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Entry version 74 (31 Jul 2019)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

Transmembrane protein 132E

Gene

Tmem132e

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Transmembrane protein 132EImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tmem132eImported
Synonyms:RGD1565522_predictedImported
ORF Names:rCG_35134Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Rat genome database

More...
RGDi
1565522 Tmem132e

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei798 – 823HelicalSequence analysisAdd BLAST26

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501408781826 – 983Sequence analysisAdd BLAST958

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000007455 Expressed in 9 organ(s), highest expression level in brain

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 175TMEM132D_NInterPro annotationAdd BLAST131
Domaini359 – 705TMEM132InterPro annotationAdd BLAST347
Domaini785 – 850TMEM132D_CInterPro annotationAdd BLAST66

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni472 – 495DisorderedSequence analysisAdd BLAST24
Regioni724 – 777DisorderedSequence analysisAdd BLAST54
Regioni870 – 973DisorderedSequence analysisAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi878 – 911PolarSequence analysisAdd BLAST34
Compositional biasi918 – 933PolarSequence analysisAdd BLAST16
Compositional biasi939 – 955AcidicSequence analysisAdd BLAST17

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4789 Eukaryota
ENOG410XQCD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158479

KEGG Orthology (KO)

More...
KOi
K17599

Database of Orthologous Groups

More...
OrthoDBi
598074at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314981

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026307 TMEM132
IPR031436 TMEM132_C
IPR031437 TMEM132_M
IPR031435 TMEM132_N

The PANTHER Classification System

More...
PANTHERi
PTHR13388 PTHR13388, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16070 TMEM132, 1 hit
PF15706 TMEM132D_C, 1 hit
PF15705 TMEM132D_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

D4A2A3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPGMLGRRG AALLCLSVLL AHAASRSHPA SPSPPGPQAS PVLPVSYRLS
60 70 80 90 100
HTRLAFFLKE ARPPTPTAMN GSLQRSEPFV VFQTKELPVL NVSLGPFSTS
110 120 130 140 150
QVVARELLQP SSTLDIPERL TVNWKVRAFI VRARVPASQP VAQVLFYVAG
160 170 180 190 200
RDWDDFGVTE RLPCVRLHAF RDAREHPLLR IGSISLFRPP PRRAMQEHRL
210 220 230 240 250
DSNLMIRLPD RPLRPGEVLS ILLYLAPNSS SAASPSLEHF TLRVKAKKGV
260 270 280 290 300
TLLGTKSRNG QWHVTSELLT GAKHSTATVD VAWAQGTPLP PWESQGPLEI
310 320 330 340 350
LQLDFEMENF TSQSVKRRIM WHIDYRGHSA LPDLERAVTE LTVIQRDVQA
360 370 380 390 400
ILPLAMDTEI INTAILTGRT VAIPVKVIAI EVTGVVLDVS DLVECQSHRE
410 420 430 440 450
DIIKVSSSCD YVFVSGKESR GSMNARVTFR YDVLSAPLEM TVWVPKLPLH
460 470 480 490 500
IELSDARLSQ VKGWRVPILP DRRSARESED EEEEEEERRQ SANRGCTLQY
510 520 530 540 550
QHATLQVFTQ FHTTSSEGTE QVVTMLGPDW LVEVTDLVSD FMRVGDPRVA
560 570 580 590 600
HLVDSNTLAG LEPGTTPFKV VSPLTEAVLG ETLLTVTEEK VSITQLQAQV
610 620 630 640 650
VASLTLSLRP SPGSSHTILA TTAAQPTLSS VKQEALLSLW LSYSDGTTAP
660 670 680 690 700
LSLYSPRDYG LLVNSLDERV ATVTQDKAFP LLVAEAEGAG DLLRAELTIS
710 720 730 740 750
ESCQKTKRKS VLATTPVGLR VHFGRDEEDP TYDYPGPSQP GPGGGEDEAR
760 770 780 790 800
GAGPPGTAIP AGEVPGLGTA GPMPPTEDFL PLPTGFLQMP RGLTDLEIGM
810 820 830 840 850
YALLGVFCLA ILVFLINCIV FVLRYRHKRI PPEGQTSMDH SHHWVFLGNG
860 870 880 890 900
QPLRVQGELS PPAGSALETV PACCHGDHHS SGSSQTSVQS QVHGRGDGSS
910 920 930 940 950
GGSARDQTED PASSPTSKRK RVKFTTFTTL PSEELAYDSV PAGEEDEEDE
960 970 980
EDLGWGCPDV AGTTRPTPPP DLHNYMRRIK DIA
Length:983
Mass (Da):107,236
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3449F9EA89EDDA48
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A096MJF9A0A096MJF9_RAT
Transmembrane protein 132E
Tmem132e
1,073Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07030133 Genomic DNA No translation available.
AABR07030134 Genomic DNA No translation available.
CH473948 Genomic DNA Translation: EDM05442.1

NCBI Reference Sequences

More...
RefSeqi
NP_001127882.1, NM_001134410.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000055999; ENSRNOP00000052853; ENSRNOG00000007455

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
287564

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:287564

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07030133 Genomic DNA No translation available.
AABR07030134 Genomic DNA No translation available.
CH473948 Genomic DNA Translation: EDM05442.1
RefSeqiNP_001127882.1, NM_001134410.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSRNOT00000055999; ENSRNOP00000052853; ENSRNOG00000007455
GeneIDi287564
KEGGirno:287564

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
124842
RGDi1565522 Tmem132e

Phylogenomic databases

eggNOGiKOG4789 Eukaryota
ENOG410XQCD LUCA
GeneTreeiENSGT00940000158479
KOiK17599
OrthoDBi598074at2759
TreeFamiTF314981

Gene expression databases

BgeeiENSRNOG00000007455 Expressed in 9 organ(s), highest expression level in brain

Family and domain databases

InterProiView protein in InterPro
IPR026307 TMEM132
IPR031436 TMEM132_C
IPR031437 TMEM132_M
IPR031435 TMEM132_N
PANTHERiPTHR13388 PTHR13388, 2 hits
PfamiView protein in Pfam
PF16070 TMEM132, 1 hit
PF15706 TMEM132D_C, 1 hit
PF15705 TMEM132D_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD4A2A3_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4A2A3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: July 31, 2019
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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