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Entry version 92 (07 Oct 2020)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

P53-induced protein with a death domain-like

Gene

Pidd1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-6803207, TP53 Regulates Transcription of Caspase Activators and Caspases

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S68.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
P53-induced protein with a death domain-likeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pidd1Imported
Synonyms:LOC100911519Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
6492303, LOC100911519
1311792, Pidd1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
D3ZZY5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000018710, Expressed in adult mammalian kidney and 7 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-48600N

Protein interaction database and analysis system

More...
IntActi
D3ZZY5, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000065320

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZZY5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini327 – 461ZU5InterPro annotationAdd BLAST135
Domaini462 – 603ZU5InterPro annotationAdd BLAST142
Domaini795 – 880DeathInterPro annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 21DisorderedSequence analysisAdd BLAST21
Regioni890 – 917DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi899 – 917PolarSequence analysisAdd BLAST19

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeatARBA annotation, RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619, Eukaryota
KOG4177, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161780

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017883_0_0_1

KEGG Orthology (KO)

More...
KOi
K10130

Identification of Orthologs from Complete Genome Data

More...
OMAi
WVWLEEH

Database of Orthologous Groups

More...
OrthoDBi
176487at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331183

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR019502, Peptidase_S68_pidd
IPR000906, ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00531, Death, 1 hit
PF13855, LRR_8, 1 hit
PF10461, Peptidase_S68, 1 hit
PF00791, ZU5, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00005, DEATH, 1 hit
SM00369, LRR_TYP, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50017, DEATH_DOMAIN, 1 hit
PS51450, LRR, 7 hits
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZZY5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVLEGPKP EETAAAAEDA ARPTVEAVAS RPGVPILLAG NQLNLDLRPG
60 70 80 90 100
GCRRLQYLCS QQHTQLLQVE FLRLSTHEDP RLLDDTLAKV PWSLLRLRSL
110 120 130 140 150
VLKGGQSRGA LGACLHGTLT TLPASMRDLA CLAHLDLSFN RLETLPTCVL
160 170 180 190 200
ELHSLDALLL SHNCLSELPE ALGALPTLTF LTVTHNLLER LPPTLGSLST
210 220 230 240 250
LQRLDLSENL LDTIPSEIGD LSSLRELNLA SNRLQHLPAS LAGLRSLRLL
260 270 280 290 300
VLHSNLLTSV PPGLAHLPLI TRLDLRDNQL RDLPAELLDA PFVRLQGNPL
310 320 330 340 350
GEASPAPPSP PDISQVPEMP RLFLTSDLDS FLVTPHGCSV TLACGVRLQF
360 370 380 390 400
PAGATTTPIT IHYRLWLPEP GLVSLGPHDF LLSGVLELQP HGVAFQQNVS
410 420 430 440 450
LWLLFVPPRV RVRRCREVVV RTRSDNIWND LETHLEEEAP KRRWARCQVP
460 470 480 490 500
HFSWFLVVLR PVSNTCLLPP EGALLCSSGH PGVKVTFPPG VTEEPRQVSM
510 520 530 540 550
QVVHMAGLEL RALLEESEAA VSPLLCLSQS GPPSFLQPVT VQLPLPPGVT
560 570 580 590 600
GFSLDRSHLH LLYRTPLTST WDDISTQVAL EFTHLYARFQ VTHFSWYWLW
610 620 630 640 650
YTTKTCVGGL ARKAWERLRL HRVNLIALQR RRDPEQVLLQ CLPRSKVDAT
660 670 680 690 700
LSRLLDRYRG PEPSETVEMF EGEKFFAAFE RGIDVDADRP DCVDGRICFV
710 720 730 740 750
FYSHLKNMKE VYITTALDRE AQDVRGQVSF YRGSLPMEVP EEAEAARRRK
760 770 780 790 800
GTDALWMATL PIKLPRLRGA QGSGQGTDFS LMPLNLGDAE TGFLTQSNLL
810 820 830 840 850
SVASRLGSDW PTVALHLGMP YRKLQRIRHE FRDDLDGQIR HMLFSWAESQ
860 870 880 890 900
TGQPGAVGHL VQALEQSDRQ DVAEEVRAIL ELGRHKYQDS IRRTGLAPED
910
STLPSTSALQ NPESAQA
Length:917
Mass (Da):101,823
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8954C5BF0537A5DE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07006025 Genomic DNA No translation available.
AC109542 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001099788.2, NM_001106318.2
XP_003749059.1, XM_003749011.4
XP_008772966.1, XM_008774744.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000025290; ENSRNOP00000025291; ENSRNOG00000018710
ENSRNOT00000072774; ENSRNOP00000065320; ENSRNOG00000049179

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100911519
293625

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:100911519
rno:293625

UCSC genome browser

More...
UCSCi
RGD:1311792, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07006025 Genomic DNA No translation available.
AC109542 Genomic DNA No translation available.
RefSeqiNP_001099788.2, NM_001106318.2
XP_003749059.1, XM_003749011.4
XP_008772966.1, XM_008774744.2

3D structure databases

SMRiD3ZZY5
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-48600N
IntActiD3ZZY5, 2 interactors
STRINGi10116.ENSRNOP00000065320

Protein family/group databases

MEROPSiS68.001

Proteomic databases

PRIDEiD3ZZY5

Genome annotation databases

EnsembliENSRNOT00000025290; ENSRNOP00000025291; ENSRNOG00000018710
ENSRNOT00000072774; ENSRNOP00000065320; ENSRNOG00000049179
GeneIDi100911519
293625
KEGGirno:100911519
rno:293625
UCSCiRGD:1311792, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55367
RGDi6492303, LOC100911519
1311792, Pidd1

Phylogenomic databases

eggNOGiKOG0619, Eukaryota
KOG4177, Eukaryota
GeneTreeiENSGT00940000161780
HOGENOMiCLU_017883_0_0_1
KOiK10130
OMAiWVWLEEH
OrthoDBi176487at2759
TreeFamiTF331183

Enzyme and pathway databases

ReactomeiR-RNO-6803207, TP53 Regulates Transcription of Caspase Activators and Caspases

Gene expression databases

BgeeiENSRNOG00000018710, Expressed in adult mammalian kidney and 7 other tissues

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR019502, Peptidase_S68_pidd
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF00531, Death, 1 hit
PF13855, LRR_8, 1 hit
PF10461, Peptidase_S68, 1 hit
PF00791, ZU5, 2 hits
SMARTiView protein in SMART
SM00005, DEATH, 1 hit
SM00369, LRR_TYP, 7 hits
SUPFAMiSSF47986, SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017, DEATH_DOMAIN, 1 hit
PS51450, LRR, 7 hits
PS51145, ZU5, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3ZZY5_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZZY5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: October 7, 2020
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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