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Protein
Submitted name:

Sacsin molecular chaperone

Gene

Sacs

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Sacsin molecular chaperoneImported
Gene namesi
Name:SacsImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1307281 Sacs

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiD4A1D3
PeptideAtlasiD4A1D3
PRIDEiD4A1D3

Expressioni

Gene expression databases

BgeeiENSRNOG00000014509 Expressed in 9 organ(s), highest expression level in brain

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4317 – 4404JInterPro annotationAdd BLAST88
Domaini4462 – 4578HEPNInterPro annotationAdd BLAST117

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili3517 – 3537Sequence analysisAdd BLAST21
Coiled coili4356 – 4376Sequence analysisAdd BLAST21
Coiled coili4520 – 4540Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IGIN Eukaryota
ENOG410XQZM LUCA
GeneTreeiENSGT00390000016695
InParanoidiD4A1D3
KOiK17592
OMAiCFKDAEE
OrthoDBiEOG091G007C
TreeFamiTF331145

Family and domain databases

Gene3Di1.10.287.110, 1 hit
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR036890 HATPase_C_sf
IPR007842 HEPN_dom
IPR036869 J_dom_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF05168 HEPN, 1 hit
SMARTiView protein in SMART
SM00748 HEPN, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF54236 SSF54236, 1 hit
SSF55874 SSF55874, 3 hits
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit
PS50910 HEPN, 1 hit

Sequencei

Sequence statusi: Complete.

D4A1D3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTEETRWVR VTVLRGCVGC RTVAVRATAT GRDLKERIFA ETGFPVAEQR
60 70 80 90 100
LWRGDREIPD WIKIGDLTSK TCLFVNLQSK GLKGGGRFGQ TTPPLVDFLK
110 120 130 140 150
DILRRYPEGG QILKELIQNA EDAGATEVKF LYDETQYGTE TLWSKDMAQY
160 170 180 190 200
QGSALYVYNN AVFTPEDWHG IQEIARSRKK DDPLKVGRFG IGFNSVYHIT
210 220 230 240 250
DVPCIFSGDQ IGMLDPHQTL FGPHESGQCW NLKDDIKEIN ELPDQFAPFI
260 270 280 290 300
GVFGSTKETF TNGSFPGTFF RFPLRLQPSQ LSSNLYTKQK VLELFDSFRA
310 320 330 340 350
DADTVLLFLK SVQAVSLHVR EADGTEKLVF RVTASENKTL KHERPNSIKI
360 370 380 390 400
LGTAISNYCK KIPSNSVTCV TYHINIALED ESTKDAQKTS WLVCNSVGGR
410 420 430 440 450
GISSKLDSLA DELKFVPIIG LAMSLSGRDE ENGATSDFSG KAFCFLPLPP
460 470 480 490 500
GEESRTGLPV HISGFFGLTD NRRSIKWREL DQWRDPAALW NQFLIVNVVP
510 520 530 540 550
KAYATLILDS IKRLETEKSS DFPLSVDAIY KLWPEASKVK AHWHPVLGPL
560 570 580 590 600
FSELFQHAVI YSVGGEWVKL EQVHFSELDE SLESTQSVLN YLQRSGKQIA
610 620 630 640 650
RVPGNLAAAV QLSAASATST ASPVRKVTPV WVRQVLRKCA HLGSAEEKLH
660 670 680 690 700
LLEFVLSDQA YSELLGLELL PLQSGAFVPF SSSVSDQDVV YITSEEFPRS
710 720 730 740 750
LFPGLEARLI LENLKPHLLA ALKEAAQTRA QQLLWGYSGR PCTQLQLLNP
760 770 780 790 800
ERFARLIKEV MNTFWPGREL VVQWYPLSED KHHPSISWLK MVWKNLYIHF
810 820 830 840 850
SEDLTLFDEM PLIPRTPLDA DQTCVELIRL RVPSVVILDD ETEAQLPEFL
860 870 880 890 900
ADIVQKLGGI VLKRLDTSLQ HPLVKKYIHS PLPSAILQIM EKIPLQKLCN
910 920 930 940 950
QIASLLPTHK DALRKFLASL TDTSEKEKRI IQELTIFKRI NHSSDQGISS
960 970 980 990 1000
YTKLKGCKVL DHTAKLPTEL RLSVSVIDSS DEATIRLANM LKIEKLKTTS
1010 1020 1030 1040 1050
CLKFVLKDIE NAFYTQEEVT RLMLWILENL SSLKNENPSV LDWLMPLKFI
1060 1070 1080 1090 1100
HMSQEHVVAA SDLFDPDIEV LRDLFYNEEE ACFPPAVFTS PDILHSLRQI
1110 1120 1130 1140 1150
GLKNEASLKE KDVVQVAKKI EALQVSSCQN QDVLLKKAKT LLLVLNKNHT
1160 1170 1180 1190 1200
LLQSSEGKMA LKKIKWVPAC KERPPNYPGS LVWKGDLCNL CAPPDMCDAA
1210 1220 1230 1240 1250
HAVLVGSSLP LVESAHVSLE KTLGIFTKPT ISAVLKHFKI VVDWYTSKTF
1260 1270 1280 1290 1300
SDEDYYQFQH ILLEIYGFMH DHLSEGKDSF KALKYPWVWT GKNFCPLAQA
1310 1320 1330 1340 1350
VIKPIHDLDL QPYLYNVPKT MAKFHQLFKA CGSIEELTSD HISMVIQKVY
1360 1370 1380 1390 1400
LKSDQELSEE ESKQNLHLML NIMRWLYSNQ IPASPNTPVP IYHSKNPSKL
1410 1420 1430 1440 1450
VMKPIHECCY CDIKVDDLND LLEDSVEPII LVHEDIPMKT AEWLKVPCLS
1460 1470 1480 1490 1500
TRLINPENMG FEQSGQREPL TVRIKNILEE YPSVSDIFKE LLQNADDANA
1510 1520 1530 1540 1550
TECSFMIDMR RNMDIRENLL DPGMAACHGP ALWSFNNSEF SDSDFINITR
1560 1570 1580 1590 1600
LGESLKRGEV DKVGKFGLGF NSVYHITDIP IIMSREFMIM FDPNINHISK
1610 1620 1630 1640 1650
HIKDRSNPGI KINWSKQQKR LRKFPNQFKP FIDVFGCQLP LAVEAPYSYN
1660 1670 1680 1690 1700
GTLFRLSFRT QQEAKVSEVS STCYNTADIY SLVDEFSLCG HRLIIFTQSV
1710 1720 1730 1740 1750
NSMYLKYLKI EETNPTLAQD TIIIKKKACP SKALNAPVLS VLKEAAKLMK
1760 1770 1780 1790 1800
TCSSSNKKLP TDVPKSSCIL QITVEEFHHV FRRIADLQSP LFRGPDDDPA
1810 1820 1830 1840 1850
TLFEMAKSGQ SKKPSDELPQ KTVDCTTWLI CTCMDTGEAL KFSLNESGRR
1860 1870 1880 1890 1900
LGLVPCGAVG VLLHETQEQK WTVKPHIGEV FCYLPLRIKT GLPIHINGCF
1910 1920 1930 1940 1950
AVTSNRKEIW KTDTKGRWNT TFMRHVIVKA YLQALSVLRD LAISGELIDY
1960 1970 1980 1990 2000
TYYAVWPDPD VVHDDFSVIC QGFYEDIAHG KGKDLTRVFS DGSMWVSMKN
2010 2020 2030 2040 2050
VRFLDDSILQ RKDVGSAAFK IFLKYLKKTG SKNLCAVELP SSVKVGFEEA
2060 2070 2080 2090 2100
GCKQILLENT FSEKQFFSEV FFPNIQEIEA ELRDPLMNFV LNEKLDEFSG
2110 2120 2130 2140 2150
ILRVTPCVPC SLEGHPLVLP SRLIHPEGRV AKLFDIKDGR FPYGSTQDYL
2160 2170 2180 2190 2200
NPIILIKLVQ LGMAKDDILW DDMLERAESV AEINKSDHAA ACLRSSILLS
2210 2220 2230 2240 2250
LIDEKLKIRD PRAKDFAAKY QTIPFLPFLT KPAGFSLEWK GNSFKPETMF
2260 2270 2280 2290 2300
AATDLYTAEY QDIVCLLQPI LNENSHSFRG CGSVSLAVKE FLGLLKKPTV
2310 2320 2330 2340 2350
DLVINQLKQV AKSVDDGITL YQENITNACY KYLHEAILQN EMAKATIIEK
2360 2370 2380 2390 2400
LKPFCFILVE NVYVESEKVS FHLNFEAAPY LYQLPNKYKN NFRELFESVG
2410 2420 2430 2440 2450
VRQSFTVEDF ALVLESIDQE RGKKQITEEN FQLCRRIISE GIWSLIREKR
2460 2470 2480 2490 2500
QEFCEKNYGK ILLPDTNLLL LPAKSLCYND CPWIKVKDSS VKYCHADIPR
2510 2520 2530 2540 2550
EVAVKLGAIP KRHKALERYA SNICFTAPGT EFGQKEKLTS RIKSILNAYP
2560 2570 2580 2590 2600
SEKEMLKELL QNADDAKATE ICFVFDPRQH PVDRIFDDKW APLQGPALCV
2610 2620 2630 2640 2650
YNNQPFTEDD VRGIQNLGKG TKEGNPCKTG QYGIGFNSVY HITDCPSFIS
2660 2670 2680 2690 2700
GNDILCIFDP HARYAPGATS VSPGRMFRDL DADFRTQFSD VLDLYLGNHF
2710 2720 2730 2740 2750
KLDNCTMFRF PLRNAEMAQV SEISSVPSSD RMVQNLLDKL RSDGAELLMF
2760 2770 2780 2790 2800
LNHMEKISIC EIDKATGGLN VLYSVKGKIT DGDRLKRKQF HASVIDSVTK
2810 2820 2830 2840 2850
KRQLKDIPVQ QITYTMDTED SEGNLTTWLI CNRSGFSSMD KVSKSVISAH
2860 2870 2880 2890 2900
RNQDITLFPR GGVAACITHN YKKPHRAFCF LPLSLETGLP FHVNGHFALD
2910 2920 2930 2940 2950
SARRNLWRDD NGVGVRSDWN NSLMTALIAP AYVELLIQLK KRYFPGSDPT
2960 2970 2980 2990 3000
LSVLQNTPIH VVKDTLKKFL SFFPVNRLDL QPDLYCLVKA LYSCIHEDMK
3010 3020 3030 3040 3050
RLLPVVRAPN IDGSDLHSAV IITWINMSTS NKTKPFFDNL LQDELQHLKN
3060 3070 3080 3090 3100
ADYNITTRKT VAENVYRLKH LLLEIGFNLV YNCDETANLY HCLVDAAIPV
3110 3120 3130 3140 3150
SYVTPADVRS FLMTFSSPDT NCHIGKLPCR LQQTNLKLFH SLKLLVDYCF
3160 3170 3180 3190 3200
KDAEESEFEV EGLPLLITLD SVLQIFDGKR PKFLTTYHEL IPSRKDLFMN
3210 3220 3230 3240 3250
TLYLKYSSVL LNCKVAKVFD ISSFADLLSS VLPREYKTKN CAKWKDNFAS
3260 3270 3280 3290 3300
ESWLKNAWHF ISESVSVTDD QEEPKPAFDV IVDILKDWAL LPGTKFTVSA
3310 3320 3330 3340 3350
SQLVVPEGDV LIPLSLMHIA VFPNAQSDKV FHALMKAGCI QLALNKICSK
3360 3370 3380 3390 3400
DSALVPLLSC HTANIDSPAS ILKAVHYMVQ TSTFRTEKLV ENDFEALLMY
3410 3420 3430 3440 3450
FNCNLSHLMS QDDLKILKSL PCYKSISGRY MSIAKFGTCY VLTKSIPSAE
3460 3470 3480 3490 3500
VEKWTQSSSS AFLEEKVHLK ELYEVLGCVP VDDLEVYLKH LLPKIENLSY
3510 3520 3530 3540 3550
DAKLEHLIYL KNRLASIEEL SETKEQLFEK LESLLIIHDA NNRLKQAKHF
3560 3570 3580 3590 3600
YDRTVRVFEV MLPEKLFIPK EFFKKLEQVI KPKNQVVFMT SWVEFLRNIG
3610 3620 3630 3640 3650
LKHVLSQQQL LQFAKEISVR ANTENWSKET LQNTVDILLH HIFQERTDLL
3660 3670 3680 3690 3700
SGNFLKELSL IPFLCPERAP AEYIRFHPQY QEVNGTLPLI KFNGAQVNPK
3710 3720 3730 3740 3750
FKQCDVLQLL WTSCPILPEK ATPLSIKEQE GSSLAPQEQL EQVLNMLNVN
3760 3770 3780 3790 3800
LDPPLDKVIN NCRNICNITT LDEEMVKTRA KVLRSIYEFL SAEKREFRFQ
3810 3820 3830 3840 3850
LRGVAFVMVE DGWKLLKPEE VVINLEYEAD FKPYLYKLPL ELGTFHQLFK
3860 3870 3880 3890 3900
HLGTEDIIST KQYVEVLSRI FKNSEGKQLD PNEMRTVKRV VSGLFKSLQN
3910 3920 3930 3940 3950
DSVKVRSDLE NARDLALYLP SQDGRLVKSS ILVFDDAPHY KSRIQGNIGV
3960 3970 3980 3990 4000
QMLVDLSQCY LGKDHGFHTK LIMLFPQKLR PRLLSSILEE QLDEETPKVC
4010 4020 4030 4040 4050
QFGALCSLQG RLQLLLSSEQ FITGLIRIMK HENDNAFLAN EEKAIRLCKA
4060 4070 4080 4090 4100
LREGLKVSCF EKLQTTLRVK GFNPIPHSRS ETFAFLKRFG NAVILLYIQH
4110 4120 4130 4140 4150
SDSKDINFLL ALAMTLKSAT DNLISDTSYL IAMLGCNDIY RISEKLDSLG
4160 4170 4180 4190 4200
VKYDSSEPSK LELPMPGTPI PAEIHYTLLM DPMNVFYPGE YVGYLVDAEG
4210 4220 4230 4240 4250
GDIYGSYQPT YTYAIIVQEV EREDADNASF LGKIYQIDIG YSEYKIVSSL
4260 4270 4280 4290 4300
DLYKFSRPDE SSQSRDSAPT TPTSPTEFLT PGLRSIPPLF SGKESHKPAS
4310 4320 4330 4340 4350
SKHHSPRKLK VNALPEILKE VTSVVEQAWK LPESERKKII RRLYLKWHPD
4360 4370 4380 4390 4400
KNPENHDIAN EVFKHLQNEI NRLEKQAFLD QNADRASRRT FSTSASRFQS
4410 4420 4430 4440 4450
DKYSFQRFYT SWNQEATSHK SERQQQSKEK CPPSAGQTYS QRFFVPPTFK
4460 4470 4480 4490 4500
SVGNPVEARR WLRQARANFS AARNDLHKNA NEWVCFKCYL STKLALIAAD
4510 4520 4530 4540 4550
YAVRGKSDKD VKPTALAQKI EEYSQQLEGL TNDVHTLEAY GVDSLKTRYP
4560 4570 4580 4590
DLLPFPQIPN DRFTSEVAMR VMECTACIII KLENFIQQKV
Length:4,590
Mass (Da):521,482
Last modified:July 22, 2015 - v2
Checksum:i3CD7B68B7335182B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07018124 Genomic DNA No translation available.
RefSeqiXP_006222035.1, XM_006221973.3
XP_006252229.1, XM_006252167.3

Genome annotation databases

EnsembliENSRNOT00000019551; ENSRNOP00000019551; ENSRNOG00000014509
GeneIDi305940
KEGGirno:305940

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07018124 Genomic DNA No translation available.
RefSeqiXP_006222035.1, XM_006221973.3
XP_006252229.1, XM_006252167.3

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiD4A1D3
PeptideAtlasiD4A1D3
PRIDEiD4A1D3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019551; ENSRNOP00000019551; ENSRNOG00000014509
GeneIDi305940
KEGGirno:305940

Organism-specific databases

CTDi26278
RGDi1307281 Sacs

Phylogenomic databases

eggNOGiENOG410IGIN Eukaryota
ENOG410XQZM LUCA
GeneTreeiENSGT00390000016695
InParanoidiD4A1D3
KOiK17592
OMAiCFKDAEE
OrthoDBiEOG091G007C
TreeFamiTF331145

Gene expression databases

BgeeiENSRNOG00000014509 Expressed in 9 organ(s), highest expression level in brain

Family and domain databases

Gene3Di1.10.287.110, 1 hit
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR036890 HATPase_C_sf
IPR007842 HEPN_dom
IPR036869 J_dom_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF05168 HEPN, 1 hit
SMARTiView protein in SMART
SM00748 HEPN, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF54236 SSF54236, 1 hit
SSF55874 SSF55874, 3 hits
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit
PS50910 HEPN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD4A1D3_RAT
AccessioniPrimary (citable) accession number: D4A1D3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: November 7, 2018
This is version 64 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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