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UniProtKB - D4A0R1 (D4A0R1_RAT)

Entry version 84 (22 Apr 2020)
Sequence version 3 (22 Jul 2015)
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Protein
Submitted name:

Zinc finger protein, multitype 2

Gene

Zfpm2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-983231 Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zinc finger protein, multitype 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Zfpm2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		D4A0R1

PRoteomics IDEntifications database

More...PRIDEi		D4A0R1

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		D4A0R1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000004109 Expressed in heart and 8 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		D4A0R1 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000035072

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		D4A0R1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini183 – 216CCHC FOG-typeInterPro annotationAdd BLAST34
Domaini235 – 264C2H2-typeInterPro annotationAdd BLAST30
Domaini302 – 324C2H2-typeInterPro annotationAdd BLAST23
Domaini481 – 514CCHC FOG-typeInterPro annotationAdd BLAST34
Domaini620 – 653CCHC FOG-typeInterPro annotationAdd BLAST34
Domaini787 – 820CCHC FOG-typeInterPro annotationAdd BLAST34
Domaini1052 – 1085CCHC FOG-typeInterPro annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 41DisorderedSequence analysisAdd BLAST41
Regioni326 – 378DisorderedSequence analysisAdd BLAST53
Regioni576 – 623DisorderedSequence analysisAdd BLAST48
Regioni946 – 969DisorderedSequence analysisAdd BLAST24
Regioni1003 – 1032DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 31PolyampholyteSequence analysisAdd BLAST17
Compositional biasi326 – 340PolyampholyteSequence analysisAdd BLAST15
Compositional biasi341 – 370PolarSequence analysisAdd BLAST30
Compositional biasi946 – 964PolarSequence analysisAdd BLAST19

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063823

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010755_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		D4A0R1

Identification of Orthologs from Complete Genome Data

More...OMAi		NQRPETQ

TreeFam database of animal gene trees

More...TreeFami		TF331342

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039746 FOG
IPR034731 ZF_CCHC_FOG
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

The PANTHER Classification System

More...PANTHERi		PTHR12958 PTHR12958, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355 ZnF_C2H2, 8 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667 SSF57667, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51810 ZF_CCHC_FOG, 5 hits
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D4A0R1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
FCYIPGDDEG IQEPAESDGD SHSDKPGQPG VETDDWDGPG ELEVFQRDGE 
        60         70         80         90        100
RKIQSRQQLP VGTTWGPFAG KMDLNNNSLK TKAQVSMVLT AGPKWLLDVT 
       110        120        130        140        150
WQGVEDSKNN CIVYSKGGQL WCTTTKAISE GEELIAFVVD FDSRLQTASQ 
       160        170        180        190        200
MTLTEGMYPA RLLDSIQLLP QQAAMASILP TAIVNKDIFP CKSCGIWYRS 
       210        220        230        240        250
ERNLQAHLMY YCSGRQREAA PVSEENEDST HQISSLCPFP QCTKSFSNAR 
       260        270        280        290        300
ALEMHLTSHS GVKMEEFLPP GASLKCTVCS YTADSVINFH QHLFSHLTQA 
       310        320        330        340        350
AFRCNHCHFG FQTQRELLQH QELHVPGGKL PRESDMEHSP SGTEDSLQPA 
       360        370        380        390        400
TDLLARSDLS QSQKAMPTKD ASSDTELDKC EKKTQLFLTN QRPEMQPAAN 
       410        420        430        440        450
KQNFSYTKIK SEPSSPRLAS SPVQPNLGPS FPVGPFLSQF AFPQDITMVP 
       460        470        480        490        500
QASEILAKMS ELVHRRLRHG SSSYPPVIYS PLMPKGATCF ECNITFNNLD 
       510        520        530        540        550
NYLVHKKHYC SSRWQQMAKS PEFPSVSEKI PEALSPNTGQ TSINLLNPAA 
       560        570        580        590        600
HPPDPENPLL QTSCINSSTV LDLIGPNGKG HEKDFSTQAK KLPTSNNNDD 
       610        620        630        640        650
KINGKPVDVK NPSGPLVDGE SDPNKTTCEA CNITFSRHET YMVHKQYYCA 
       660        670        680        690        700
TRHDPPLKRS ASNKVPAMQR TMRTRKRRKM YEMCLPEQEQ RPPLVQQRFL 
       710        720        730        740        750
DVANLSNPCS STQEPTEGLG ECYHPRCDIF PGIVSKHLET SLAINKCVPV 
       760        770        780        790        800
PKCDTTHSSV SCLEMDVPID LSKKCLSQSE RTTASPKRLL DYHECTVCKI 
       810        820        830        840        850
SFNKVENYLA HKQNFCPVTA HQRNDLGQLD GKVFPNPESE RNSPEVSFER 
       860        870        880        890        900
NMIKCEKNGN PKQPSPNGNL FSSHLATLQG LKVFSEAAQL IATKEENKHL 
       910        920        930        940        950
FLPQCLYPGA IKKTKGADQL SPYYGIKPSD YIAGSLVIHN TDVEQNTNTE 
       960        970        980        990       1000
NESPKGQASS NGCAVPKKDS LPLLPKNRGM VIVNGGLKQD ERPTANPQQE 
      1010       1020       1030       1040       1050
NISQNAQHED GHKSPSWISE NPLAANENVS PGIPCAEEQL SSIAKGVNGS 
      1060       1070       1080       1090
TQAPSSGKYC RLCDIQFNNL SNFITHKKFY CSSHAAEHVK
Length:1,090
Mass (Da):120,779
Last modified:July 22, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2013AF68E5D0C95F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AABR07057593 Genomic DNA No translation available.
AABR07057594 Genomic DNA No translation available.
AABR07057595 Genomic DNA No translation available.
AABR07057596 Genomic DNA No translation available.
AABR07057597 Genomic DNA No translation available.
AABR07057598 Genomic DNA No translation available.
AABR07057599 Genomic DNA No translation available.
AABR07057600 Genomic DNA No translation available.
AABR07057601 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000029419; ENSRNOP00000035072; ENSRNOG00000004109

UCSC genome browser

More...UCSCi		RGD:1306021 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07057593 Genomic DNA No translation available.
AABR07057594 Genomic DNA No translation available.
AABR07057595 Genomic DNA No translation available.
AABR07057596 Genomic DNA No translation available.
AABR07057597 Genomic DNA No translation available.
AABR07057598 Genomic DNA No translation available.
AABR07057599 Genomic DNA No translation available.
AABR07057600 Genomic DNA No translation available.
AABR07057601 Genomic DNA No translation available.

3D structure databases

SMRiD4A0R1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035072

PTM databases

PhosphoSitePlusiD4A0R1

Proteomic databases

PaxDbiD4A0R1
PRIDEiD4A0R1

Genome annotation databases

EnsembliENSRNOT00000029419; ENSRNOP00000035072; ENSRNOG00000004109
UCSCiRGD:1306021 rat

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063823
HOGENOMiCLU_010755_0_0_1
InParanoidiD4A0R1
OMAiNQRPETQ
TreeFamiTF331342

Enzyme and pathway databases

ReactomeiR-RNO-983231 Factors involved in megakaryocyte development and platelet production

Gene expression databases

BgeeiENSRNOG00000004109 Expressed in heart and 8 other tissues
GenevisibleiD4A0R1 RN

Family and domain databases

InterProiView protein in InterPro
IPR039746 FOG
IPR034731 ZF_CCHC_FOG
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR12958 PTHR12958, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS51810 ZF_CCHC_FOG, 5 hits
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD4A0R1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4A0R1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: April 22, 2020
This is version 84 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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