Bhlhe22

Functionⁱ

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro
protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

neurogenesis Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Basic helix-loop-helix family, member e22Imported
Gene namesⁱ	Name:Bhlhe22Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 2

Organism-specific databases

Rat genome database More...RGDⁱ	1305451 Bhlhe22

RGDⁱ

1305451 Bhlhe22

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	D4A287
PRIDEⁱ	D4A287

PTM databases

iPTMnetⁱ	D4A287
PhosphoSitePlusⁱ	D4A287

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000021745 Expressed in 8 organ(s), highest expression level in brain

Bgeeⁱ

ENSRNOG00000021745 Expressed in 8 organ(s), highest expression level in brain

Interactionⁱ

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000038593

STRINGⁱ

10116.ENSRNOP00000038593

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	213 – 267	BHLHInterPro annotationAdd BLAST		55

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	219 – 239	Sequence analysisAdd BLAST		21

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG3898 Eukaryota ENOG410ZDH5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063239
InParanoidⁱ	D4A287
OMAⁱ	CKQCTDK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G129L
PhylomeDBⁱ	D4A287
TreeFamⁱ	TF322733

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR032654 Bhlhe22 IPR036638 HLH_DNA-bd_sf
PANTHERⁱ	PTHR19290:SF52 PTHR19290:SF52, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

D4A287-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MERGLHLGAA AASEDDLFLH KSLGASAAKR LEAAFRSTPP GMDLSLAPPT 
        60         70         80         90        100
RERPASSSSP LGCFEPADPE GAGLLLPPPG GGGGASGGGV SVPGLLVGSA 
       110        120        130        140        150
GVGGEPSLSS LPAGAALCLK YGESAGRGSV AESSGGEHSP DDDSDGRCEL 
       160        170        180        190        200
VLRAGGPDPR ASPGAGSGGA KVAEGCSNAH LHGGSGLPPG GPTSGSGGNG 
       210        220        230        240        250
GGGSSKKSKE QKALRLNINA RERRRMHDLN DALDELRAVI PYAHSPSVRK 
       260        270        280        290        300
LSKIATLLLA KNYILMQAQA LEEMRRLVAY LNQGQAISAA SLPSSAAAAA 
       310        320        330        340        350
AAAALHPALG AYEQAAGYPF SAGLPPAASC PEKCALFNSV SSSLCKQCTE 

KP

Length:352

Mass (Da):34,982

Last modified:April 20, 2010 - v1

Checksum:ⁱ62361B68C23CE010

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07009549 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AABR07009549 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENSRNOT00000033940; ENSRNOP00000038593; ENSRNOG00000021745
UCSC genome browser More...UCSCⁱ	RGD:1305451 rat

Protein	Similar proteins		Species	Score	Length	Source
D4A287	Class E basic helix-loop-helix protein 22		MOUSE		355	UniRef90_Q8C6A8
Class E basic helix-loop-helix protein 22		MESAU		365
Uncharacterized protein		FELCA		374
Uncharacterized protein		Cebus capucinus imitator		371
class E basic helix-loop-helix protein 22		Enhydra lutris kenyoni		370
+42

Protein	Similar proteins		Species	Score	Length	Source
D4A287	Class E basic helix-loop-helix protein 22		MOUSE		355	UniRef50_Q8C6A8
Class E basic helix-loop-helix protein 22		MESAU		365
Class E basic helix-loop-helix protein 22		HUMAN		381
Uncharacterized protein		FELCA		374
Uncharacterized protein		Cebus capucinus imitator		371
+67

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07009549 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AABR07009549 Genomic DNA No translation available.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000038593

STRINGⁱ

10116.ENSRNOP00000038593

PTM databases

iPTMnetⁱ	D4A287
PhosphoSitePlusⁱ	D4A287

Proteomic databases

PaxDbⁱ	D4A287
PRIDEⁱ	D4A287

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000033940; ENSRNOP00000038593; ENSRNOG00000021745
UCSCⁱ	RGD:1305451 rat

Organism-specific databases

RGDⁱ	1305451 Bhlhe22

Phylogenomic databases

eggNOGⁱ	KOG3898 Eukaryota ENOG410ZDH5 LUCA
GeneTreeⁱ	ENSGT00530000063239
InParanoidⁱ	D4A287
OMAⁱ	CKQCTDK
OrthoDBⁱ	EOG091G129L
PhylomeDBⁱ	D4A287
TreeFamⁱ	TF322733

Gene expression databases

Bgeeⁱ	ENSRNOG00000021745 Expressed in 8 organ(s), highest expression level in brain

Bgeeⁱ

ENSRNOG00000021745 Expressed in 8 organ(s), highest expression level in brain

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR032654 Bhlhe22 IPR036638 HLH_DNA-bd_sf
PANTHERⁱ	PTHR19290:SF52 PTHR19290:SF52, 1 hit
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D4A287_RAT
Accessionⁱ	D4A287Primary (citable) accession number: D4A287
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 20, 2010
	Last sequence update:	April 20, 2010
	Last modified:	November 7, 2018
	This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D4A287 (D4A287_RAT)

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Basic helix-loop-helix family, member e22

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ