Nuclear factor, erythroid 2-like 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cholesterol binding Source: RGDInferred from sequence orthologyⁱ
  • "NRF1 is an ER membrane sensor that is central to cholesterol homeostasis."
    Widenmaier S.B., Snyder N.A., Nguyen T.B., Arduini A., Lee G.Y., Arruda A.P., Saksi J., Bartelt A., Hotamisligil G.S.
    Cell 171:1094-1109(2017) [PubMed] [Europe PMC] [Abstract]
• chromatin binding Source: RGDInferred from sequence orthologyⁱ
  • "Induction of Herpud1 expression by ER stress is regulated by Nrf1."
    Ho D.V., Chan J.Y.
    FEBS Lett. 589:615-620(2015) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3."
    Kobayashi A., Ito E., Toki T., Kogame K., Takahashi S., Igarashi K., Hayashi N., Yamamoto M.
    J. Biol. Chem. 274:6443-6452(1999) [PubMed] [Europe PMC] [Abstract]
  • "The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts."
    Kwong M., Kan Y.W., Chan J.Y.
    J. Biol. Chem. 274:37491-37498(1999) [PubMed] [Europe PMC] [Abstract]
  • "TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter."
    Myhrstad M.C., Husberg C., Murphy P., Nordstroem O., Blomhoff R., Moskaug J.O., Kolstoe A.B.
    Biochim. Biophys. Acta 1517:212-219(2001) [PubMed] [Europe PMC] [Abstract]
  • "Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells."
    Radhakrishnan S.K., Lee C.S., Young P., Beskow A., Chan J.Y., Deshaies R.J.
    Mol. Cell 38:17-28(2010) [PubMed] [Europe PMC] [Abstract]
  • "NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1beta genes."
    Hirotsu Y., Hataya N., Katsuoka F., Yamamoto M.
    Mol. Cell. Biol. 32:2760-2770(2012) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "The CCAAT enhancer-binding protein (C/EBP)beta and Nrf1 interact to regulate dentin sialophosphoprotein (DSPP) gene expression during odontoblast differentiation."
    Narayanan K., Ramachandran A., Peterson M.C., Hao J., Kolstoe A.B., Friedman A.D., George A.
    J. Biol. Chem. 279:45423-45432(2004) [PubMed] [Europe PMC] [Abstract]
  • "NRF1 is an ER membrane sensor that is central to cholesterol homeostasis."
    Widenmaier S.B., Snyder N.A., Nguyen T.B., Arduini A., Lee G.Y., Arruda A.P., Saksi J., Bartelt A., Hotamisligil G.S.
    Cell 171:1094-1109(2017) [PubMed] [Europe PMC] [Abstract]
• promoter-specific chromatin binding Source: RGDInferred from sequence orthologyⁱ
  • "Induction of Herpud1 expression by ER stress is regulated by Nrf1."
    Ho D.V., Chan J.Y.
    FEBS Lett. 589:615-620(2015) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: RGDInferred from sequence orthologyⁱ
  • "Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model."
    Tong K.I., Katoh Y., Kusunoki H., Itoh K., Tanaka T., Yamamoto M.
    Mol. Cell. Biol. 26:2887-2900(2006) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: RGDInferred from sequence orthologyⁱ
  • "Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model."
    Tong K.I., Katoh Y., Kusunoki H., Itoh K., Tanaka T., Yamamoto M.
    Mol. Cell. Biol. 26:2887-2900(2006) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1."
    Johnsen O., Skammelsrud N., Luna L., Nishizawa M., Prydz H., Kolstoe A.B.
    Nucleic Acids Res. 24:4289-4297(1996) [PubMed] [Europe PMC] [Abstract]
  • "Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription."
    Johnsen O., Murphy P., Prydz H., Kolsto A.B.
    Nucleic Acids Res. 26:512-520(1998) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts."
    Kwong M., Kan Y.W., Chan J.Y.
    J. Biol. Chem. 274:37491-37498(1999) [PubMed] [Europe PMC] [Abstract]
  • "TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter."
    Myhrstad M.C., Husberg C., Murphy P., Nordstroem O., Blomhoff R., Moskaug J.O., Kolstoe A.B.
    Biochim. Biophys. Acta 1517:212-219(2001) [PubMed] [Europe PMC] [Abstract]
  • "Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells."
    Radhakrishnan S.K., Lee C.S., Young P., Beskow A., Chan J.Y., Deshaies R.J.
    Mol. Cell 38:17-28(2010) [PubMed] [Europe PMC] [Abstract]
  • "NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1beta genes."
    Hirotsu Y., Hataya N., Katsuoka F., Yamamoto M.
    Mol. Cell. Biol. 32:2760-2770(2012) [PubMed] [Europe PMC] [Abstract]
  • "NRF1 is an ER membrane sensor that is central to cholesterol homeostasis."
    Widenmaier S.B., Snyder N.A., Nguyen T.B., Arduini A., Lee G.Y., Arruda A.P., Saksi J., Bartelt A., Hotamisligil G.S.
    Cell 171:1094-1109(2017) [PubMed] [Europe PMC] [Abstract]
  • "Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1."
    Johnsen O., Skammelsrud N., Luna L., Nishizawa M., Prydz H., Kolstoe A.B.
    Nucleic Acids Res. 24:4289-4297(1996) [PubMed] [Europe PMC] [Abstract]
  • "Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription."
    Johnsen O., Murphy P., Prydz H., Kolsto A.B.
    Nucleic Acids Res. 26:512-520(1998) [PubMed] [Europe PMC] [Abstract]
• transcription coactivator activity Source: RGDInferred from sequence orthologyⁱ
  • "Characterization of Nrf1b, a novel isoform of the nuclear factor-erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genes."
    Kwong E.K., Kim K.M., Penalosa P.J., Chan J.Y.
    PLoS ONE 7:E48404-E48404(2012) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cell redox homeostasis Source: RGDInferred from sequence orthologyⁱ
  • "The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts."
    Kwong M., Kan Y.W., Chan J.Y.
    J. Biol. Chem. 274:37491-37498(1999) [PubMed] [Europe PMC] [Abstract]
  • "TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter."
    Myhrstad M.C., Husberg C., Murphy P., Nordstroem O., Blomhoff R., Moskaug J.O., Kolstoe A.B.
    Biochim. Biophys. Acta 1517:212-219(2001) [PubMed] [Europe PMC] [Abstract]
• cellular homeostasis Source: RGDInferred from sequence orthologyⁱ
  • "Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity."
    Bartelt A., Widenmaier S.B., Schlein C., Johann K., Goncalves R.L.S., Eguchi K., Fischer A.W., Parlakgul G., Snyder N.A., Nguyen T.B., Bruns O.T., Franke D., Bawendi M.G., Lynes M.D., Leiria L.O., Tseng Y.H., Inouye K.E., Arruda A.P., Hotamisligil G.S.
    Nat. Med. 24:292-303(2018) [PubMed] [Europe PMC] [Abstract]
• cellular response to cholesterol Source: RGDInferred from sequence orthologyⁱ
  • "NRF1 is an ER membrane sensor that is central to cholesterol homeostasis."
    Widenmaier S.B., Snyder N.A., Nguyen T.B., Arduini A., Lee G.Y., Arruda A.P., Saksi J., Bartelt A., Hotamisligil G.S.
    Cell 171:1094-1109(2017) [PubMed] [Europe PMC] [Abstract]
• cellular response to cold Source: RGDInferred from sequence orthologyⁱ
  • "Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity."
    Bartelt A., Widenmaier S.B., Schlein C., Johann K., Goncalves R.L.S., Eguchi K., Fischer A.W., Parlakgul G., Snyder N.A., Nguyen T.B., Bruns O.T., Franke D., Bawendi M.G., Lynes M.D., Leiria L.O., Tseng Y.H., Inouye K.E., Arruda A.P., Hotamisligil G.S.
    Nat. Med. 24:292-303(2018) [PubMed] [Europe PMC] [Abstract]
• cellular response to copper ion Source: Ensembl
• cellular response to oxidative stress Source: RGDInferred from sequence orthologyⁱ
  • "The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts."
    Kwong M., Kan Y.W., Chan J.Y.
    J. Biol. Chem. 274:37491-37498(1999) [PubMed] [Europe PMC] [Abstract]
  • "TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter."
    Myhrstad M.C., Husberg C., Murphy P., Nordstroem O., Blomhoff R., Moskaug J.O., Kolstoe A.B.
    Biochim. Biophys. Acta 1517:212-219(2001) [PubMed] [Europe PMC] [Abstract]
• cholesterol homeostasis Source: RGDInferred from sequence orthologyⁱ
  • "NRF1 is an ER membrane sensor that is central to cholesterol homeostasis."
    Widenmaier S.B., Snyder N.A., Nguyen T.B., Arduini A., Lee G.Y., Arruda A.P., Saksi J., Bartelt A., Hotamisligil G.S.
    Cell 171:1094-1109(2017) [PubMed] [Europe PMC] [Abstract]
• cysteine transport Source: RGDInferred from sequence orthologyⁱ
  • "Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes."
    Tsujita T., Peirce V., Baird L., Matsuyama Y., Takaku M., Walsh S.V., Griffin J.L., Uruno A., Yamamoto M., Hayes J.D.
    Mol. Cell. Biol. 34:3800-3816(2014) [PubMed] [Europe PMC] [Abstract]
• erythrocyte differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice."
    Chan J.Y., Kwong M., Lu R., Chang J., Wang B., Yen T.S., Kan Y.W.
    EMBO J. 17:1779-1787(1998) [PubMed] [Europe PMC] [Abstract]
• fructose 6-phosphate metabolic process Source: RGDInferred from sequence orthologyⁱ
  • "Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice."
    Hirotsu Y., Higashi C., Fukutomi T., Katsuoka F., Tsujita T., Yagishita Y., Matsuyama Y., Motohashi H., Uruno A., Yamamoto M.
    Genes Cells 19:650-665(2014) [PubMed] [Europe PMC] [Abstract]
• glial cell fate commitment Source: RGDInferred from sequence orthologyⁱ
  • "Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions."
    Molofsky A.V., Glasgow S.M., Chaboub L.S., Tsai H.H., Murnen A.T., Kelley K.W., Fancy S.P., Yuen T.J., Madireddy L., Baranzini S., Deneen B., Rowitch D.H., Oldham M.C.
    Glia 61:1518-1532(2013) [PubMed] [Europe PMC] [Abstract]
• glucose 6-phosphate metabolic process Source: RGDInferred from sequence orthologyⁱ
  • "Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice."
    Hirotsu Y., Higashi C., Fukutomi T., Katsuoka F., Tsujita T., Yagishita Y., Matsuyama Y., Motohashi H., Uruno A., Yamamoto M.
    Genes Cells 19:650-665(2014) [PubMed] [Europe PMC] [Abstract]
• glutathione metabolic process Source: RGDInferred from sequence orthologyⁱ
  • "Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes."
    Tsujita T., Peirce V., Baird L., Matsuyama Y., Takaku M., Walsh S.V., Griffin J.L., Uruno A., Yamamoto M., Hayes J.D.
    Mol. Cell. Biol. 34:3800-3816(2014) [PubMed] [Europe PMC] [Abstract]
• lipid homeostasis Source: RGDInferred from sequence orthologyⁱ
  • "NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1beta genes."
    Hirotsu Y., Hataya N., Katsuoka F., Yamamoto M.
    Mol. Cell. Biol. 32:2760-2770(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "The CCAAT enhancer-binding protein (C/EBP)beta and Nrf1 interact to regulate dentin sialophosphoprotein (DSPP) gene expression during odontoblast differentiation."
    Narayanan K., Ramachandran A., Peterson M.C., Hao J., Kolstoe A.B., Friedman A.D., George A.
    J. Biol. Chem. 279:45423-45432(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription from RNA polymerase II promoter in response to stress Source: RGDInferred from sequence orthologyⁱ
  • "NRF1 is an ER membrane sensor that is central to cholesterol homeostasis."
    Widenmaier S.B., Snyder N.A., Nguyen T.B., Arduini A., Lee G.Y., Arruda A.P., Saksi J., Bartelt A., Hotamisligil G.S.
    Cell 171:1094-1109(2017) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3."
    Kobayashi A., Ito E., Toki T., Kogame K., Takahashi S., Igarashi K., Hayashi N., Yamamoto M.
    J. Biol. Chem. 274:6443-6452(1999) [PubMed] [Europe PMC] [Abstract]
  • "Characterization of Nrf1b, a novel isoform of the nuclear factor-erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genes."
    Kwong E.K., Kim K.M., Penalosa P.J., Chan J.Y.
    PLoS ONE 7:E48404-E48404(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter in response to stress Source: RGDInferred from sequence orthologyⁱ
  • "The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts."
    Kwong M., Kan Y.W., Chan J.Y.
    J. Biol. Chem. 274:37491-37498(1999) [PubMed] [Europe PMC] [Abstract]
  • "TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter."
    Myhrstad M.C., Husberg C., Murphy P., Nordstroem O., Blomhoff R., Moskaug J.O., Kolstoe A.B.
    Biochim. Biophys. Acta 1517:212-219(2001) [PubMed] [Europe PMC] [Abstract]
  • "Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells."
    Radhakrishnan S.K., Lee C.S., Young P., Beskow A., Chan J.Y., Deshaies R.J.
    Mol. Cell 38:17-28(2010) [PubMed] [Europe PMC] [Abstract]
• protein polyubiquitination Source: RGDInferred from sequence orthologyⁱ
  • "Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction."
    Kobayashi A., Tsukide T., Miyasaka T., Morita T., Mizoroki T., Saito Y., Ihara Y., Takashima A., Noguchi N., Fukamizu A., Hirotsu Y., Ohtsuji M., Katsuoka F., Yamamoto M.
    Genes Cells 16:692-703(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of fatty acid metabolic process Source: RGDInferred from sequence orthologyⁱ
  • "Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes."
    Tsujita T., Peirce V., Baird L., Matsuyama Y., Takaku M., Walsh S.V., Griffin J.L., Uruno A., Yamamoto M., Hayes J.D.
    Mol. Cell. Biol. 34:3800-3816(2014) [PubMed] [Europe PMC] [Abstract]
• regulation of gene expression Source: RGDInferred from sequence orthologyⁱ
  • "Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice."
    Hirotsu Y., Higashi C., Fukutomi T., Katsuoka F., Tsujita T., Yagishita Y., Matsuyama Y., Motohashi H., Uruno A., Yamamoto M.
    Genes Cells 19:650-665(2014) [PubMed] [Europe PMC] [Abstract]
  • "Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes."
    Tsujita T., Peirce V., Baird L., Matsuyama Y., Takaku M., Walsh S.V., Griffin J.L., Uruno A., Yamamoto M., Hayes J.D.
    Mol. Cell. Biol. 34:3800-3816(2014) [PubMed] [Europe PMC] [Abstract]
  • "Possible roles of the transcription factor Nrf1 (NFE2L1) in neural homeostasis by regulating the gene expression of deubiquitinating enzymes."
    Taniguchi H., Okamuro S., Koji M., Waku T., Kubo K., Hatanaka A., Sun Y., Chowdhury A.M.M.A., Fukamizu A., Kobayashi A.
    Biochem. Biophys. Res. Commun. 484:176-183(2017) [PubMed] [Europe PMC] [Abstract]
• regulation of glucose metabolic process Source: RGDInferred from sequence orthologyⁱ
  • "Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice."
    Hirotsu Y., Higashi C., Fukutomi T., Katsuoka F., Tsujita T., Yagishita Y., Matsuyama Y., Motohashi H., Uruno A., Yamamoto M.
    Genes Cells 19:650-665(2014) [PubMed] [Europe PMC] [Abstract]
• regulation of inflammatory response Source: RGDInferred from sequence orthologyⁱ
  • "NRF1 is an ER membrane sensor that is central to cholesterol homeostasis."
    Widenmaier S.B., Snyder N.A., Nguyen T.B., Arduini A., Lee G.Y., Arruda A.P., Saksi J., Bartelt A., Hotamisligil G.S.
    Cell 171:1094-1109(2017) [PubMed] [Europe PMC] [Abstract]
  • "Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity."
    Bartelt A., Widenmaier S.B., Schlein C., Johann K., Goncalves R.L.S., Eguchi K., Fischer A.W., Parlakgul G., Snyder N.A., Nguyen T.B., Bruns O.T., Franke D., Bawendi M.G., Lynes M.D., Leiria L.O., Tseng Y.H., Inouye K.E., Arruda A.P., Hotamisligil G.S.
    Nat. Med. 24:292-303(2018) [PubMed] [Europe PMC] [Abstract]
• regulation of lipid metabolic process Source: RGDInferred from sequence orthologyⁱ
  • "Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes."
    Tsujita T., Peirce V., Baird L., Matsuyama Y., Takaku M., Walsh S.V., Griffin J.L., Uruno A., Yamamoto M., Hayes J.D.
    Mol. Cell. Biol. 34:3800-3816(2014) [PubMed] [Europe PMC] [Abstract]
• regulation of mitotic nuclear division Source: RGDInferred from sequence orthologyⁱ
  • "Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability."
    Oh D.H., Rigas D., Cho A., Chan J.Y.
    FEBS J. 279:4121-4130(2012) [PubMed] [Europe PMC] [Abstract]
• regulation of nucleus organization Source: RGDInferred from sequence orthologyⁱ
  • "Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability."
    Oh D.H., Rigas D., Cho A., Chan J.Y.
    FEBS J. 279:4121-4130(2012) [PubMed] [Europe PMC] [Abstract]
• regulation of odontoblast differentiation Source: RGDInferred from sequence orthologyⁱ
  • "The CCAAT enhancer-binding protein (C/EBP)beta and Nrf1 interact to regulate dentin sialophosphoprotein (DSPP) gene expression during odontoblast differentiation."
    Narayanan K., Ramachandran A., Peterson M.C., Hao J., Kolstoe A.B., Friedman A.D., George A.
    J. Biol. Chem. 279:45423-45432(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of proteasomal protein catabolic process Source: RGDInferred from sequence orthologyⁱ
  • "A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways."
    Baird L., Tsujita T., Kobayashi E.H., Funayama R., Nagashima T., Nakayama K., Yamamoto M.
    Mol. Cell. Biol. 37:0-0(2017) [PubMed] [Europe PMC] [Abstract]
  • "Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity."
    Bartelt A., Widenmaier S.B., Schlein C., Johann K., Goncalves R.L.S., Eguchi K., Fischer A.W., Parlakgul G., Snyder N.A., Nguyen T.B., Bruns O.T., Franke D., Bawendi M.G., Lynes M.D., Leiria L.O., Tseng Y.H., Inouye K.E., Arruda A.P., Hotamisligil G.S.
    Nat. Med. 24:292-303(2018) [PubMed] [Europe PMC] [Abstract]
• regulation of response to endoplasmic reticulum stress Source: RGDInferred from sequence orthologyⁱ
  • "Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity."
    Bartelt A., Widenmaier S.B., Schlein C., Johann K., Goncalves R.L.S., Eguchi K., Fischer A.W., Parlakgul G., Snyder N.A., Nguyen T.B., Bruns O.T., Franke D., Bawendi M.G., Lynes M.D., Leiria L.O., Tseng Y.H., Inouye K.E., Arruda A.P., Hotamisligil G.S.
    Nat. Med. 24:292-303(2018) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability."
    Oh D.H., Rigas D., Cho A., Chan J.Y.
    FEBS J. 279:4121-4130(2012) [PubMed] [Europe PMC] [Abstract]
  • "Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice."
    Lee C.S., Ho D.V., Chan J.Y.
    FEBS J. 280:3609-3620(2013) [PubMed] [Europe PMC] [Abstract]
  • "The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1beta; both are also inhibited by the small dominant-negative Nrf1gamma/delta isoforms that down-regulate ARE-battery gene expression."
    Zhang Y., Qiu L., Li S., Xiang Y., Chen J., Ren Y.
    PLoS ONE 9:e109159-e109159(2014) [PubMed] [Europe PMC] [Abstract]
  • "Induction of Herpud1 expression by ER stress is regulated by Nrf1."
    Ho D.V., Chan J.Y.
    FEBS Lett. 589:615-620(2015) [PubMed] [Europe PMC] [Abstract]
  • "A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways."
    Baird L., Tsujita T., Kobayashi E.H., Funayama R., Nagashima T., Nakayama K., Yamamoto M.
    Mol. Cell. Biol. 37:0-0(2017) [PubMed] [Europe PMC] [Abstract]
• response to endoplasmic reticulum stress Source: RGDInferred from sequence orthologyⁱ
  • "Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice."
    Lee C.S., Ho D.V., Chan J.Y.
    FEBS J. 280:3609-3620(2013) [PubMed] [Europe PMC] [Abstract]
  • "Induction of Herpud1 expression by ER stress is regulated by Nrf1."
    Ho D.V., Chan J.Y.
    FEBS Lett. 589:615-620(2015) [PubMed] [Europe PMC] [Abstract]
• spinal cord motor neuron differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction."
    Kobayashi A., Tsukide T., Miyasaka T., Morita T., Mizoroki T., Saito Y., Ihara Y., Takashima A., Noguchi N., Fukamizu A., Hirotsu Y., Ohtsuji M., Katsuoka F., Yamamoto M.
    Genes Cells 16:692-703(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• protein domain specific binding Source: RGDInferred from sequence orthologyⁱ
  • "Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model."
    Tong K.I., Katoh Y., Kusunoki H., Itoh K., Tanaka T., Yamamoto M.
    Mol. Cell. Biol. 26:2887-2900(2006) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1."
    Johnsen O., Skammelsrud N., Luna L., Nishizawa M., Prydz H., Kolstoe A.B.
    Nucleic Acids Res. 24:4289-4297(1996) [PubMed] [Europe PMC] [Abstract]
  • "Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription."
    Johnsen O., Murphy P., Prydz H., Kolsto A.B.
    Nucleic Acids Res. 26:512-520(1998) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MLSLKKYLTE GLLQFTILLS LIGVRVDVDT YLTSQLPPLR EIILGPSSAY 
        60         70         80         90        100
TQTQFHNLRN TLDGYGIHPK SIDLDNYFTA RRLLSQVRAL DRFQVPTTEV 
       110        120        130        140        150
NAWLVHRDPE GSVSGSQPNS GLALESSSGL QDVTVPDNGV RESEPEQGFS 
       160        170        180        190        200
EDLEDLGAVA PPVSGDLTKE DIDLIDILWR QDIDLGAGRE VFDYSHRQKE 
       210        220        230        240        250
QDVDKELQDG GEREDTWSGE GAEALARDLL VDGETGESFP AQFPADVSSI 
       260        270        280        290        300
TEAVPSESES PALQNSLLSP LLTGTESPFD LEQQWQDLMS IMEMQAMEVN 
       310        320        330        340        350
TSASEILYSA PPGDPLTTNY SLAPNTPINQ NVSLHQASLG GCSQDFSLFS 
       360        370        380        390        400
PEVESLPVAS SSTLLPLVPS NSTSLNSTFG STNLAGLFFP SQLNGTANDT 
       410        420        430        440        450
SGPELPDPLG GLLDEAMLDE ISLMDLAIEE GFNPGQASQL EEEFDSDSGL 
       460        470        480        490        500
SLDSSHSPSS LSSSEGSSSS SSSSSSASSS ASSSFSEEGA VGYSSDSETL 
       510        520        530        540        550
DLEEAEGAVG YQPEYSKFCR MSYQDPSQLS CLPYLEHVGH NHTYNMAPSA 
       560        570        580        590        600
LDSADLPPPS TLKKGSKEKQ ADFLDKQMSR DEHRARAMKI PFTNDKIINL 
       610        620        630        640        650
PVEEFNELLS KYQLSEAQLS LIRDIRRRGK NKMAAQNCRK RKLDTILNLE 
       660        670 
RDVEDLQRDK ARLLREKEIY RTVTD                            

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ