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Entry version 68 (16 Jan 2019)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

RIC1 homolog, RAB6A GEF complex partner 1

Gene

Ric1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-6811438 Intra-Golgi traffic
R-RNO-6811440 Retrograde transport at the Trans-Golgi-Network
R-RNO-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
RIC1 homolog, RAB6A GEF complex partner 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ric1Imported
Synonyms:RGD1310016Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

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RGDi
1310016 Ric1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D4A224

PeptideAtlas

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PeptideAtlasi
D4A224

PRoteomics IDEntifications database

More...
PRIDEi
D4A224

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D4A224

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
D4A224

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000016172 Expressed in 9 organ(s), highest expression level in lung

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000021783

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini734 – 986RIC1InterPro annotationAdd BLAST253

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2006 Eukaryota
ENOG410XT5J LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002955

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D4A224

KEGG Orthology (KO)

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KOi
K20476

Identification of Orthologs from Complete Genome Data

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OMAi
LLVYTYD

Database of Orthologous Groups

More...
OrthoDBi
261419at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D4A224

TreeFam database of animal gene trees

More...
TreeFami
TF105927

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011044 Quino_amine_DH_bsu
IPR009771 Ribosome_control_1
IPR040096 Ric1
IPR015943 WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR22746 PTHR22746, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07064 RIC1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50969 SSF50969, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D4A224-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYFLSGWPKR LLCAPRSPAE APLHVQSDPR RAFFAVLAPA RLSIWYSRPS
60 70 80 90 100
VLIVTYKEPA KSSAQFGSYT QAEWRPNSTM IAVSTANGYI LFFHITSSRG
110 120 130 140 150
DKYLYEPVYP KGSPQMKGIP HFKEEHCAPA LNLEMKKILD LQAPIMSLQS
160 170 180 190 200
VLEDLLVATS DGLLHLIHWE GMTNGRKAIN LSTVPFSVDL QSSRVGSFLG
210 220 230 240 250
FADVHIKDME YCATLDGFAV VFNDGKVGFI TPVSSRFTAE QLHGVWPQDV
260 270 280 290 300
VDGTCVAVNN KYRLMAFGCA SGSVQVYTID NTTGAMLLSH KLELTAKQYP
310 320 330 340 350
DIWNKTGAVK LIRWSPDNSA VIVTWEYGGL SLWSVFGAQL ICTLGGDFAY
360 370 380 390 400
RSDGTKKDPL KINSMSWGAE GYHLWVISEF GSQHTQTDTD LGSAVKEPSI
410 420 430 440 450
LLFQFIKSVL TVNPCMSNQE QVLLQGEDRL YLNCGEASQT QNLKYSSARA
460 470 480 490 500
EHMPRHEKSP FADGGLESPG LSTLLGHRHW HVVQISSTYL ESNWPIRFSA
510 520 530 540 550
IDKLGQNIAV AGKFGFAHYS LLTKKWKLFG NITQEQNMIV TGGLAWWNDF
560 570 580 590 600
MVLACYNLSD RQEELRIYLR TSNLDNAFAH VTKAPIETLL LSVFRDMVVV
610 620 630 640 650
FRADCSICLY SIERKSDGSS TTASVQVLQE VSMSRYIPHP FLVVSVTLTS
660 670 680 690 700
VSTENGITLK MPQQARDAES IMLNLAGQLI MMQRDRSGPQ IREKDSNPSQ
710 720 730 740 750
RKLLPFCPPV VLAQSVENVW TTCRANKQKR HLLEALWLSC GGAGMKVWLP
760 770 780 790 800
LFPRDHRKPH SFLSQRIMLP FHINIYPLAV LFEDALVLGA VNDTLLYDSL
810 820 830 840 850
YTRNSAREQL EVLFPFCVVE RTSQIYLHHI LRQLLVRNLG EQALLLAQSC
860 870 880 890 900
AALAYFPHVL ELMLHEVLEE EASSREPIPD PLLPTVAKFI SEFPLFLQTV
910 920 930 940 950
VHCARKTEYA LWNYLFAAVG NPKDLFEECL MAQDLDTAAS YLIILQNMEV
960 970 980 990 1000
PAVSRQHATL LFNTALEQGK WDLCRHMIRF LKAIGSGESE TPPSTPTSQE
1010 1020 1030 1040 1050
PSSSGGFEFF RNRSISLSQS AENVPPGKFG LQKTLSMPTG PSGKRWSKDS
1060 1070 1080 1090 1100
DCAENMYIDM MLWRHARRLL EDVRLKDLGC FAAQLGFELI SWLCKERTRA
1110 1120 1130 1140 1150
ARVDNFVVAL KRLHKDFLWP LPIIPASSIS SPFKNGKCRA VGEQLLKSQS
1160 1170 1180 1190 1200
ADPFLTPEMD AGISTIQRSQ SWLSSIGPTH RDADIASSPG PQMQDAFLSP
1210 1220 1230 1240 1250
LSNRGDECSI GSATDLTESS SMVDGDWTMV DENFSTLSLT QSELEHISME
1260 1270 1280 1290 1300
LASKGPHKSQ VQLRYLLHIF MEAGCLDWCV VIGLILKESS VVSQILGIAQ
1310 1320 1330 1340 1350
SSEIDGEMLQ NIKAGLHAVD RWASTDCPGY KPFLNIIKPQ LQKLSEITEE
1360 1370 1380 1390 1400
LVQPDTFQPI TVGKSPEQTS PRAEESRGSS SHGSITQSET GSNNSMVSRK
1410 1420
EEDTTQADEE EPFQDGAYDC SVS
Length:1,423
Mass (Da):158,654
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA1AC33DE6F7350A0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07072041 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
XP_001079614.4, XM_001079614.5
XP_219778.5, XM_219778.9

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000021783; ENSRNOP00000021783; ENSRNOG00000016172

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
309306

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:309306

UCSC genome browser

More...
UCSCi
RGD:1310016 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072041 Genomic DNA No translation available.
RefSeqiXP_001079614.4, XM_001079614.5
XP_219778.5, XM_219778.9

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021783

PTM databases

iPTMnetiD4A224
PhosphoSitePlusiD4A224

Proteomic databases

PaxDbiD4A224
PeptideAtlasiD4A224
PRIDEiD4A224

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021783; ENSRNOP00000021783; ENSRNOG00000016172
GeneIDi309306
KEGGirno:309306
UCSCiRGD:1310016 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57589
RGDi1310016 Ric1

Phylogenomic databases

eggNOGiKOG2006 Eukaryota
ENOG410XT5J LUCA
GeneTreeiENSGT00390000002955
InParanoidiD4A224
KOiK20476
OMAiLLVYTYD
OrthoDBi261419at2759
PhylomeDBiD4A224
TreeFamiTF105927

Enzyme and pathway databases

ReactomeiR-RNO-6811438 Intra-Golgi traffic
R-RNO-6811440 Retrograde transport at the Trans-Golgi-Network
R-RNO-8876198 RAB GEFs exchange GTP for GDP on RABs

Gene expression databases

BgeeiENSRNOG00000016172 Expressed in 9 organ(s), highest expression level in lung

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR011044 Quino_amine_DH_bsu
IPR009771 Ribosome_control_1
IPR040096 Ric1
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22746 PTHR22746, 1 hit
PfamiView protein in Pfam
PF07064 RIC1, 1 hit
SUPFAMiSSF50969 SSF50969, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD4A224_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4A224
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: January 16, 2019
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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