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UniProtKB - D4A2E3 (D4A2E3_RAT)
Protein
Submitted name:
Neurogenin 2
Gene
Neurog2
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- E-box binding Source: RGD
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- axon guidance Source: RGD
- cell fate commitment Source: RGD
- cell maturation Source: RGD
- central nervous system neuron development Source: RGD
- forebrain development Source: RGD
- neurogenesis Source: RGD
- neuron differentiation Source: RGD
- neuron migration Source: RGD
- positive regulation of DNA-binding transcription factor activity Source: RGD
- positive regulation of neuron differentiation Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Names & Taxonomyi
Protein namesi | Submitted name: Neurogenin 2Submitted name: RCG28897Imported |
Gene namesi | Name:Neurog2Imported ORF Names:rCG_28897Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1309061, Neurog2 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000010972, Expressed in liver and 4 other tissues |
Interactioni
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000014570 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 112 – 164 | BHLHInterPro annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 21 – 74 | DisorderedSequence analysisAdd BLAST | 54 | |
Regioni | 197 – 253 | DisorderedSequence analysisAdd BLAST | 57 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 118 – 138 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 201 – 236 | Polar residuesSequence analysisAdd BLAST | 36 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG3898, Eukaryota |
GeneTreei | ENSGT00940000162895 |
HOGENOMi | CLU_097959_0_0_1 |
OMAi | GLVHECK |
OrthoDBi | 1524429at2759 |
TreeFami | TF315153 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032655, Ngn2 |
PANTHERi | PTHR19290:SF105, PTHR19290:SF105, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
D4A2E3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFVKSETLEL KEEEEVLMLL GSASPASATL TPMSSSADEE EDEELRRPGA
60 70 80 90 100
ARGQRGAEAG QGVQGSSASG AGGCRPGRLL GLVHECKRRP SRARAVSRGA
110 120 130 140 150
KTAETVQRIK KTRRLKANNR ERNRMHNLNA ALDALREVLP TFPEDAKLTK
160 170 180 190 200
IETLRFAHNY IWALTETLRL ADHCAGGGSL QGALFSEAVL LSPGAALGAS
210 220 230 240 250
GDSPSPSSSW SCTNSPASSS NSTSPYSCTL SPASPGSDVD YWQPPPPEKH
260
RYAPHLPLAR DCI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473952 Genomic DNA Translation: EDL82153.1 |
RefSeqi | XP_008759703.1, XM_008761481.2 XP_008773484.1, XM_008775262.2 |
Genome annotation databases
Ensembli | ENSRNOT00000014570.5; ENSRNOP00000014570.3; ENSRNOG00000010972.5 |
GeneIDi | 295475 |
KEGGi | rno:295475 |
UCSCi | RGD:1309061, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473952 Genomic DNA Translation: EDL82153.1 |
RefSeqi | XP_008759703.1, XM_008761481.2 XP_008773484.1, XM_008775262.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000014570 |
Genome annotation databases
Ensembli | ENSRNOT00000014570.5; ENSRNOP00000014570.3; ENSRNOG00000010972.5 |
GeneIDi | 295475 |
KEGGi | rno:295475 |
UCSCi | RGD:1309061, rat |
Organism-specific databases
CTDi | 63973 |
RGDi | 1309061, Neurog2 |
Phylogenomic databases
eggNOGi | KOG3898, Eukaryota |
GeneTreei | ENSGT00940000162895 |
HOGENOMi | CLU_097959_0_0_1 |
OMAi | GLVHECK |
OrthoDBi | 1524429at2759 |
TreeFami | TF315153 |
Gene expression databases
Bgeei | ENSRNOG00000010972, Expressed in liver and 4 other tissues |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032655, Ngn2 |
PANTHERi | PTHR19290:SF105, PTHR19290:SF105, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | D4A2E3_RAT | |
Accessioni | D4A2E3Primary (citable) accession number: D4A2E3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | May 25, 2022 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |