binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000061935

STRINGⁱ

10116.ENSRNOP00000061935

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	621 – 666	BZIPInterPro annotationAdd BLAST		46

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	639 – 673	Sequence analysisAdd BLAST		35

Sequence similaritiesⁱ

Belongs to the bZIP family.SAAS annotation

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG3863 Eukaryota ENOG410ZGMS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148991
OMAⁱ	HKHSGPS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02EB

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827 bZIP IPR004826 bZIP_Maf IPR029847 Nrf1_NFE2L1 IPR008917 TF_DNA-bd_sf
PANTHERⁱ	PTHR24411:SF31 PTHR24411:SF31, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03131 bZIP_Maf, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
SUPFAMⁱ	SSF47454 SSF47454, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

D4A349-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLSLKKYLTE GLLQFTILLS LIGVRVDVDT YLTSQLPPLR EIILGPSSAY 
        60         70         80         90        100
TQTQFHNLRN TLDGYGIHPK SIDLDNYFTA RRLLSQVRAL DRFQVPTTEV 
       110        120        130        140        150
NAWLVHRDPE GSVSGSQPNS GLALESSSGL QDVTVPDNGV RESEPEQGFS 
       160        170        180        190        200
EDLEDLGAVA PPVSGDLTKE DIDLIDILWR QDIDLGAGRE VFDYSHRQKE 
       210        220        230        240        250
QDVDKELQDG GEREDTWSGE GAEALARDLL VDGETGESFP AQFPADVSSI 
       260        270        280        290        300
TEAVPSESES PALQNSLLSP LLTGTESPFD LEQQWQDLMS IMEMQAMEVN 
       310        320        330        340        350
TSASEILYSA PPGDPLTTNY SLAPNTPINQ NVSLHQASLG GCSQDFSLFS 
       360        370        380        390        400
PEVESLPVAS SSTLLPLVPS NSTSLNSTFG STNLAGLFFP SQLNGTANDT 
       410        420        430        440        450
SGPELPDPLG GLLDEAMLDE ISLMDLAIEE GFNPGQASQL EEEFDSDSGL 
       460        470        480        490        500
SLDSSHSPSS LSSSEGSSSS SSSSSSASSS ASSSFSEEGA VGYSSDSETL 
       510        520        530        540        550
DLEEAEGAVG YQPEYSKFCR MSYQDPSQLS CLPYLEHVGH NHTYNMAPSA 
       560        570        580        590        600
LDSADLPPPS TLKKGSKEKQ ADFLDKQMSR DEHRARAMKI PFTNDKIINL 
       610        620        630        640        650
PVEEFNELLS KYQLSEAQLS LIRDIRRRGK NKMAAQNCRK RKLDTILNLE 
       660        670 
RDVEDLQRDK ARLLREKEIY RTVTD

Length:675

Mass (Da):73,722

Last modified:July 22, 2015 - v2

Checksum:ⁱ99CB08614FF6ADB5

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC136178 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC136178 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENSRNOT00000067542; ENSRNOP00000061935; ENSRNOG00000008830

Ensemblⁱ

ENSRNOT00000067542; ENSRNOP00000061935; ENSRNOG00000008830

Protein	Similar proteins		Species	Score	Length	Source
D4A349	Nuclear factor, erythroid 2 like 1		OTOGA		765	UniRef90_D4A349
Nuclear factor, erythroid 2 like 1		LOXAF		747
nuclear factor erythroid 2-related factor 1 isoform X2		DIPOR		732
nuclear factor erythroid 2-related factor 1 isoform X4		LIPVE		621
Uncharacterized protein		PIG		621
+58

Protein	Similar proteins		Species	Score	Length	Source
D4A349	Endoplasmic reticulum membrane sensor NFE2L1		MOUSE		741	UniRef50_Q61985
Uncharacterized protein		FELCA		833
Uncharacterized protein		NOMLE		757
Putative bzip transcription factor nrf1 (Fragment)		DESRO		755
nuclear factor erythroid 2-related factor 1 isoform X2		LEPWE		748
+169

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC136178 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC136178 Genomic DNA No translation available.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000061935

STRINGⁱ

10116.ENSRNOP00000061935

Proteomic databases

PaxDbⁱ	D4A349

PaxDbⁱ

D4A349

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000067542; ENSRNOP00000061935; ENSRNOG00000008830

Ensemblⁱ

ENSRNOT00000067542; ENSRNOP00000061935; ENSRNOG00000008830

Organism-specific databases

RGDⁱ	1311972 Nfe2l1

Phylogenomic databases

eggNOGⁱ	KOG3863 Eukaryota ENOG410ZGMS LUCA
GeneTreeⁱ	ENSGT00920000148991
OMAⁱ	HKHSGPS
OrthoDBⁱ	EOG091G02EB

Gene expression databases

Bgeeⁱ	ENSRNOG00000008830 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue

Bgeeⁱ

ENSRNOG00000008830 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827 bZIP IPR004826 bZIP_Maf IPR029847 Nrf1_NFE2L1 IPR008917 TF_DNA-bd_sf
PANTHERⁱ	PTHR24411:SF31 PTHR24411:SF31, 1 hit
Pfamⁱ	View protein in Pfam PF03131 bZIP_Maf, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
SUPFAMⁱ	SSF47454 SSF47454, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D4A349_RAT
Accessionⁱ	D4A349Primary (citable) accession number: D4A349
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 20, 2010
	Last sequence update:	July 22, 2015
	Last modified:	September 12, 2018
	This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D4A349 (D4A349_RAT)

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Nuclear factor, erythroid 2-like 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ