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Entry version 76 (26 Feb 2020)
Sequence version 2 (22 Jul 2015)
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Protein
Submitted name:

Marker of proliferation Ki-67

Gene

Mki67

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Marker of proliferation Ki-67Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mki67Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
1305476 Mki67

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
D4A0Y6

PeptideAtlas

More...
PeptideAtlasi
D4A0Y6

PRoteomics IDEntifications database

More...
PRIDEi
D4A0Y6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D4A0Y6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D4A0Y6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000028137 Expressed in colon and 9 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000067150

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D4A0Y6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 76FHAInterPro annotationAdd BLAST50

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni98 – 354DisorderedSequence analysisAdd BLAST257
Regioni369 – 434DisorderedSequence analysisAdd BLAST66
Regioni473 – 574DisorderedSequence analysisAdd BLAST102
Regioni618 – 653DisorderedSequence analysisAdd BLAST36
Regioni706 – 745DisorderedSequence analysisAdd BLAST40
Regioni760 – 830DisorderedSequence analysisAdd BLAST71
Regioni850 – 902DisorderedSequence analysisAdd BLAST53
Regioni985 – 1030DisorderedSequence analysisAdd BLAST46
Regioni1073 – 1206DisorderedSequence analysisAdd BLAST134
Regioni1249 – 1326DisorderedSequence analysisAdd BLAST78
Regioni1371 – 1448DisorderedSequence analysisAdd BLAST78
Regioni1492 – 1569DisorderedSequence analysisAdd BLAST78
Regioni1613 – 1689DisorderedSequence analysisAdd BLAST77
Regioni1733 – 1810DisorderedSequence analysisAdd BLAST78
Regioni1855 – 1931DisorderedSequence analysisAdd BLAST77
Regioni1975 – 2024DisorderedSequence analysisAdd BLAST50
Regioni2150 – 2291DisorderedSequence analysisAdd BLAST142
Regioni2303 – 2346DisorderedSequence analysisAdd BLAST44
Regioni2505 – 2568DisorderedSequence analysisAdd BLAST64
Regioni2644 – 2765DisorderedSequence analysisAdd BLAST122
Regioni2870 – 3099DisorderedSequence analysisAdd BLAST230

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili910 – 930Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi98 – 143PolyampholyteSequence analysisAdd BLAST46
Compositional biasi171 – 191PolyampholyteSequence analysisAdd BLAST21
Compositional biasi205 – 228PolarSequence analysisAdd BLAST24
Compositional biasi229 – 271PolyampholyteSequence analysisAdd BLAST43
Compositional biasi272 – 291PolarSequence analysisAdd BLAST20
Compositional biasi319 – 336PolyampholyteSequence analysisAdd BLAST18
Compositional biasi623 – 637BasicSequence analysisAdd BLAST15
Compositional biasi638 – 653PolarSequence analysisAdd BLAST16
Compositional biasi706 – 742PolarSequence analysisAdd BLAST37
Compositional biasi760 – 814PolarSequence analysisAdd BLAST55
Compositional biasi815 – 830PolyampholyteSequence analysisAdd BLAST16
Compositional biasi854 – 871PolarSequence analysisAdd BLAST18
Compositional biasi872 – 895PolyampholyteSequence analysisAdd BLAST24
Compositional biasi985 – 1001PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1002 – 1016PolarSequence analysisAdd BLAST15
Compositional biasi1078 – 1092PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1115 – 1135PolarSequence analysisAdd BLAST21
Compositional biasi1152 – 1193PolarSequence analysisAdd BLAST42
Compositional biasi1256 – 1271PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1272 – 1306PolarSequence analysisAdd BLAST35
Compositional biasi1377 – 1392PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1393 – 1427PolarSequence analysisAdd BLAST35
Compositional biasi1498 – 1513PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1514 – 1548PolarSequence analysisAdd BLAST35
Compositional biasi1619 – 1634PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1635 – 1669PolarSequence analysisAdd BLAST35
Compositional biasi1740 – 1756PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1757 – 1790PolarSequence analysisAdd BLAST34
Compositional biasi1861 – 1876PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1877 – 1911PolarSequence analysisAdd BLAST35
Compositional biasi1982 – 1997PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1998 – 2024PolarSequence analysisAdd BLAST27
Compositional biasi2206 – 2220PolarSequence analysisAdd BLAST15
Compositional biasi2221 – 2236PolyampholyteSequence analysisAdd BLAST16
Compositional biasi2237 – 2270PolarSequence analysisAdd BLAST34
Compositional biasi2309 – 2346PolarSequence analysisAdd BLAST38
Compositional biasi2520 – 2534PolyampholyteSequence analysisAdd BLAST15
Compositional biasi2535 – 2553PolarSequence analysisAdd BLAST19
Compositional biasi2699 – 2718PolarSequence analysisAdd BLAST20
Compositional biasi2719 – 2735PolyampholyteSequence analysisAdd BLAST17
Compositional biasi2918 – 2995PolyampholyteSequence analysisAdd BLAST78
Compositional biasi2996 – 3029PolarSequence analysisAdd BLAST34
Compositional biasi3032 – 3047PolyampholyteSequence analysisAdd BLAST16
Compositional biasi3059 – 3099PolyampholyteSequence analysisAdd BLAST41

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JR7C Eukaryota
ENOG410ZXYW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154352

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000534_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D4A0Y6

KEGG Orthology (KO)

More...
KOi
K17582

Identification of Orthologs from Complete Genome Data

More...
OMAi
GNSTGHK

Database of Orthologous Groups

More...
OrthoDBi
290017at2759

TreeFam database of animal gene trees

More...
TreeFami
TF336000

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00060 FHA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000253 FHA_dom
IPR012568 KI67R
IPR029334 PP1-bd
IPR008984 SMAD_FHA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00498 FHA, 1 hit
PF08065 KI67R, 15 hits
PF15276 PP1_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00240 FHA, 1 hit
SM01295 K167R, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49879 SSF49879, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D4A0Y6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSARLVTI KRSGDDGAHF PLSLSSCLFG RSIECDIRIQ LPVVSKKHCK
60 70 80 90 100
IEVKEQEAIL YNFSSANPTQ VNGTIINEPV QLKHGDIITI IDRSFRYEDG
110 120 130 140 150
SHDGSRPTEF PRKSLGKEPA RRASRDTISA DPDGKDQDTK ASKMTASRRS
160 170 180 190 200
FVYAKGLSAD SPASDDSKDS VTQDSSGHVE QHDRRNLGEP TSGDLFKKFR
210 220 230 240 250
ATRSSYGDLK SSPAQSLSNS NKNESPFEKL YQSMKEELDV KSEKSHRKSE
260 270 280 290 300
PQFDRAAEES WETERLVSCK ARPKSSRSTP VTATSSPKVG KSWTERWRGG
310 320 330 340 350
VGPVQTPTET AKMKTPVQKA QQLKDEDSRV PGRRNSVNLD ESESAQAVHK
360 370 380 390 400
IVTPGKLVTR NQAAVKVGHV ASPANTPEHS SSKKRRSIPA DMEVPCAETQ
410 420 430 440 450
KRLSLTQCLA PGEKKSPKDS FSKPEKLGTV AKQTCSGITG LSSIDISNCG
460 470 480 490 500
DSINKSEGVP LKRRRVSFGG HLRPELFDEN LPPNTPLKRG ETPTKRKSLG
510 520 530 540 550
THSPAGLKKI IKERPPSPGK QESPGVTPPR TNDERRRSGR TSLASSGSKF
560 570 580 590 600
LYETDIPKKA GRKSGNLPAK RASISRSQHG ILQMICSKRR SGASEANLIV
610 620 630 640 650
AKSWADVVKL GVKQTQMKVV KHVPQKQTRK RQRRPSTPKK PTSSLHDQFT
660 670 680 690 700
TGHANSPCTI VIGRAQTEKA SMPARPYKML NNLMLNWKMD FSEDLSGLTE
710 720 730 740 750
MFKTPVKEKQ QQMSDVGSIL SDSENLSERQ LQGTNSEDTP PPTASEILGE
760 770 780 790 800
KVLLSTQNAA KQQSNKYSAS STLRRQSIKH ENTVQTPKNV HNITQIEKKT
810 820 830 840 850
PASETEPLKT ASSMSKLRRS RELRHTLVKS KNEKTEAVLA KSITGRHLRK
860 870 880 890 900
TFQGQEVDQQ VQGSENSSQR CEENSKLSED SEKTSARRSS ARKQKLTKDL
910 920 930 940 950
VGSQMVTQSA DCAEDLLSQE QGTIQNLEES MYTQNTSKSD QGVAKQKVNT
960 970 980 990 1000
VVDATRVKRW SKTPVKMTHP LEGAADFTEH FETPDLKDEP IGDDETKVLC
1010 1020 1030 1040 1050
KSPQPKTENL KASAKPRTST SRRKVDRKEE LSAVTKLIHM SGESRHTPKV
1060 1070 1080 1090 1100
LKLEHGDIKA LRQSENEMLA ATVTGSKRPL EKAKEKAQPV EDLTGFEELF
1110 1120 1130 1140 1150
LSPVPGDKIT KMPSKSPHTE SVRTPASTKR LSTTGLSKVD VREEPATLGK
1160 1170 1180 1190 1200
RTKSSGRVTG TPAPAQEDND TTTFMETPKQ KLDFTGNSTG HKRRSQASKN
1210 1220 1230 1240 1250
RAQPLEDLDG FQELFQTPAA ARTPVTVDES AKVSLESVQP QLVITSASTK
1260 1270 1280 1290 1300
RLSKTGLSKV DVREEPSTLG KRTKSSDTVT GTPAPVQEEN NTMAFMQTPK
1310 1320 1330 1340 1350
QKLDFTGNST GHKRRSRASK NRAQPLEDLD GFQELFQTPA AASDPVTVDE
1360 1370 1380 1390 1400
SAKVSLESVQ PQLVITPAST KRLSKTGLSK VDVREEPSTL GKRTKSSDTV
1410 1420 1430 1440 1450
TGTPAPVQEE NNTTAFMQTP KQKLDFTGNS TGHKRRSRAS KNRAQPLEDL
1460 1470 1480 1490 1500
DGFQELFQTP AAASDPVTVD ESAKVSLESV QPQLVITPAS TKRLSKTGLS
1510 1520 1530 1540 1550
KVDVREEPST LGKRTKSSDT VTGTPAPVQD ENNTTAFMQT PKQKLDFTGN
1560 1570 1580 1590 1600
STGHKRRSRA SKNRAQPLED LDGFQELFQT PAAASDPVTV DESAKVSLES
1610 1620 1630 1640 1650
VQPQLVITPA STKRLSKTGL SKVDVREEPS TLGKRTKSSD TVTGTPAPVQ
1660 1670 1680 1690 1700
EENNTMAFMQ TPKQKLDFTG NSTGHKRRSR ASKNRAQPLE DLDGFQELFQ
1710 1720 1730 1740 1750
TPAAASDPVT VDESAKVSLE SVQPQLVITP ASTKRLSKTG LSKVDVREEP
1760 1770 1780 1790 1800
STLGKRRKSS DTVTGTPAPV QDENNTMAFM QTPKQKLDFT GNSTGHKRRS
1810 1820 1830 1840 1850
RASKNRAQPL EDLDGFQELF QTPAAASDPV TVDESAKVSL ESVQPQLVIT
1860 1870 1880 1890 1900
PASTKRLSKT GLSKVDVREE PSTLGKRTKS SDTVTGTPAP VQDENNTTAF
1910 1920 1930 1940 1950
MQTPKQKLDF TGNSTGHKRR SRASKNRAQP LEDLDGFQEL FQTPAAASDP
1960 1970 1980 1990 2000
VTVDESAKVS LESVQPQLVI TPASTKRLSK TGLSKVDVRE EPSTLGKRTK
2010 2020 2030 2040 2050
SSGRVTGTPA PVQEENNTTT FMETPKQKLE SLGDLTGLRK QSRTPKAKAQ
2060 2070 2080 2090 2100
YLEDISGFQE GFQTPDHANG PLAVGKTKKM SFISPQPGRP VRTQNNRKSL
2110 2120 2130 2140 2150
PKISLRQVDV TGGISVLGKQ SPGRALTAPV QADNGIKAIM ETPKETLATA
2160 2170 2180 2190 2200
ADLTGFTRPQ QTPKEKDQPL EDYGGFQELF QTPAGASDSV TVEESKKMPV
2210 2220 2230 2240 2250
ESLQPQPVRT PASTKRLSKT GLSKVDVREE PSTPGKRTKS SDTVTGTPAP
2260 2270 2280 2290 2300
VPEENDTTPF MQTPKQKLEF TGNSAGHKRR SRTPKTRAQP LEDLDGFQEL
2310 2320 2330 2340 2350
FQTPAGASDP VTVDESTKVS LESSQPLPVI TPASTKRLSK TPGQNKDLVT
2360 2370 2380 2390 2400
LDNLAKMPGS SPPPEPIDTS VISGRQLRTR LRNLYVKNEL SEDGMHPKMS
2410 2420 2430 2440 2450
GEIVDSSRAP GGEEKVIKAR KQCVKRKLDT AVNLPSSKRQ RIAGAEEPQT
2460 2470 2480 2490 2500
LEDLPGFQEL CQAPCLVMDS VIVDKTTKVP SKSPEPVDTT SEIKPRRRLK
2510 2520 2530 2540 2550
RLGVTEEPIP QRTTTRVLRQ TRNTHKEPID SSNGVDEFKE SSAQKQDPAI
2560 2570 2580 2590 2600
SLTGRRNQPR KVKEKTQPLE ELTSFQEEIA TRMSCKSPQP EEKKTLVGLK
2610 2620 2630 2640 2650
KQLRIQLFKV GVEEEPTAQR KQPARETRSR LKEPMGNRIN VEELKKSTEQ
2660 2670 2680 2690 2700
KIDPVASMTV SKRPRRIPKE KAQTVELAGL KGPIQTLGHT EESARDKEPT
2710 2720 2730 2740 2750
QMPCNSLQPE QVDSLQPSPR RPRTRHGKVE ADKPSAVRKT VPTSRQSVRS
2760 2770 2780 2790 2800
RKVTEIDDNG TKASKAPVKQ TLDTVAKETD SKRQLRTRKN GVQPLEVLGD
2810 2820 2830 2840 2850
SKEITQISDH SEKLRHDTNI LKSTLQQKPD SMKPLRKCRR VLRTSKEDPK
2860 2870 2880 2890 2900
EVLMDTSDLA ALQSKSNLYL SPPRKSARDG RILKTRTLCS VTPKQEATGE
2910 2920 2930 2940 2950
KPVHKKQRAA STKRQVSPEP VKVKHLRSVS HKRESVEEHI STIMQIEEME
2960 2970 2980 2990 3000
AKRENPVTPD QSSRYRKKTE KQPSPKFDAS AEKVGIKKNE KTMKISQETE
3010 3020 3030 3040 3050
PQNPDPGTKK SSSLGKVSGK RTCLRSRGQT EIPQPHEAEE KTRKSGAEIS
3060 3070 3080 3090 3100
IKTQQEKGVS GDPDVRRLRS RQTRVTLDNE PKPRVTRGAK KDAKTLKKDE
3110
DIVYTKILRT RSHQKSETV
Length:3,119
Mass (Da):343,351
Last modified:July 22, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i93AA5107CEAA3705
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07005944 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001258295.1, NM_001271366.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000038176; ENSRNOP00000038727; ENSRNOG00000028137

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
291234

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:291234

UCSC genome browser

More...
UCSCi
RGD:1305476 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07005944 Genomic DNA No translation available.
RefSeqiNP_001258295.1, NM_001271366.1

3D structure databases

SMRiD4A0Y6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067150

PTM databases

iPTMnetiD4A0Y6
PhosphoSitePlusiD4A0Y6

Proteomic databases

jPOSTiD4A0Y6
PeptideAtlasiD4A0Y6
PRIDEiD4A0Y6

Genome annotation databases

EnsembliENSRNOT00000038176; ENSRNOP00000038727; ENSRNOG00000028137
GeneIDi291234
KEGGirno:291234
UCSCiRGD:1305476 rat

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4288
RGDi1305476 Mki67

Phylogenomic databases

eggNOGiENOG410JR7C Eukaryota
ENOG410ZXYW LUCA
GeneTreeiENSGT00940000154352
HOGENOMiCLU_000534_0_0_1
InParanoidiD4A0Y6
KOiK17582
OMAiGNSTGHK
OrthoDBi290017at2759
TreeFamiTF336000

Gene expression databases

BgeeiENSRNOG00000028137 Expressed in colon and 9 other tissues

Family and domain databases

CDDicd00060 FHA, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR012568 KI67R
IPR029334 PP1-bd
IPR008984 SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF00498 FHA, 1 hit
PF08065 KI67R, 15 hits
PF15276 PP1_bind, 1 hit
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SM01295 K167R, 16 hits
SUPFAMiSSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD4A0Y6_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4A0Y6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: February 26, 2020
This is version 76 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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