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UniProtKB - D4A349 (D4A349_RAT)
Protein
Endoplasmic reticulum membrane sensor NFE2L1
Gene
Nfe2l1
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- cholesterol binding Source: RGD
- chromatin binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- identical protein binding Source: RGD
- promoter-specific chromatin binding Source: RGD
- protein-containing complex binding Source: RGD
- protein domain specific binding Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
GO - Biological processi
- cell redox homeostasis Source: RGD
- cellular homeostasis Source: RGD
- cellular response to cholesterol Source: RGD
- cellular response to cold Source: RGD
- cellular response to copper ion Source: RGD
- cellular response to oxidative stress Source: RGD
- cholesterol homeostasis Source: RGD
- cholesterol metabolic process Source: UniProtKB-KW
- cysteine transport Source: RGD
- erythrocyte differentiation Source: RGD
- fructose 6-phosphate metabolic process Source: RGD
- glial cell fate commitment Source: RGD
- glucose 6-phosphate metabolic process Source: RGD
- glutathione metabolic process Source: RGD
- lipid homeostasis Source: RGD
- negative regulation of transcription from RNA polymerase II promoter in response to stress Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of transcription from RNA polymerase II promoter in response to stress Source: RGD
- protein polyubiquitination Source: RGD
- regulation of fatty acid metabolic process Source: RGD
- regulation of gene expression Source: RGD
- regulation of glucose metabolic process Source: RGD
- regulation of inflammatory response Source: RGD
- regulation of lipid metabolic process Source: RGD
- regulation of mitotic nuclear division Source: RGD
- regulation of nucleus organization Source: RGD
- regulation of proteasomal protein catabolic process Source: RGD
- regulation of response to endoplasmic reticulum stress Source: RGD
- regulation of transcription by RNA polymerase II Source: RGD
- response to endoplasmic reticulum stress Source: RGD
- spinal cord motor neuron differentiation Source: RGD
Keywordsi
Molecular function | ActivatorARBA annotation, DNA-bindingARBA annotation, RepressorARBA annotation |
Biological process | Cholesterol metabolismARBA annotation, Lipid metabolism, Steroid metabolism, Sterol metabolism, Transcription, Transcription regulationARBA annotation |
Ligand | Lipid-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Endoplasmic reticulum membrane sensor NFE2L1ARBA annotationAlternative name(s): Nuclear factor erythroid 2-related factor 1ARBA annotation Nuclear factor, erythroid derived 2, like 1ARBA annotation |
Gene namesi | Name:Nfe2l1Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1311972, Nfe2l1 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Endoplasmic reticulum
- Endoplasmic reticulum membrane ARBA annotation; Single-pass type II membrane protein ARBA annotation
- Endoplasmic reticulum membrane ARBA annotation; Single-pass type III membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Single-pass type II membrane protein ARBA annotation
- Membrane ARBA annotation; Single-pass type III membrane protein ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum Source: RGD
- endoplasmic reticulum membrane Source: RGD
- integral component of endoplasmic reticulum membrane Source: RGD
Nucleus
- nucleus Source: RGD
- RNA polymerase II transcription regulator complex Source: RGD
Other locations
- protein-containing complex Source: RGD
Keywords - Cellular componenti
Endoplasmic reticulumARBA annotation, Membrane, NucleusARBA annotationPTM / Processingi
Keywords - PTMi
GlycoproteinARBA annotation, Ubl conjugationARBA annotationProteomic databases
PaxDbi | D4A349 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000008830, Expressed in skeletal muscle tissue and 21 other tissues |
Interactioni
GO - Molecular functioni
- identical protein binding Source: RGD
- protein domain specific binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000061935 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal-anchorARBA annotation, Transmembrane, Transmembrane helixARBA annotationPhylogenomic databases
eggNOGi | KOG3863, Eukaryota |
GeneTreei | ENSGT00950000182892 |
HOGENOMi | CLU_024173_1_0_1 |
InParanoidi | D4A349 |
OMAi | LQAMDVN |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR004826, bZIP_Maf IPR029847, NFE2L1 IPR008917, TF_DNA-bd_sf |
PANTHERi | PTHR24411:SF31, PTHR24411:SF31, 2 hits |
Pfami | View protein in Pfam PF03131, bZIP_Maf, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF47454, SSF47454, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
D4A349-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSLKKYLTE GLLQFTILLS LIGVRVDVDT YLTSQLPPLR EIILGPSSAY
60 70 80 90 100
TQTQFHNLRN TLDGYGIHPK SIDLDNYFTA RRLLSQVRAL DRFQVPTTEV
110 120 130 140 150
NAWLVHRDPE GSVSGSQPNS GLALESSSGL QDVTVPDNGV RESEPEQGFS
160 170 180 190 200
EDLEDLGAVA PPVSGDLTKE DIDLGAGREV FDYSHRQKEQ DVDKELQDGG
210 220 230 240 250
EREDTWSGEG AEALARDLLV DGETGESFPA QFPADVSSIT EAVPSESESP
260 270 280 290 300
ALQNSLLSPL LTGTESPFDL EQQWQDLMSI MEMQAMEVNT SASEILYSAP
310 320 330 340 350
PGDPLTTNYS LAPNTPINQN VSLHQASLGG CSQDFSLFSP EVESLPVASS
360 370 380 390 400
STLLPLVPSN STSLNSTFGS TNLAGLFFPS QLNGTANDTS GPELPDPLGG
410 420 430 440 450
LLDEAMLDEI SLMDLAIEEG FNPGQASQLE EEFDSDSGLS LDSSHSPSSL
460 470 480 490 500
SSSEGSSSSS SSSSSASSSA SSSFSEEGAV GYSSDSETLD LEEAEGAVGY
510 520 530 540 550
QPEYSKFCRM SYQDPSQLSC LPYLEHVGHN HTYNMAPSAL DSADLPPPST
560 570 580 590 600
LKKGSKEKQA DFLDKQMSRD EHRARAMKIP FTNDKIINLP VEEFNELLSK
610 620 630 640 650
YQLSEAQLSL IRDIRRRGKN KMAAQNCRKR KLDTILNLER DVEDLQRDKA
660 670 680 690 700
RLLREKVEFL RSLRQMKQKV QSLYQEVFGR LRDENGRPYS PSQYALQYAG
710 720
DGSVLLIPRT MADQQARRQE RKPKDRRK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A8I6A8A5 | A0A8I6A8A5_RAT | NFE2-like bZIP transcription factor... | Nfe2l1 Nfe2l1_predicted, rCG_32666 | 739 | Annotation score: | ||
A0A8I6A9I5 | A0A8I6A9I5_RAT | NFE2-like bZIP transcription factor... | Nfe2l1 | 581 | Annotation score: |
Genome annotation databases
Ensembli | ENSRNOT00000067542.4; ENSRNOP00000061935.3; ENSRNOG00000008830.8 |
Similar proteinsi
Cross-referencesi
3D structure databases
AlphaFoldDBi | D4A349 |
SMRi | D4A349 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000061935 |
Proteomic databases
PaxDbi | D4A349 |
Genome annotation databases
Ensembli | ENSRNOT00000067542.4; ENSRNOP00000061935.3; ENSRNOG00000008830.8 |
Organism-specific databases
RGDi | 1311972, Nfe2l1 |
Phylogenomic databases
eggNOGi | KOG3863, Eukaryota |
GeneTreei | ENSGT00950000182892 |
HOGENOMi | CLU_024173_1_0_1 |
InParanoidi | D4A349 |
OMAi | LQAMDVN |
Gene expression databases
Bgeei | ENSRNOG00000008830, Expressed in skeletal muscle tissue and 21 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR004826, bZIP_Maf IPR029847, NFE2L1 IPR008917, TF_DNA-bd_sf |
PANTHERi | PTHR24411:SF31, PTHR24411:SF31, 2 hits |
Pfami | View protein in Pfam PF03131, bZIP_Maf, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF47454, SSF47454, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | D4A349_RAT | |
Accessioni | D4A349Primary (citable) accession number: D4A349 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | May 25, 2022 | |
Last modified: | May 25, 2022 | |
This is version 100 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |