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Entry version 93 (29 Sep 2021)
Sequence version 1 (20 Apr 2010)
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Protein

Methenyltetrahydrofolate cyclohydrolase

Gene

Mthfd2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseARBA annotation
Biological processOne-carbon metabolismARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-196757, Metabolism of folate and pterines

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methenyltetrahydrofolate cyclohydrolaseARBA annotation (EC:3.5.4.9ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mthfd2Imported
ORF Names:rCG_56426Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Rat genome database

More...
RGDi
1311313, Mthfd2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
D4A1Y5

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D4A1Y5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000010833, Expressed in pancreas and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000014603

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D4A1Y5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 154THF_DHG_CYHInterPro annotationAdd BLAST117
Domaini157 – 329THF_DHG_CYH_CInterPro annotationAdd BLAST173

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0089, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154863

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_034045_0_1_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
WSKKTCE

Database of Orthologous Groups

More...
OrthoDBi
1004679at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D4A1Y5

TreeFam database of animal gene trees

More...
TreeFami
TF323998

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01080, NAD_bind_m-THF_DH_Cyclohyd, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01576, THF_DHG_CYH, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036291, NAD(P)-bd_dom_sf
IPR000672, THF_DH/CycHdrlase
IPR020630, THF_DH/CycHdrlase_cat_dom
IPR020867, THF_DH/CycHdrlase_CS
IPR020631, THF_DH/CycHdrlase_NAD-bd_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00763, THF_DHG_CYH, 1 hit
PF02882, THF_DHG_CYH_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00085, THFDHDRGNASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735, SSF51735, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00766, THF_DHG_CYH_1, 1 hit
PS00767, THF_DHG_CYH_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D4A1Y5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSVSLSALA VRLLRPTHGC HSRLQSFHLA AVRNEAVVIS GRKLAQQIKQ
60 70 80 90 100
EVRQEVEEWV ASGNKRPHLS VILVGDNPAS HSYVLNKTRA AAEVGINSET
110 120 130 140 150
IVKPASVSEE ELLNSIRTLN DDENVDGLLV QLPLPEHIDE RKICNAVSPD
160 170 180 190 200
KDVDGFHVIN VGRMCLDQYS MLPATPWGVW EILKRTGIPT LGKNVVVAGR
210 220 230 240 250
SKNVGMPIAM LLHTDGAHER PGGDATVTIS HRHTPKEQLK KHTILADIVI
260 270 280 290 300
SAAGIPNLIT ADMIKEGATV IDVGINRVQD PVTAKPKLVG DVDFEGVKKK
310 320 330 340
AGYITPVPGG VGPMTVAMLM KNTIIAAKKV LRPEELEVLK STQRGVATN
Length:349
Mass (Da):37,717
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7B89D307DC81389
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC110623 Genomic DNA No translation available.
CH473957 Genomic DNA Translation: EDL91136.1

NCBI Reference Sequences

More...
RefSeqi
NP_001102868.1, NM_001109398.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000014603; ENSRNOP00000014603; ENSRNOG00000010833

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
680308

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:680308

UCSC genome browser

More...
UCSCi
RGD:1311313, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110623 Genomic DNA No translation available.
CH473957 Genomic DNA Translation: EDL91136.1
RefSeqiNP_001102868.1, NM_001109398.1

3D structure databases

SMRiD4A1Y5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014603

PTM databases

PhosphoSitePlusiD4A1Y5

Proteomic databases

PRIDEiD4A1Y5

Genome annotation databases

EnsembliENSRNOT00000014603; ENSRNOP00000014603; ENSRNOG00000010833
GeneIDi680308
KEGGirno:680308
UCSCiRGD:1311313, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10797
RGDi1311313, Mthfd2

Phylogenomic databases

eggNOGiKOG0089, Eukaryota
GeneTreeiENSGT00940000154863
HOGENOMiCLU_034045_0_1_1
OMAiWSKKTCE
OrthoDBi1004679at2759
PhylomeDBiD4A1Y5
TreeFamiTF323998

Enzyme and pathway databases

ReactomeiR-RNO-196757, Metabolism of folate and pterines

Gene expression databases

BgeeiENSRNOG00000010833, Expressed in pancreas and 20 other tissues

Family and domain databases

CDDicd01080, NAD_bind_m-THF_DH_Cyclohyd, 1 hit
HAMAPiMF_01576, THF_DHG_CYH, 1 hit
InterProiView protein in InterPro
IPR036291, NAD(P)-bd_dom_sf
IPR000672, THF_DH/CycHdrlase
IPR020630, THF_DH/CycHdrlase_cat_dom
IPR020867, THF_DH/CycHdrlase_CS
IPR020631, THF_DH/CycHdrlase_NAD-bd_dom
PfamiView protein in Pfam
PF00763, THF_DHG_CYH, 1 hit
PF02882, THF_DHG_CYH_C, 1 hit
PRINTSiPR00085, THFDHDRGNASE
SUPFAMiSSF51735, SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00766, THF_DHG_CYH_1, 1 hit
PS00767, THF_DHG_CYH_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD4A1Y5_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4A1Y5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 29, 2021
This is version 93 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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