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Entry version 62 (05 Jun 2019)
Sequence version 2 (03 Apr 2013)
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Protein
Submitted name:

CST telomere replication complex component 1

Gene

Ctc1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CST telomere replication complex component 1Imported
Submitted name:
Similar to novel protein (Predicted), isoform CRA_bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ctc1Imported
Synonyms:RGD1563106_predictedImported
ORF Names:rCG_34808Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Rat genome database

More...
RGDi
1563106 Ctc1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
D4A261

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000005357 Expressed in 10 organ(s), highest expression level in testis

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000007447

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
D4A261

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGVR Eukaryota
ENOG410Y8V3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011553

KEGG Orthology (KO)

More...
KOi
K23311

Identification of Orthologs from Complete Genome Data

More...
OMAi
FLWTLCT

Database of Orthologous Groups

More...
OrthoDBi
163417at2759

TreeFam database of animal gene trees

More...
TreeFami
TF335866

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029156 CTC1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15489 CTC1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D4A261-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAACRAQPPT SEEAWLEAAQ AFIQETLCPV DEEPNEQVTR SVIDCVKETW
60 70 80 90 100
LSQGENQDLT LPLSYSFVSV QNLKTNQHLP CCSHLSWSDN AYQAWTRGAG
110 120 130 140 150
PGGSVLPREQ LLLLGTLVDL LGDLEQESRS GGLYVRDNTG TLDCELIDLD
160 170 180 190 200
LSWLGHLFLF PSWSYLPPAK RNSLGAGHLE LWGTPVPVFP LTVSPGPLTP
210 220 230 240 250
IPVLYPEKAS YLLRYRKKCK IKELNLAGKL VHLSALMVTQ NKRYFIMTLG
260 270 280 290 300
ELAQAGSQVS VIVQIPAQMV WHRVLRPGRA YVLTKLRITK TRGHRSCIWT
310 320 330 340 350
TIPSSTLMPL RPGYVQELEL DVAFADAGHK PLPEPTSSRD SRGQEGLVRG
360 370 380 390 400
SKVLHYLGTV TDVLNESASL YILDGQLILC LAYQKIHGLR RVIRPGVCLE
410 420 430 440 450
LRDVHLLQGL GGGTTKPVLA LCLHGTVRLQ GFSCLKPQNL PSYKVHGASL
460 470 480 490 500
YEQLVWKCQL GLPLYLWATK ALEELVYKLC PHVLRCQQFL KHSSPGKPSL
510 520 530 540 550
GLQLLAPSWD VLIPPGSPIR HAHSEILEEP HNCPLQKYTP LQTPYTFPTI
560 570 580 590 600
LALAEEGQHR AWATFDPRAL LPFPEAFHLT SCQLNRRLAW SWLCLPSSMF
610 620 630 640 650
QPAPVLLGVL VASSHKGCLQ LRDVRGSLPC IPLPESSQPL IDPKLIGCLV
660 670 680 690 700
RVEKFQLVVE REVRSSFPSW EELGMASLIQ KKQARVYVQF YLADALILPV
710 720 730 740 750
PRPTVGLEPS ETASSCPEGP QVGQSRLFLL FYKEALMKRN FCLLPGDSSR
760 770 780 790 800
PAEPTLSFRV SGTWLCGTQK REGSGWSPPE SLAAENKDQK VFFIFLGSSV
810 820 830 840 850
QWFPFLYPNQ VYRLVAPDST PALFETNHSS GTPHRPLELT DYVSCLTIQE
860 870 880 890 900
DWTLELGSSQ DIPNVLEVPR TLSESSLAHL LSDNSPNFLV SFSAEVLSRI
910 920 930 940 950
LCEPPLALRR IKPGNAGAIK AGVKLTVALE MEDCDYPPHL DIYIEDPHLP
960 970 980 990 1000
PPIGLLPGAR VHFSQLEKKI SRSNVVYCCF RSTTSVQVLS FPPETKASAP
1010 1020 1030 1040 1050
LPHICLAELL QGDRPPFQAT TSCHIVYVLS LQILWVCAHC TSICPQGKCS
1060 1070 1080 1090 1100
RQDPSCPSQR AISQASIRLL VEDGTAEATV TCRNHHVATT LGLSPSEWSN
1110 1120 1130 1140 1150
VLDRARGPGR VALQFKGPGA QTESASKTGE PLTLLLQTLC TSPFVLRPIK
1160 1170 1180 1190 1200
LSFALERRPC DITPIEPPRL QQFQCGELPL LTRVNPRLRL VCLSLQEPEL
1210
PSPPQASAAA S
Length:1,211
Mass (Da):133,912
Last modified:April 3, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF05855F9DC37435D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC129753 Genomic DNA No translation available.
CH473948 Genomic DNA Translation: EDM04832.1

NCBI Reference Sequences

More...
RefSeqi
NP_001100480.1, NM_001107010.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000007447; ENSRNOP00000007447; ENSRNOG00000005357

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
303238

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:303238

UCSC genome browser

More...
UCSCi
RGD:1563106 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129753 Genomic DNA No translation available.
CH473948 Genomic DNA Translation: EDM04832.1
RefSeqiNP_001100480.1, NM_001107010.1

3D structure databases

SMRiD4A261
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007447

Proteomic databases

PRIDEiD4A261

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007447; ENSRNOP00000007447; ENSRNOG00000005357
GeneIDi303238
KEGGirno:303238
UCSCiRGD:1563106 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80169
RGDi1563106 Ctc1

Phylogenomic databases

eggNOGiENOG410IGVR Eukaryota
ENOG410Y8V3 LUCA
GeneTreeiENSGT00390000011553
KOiK23311
OMAiFLWTLCT
OrthoDBi163417at2759
TreeFamiTF335866

Gene expression databases

BgeeiENSRNOG00000005357 Expressed in 10 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR029156 CTC1
PfamiView protein in Pfam
PF15489 CTC1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD4A261_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4A261
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: June 5, 2019
This is version 62 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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