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UniProtKB - D4A287 (D4A287_RAT)
Protein
Class E basic helix-loop-helix protein 22
Gene
Bhlhe22
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- chromatin binding Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
- identical protein binding Source: RGD
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- anterior commissure morphogenesis Source: RGD
- central nervous system projection neuron axonogenesis Source: RGD
- cerebral cortex regionalization Source: RGD
- corpus callosum morphogenesis Source: RGD
- corticospinal tract morphogenesis Source: RGD
- negative regulation of transcription, DNA-templated Source: RGD
- neuron differentiation Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- retinal bipolar neuron differentiation Source: RGD
- retina morphogenesis in camera-type eye Source: RGD
Keywordsi
Molecular function | RepressorARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Class E basic helix-loop-helix protein 22ARBA annotationAlternative name(s): Class B basic helix-loop-helix protein 5ARBA annotation |
Gene namesi | ORF Names:rCG_41654Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1305451, Bhlhe22 |
Subcellular locationi
Nucleus
- nucleus Source: RGD
Keywords - Cellular componenti
NucleusARBA annotationPTM / Processingi
Proteomic databases
PaxDbi | D4A287 |
PTM databases
iPTMneti | D4A287 |
PhosphoSitePlusi | D4A287 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000021745, Expressed in brain and 18 other tissues |
Interactioni
GO - Molecular functioni
- identical protein binding Source: RGD
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000038593 |
Family & Domainsi
Phylogenomic databases
eggNOGi | KOG3898, Eukaryota |
GeneTreei | ENSGT00940000162962 |
HOGENOMi | CLU_070971_0_0_1 |
InParanoidi | D4A287 |
OMAi | SDGRCDM |
PhylomeDBi | D4A287 |
TreeFami | TF322733 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR032654, Bhlhe22 IPR036638, HLH_DNA-bd_sf |
PANTHERi | PTHR19290:SF52, PTHR19290:SF52, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
D4A287-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERGLHLGAA AASEDDLFLH KSLGASAAKR LEAAFRSTPP GMDLSLAPPT
60 70 80 90 100
RERPASSSSP LGCFEPADPE GAGLLLPPPG GGGGASGGGV SVPGLLVGSA
110 120 130 140 150
GVGGEPSLSS LPAGAALCLK YGESAGRGSV AESSGGEQSP DDDSDGRCEL
160 170 180 190 200
VLRAGGPDPR ASPGAGSGGA KVAEGCSNAH LHGGSGLPPG GPTSGSGGNG
210 220 230 240 250
GGGSSKKSKE QKALRLNINA RERRRMHDLN DALDELRAVI PYAHSPSVRK
260 270 280 290 300
LSKIATLLLA KNYILMQAQA LEEMRRLVAY LNQGQAISAA SLPSSAAAAA
310 320 330 340 350
AAAALHPALG AYEQAAGYPF SAGLPPAASC PEKCALFNSV SSSLCKQCTE
KP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473961 Genomic DNA Translation: EDM01053.1 |
Genome annotation databases
Ensembli | ENSRNOT00000033940.5; ENSRNOP00000038593.4; ENSRNOG00000021745.5 |
UCSCi | RGD:1305451, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473961 Genomic DNA Translation: EDM01053.1 |
3D structure databases
AlphaFoldDBi | D4A287 |
SMRi | D4A287 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000038593 |
PTM databases
iPTMneti | D4A287 |
PhosphoSitePlusi | D4A287 |
Proteomic databases
PaxDbi | D4A287 |
Genome annotation databases
Ensembli | ENSRNOT00000033940.5; ENSRNOP00000038593.4; ENSRNOG00000021745.5 |
UCSCi | RGD:1305451, rat |
Organism-specific databases
RGDi | 1305451, Bhlhe22 |
Phylogenomic databases
eggNOGi | KOG3898, Eukaryota |
GeneTreei | ENSGT00940000162962 |
HOGENOMi | CLU_070971_0_0_1 |
InParanoidi | D4A287 |
OMAi | SDGRCDM |
PhylomeDBi | D4A287 |
TreeFami | TF322733 |
Gene expression databases
Bgeei | ENSRNOG00000021745, Expressed in brain and 18 other tissues |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR032654, Bhlhe22 IPR036638, HLH_DNA-bd_sf |
PANTHERi | PTHR19290:SF52, PTHR19290:SF52, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | D4A287_RAT | |
Accessioni | D4A287Primary (citable) accession number: D4A287 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | May 25, 2022 | |
Last modified: | May 25, 2022 | |
This is version 75 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |