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UniProtKB - D4A314 (D4A314_RAT)
Protein
Submitted name:
GLIS family zinc finger 3
Gene
Glis3
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- transcription by RNA polymerase II Source: RGD
Keywordsi
Molecular function | ActivatorARBA annotation, DNA-bindingARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: GLIS family zinc finger 3Imported |
Gene namesi | Name:Glis3Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1565505, Glis3 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nucleus Source: RGD
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000014768, Expressed in adult mammalian kidney and 19 other tissues |
Interactioni
Protein-protein interaction databases
IntActi | D4A314, 1 interactor |
MINTi | D4A314 |
STRINGi | 10116.ENSRNOP00000019816 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 500 – 530 | C2H2-typeInterPro annotationAdd BLAST | 31 | |
Domaini | 539 – 566 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 567 – 596 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 597 – 626 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 627 – 656 | C2H2-typeInterPro annotationAdd BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 115 – 136 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 235 – 304 | DisorderedSequence analysisAdd BLAST | 70 | |
Regioni | 395 – 492 | DisorderedSequence analysisAdd BLAST | 98 | |
Regioni | 648 – 667 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 678 – 825 | DisorderedSequence analysisAdd BLAST | 148 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 21 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 235 – 249 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 258 – 275 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 403 – 428 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 444 – 464 | Pro residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 744 – 758 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 795 – 825 | Polar residuesSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the GLI C2H2-type zinc-finger protein family.ARBA annotation
Keywords - Domaini
RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000156896 |
HOGENOMi | CLU_014147_1_0_1 |
InParanoidi | D4A314 |
OMAi | GGMSGTH |
TreeFami | TF350216 |
Family and domain databases
InterProi | View protein in InterPro IPR043359, GLI-like IPR030405, GLIS3 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR45718, PTHR45718, 1 hit PTHR45718:SF1, PTHR45718:SF1, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
i Sequence
Sequence statusi: Complete.
D4A314-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNERSCGMNL HRTSRTPQRP GLLSGQHVLP ARAHSGTPCS SSCASTPSPT
60 70 80 90 100
LGSLANSLHL KMSSGAGMAP QSNMAASPIH LPALSPRRQL LANGKPQFQV
110 120 130 140 150
TQAGVMAASH TLKPKQQEFG DPFSPNPEKG ALGFGPQCKS IGKGSCNNLV
160 170 180 190 200
VTSSPMMVQR LGPISPPASQ VSTACKQISP SLPRAVNAVN LNRPPSDTRS
210 220 230 240 250
VILQESLVST TLSLTESQSA LSVKQEWSQS YRGFPSLSSN HSSQNGMDLG
260 270 280 290 300
DLLSLPPGTP VSGNSVSNSL PPYLFGMENS HSPYPSPRHS ATRPHSTRSK
310 320 330 340 350
KRALSLSPLS DGIGIDFNTI IRTSPTSLVA YINGSRASPA NMSPQSEVYG
360 370 380 390 400
HFLGVRGSCI PQSCAVSSGQ KGVLVTSGGH TLPGYGEDGT LEYERMQQLE
410 420 430 440 450
HGGLQPGSGN SMVLQPGLPG QDGQTANMLK TERLEEFPAS ALDLPSAPPL
460 470 480 490 500
PLPPPQGPPP PYHAHPHLHH PELLPHTQSL PLAQAGLEED GELEDSGGKH
510 520 530 540 550
CCRWIDCSAL YDQQEELVRH IEKVHIDQRK GEDFTCFWTG CPRRYKPFNA
560 570 580 590 600
RYKLLIHMRV HSGEKPNKCT FEGCKKAFSR LENLKIHLRS HTGEKPYLCQ
610 620 630 640 650
HPGCQKAFSN SSDRAKHQRT HLDTKPYACQ IPGCTKRYTD PSSLRKHVKA
660 670 680 690 700
HSSKEQQARK KLRSSTELHP DLLTDCLAVQ PLQPATSPRD AADRTVGHSP
710 720 730 740 750
GPGPGPGFGX QLISAPIFAS NHSTRSGTAA GAVPPPHPVS HPSPGHNVQG
760 770 780 790 800
SPHNPSSHLP PLTAVDAGTE RFAPPTPSPH HISPGRVPAP QSLLQRAQAP
810 820 830 840 850
HTQQPPGSLL KPYQPETNSS FQSNGIHVHG FYGQLQTFCP PNYPDSQRSV
860 870 880 890 900
PSSSSCSMVP SFEDCLVPTS MGQAGFDVFH RALSTHSGIT VYDLPSASSS
910 920 930
LFGESLRSGP EDPTFLQLSA VDRCPSQLSS VYTEG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07006682 Genomic DNA No translation available. AABR07006683 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSRNOT00000019816; ENSRNOP00000019816; ENSRNOG00000014768 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07006682 Genomic DNA No translation available. AABR07006683 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Protein-protein interaction databases
IntActi | D4A314, 1 interactor |
MINTi | D4A314 |
STRINGi | 10116.ENSRNOP00000019816 |
Proteomic databases
PaxDbi | D4A314 |
Genome annotation databases
Ensembli | ENSRNOT00000019816; ENSRNOP00000019816; ENSRNOG00000014768 |
Organism-specific databases
RGDi | 1565505, Glis3 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000156896 |
HOGENOMi | CLU_014147_1_0_1 |
InParanoidi | D4A314 |
OMAi | GGMSGTH |
TreeFami | TF350216 |
Gene expression databases
Bgeei | ENSRNOG00000014768, Expressed in adult mammalian kidney and 19 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR043359, GLI-like IPR030405, GLIS3 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR45718, PTHR45718, 1 hit PTHR45718:SF1, PTHR45718:SF1, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | D4A314_RAT | |
Accessioni | D4A314Primary (citable) accession number: D4A314 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | July 22, 2015 | |
Last modified: | January 19, 2022 | |
This is version 80 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |