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UniProtKB - D4A0R1 (D4A0R1_RAT)
Protein
Submitted name:
Zinc finger protein, multitype 2
Gene
Zfpm2
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II-specific DNA-binding transcription factor binding Source: Ensembl
- transcription coactivator activity Source: RGD
- transcription corepressor activity Source: RGD
GO - Biological processi
- cardiac muscle tissue development Source: RGD
- cell differentiation Source: GO_Central
- embryonic organ development Source: RGD
- heart development Source: RGD
- in utero embryonic development Source: RGD
- lung development Source: RGD
- negative regulation of cell death Source: RGD
- negative regulation of fat cell differentiation Source: RGD
- negative regulation of female gonad development Source: RGD
- negative regulation of transcription, DNA-templated Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- outflow tract septum morphogenesis Source: RGD
- positive regulation of cardiac muscle cell proliferation Source: RGD
- positive regulation of male gonad development Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- right ventricular cardiac muscle tissue morphogenesis Source: RGD
- vasculogenesis Source: RGD
- ventricular septum morphogenesis Source: RGD
Keywordsi
Biological process | Transcription, Transcription regulationARBA annotation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-983231, Factors involved in megakaryocyte development and platelet production |
Names & Taxonomyi
Protein namesi | Submitted name: Zinc finger protein, multitype 2Imported |
Gene namesi | Name:Zfpm2Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1306021, Zfpm2 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: RGD
Other locations
- cytoplasm Source: RGD
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000004109, Expressed in cerebellum and 19 other tissues |
Genevisiblei | D4A0R1, RN |
Interactioni
GO - Molecular functioni
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000035072 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 183 – 216 | CCHC FOG-typeInterPro annotationAdd BLAST | 34 | |
Domaini | 235 – 264 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 302 – 324 | C2H2-typeInterPro annotationAdd BLAST | 23 | |
Domaini | 481 – 514 | CCHC FOG-typeInterPro annotationAdd BLAST | 34 | |
Domaini | 620 – 653 | CCHC FOG-typeInterPro annotationAdd BLAST | 34 | |
Domaini | 787 – 820 | CCHC FOG-typeInterPro annotationAdd BLAST | 34 | |
Domaini | 1052 – 1085 | CCHC FOG-typeInterPro annotationAdd BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 41 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 326 – 378 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 576 – 623 | DisorderedSequence analysisAdd BLAST | 48 | |
Regioni | 946 – 969 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 1003 – 1032 | DisorderedSequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 15 – 31 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 326 – 340 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 341 – 370 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 946 – 964 | Polar residuesSequence analysisAdd BLAST | 19 |
Keywords - Domaini
RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00530000063823 |
HOGENOMi | CLU_010755_0_0_1 |
InParanoidi | D4A0R1 |
OMAi | LKHPMSI |
TreeFami | TF331342 |
Family and domain databases
InterProi | View protein in InterPro IPR039746, FOG IPR034731, ZF_CCHC_FOG IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR12958, PTHR12958, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 8 hits |
SUPFAMi | SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS51810, ZF_CCHC_FOG, 5 hits PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
i Sequence
Sequence statusi: Complete.
D4A0R1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
FCYIPGDDEG IQEPAESDGD SHSDKPGQPG VETDDWDGPG ELEVFQRDGE
60 70 80 90 100
RKIQSRQQLP VGTTWGPFAG KMDLNNNSLK TKAQVSMVLT AGPKWLLDVT
110 120 130 140 150
WQGVEDSKNN CIVYSKGGQL WCTTTKAISE GEELIAFVVD FDSRLQTASQ
160 170 180 190 200
MTLTEGMYPA RLLDSIQLLP QQAAMASILP TAIVNKDIFP CKSCGIWYRS
210 220 230 240 250
ERNLQAHLMY YCSGRQREAA PVSEENEDST HQISSLCPFP QCTKSFSNAR
260 270 280 290 300
ALEMHLTSHS GVKMEEFLPP GASLKCTVCS YTADSVINFH QHLFSHLTQA
310 320 330 340 350
AFRCNHCHFG FQTQRELLQH QELHVPGGKL PRESDMEHSP SGTEDSLQPA
360 370 380 390 400
TDLLARSDLS QSQKAMPTKD ASSDTELDKC EKKTQLFLTN QRPEMQPAAN
410 420 430 440 450
KQNFSYTKIK SEPSSPRLAS SPVQPNLGPS FPVGPFLSQF AFPQDITMVP
460 470 480 490 500
QASEILAKMS ELVHRRLRHG SSSYPPVIYS PLMPKGATCF ECNITFNNLD
510 520 530 540 550
NYLVHKKHYC SSRWQQMAKS PEFPSVSEKI PEALSPNTGQ TSINLLNPAA
560 570 580 590 600
HPPDPENPLL QTSCINSSTV LDLIGPNGKG HEKDFSTQAK KLPTSNNNDD
610 620 630 640 650
KINGKPVDVK NPSGPLVDGE SDPNKTTCEA CNITFSRHET YMVHKQYYCA
660 670 680 690 700
TRHDPPLKRS ASNKVPAMQR TMRTRKRRKM YEMCLPEQEQ RPPLVQQRFL
710 720 730 740 750
DVANLSNPCS STQEPTEGLG ECYHPRCDIF PGIVSKHLET SLAINKCVPV
760 770 780 790 800
PKCDTTHSSV SCLEMDVPID LSKKCLSQSE RTTASPKRLL DYHECTVCKI
810 820 830 840 850
SFNKVENYLA HKQNFCPVTA HQRNDLGQLD GKVFPNPESE RNSPEVSFER
860 870 880 890 900
NMIKCEKNGN PKQPSPNGNL FSSHLATLQG LKVFSEAAQL IATKEENKHL
910 920 930 940 950
FLPQCLYPGA IKKTKGADQL SPYYGIKPSD YIAGSLVIHN TDVEQNTNTE
960 970 980 990 1000
NESPKGQASS NGCAVPKKDS LPLLPKNRGM VIVNGGLKQD ERPTANPQQE
1010 1020 1030 1040 1050
NISQNAQHED GHKSPSWISE NPLAANENVS PGIPCAEEQL SSIAKGVNGS
1060 1070 1080 1090
TQAPSSGKYC RLCDIQFNNL SNFITHKKFY CSSHAAEHVK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07057593 Genomic DNA No translation available. AABR07057594 Genomic DNA No translation available. AABR07057595 Genomic DNA No translation available. AABR07057596 Genomic DNA No translation available. AABR07057597 Genomic DNA No translation available. AABR07057598 Genomic DNA No translation available. AABR07057599 Genomic DNA No translation available. AABR07057600 Genomic DNA No translation available. AABR07057601 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSRNOT00000029419; ENSRNOP00000035072; ENSRNOG00000004109 |
UCSCi | RGD:1306021, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07057593 Genomic DNA No translation available. AABR07057594 Genomic DNA No translation available. AABR07057595 Genomic DNA No translation available. AABR07057596 Genomic DNA No translation available. AABR07057597 Genomic DNA No translation available. AABR07057598 Genomic DNA No translation available. AABR07057599 Genomic DNA No translation available. AABR07057600 Genomic DNA No translation available. AABR07057601 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000035072 |
PTM databases
PhosphoSitePlusi | D4A0R1 |
Proteomic databases
PaxDbi | D4A0R1 |
Genome annotation databases
Ensembli | ENSRNOT00000029419; ENSRNOP00000035072; ENSRNOG00000004109 |
UCSCi | RGD:1306021, rat |
Organism-specific databases
RGDi | 1306021, Zfpm2 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00530000063823 |
HOGENOMi | CLU_010755_0_0_1 |
InParanoidi | D4A0R1 |
OMAi | LKHPMSI |
TreeFami | TF331342 |
Enzyme and pathway databases
Reactomei | R-RNO-983231, Factors involved in megakaryocyte development and platelet production |
Gene expression databases
Bgeei | ENSRNOG00000004109, Expressed in cerebellum and 19 other tissues |
Genevisiblei | D4A0R1, RN |
Family and domain databases
InterProi | View protein in InterPro IPR039746, FOG IPR034731, ZF_CCHC_FOG IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR12958, PTHR12958, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 8 hits |
SUPFAMi | SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS51810, ZF_CCHC_FOG, 5 hits PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | D4A0R1_RAT | |
Accessioni | D4A0R1Primary (citable) accession number: D4A0R1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | July 22, 2015 | |
Last modified: | January 19, 2022 | |
This is version 91 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |